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The map label for this gene is ribD [H]

Identifier: 37679045

GI number: 37679045

Start: 866213

End: 867319

Strand: Direct

Name: ribD [H]

Synonym: VV0861

Alternate gene names: 37679045

Gene position: 866213-867319 (Clockwise)

Preceding gene: 161486648

Following gene: 161486647

Centisome position: 25.82

GC content: 52.12

Gene sequence:

>1107_bases
ATGTCGGAATTTACTGCAATCGATAGACAAATGATGCTGCGCGCCATTGCTTTGGCGAAACGCGGCCTCTATACCACCGC
ACCTAATCCTAATGTTGGTTGTGTATTACTGCGCGACGGCGAAATTGTCGGAGAAGGTTTTCACTTTCGCGCTGGCGAGC
CTCATGCGGAAGTGCACGCGATGCGCATGGCTGCTGACAAAGCCAAAGGTGCGACCGCTTATGTCACGCTAGAGCCTTGT
TCACACTATGGTCGAACGCCCCCGTGTGCGGAAGGCTTAATTAAAGCTGGGGTAAGCCGAGTGGTGTGTGCAATGGAAGA
CCCAAACCCCCAAGTCGCGGGGAGAGGTTTTGCCATGTTGCGAGAGGCAGGGATCGAGGTATCGGTGGGCCTACTTCAAG
CAGAAGCAGAAGCACTGAATCCTGCTTTTATTAAGCGAATGAAAACGGGCATGCCGTTTGTTCAACTCAAAATGGCCGCG
TCCCTCGATGGTCAAACGGCTTTAGCCAATGGCAAGAGTCAGTGGATCACCTCACCACAAGCTCGCCGAGATGTGCAACG
TTTTCGGGCGCAATCAGGGGCGATTTTGTCCACCAGTAAAACGGTGCTCGCTGACAATGCGTCTCTTAATGTTCGTTGGT
CCGAGTTACCTTCATCTGTGCAACGCGCTTTACCGCAAGAACAGCTGCGTCAGCCCACTCGTGTTGTGTTAGACAGACAA
GCCGAGCTTTCGCCGGAGCTAAAACTTTACCAAACCGAGGGTGAGCGACTCATTGTTGGTCCTAAAGGCGATCTCCCTGC
ACCTTTGGATGAGCACGGACAGATCAATTTGCCCCAACTGTTCACGCAACTGAGTCAAACACAGTCAATCAACCATCTTT
GGGTTGAAGCGGGAGCAACGCTGGCCGCAGGACTGATAAAACACCAGTTGGTGGACGAACTGATTGTTTACCTCGCCCCC
AAACTGATGGGCAGTGATGGACGTGGATTGATGGGTGCGCTCGGTTTGCAAGCCATGTCACACGTGATCGATTTAGACAT
TAAAGATGTGCGAATGGTTGGGCCGGATATCCGCATCATTGCGCACATCAAAGCAAAAGAAAGTTGA

Upstream 100 bases:

>100_bases
TATATTCGCTTTGCTTCCGTATACCGTAGTTTTGAAGATATTCGTGAATTTGGTGAAGAAATCGCCAGATTGGAAGATTA
ACGCAAGGTAACGGTTCACC

Downstream 100 bases:

>100_bases
TATGTTCACAGGAATTATCGAAGCAGTTGGAACCTTGGCTGCGATTACCCCGAGAGGGGAAGATATTACCGTTACGGTTA
ACACAGGCAAGCTCGATATG

Product: pyrimidine reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSEFTAIDRQMMLRAIALAKRGLYTTAPNPNVGCVLLRDGEIVGEGFHFRAGEPHAEVHAMRMAADKAKGATAYVTLEPC
SHYGRTPPCAEGLIKAGVSRVVCAMEDPNPQVAGRGFAMLREAGIEVSVGLLQAEAEALNPAFIKRMKTGMPFVQLKMAA
SLDGQTALANGKSQWITSPQARRDVQRFRAQSGAILSTSKTVLADNASLNVRWSELPSSVQRALPQEQLRQPTRVVLDRQ
AELSPELKLYQTEGERLIVGPKGDLPAPLDEHGQINLPQLFTQLSQTQSINHLWVEAGATLAAGLIKHQLVDELIVYLAP
KLMGSDGRGLMGALGLQAMSHVIDLDIKDVRMVGPDIRIIAHIKAKES

Sequences:

