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The map label for this gene is guaB [H]

Identifier: 37678959

GI number: 37678959

Start: 780530

End: 781999

Strand: Direct

Name: guaB [H]

Synonym: VV0775

Alternate gene names: 37678959

Gene position: 780530-781999 (Clockwise)

Preceding gene: 37678957

Following gene: 37678960

Centisome position: 23.27

GC content: 49.8

Gene sequence:

>1470_bases
TTGCAAATGCTAAGAATTGCCAAAGAAGCGCTGACATTCGATGACGTACTACTCGTGCCAGCTCACTCCACTGTTCTCCC
AAACACAGCTGATCTTCGCACTCAGTTGACCAAAAACATCACACTGAACATTCCTATGATCTCTGCCTCGATGGATACCG
TGACGGAAGCTCGTCTCGCTATTGCACTTGCGCAGGAAGGTGGCATTGGCTTTATTCACAAGAATATGTCTATTGAACAG
CAAGCTGCTGAAGTTCGTAAAGTGAAGAAGTTTGAAGCGGGTGTGGTAACGGATCCTGTCACTGTAAGCCCTGATGCGAC
CATCGCGGATGTGGTTGCGCTGACCGACAAGCACGGTTTTGCTGGTTTCCCAGTGGTTACTGAAAGCAATGAGCTAGTGG
GTATCATCACCGGTCGTGACGTACGTTTTGTGACAGACCTGTCTAAGAAAGTCTCTTCTGTCATGACACCAAAAGAAAAC
TTGGCTGCCGTAAAAGAAGGTGCAACTCGCGCTGAAGTGCAAGAAAAAATGCATGAAGCCCGCGTTGAGAAAGTACTGGT
TGTGAATGATGATTTCCAATTGACCGGCATGATCACGGCAAAAGACTTCCACAAAGCAGAACGTAAACCAAACGCATGTA
AAGATGCGCAAGGTCGTCTACGCGTAGGCGCAGCGGTTGGTGCGGGCGCGGGTAACGAAGAACGCGTTGCTGCACTGGTT
GAAGCCGGTGTTGATGTACTGTTGATTGACTCTTCACATGGTCACTCAGAAGGTGTTCTACAACGCATTCGTGATACACG
AGCAGCATTCCCTAATCTTGATATCATTGGCGGCAACGTTGCGACAGCGGCGGGTGCAAAAGCCCTGATTGAAGCGGGTG
TTAGCGCAGTAAAAGTGGGTATTGGCCCAGGCTCTATCTGTACGACTCGTATCGTTACTGGCGTAGGTGTTCCACAAATC
ACCGCGATTGCAGACGCAGCGGAAGTAGCGAACCAATATGGCGTGCCAGTGATTGCTGATGGCGGTATCCGTTTCTCTGG
TGATATCTGTAAAGCGATTGCGGCGGGCGCATCTTGTGTGATGGTTGGTTCTATGTTTGCGGGTACTGAAGAAGCACCGG
GTGAAGTGATTCTTTACAACGGCCGTTCTTACAAAGCTTACCGTGGTATGGGTTCTTTGGGCGCAATGTCTCAAGGTTCT
TCAGATCGTTACTTCCAGTCAGACAACGCAGCAGACAAGCTGGTACCAGAAGGTATCGAAGGCCGTATCGCGTACAAAGG
CCGCCTAAAAGAGATCGTTCACCAGCAAATGGGTGGTCTACGTTCAAGCATGGGCCTAACAGGCAGTGCAACGATCGAAG
AAATGCGCACTAAAGCTGAATTCGTACGCATTACGGGCGCGGGCATGCAAGAGTCTCACGTGCACGATGTACAAATCACC
AAAGAAGCACCTAACTATCGCTTGGGTTAA

Upstream 100 bases:

>100_bases
TATCTAATCCAAATGTAGCAAGTTGCTTAAAGCCTGCTGCCCTCATTATGCGAAACGATGAGATTGGATTGTTCTTTTTA
CCTCTACATATTGTGAGATA

Downstream 100 bases:

>100_bases
TTGACCCTGAGTTGAAATTTAAAGCTTATGGGGAGCGAGATGGGCTCCCCATCCACCAAATTTGATATCGAGATTAACCT
CAATGACTAAAAATATTCAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MQMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNITLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAEVRKVKKFEAGVVTDPVTVSPDATIADVVALTDKHGFAGFPVVTESNELVGIITGRDVRFVTDLSKKVSSVMTPKEN
LAAVKEGATRAEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDAQGRLRVGAAVGAGAGNEERVAALV
EAGVDVLLIDSSHGHSEGVLQRIRDTRAAFPNLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAEVANQYGVPVIADGGIRFSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILYNGRSYKAYRGMGSLGAMSQGS
SDRYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEEMRTKAEFVRITGAGMQESHVHDVQIT
KEAPNYRLG

