Click here to switch to the map view.

The map label for this gene is tcyP [H]

Identifier: 37679207

GI number: 37679207

Start: 1020804

End: 1022210

Strand: Direct

Name: tcyP [H]

Synonym: VV1023

Alternate gene names: 37679207

Gene position: 1020804-1022210 (Clockwise)

Preceding gene: 37679206

Following gene: 37679208

Centisome position: 30.43

GC content: 48.19

Gene sequence:

>1407_bases
ATGAGCTTATCATTTATCGCATTAAGCGTATTGTTCTTCGGGTTCTACGCGTTACTTGCGAACTTTAAAAAACAGAAGAA
AAGCTTTAACTTCCGCGTACTGAGTGCGCTTGCTGCTGGTCTGTTATTTGGCGGCGCGATTCAACTCGTATTCGGTGTTG
GTAACGTTGCTACCGCAGGATTTGCCGAGCTGATTTCTGTGTTTGGCAAAGGCTACATCAAGCTACTGCAAATGATCGTG
ATTCCACTGGTCTTCGTTGCCATGATTTCGTCAATCATGAACGTAGAGGGCGGTGGCGCTCTATCTCGTATCGCGCCCAA
AATCATCGGTATTCTACTTTTCACTTGTGCTATCTCCGCCGCTGTGGGCATCGCAAGTATTTACCTATTCGGTATCGATG
CCAATGCGCTTGTGAGTACAATTGGTACCAACAGCGCCATTGAAGCGCGCGGCAATGCTTTGGTTGCAACCCAGAGTGCA
ATGGCCAGCAGTGGCTTATCTGGCATGGCGTTATCCATTATCCCAACCAATATTTTCGACATGCTAACGGGCTCTCAGCG
CACTTCAACGCTATCGACGGTACTGTTCGGTATGTTCCTTGGCTACTGTATCCTGCAAGTGAAAAACCGTAAGCCGGAGA
AAGTGCAAAACTTCGTTGATTTCATCAATGCTGCCAAAGAAGTGGTACTTTCAATGGTACGTGAGATTCTCAAGCTGACG
CCTTACGGTGTGTTTGCTCTGATGACCACGTTCATGATGACCAACGATTTGTTCGCACTGGCAGAAATGGGGCGCTTCCT
ACTTGCAAGTTACGTGGCCATTGGTGTGATGTTTGCTATCCACTTCGTGATGGTGTCTATGTTTGGTCTATCGCCTGCGA
AGTTCATGAAGAAGACTTGGCCTGTACTCGTCTTTGGTTTTGGATCTCGCTCAAGTATGGCTGCTATTCCACTCAACGTA
GAAACGCAAACTCAGCGTTTGGGCGTGGATGAAGAAACGGCAAATATGTCAGCAACATTTGGTACCAGTATCGGCCAGAA
TGGGTGTGCGGGTATTTACCCTGCAATGCTTGCAATCATGGCGTCTCAAGTGATGGGCATTCCAGTTGATTTAAGTTTTG
TGCTACAGCTGATCGCCGTTATCGCGATTGCGTCATTCGGCATTGCCGGTGTGGGTGGCGGTGCAACGTTCGCAGCAGTG
GCGGTACTAACCATTATGGGCCTTGATATCACGGTGGTAGCGATTCTAGTTTCGATCGAAGCATTAATCGATATGGCTCG
TACTGCGCTTAACATCTCTGGTTCAATGCTGTCTGGTGTGCTTACCGCGAAGAAGAATGGCTCGTTAAATCTTGAGCAAT
ACAACGCAGAGAATGGCGCAACAGCGACCAAAGAAGCGGCGGTGTAA

Upstream 100 bases:

>100_bases
AGCGGCACGACTGCCAAAAGACGCGTTAGTTGAAATTGAAGCCATTGCCTACAAAAAGTAACGGCCATCCGGAAACCATG
AGCATCAATAGGAGACTCTC

Downstream 100 bases:

>100_bases
TGTGTAAACGAAATGGAGAGCACCCATAAGGGTGCTCTTCGGTTTTCCTAAGTTCAGTTTATTTAGGTAGTAAATATGAA
AGTTGTTGTCGTAGGCGGTA

Product: sodium/dicarboxylate symporter

Products: NA

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSLSFIALSVLFFGFYALLANFKKQKKSFNFRVLSALAAGLLFGGAIQLVFGVGNVATAGFAELISVFGKGYIKLLQMIV
IPLVFVAMISSIMNVEGGGALSRIAPKIIGILLFTCAISAAVGIASIYLFGIDANALVSTIGTNSAIEARGNALVATQSA
MASSGLSGMALSIIPTNIFDMLTGSQRTSTLSTVLFGMFLGYCILQVKNRKPEKVQNFVDFINAAKEVVLSMVREILKLT
PYGVFALMTTFMMTNDLFALAEMGRFLLASYVAIGVMFAIHFVMVSMFGLSPAKFMKKTWPVLVFGFGSRSSMAAIPLNV
ETQTQRLGVDEETANMSATFGTSIGQNGCAGIYPAMLAIMASQVMGIPVDLSFVLQLIAVIAIASFGIAGVGGGATFAAV
AVLTIMGLDITVVAILVSIEALIDMARTALNISGSMLSGVLTAKKNGSLNLEQYNAENGATATKEAAV

Sequences:

>Translated_468_residues
MSLSFIALSVLFFGFYALLANFKKQKKSFNFRVLSALAAGLLFGGAIQLVFGVGNVATAGFAELISVFGKGYIKLLQMIV
IPLVFVAMISSIMNVEGGGALSRIAPKIIGILLFTCAISAAVGIASIYLFGIDANALVSTIGTNSAIEARGNALVATQSA
MASSGLSGMALSIIPTNIFDMLTGSQRTSTLSTVLFGMFLGYCILQVKNRKPEKVQNFVDFINAAKEVVLSMVREILKLT
PYGVFALMTTFMMTNDLFALAEMGRFLLASYVAIGVMFAIHFVMVSMFGLSPAKFMKKTWPVLVFGFGSRSSMAAIPLNV
ETQTQRLGVDEETANMSATFGTSIGQNGCAGIYPAMLAIMASQVMGIPVDLSFVLQLIAVIAIASFGIAGVGGGATFAAV
AVLTIMGLDITVVAILVSIEALIDMARTALNISGSMLSGVLTAKKNGSLNLEQYNAENGATATKEAAV
>Mature_467_residues
SLSFIALSVLFFGFYALLANFKKQKKSFNFRVLSALAAGLLFGGAIQLVFGVGNVATAGFAELISVFGKGYIKLLQMIVI
PLVFVAMISSIMNVEGGGALSRIAPKIIGILLFTCAISAAVGIASIYLFGIDANALVSTIGTNSAIEARGNALVATQSAM
ASSGLSGMALSIIPTNIFDMLTGSQRTSTLSTVLFGMFLGYCILQVKNRKPEKVQNFVDFINAAKEVVLSMVREILKLTP
YGVFALMTTFMMTNDLFALAEMGRFLLASYVAIGVMFAIHFVMVSMFGLSPAKFMKKTWPVLVFGFGSRSSMAAIPLNVE
TQTQRLGVDEETANMSATFGTSIGQNGCAGIYPAMLAIMASQVMGIPVDLSFVLQLIAVIAIASFGIAGVGGGATFAAVA
VLTIMGLDITVVAILVSIEALIDMARTALNISGSMLSGVLTAKKNGSLNLEQYNAENGATATKEAAV

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=284, Percent_Identity=23.943661971831, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788024, Length=462, Percent_Identity=41.5584415584416, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1790514, Length=443, Percent_Identity=26.410835214447, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789947, Length=440, Percent_Identity=23.1818181818182, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789473, Length=283, Percent_Identity=27.208480565371, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71983106, Length=257, Percent_Identity=25.2918287937743, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983099, Length=257, Percent_Identity=25.2918287937743, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193206654, Length=457, Percent_Identity=22.1006564551422, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193206505, Length=431, Percent_Identity=22.969837587007, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583025, Length=431, Percent_Identity=23.2018561484919, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137668, Length=431, Percent_Identity=23.2018561484919, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583023, Length=431, Percent_Identity=23.2018561484919, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49083; Mature: 48952

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSFIALSVLFFGFYALLANFKKQKKSFNFRVLSALAAGLLFGGAIQLVFGVGNVATAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FAELISVFGKGYIKLLQMIVIPLVFVAMISSIMNVEGGGALSRIAPKIIGILLFTCAISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AVGIASIYLFGIDANALVSTIGTNSAIEARGNALVATQSAMASSGLSGMALSIIPTNIFD
HHHHHHHHHEECCHHHHHHHHCCCCCHHCCCCEEEEEHHHHHHCCCCCCEEHHHHHHHHH
MLTGSQRTSTLSTVLFGMFLGYCILQVKNRKPEKVQNFVDFINAAKEVVLSMVREILKLT
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYGVFALMTTFMMTNDLFALAEMGRFLLASYVAIGVMFAIHFVMVSMFGLSPAKFMKKTW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
PVLVFGFGSRSSMAAIPLNVETQTQRLGVDEETANMSATFGTSIGQNGCAGIYPAMLAIM
CEEEEECCCCCCCEEEECCCCHHHHHCCCCHHHCCCCHHCCCCCCCCCCCHHHHHHHHHH
ASQVMGIPVDLSFVLQLIAVIAIASFGIAGVGGGATFAAVAVLTIMGLDITVVAILVSIE
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDMARTALNISGSMLSGVLTAKKNGSLNLEQYNAENGATATKEAAV
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHCCC
>Mature Secondary Structure 
SLSFIALSVLFFGFYALLANFKKQKKSFNFRVLSALAAGLLFGGAIQLVFGVGNVATAG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FAELISVFGKGYIKLLQMIVIPLVFVAMISSIMNVEGGGALSRIAPKIIGILLFTCAISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AVGIASIYLFGIDANALVSTIGTNSAIEARGNALVATQSAMASSGLSGMALSIIPTNIFD
HHHHHHHHHEECCHHHHHHHHCCCCCHHCCCCEEEEEHHHHHHCCCCCCEEHHHHHHHHH
MLTGSQRTSTLSTVLFGMFLGYCILQVKNRKPEKVQNFVDFINAAKEVVLSMVREILKLT
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYGVFALMTTFMMTNDLFALAEMGRFLLASYVAIGVMFAIHFVMVSMFGLSPAKFMKKTW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
PVLVFGFGSRSSMAAIPLNVETQTQRLGVDEETANMSATFGTSIGQNGCAGIYPAMLAIM
CEEEEECCCCCCCEEEECCCCHHHHHCCCCHHHCCCCHHCCCCCCCCCCCHHHHHHHHHH
ASQVMGIPVDLSFVLQLIAVIAIASFGIAGVGGGATFAAVAVLTIMGLDITVVAILVSIE
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDMARTALNISGSMLSGVLTAKKNGSLNLEQYNAENGATATKEAAV
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA