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The map label for this gene is tyrA

Identifier: 37678886

GI number: 37678886

Start: 700385

End: 701512

Strand: Direct

Name: tyrA

Synonym: VV0702

Alternate gene names: 37678886

Gene position: 700385-701512 (Clockwise)

Preceding gene: 229047216

Following gene: 37678890

Centisome position: 20.88

GC content: 48.85

Gene sequence:

>1128_bases
ATGGCAGTTGAACTGAACGCATTGCGTGAACAGATTGATGCAGTAGACAAACAGATGTTGGCGCTATTGGCTCAGCGCTT
GGCATTGGTAGAGCAAGTTGGCCATGTGAAAAGCCAACATGGCTTACCGATTTATGCACCCGATAGAGAAGCGGCGATGC
TGGCCTCTCGTCGTGCAGAAGCCGAAAAAATCGGCGTACCTCCACAGCTCATTGAGGACATTTTGCGCCGAACCATGCGT
GAATCTTATGCCAGTGAGAAAGATTCTGGGTTTAAATGTCTCAATCCGGACTTGCGTTCTGTGGTGATCATTGGTGGTCA
TGGCCAGTTGGGTGGTCTGTTTGCTCGCATGTTTACCCTCTCGGGTTACCAGGTCAAAATCTTAGGCAGTAAGGATTGGC
ACCGCGCTGATGAGATATTGGATGGGGCAGGATTGGTGGTGGTTACCGTGCCGATTCATTTAACCCAAGGGGTGATTGAA
AAGCTGACCCAACTGCCATCGGATTGCATTTTGTGTGACCTCACTTCGATCAAGTCGAAGCCGCTGAAAACCATGCTCGA
TGTGCACTCTGGGCCGGTTGTTGGTTTGCACCCTATGTTTGGTCCCGATGTGCCGAGTTTAGCCAAGCAAGTGATTGTCT
ACTGTGATGGTCGAGGTGCTGAGCAATATCAGTGGTTACTGCAGCAGTTTAAGATTTGGGGGGCAAGCTTGTGCCAAATT
GAGGCCAGCGAACACGACCACGGCATGACGTTAATTCAAGCATTAAGGCACTTTACTTCCTTTGCCTATGGCATGCATTT
GAGTCAGGAAAATCCAAGTCTCGATAAACTGCTGAAACTGAGCTCGCCCATTTACCGTCTTGAGTTAGCGATGGTAGGGC
GTCTGTTTGCCCAAGACCCAAACTTGTATGGCGACATTATTCTTTCGTCGCAAGAGAACATCGACATGATCAAGCGTTTC
CATCGCCGCTTTGGCGAGGCACTAGAGATGTTAGATCAGCACGATAAAGCGCGTTTTGTTGAACGTTTCACGCAAGTGAG
TGATTGGTTTGGGGGGTATTCGCAGCAGTTTATGGCGGAAAGCCAAAACTTACTCAAACAAGCGAATGACAACTTGCATC
GTGATTAA

Upstream 100 bases:

>100_bases
ATCAATTGGCAGGCAACTGAGGCACTATTGCGTAAAGCACACAAAGAGTTAGTGCCACATTTAGAAAACCGTCTCAAATA
AGGATAGAGCAAGGTAAATC

Downstream 100 bases:

>100_bases
CATTTAAGCGTATTAGAAATAGAAAGAGCAGCCTGATGCTGCTCTTTCTATTTTCGGCTTACCCATTGCATTAGTTGGTT
TGCAAGCTTGGGTCGAGGCT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAVELNALREQIDAVDKQMLALLAQRLALVEQVGHVKSQHGLPIYAPDREAAMLASRRAEAEKIGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPDLRSVVIIGGHGQLGGLFARMFTLSGYQVKILGSKDWHRADEILDGAGLVVVTVPIHLTQGVIE
KLTQLPSDCILCDLTSIKSKPLKTMLDVHSGPVVGLHPMFGPDVPSLAKQVIVYCDGRGAEQYQWLLQQFKIWGASLCQI
EASEHDHGMTLIQALRHFTSFAYGMHLSQENPSLDKLLKLSSPIYRLELAMVGRLFAQDPNLYGDIILSSQENIDMIKRF
HRRFGEALEMLDQHDKARFVERFTQVSDWFGGYSQQFMAESQNLLKQANDNLHRD

