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The map label for this gene is rnd [H]

Identifier: 37679238

GI number: 37679238

Start: 1057224

End: 1058396

Strand: Direct

Name: rnd [H]

Synonym: VV1054

Alternate gene names: 37679238

Gene position: 1057224-1058396 (Clockwise)

Preceding gene: 37679237

Following gene: 37679242

Centisome position: 31.52

GC content: 49.87

Gene sequence:

>1173_bases
ATGCCAGCCGAATTCCAAGGCTGGCATTTTTATTTTCAAAGCGATAGCGAGAGACGAGTGAATTACCAAATTATTACCGA
AAACCAAGACCTAGCTAGGGTATGCAGTAAAGCGCGCGAAGCAGACGTTGTGATGTTGGATACCGAGTTTGTCCGCACCC
GAACGTATTACCCACAATTGGGCTTAATTCAGCTTTTTGATGGTGACAGCCTCTCGCTGATTGATCCAACGGTGCTGACT
GATATGAGTGCGTTTACTGAGTTGCTTAACGATGCCTCGGTAATGAAAGTGCTTCACGCGTGCGGTGAGGATTTGGAAGT
GTTCCACAACGCGTTTGGCGCGATGCCGGTGCCGATGGTGGATACGCAAATCATGGCCGCATTTTTGGGTCACGGTCTAT
CGACGGGCTTTGCCGCCTTGGTCGAGCAGTACCTTAACGTGGAACTGGATAAGAGTGAGTCGCGCACGGACTGGTTGGCT
CGCCCTCTGAGTGACAAACAGCTTGAGTACGCAGCAGCAGACGTTCACTACTTGTTGCCGCTGTACGAAATCTTGCTGGA
AAAAGTGATGGCAGCGGGCTGGTGGCAAGCGGCTCAGCAAGAGAGCGAACTGCAAGCAAGCAAGCGCGTAAAAACGCCGA
ATGCCGACAATGCTTATCTCGATATCAAAGGGGCTTGGCAGCTTAAGCCAAGAGAGCTTGCGATACTCAAGCCGCTTGCG
ACTTGGCGTATGCAAGAGGCGATTCGTCGTGACTTAGCGTTGAACTTTGTTTTCAAAGAACACGACTTACTCACGGTGGC
TCGTTTAGGCCTGACGAGCTTTAAGCGCATGGAAGAAGAGGGGATGGATGTTCGTTCTGTACAGCGTCATGGCAACCGCA
TTGCTGCGATGGTGAAGTCGGCGCGTGAGACTGATCCTGAGGATTATCCAGCACCAATTGAACGCTTGATGGATTTGCCA
GGTTACAAACAACTGTTTAAAAAACTGAAAGACGAAGTCACTCACGCTTCGAAAGCGACAGGTTTAGCGAGCGAGTTTTT
AGCGTCGAAGAAGCAGACTAATCAACTGATCAGTTGGGTATGGAAACATCAGCGCGATCAAAATCGCCTGCCAGACTTGA
TGCAAGGTTGGCGCTTAGACATTCTGGGCGAAAAAATGAACAAGCTAATTTAG

Upstream 100 bases:

>100_bases
TAAGATTTTACGTCGCGTATTACGCGATGAAAATGATGCTAAGCTTGCCAAAGAGAATGAGGCAGCGTAAGCCGCGCAAA
GTGTCACGAAGAGTGTTAAA

Downstream 100 bases:

>100_bases
AGCACGTTTGGAGCATTTGCTTTATAGATAAATAAAAACAGACGGTCTAAGCCGTCTGTTTTTCTATCCGATGAATGAAG
CGCTATTTCTCTTCATCTGG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPAEFQGWHFYFQSDSERRVNYQIITENQDLARVCSKAREADVVMLDTEFVRTRTYYPQLGLIQLFDGDSLSLIDPTVLT
DMSAFTELLNDASVMKVLHACGEDLEVFHNAFGAMPVPMVDTQIMAAFLGHGLSTGFAALVEQYLNVELDKSESRTDWLA
RPLSDKQLEYAAADVHYLLPLYEILLEKVMAAGWWQAAQQESELQASKRVKTPNADNAYLDIKGAWQLKPRELAILKPLA
TWRMQEAIRRDLALNFVFKEHDLLTVARLGLTSFKRMEEEGMDVRSVQRHGNRIAAMVKSARETDPEDYPAPIERLMDLP
GYKQLFKKLKDEVTHASKATGLASEFLASKKQTNQLISWVWKHQRDQNRLPDLMQGWRLDILGEKMNKLI

Sequences:

>Translated_390_residues
MPAEFQGWHFYFQSDSERRVNYQIITENQDLARVCSKAREADVVMLDTEFVRTRTYYPQLGLIQLFDGDSLSLIDPTVLT
DMSAFTELLNDASVMKVLHACGEDLEVFHNAFGAMPVPMVDTQIMAAFLGHGLSTGFAALVEQYLNVELDKSESRTDWLA
RPLSDKQLEYAAADVHYLLPLYEILLEKVMAAGWWQAAQQESELQASKRVKTPNADNAYLDIKGAWQLKPRELAILKPLA
TWRMQEAIRRDLALNFVFKEHDLLTVARLGLTSFKRMEEEGMDVRSVQRHGNRIAAMVKSARETDPEDYPAPIERLMDLP
GYKQLFKKLKDEVTHASKATGLASEFLASKKQTNQLISWVWKHQRDQNRLPDLMQGWRLDILGEKMNKLI
>Mature_389_residues
PAEFQGWHFYFQSDSERRVNYQIITENQDLARVCSKAREADVVMLDTEFVRTRTYYPQLGLIQLFDGDSLSLIDPTVLTD
MSAFTELLNDASVMKVLHACGEDLEVFHNAFGAMPVPMVDTQIMAAFLGHGLSTGFAALVEQYLNVELDKSESRTDWLAR
PLSDKQLEYAAADVHYLLPLYEILLEKVMAAGWWQAAQQESELQASKRVKTPNADNAYLDIKGAWQLKPRELAILKPLAT
WRMQEAIRRDLALNFVFKEHDLLTVARLGLTSFKRMEEEGMDVRSVQRHGNRIAAMVKSARETDPEDYPAPIERLMDLPG
YKQLFKKLKDEVTHASKATGLASEFLASKKQTNQLISWVWKHQRDQNRLPDLMQGWRLDILGEKMNKLI

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=231, Percent_Identity=29.8701298701299, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI50301240, Length=231, Percent_Identity=29.8701298701299, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788105, Length=372, Percent_Identity=49.1935483870968, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17531757, Length=227, Percent_Identity=28.6343612334802, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=234, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161078302, Length=252, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 44655; Mature: 44524

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEFQGWHFYFQSDSERRVNYQIITENQDLARVCSKAREADVVMLDTEFVRTRTYYPQL
CCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCC
GLIQLFDGDSLSLIDPTVLTDMSAFTELLNDASVMKVLHACGEDLEVFHNAFGAMPVPMV
CEEEEECCCCCCEECHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
DTQIMAAFLGHGLSTGFAALVEQYLNVELDKSESRTDWLARPLSDKQLEYAAADVHYLLP
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
LYEILLEKVMAAGWWQAAQQESELQASKRVKTPNADNAYLDIKGAWQLKPRELAILKPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCHHHHHHHHH
TWRMQEAIRRDLALNFVFKEHDLLTVARLGLTSFKRMEEEGMDVRSVQRHGNRIAAMVKS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHH
ARETDPEDYPAPIERLMDLPGYKQLFKKLKDEVTHASKATGLASEFLASKKQTNQLISWV
HHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKHQRDQNRLPDLMQGWRLDILGEKMNKLI
HHHHCCCCCCHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PAEFQGWHFYFQSDSERRVNYQIITENQDLARVCSKAREADVVMLDTEFVRTRTYYPQL
CCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCC
GLIQLFDGDSLSLIDPTVLTDMSAFTELLNDASVMKVLHACGEDLEVFHNAFGAMPVPMV
CEEEEECCCCCCEECHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
DTQIMAAFLGHGLSTGFAALVEQYLNVELDKSESRTDWLARPLSDKQLEYAAADVHYLLP
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
LYEILLEKVMAAGWWQAAQQESELQASKRVKTPNADNAYLDIKGAWQLKPRELAILKPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCHHHHHHHHH
TWRMQEAIRRDLALNFVFKEHDLLTVARLGLTSFKRMEEEGMDVRSVQRHGNRIAAMVKS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHH
ARETDPEDYPAPIERLMDLPGYKQLFKKLKDEVTHASKATGLASEFLASKKQTNQLISWV
HHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKHQRDQNRLPDLMQGWRLDILGEKMNKLI
HHHHCCCCCCHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]