Sequences:

>Translated_489_residues
MQMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNITLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAEVRKVKKFEAGVVTDPVTVSPDATIADVVALTDKHGFAGFPVVTESNELVGIITGRDVRFVTDLSKKVSSVMTPKEN
LAAVKEGATRAEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDAQGRLRVGAAVGAGAGNEERVAALV
EAGVDVLLIDSSHGHSEGVLQRIRDTRAAFPNLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAEVANQYGVPVIADGGIRFSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILYNGRSYKAYRGMGSLGAMSQGS
SDRYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEEMRTKAEFVRITGAGMQESHVHDVQIT
KEAPNYRLG
>Mature_489_residues
MQMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNITLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAEVRKVKKFEAGVVTDPVTVSPDATIADVVALTDKHGFAGFPVVTESNELVGIITGRDVRFVTDLSKKVSSVMTPKEN
LAAVKEGATRAEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDAQGRLRVGAAVGAGAGNEERVAALV
EAGVDVLLIDSSHGHSEGVLQRIRDTRAAFPNLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAEVANQYGVPVIADGGIRFSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILYNGRSYKAYRGMGSLGAMSQGS
SDRYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEEMRTKAEFVRITGAGMQESHVHDVQIT
KEAPNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=487, Percent_Identity=42.5051334702259, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI156616279, Length=487, Percent_Identity=42.5051334702259, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=487, Percent_Identity=42.5051334702259, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=487, Percent_Identity=42.5051334702259, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=490, Percent_Identity=41.8367346938776, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI217035152, Length=488, Percent_Identity=42.2131147540984, Blast_Score=355, Evalue=7e-98,
Organism=Homo sapiens, GI217035148, Length=487, Percent_Identity=41.4784394250513, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI217035150, Length=487, Percent_Identity=39.0143737166324, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI156104880, Length=273, Percent_Identity=35.5311355311355, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=35.6275303643725, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=35.6275303643725, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=35.6275303643725, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=35.6275303643725, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=82.340862422998, Blast_Score=757, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=35.2941176470588, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=36.4, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.8104265402844, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.1344537815126, Blast_Score=158, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=40.3726708074534, Blast_Score=348, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=39.7515527950311, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.7515527950311, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=41.4201183431953, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=101, Percent_Identity=41.5841584158416, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=40.6639004149378, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=40.6639004149378, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=41.1363636363636, Blast_Score=305, Evalue=6e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51537; Mature: 51537

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNITLNIPMISASMDTVTEARLA
CCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEEEEEECCHHHHHHHHEE
IALAQEGGIGFIHKNMSIEQQAAEVRKVKKFEAGVVTDPVTVSPDATIADVVALTDKHGF
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHEEEECCCCC
AGFPVVTESNELVGIITGRDVRFVTDLSKKVSSVMTPKENLAAVKEGATRAEVQEKMHEA
CCCCEEECCCCEEEEEECCCEEHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
RVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDAQGRLRVGAAVGAGAGNEERVAALV
HHCEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
EAGVDVLLIDSSHGHSEGVLQRIRDTRAAFPNLDIIGGNVATAAGAKALIEAGVSAVKVG
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAIADAAEVANQYGVPVIADGGIRFSGDICKAIAAGASCV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCEE
MVGSMFAGTEEAPGEVILYNGRSYKAYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIE
EEHHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
GRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEEMRTKAEFVRITGAGMQESHVHDVQIT
CEEEEHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEE
KEAPNYRLG
CCCCCCCCC
>Mature Secondary Structure
MQMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNITLNIPMISASMDTVTEARLA
CCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEEEEEECCHHHHHHHHEE
IALAQEGGIGFIHKNMSIEQQAAEVRKVKKFEAGVVTDPVTVSPDATIADVVALTDKHGF
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHEEEECCCCC
AGFPVVTESNELVGIITGRDVRFVTDLSKKVSSVMTPKENLAAVKEGATRAEVQEKMHEA
CCCCEEECCCCEEEEEECCCEEHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
RVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDAQGRLRVGAAVGAGAGNEERVAALV
HHCEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
EAGVDVLLIDSSHGHSEGVLQRIRDTRAAFPNLDIIGGNVATAAGAKALIEAGVSAVKVG
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAIADAAEVANQYGVPVIADGGIRFSGDICKAIAAGASCV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCEE
MVGSMFAGTEEAPGEVILYNGRSYKAYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIE
EEHHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
GRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEEMRTKAEFVRITGAGMQESHVHDVQIT
CEEEEHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEE
KEAPNYRLG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]