Sequences:

>Translated_375_residues
MAVELNALREQIDAVDKQMLALLAQRLALVEQVGHVKSQHGLPIYAPDREAAMLASRRAEAEKIGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPDLRSVVIIGGHGQLGGLFARMFTLSGYQVKILGSKDWHRADEILDGAGLVVVTVPIHLTQGVIE
KLTQLPSDCILCDLTSIKSKPLKTMLDVHSGPVVGLHPMFGPDVPSLAKQVIVYCDGRGAEQYQWLLQQFKIWGASLCQI
EASEHDHGMTLIQALRHFTSFAYGMHLSQENPSLDKLLKLSSPIYRLELAMVGRLFAQDPNLYGDIILSSQENIDMIKRF
HRRFGEALEMLDQHDKARFVERFTQVSDWFGGYSQQFMAESQNLLKQANDNLHRD
>Mature_374_residues
AVELNALREQIDAVDKQMLALLAQRLALVEQVGHVKSQHGLPIYAPDREAAMLASRRAEAEKIGVPPQLIEDILRRTMRE
SYASEKDSGFKCLNPDLRSVVIIGGHGQLGGLFARMFTLSGYQVKILGSKDWHRADEILDGAGLVVVTVPIHLTQGVIEK
LTQLPSDCILCDLTSIKSKPLKTMLDVHSGPVVGLHPMFGPDVPSLAKQVIVYCDGRGAEQYQWLLQQFKIWGASLCQIE
ASEHDHGMTLIQALRHFTSFAYGMHLSQENPSLDKLLKLSSPIYRLELAMVGRLFAQDPNLYGDIILSSQENIDMIKRFH
RRFGEALEMLDQHDKARFVERFTQVSDWFGGYSQQFMAESQNLLKQANDNLHRD

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=371, Percent_Identity=64.6900269541779, Blast_Score=511, Evalue=1e-146,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42115; Mature: 41984

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVELNALREQIDAVDKQMLALLAQRLALVEQVGHVKSQHGLPIYAPDREAAMLASRRAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
AEKIGVPPQLIEDILRRTMRESYASEKDSGFKCLNPDLRSVVIIGGHGQLGGLFARMFTL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKILGSKDWHRADEILDGAGLVVVTVPIHLTQGVIEKLTQLPSDCILCDLTSIKSK
CCCEEEEECCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCHHEEEEHHHHCCC
PLKTMLDVHSGPVVGLHPMFGPDVPSLAKQVIVYCDGRGAEQYQWLLQQFKIWGASLCQI
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCHHEEE
EASEHDHGMTLIQALRHFTSFAYGMHLSQENPSLDKLLKLSSPIYRLELAMVGRLFAQDP
ECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLYGDIILSSQENIDMIKRFHRRFGEALEMLDQHDKARFVERFTQVSDWFGGYSQQFMAE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SQNLLKQANDNLHRD
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVELNALREQIDAVDKQMLALLAQRLALVEQVGHVKSQHGLPIYAPDREAAMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
AEKIGVPPQLIEDILRRTMRESYASEKDSGFKCLNPDLRSVVIIGGHGQLGGLFARMFTL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKILGSKDWHRADEILDGAGLVVVTVPIHLTQGVIEKLTQLPSDCILCDLTSIKSK
CCCEEEEECCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCHHEEEEHHHHCCC
PLKTMLDVHSGPVVGLHPMFGPDVPSLAKQVIVYCDGRGAEQYQWLLQQFKIWGASLCQI
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCHHEEE
EASEHDHGMTLIQALRHFTSFAYGMHLSQENPSLDKLLKLSSPIYRLELAMVGRLFAQDP
ECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLYGDIILSSQENIDMIKRFHRRFGEALEMLDQHDKARFVERFTQVSDWFGGYSQQFMAE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SQNLLKQANDNLHRD
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]