>Translated_368_residues
MSEFTAIDRQMMLRAIALAKRGLYTTAPNPNVGCVLLRDGEIVGEGFHFRAGEPHAEVHAMRMAADKAKGATAYVTLEPC
SHYGRTPPCAEGLIKAGVSRVVCAMEDPNPQVAGRGFAMLREAGIEVSVGLLQAEAEALNPAFIKRMKTGMPFVQLKMAA
SLDGQTALANGKSQWITSPQARRDVQRFRAQSGAILSTSKTVLADNASLNVRWSELPSSVQRALPQEQLRQPTRVVLDRQ
AELSPELKLYQTEGERLIVGPKGDLPAPLDEHGQINLPQLFTQLSQTQSINHLWVEAGATLAAGLIKHQLVDELIVYLAP
KLMGSDGRGLMGALGLQAMSHVIDLDIKDVRMVGPDIRIIAHIKAKES
>Mature_367_residues
SEFTAIDRQMMLRAIALAKRGLYTTAPNPNVGCVLLRDGEIVGEGFHFRAGEPHAEVHAMRMAADKAKGATAYVTLEPCS
HYGRTPPCAEGLIKAGVSRVVCAMEDPNPQVAGRGFAMLREAGIEVSVGLLQAEAEALNPAFIKRMKTGMPFVQLKMAAS
LDGQTALANGKSQWITSPQARRDVQRFRAQSGAILSTSKTVLADNASLNVRWSELPSSVQRALPQEQLRQPTRVVLDRQA
ELSPELKLYQTEGERLIVGPKGDLPAPLDEHGQINLPQLFTQLSQTQSINHLWVEAGATLAAGLIKHQLVDELIVYLAPK
LMGSDGRGLMGALGLQAMSHVIDLDIKDVRMVGPDIRIIAHIKAKES

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=359, Percent_Identity=58.4958217270195, Blast_Score=420, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39887; Mature: 39756

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTAIDRQMMLRAIALAKRGLYTTAPNPNVGCVLLRDGEIVGEGFHFRAGEPHAEVHA
CCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCEEECCCEEECCCCCHHHHHH
MRMAADKAKGATAYVTLEPCSHYGRTPPCAEGLIKAGVSRVVCAMEDPNPQVAGRGFAML
HHHHHHHCCCCEEEEEECCHHHCCCCCHHHHHHHHHCHHHEEEEECCCCCCCCCCHHHHH
REAGIEVSVGLLQAEAEALNPAFIKRMKTGMPFVQLKMAASLDGQTALANGKSQWITSPQ
HHCCCEEEEHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCHHCCCCHHCCCCHH
ARRDVQRFRAQSGAILSTSKTVLADNASLNVRWSELPSSVQRALPQEQLRQPTRVVLDRQ
HHHHHHHHHHHCCCEEECCCEEEECCCEEEEEHHHHHHHHHHCCCHHHHCCCHHHHHCCC
AELSPELKLYQTEGERLIVGPKGDLPAPLDEHGQINLPQLFTQLSQTQSINHLWVEAGAT
CCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHH
LAAGLIKHQLVDELIVYLAPKLMGSDGRGLMGALGLQAMSHVIDLDIKDVRMVGPDIRII
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEECCCEEEE
AHIKAKES
EEEECCCC
>Mature Secondary Structure 
SEFTAIDRQMMLRAIALAKRGLYTTAPNPNVGCVLLRDGEIVGEGFHFRAGEPHAEVHA
CCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCEEECCCEEECCCCCHHHHHH
MRMAADKAKGATAYVTLEPCSHYGRTPPCAEGLIKAGVSRVVCAMEDPNPQVAGRGFAML
HHHHHHHCCCCEEEEEECCHHHCCCCCHHHHHHHHHCHHHEEEEECCCCCCCCCCHHHHH
REAGIEVSVGLLQAEAEALNPAFIKRMKTGMPFVQLKMAASLDGQTALANGKSQWITSPQ
HHCCCEEEEHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCHHCCCCHHCCCCHH
ARRDVQRFRAQSGAILSTSKTVLADNASLNVRWSELPSSVQRALPQEQLRQPTRVVLDRQ
HHHHHHHHHHHCCCEEECCCEEEECCCEEEEEHHHHHHHHHHCCCHHHHCCCHHHHHCCC
AELSPELKLYQTEGERLIVGPKGDLPAPLDEHGQINLPQLFTQLSQTQSINHLWVEAGAT
CCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHH
LAAGLIKHQLVDELIVYLAPKLMGSDGRGLMGALGLQAMSHVIDLDIKDVRMVGPDIRII
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEECCCEEEE
AHIKAKES
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]