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The map label for this gene is cvrA [H]

Identifier: 37678880

GI number: 37678880

Start: 695062

End: 696858

Strand: Direct

Name: cvrA [H]

Synonym: VV0696

Alternate gene names: 37678880

Gene position: 695062-696858 (Clockwise)

Preceding gene: 37678879

Following gene: 37678883

Centisome position: 20.72

GC content: 49.92

Gene sequence:

>1797_bases
ATGCAAACCGAAACAACCGCATTATGGCTTGCGGGTATAGGGGTAATAGGGCTCGCCTGTCAGTGGTTTGCTTGGCGGTT
AAAACTGCCTGCAATTCTATTTTTATTGGTGGCGGGCTTATTGGTTGGGCCGGTGAGTGGCTTGCTTCAGCCAGAGCTGC
TTTTGGGCGATTTGCTTTTTCCTATGGTGTCATTAGCGGTCGCTGTGATTCTGTTTGAAGGCAGCTTAACGCTGAACTTT
CGCGAAATACGCGGTGTCAGTAACACTGTTTGGAGCATAGTGACGCTCGGTGCGGTGGTTTCATGGGGATTAACCAGTAC
CGCAACTCACTATCTGCTGGGGTTTGATTGGCCGCTTGCGTTGTTGTTTGGTAGCTTGACTGTAGTAACCGGACCAACGG
TGATTGTGCCGCTGCTGCGCACCGTTAGGCCATCGACGCGTCTCTCCAATATTTTGCGTTGGGAGGGGATTTTGATCGAT
CCGCTTGGTGCTCTGTTTGTGGTGATGGTGTATGAGTTCATTGTCTCCAGCAGTGAAACGCACAGTTTGGTGGTATTGGC
GTGGATTCTGGCCATTGGCCTTGGATTAGGCGTTCTGTTTGGTCAGTTTCTCGCGGTGGTACTGCGCCGTAGCTGGCTGC
CTGAATACCTACAACCGTTTGCCGTTTTAAGCTTAGTGCTGGGCGTGTTTGCGCTCTCGAATCATCTGGAGCATGAATCG
GGTCTATTAACGGTCACAGTGATGGGGATGTGGTTAGCCAACTCCAAAGGGGTGGATATCAAGCATATTCTTCACTTTAA
AGAGCATCTCACCATTCTCTTCATTACTGGCTTGTTCATTTTGTTGGCGGCGCGTATCCAGCCGGAAGACTTTTACACAC
TCGGCATCAGCGCCTTGGTCTTATTCGCGTTTATTCAGTTTGTCTCTCGCCCGGTCTCTATCTATCTTGCGACGCTGCGC
AGCTCGCTTAATGGTAAGGAAAAGGCCTTTCTGGCTTGGGTGGCACCGCGTGGCATTGTCGCCGCGTCCATTTCGTCGTT
GTTTGCGATCAAGTTAGAATCACTCGGCATGTCTGAGGCTGCGTTGTTAGTGCCACTTACCTTTATGGTGATTATTGGCA
CTGTGGTGCTGCAAAGTGCAACGGCTCGGCCAGTGGCGGTGGCACTAGGGGTGTCAGAACCCGCTCCAAAAGGTTTCTTG
ATCATCGGAGCGAACGATGTCGCGCGTACATTAGCGCAGGCAATCAACAAGTACGATTGCCGCGTGGTGTTAACGGATTC
GAACTGGGATTACATTCGTCAAGCGCGTATGGCTGGACTGGATAACTACTTTGGCAACCCGGTATCAAGCCACGCTGATG
AGTATCTTAACTTAATTGGCATCGGGCATGTGGTGGCGCTGAGCCCTGATCGCTACTTCAATATTATGGCGTGTATGCAC
TTTCTCAACGACTTCAGTGATAAGCGGATTTTCTGTTTATACGATAAGTCCAATGGCAATGGTTCGGGTGACAAACATTC
GGTGTCCGATGGTTACAAGGGGCTGCCATTCTTAGATGAAGCGATCAGTTATAAAAAGTTAGCCAGTCTGATCAACCAAG
GGGCGGAAGTGCGTCACACCAAGATCAGTGAAAACTACACGTACGCAGATTATCGTGAAACTCACGCGAATAATTACGTG
TTGCCGCTGTTTGTGGTAGACACCAATGGGCGTGTGCAAATTTGCCACAACAGTGCGAATTTCTCGCCAAAAGAAGGCGA
GACGATTGTCTCTTTGATTAAGGTGCAAGAAGCCTAA

Upstream 100 bases:

>100_bases
TTTGTGAAGGGACAGAGCAAGCACAAAAATTCCGCATGGAATGGCAGCGTGGTTGGAATGAATACCAAAACTAATTAACC
CAACGGATGAGGCAACGGAT

Downstream 100 bases:

>100_bases
TGTCACGCGGTGACAGGTATCGACTCGTCACCGCGTGTTATCTAGGCTTTGGGATAGAGGACACCGAGGCTCGCCAAGCG
GCTCGCGCCAGTCACTTCGG

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGLLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRSWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDNYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA

Sequences:

>Translated_598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGLLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRSWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDNYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
>Mature_598_residues
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGLLQPELLLGDLLFPMVSLAVAVILFEGSLTLNF
REIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLALLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILID
PLGALFVVMVYEFIVSSSETHSLVVLAWILAIGLGLGVLFGQFLAVVLRRSWLPEYLQPFAVLSLVLGVFALSNHLEHES
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALVLFAFIQFVSRPVSIYLATLR
SSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEAALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFL
IIGANDVARTLAQAINKYDCRVVLTDSNWDYIRQARMAGLDNYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHTKISENYTYADYRETHANNYV
LPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=335, Percent_Identity=25.9701492537313, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65398; Mature: 65398

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGLLQPELLLGDLLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
PMVSLAVAVILFEGSLTLNFREIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
LLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILIDPLGALFVVMVYEFIVSSSET
HHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLVVLAWILAIGLGLGVLFGQFLAVVLRRSWLPEYLQPFAVLSLVLGVFALSNHLEHES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALV
CEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFAFIQFVSRPVSIYLATLRSSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEA
HHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
ALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFLIIGANDVARTLAQAINKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCC
RVVLTDSNWDYIRQARMAGLDNYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
EEEEECCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHT
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
KISENYTYADYRETHANNYVLPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
ECCCCCCCCCHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQTETTALWLAGIGVIGLACQWFAWRLKLPAILFLLVAGLLVGPVSGLLQPELLLGDLLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
PMVSLAVAVILFEGSLTLNFREIRGVSNTVWSIVTLGAVVSWGLTSTATHYLLGFDWPLA
HHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
LLFGSLTVVTGPTVIVPLLRTVRPSTRLSNILRWEGILIDPLGALFVVMVYEFIVSSSET
HHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCC
HSLVVLAWILAIGLGLGVLFGQFLAVVLRRSWLPEYLQPFAVLSLVLGVFALSNHLEHES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLTVTVMGMWLANSKGVDIKHILHFKEHLTILFITGLFILLAARIQPEDFYTLGISALV
CEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFAFIQFVSRPVSIYLATLRSSLNGKEKAFLAWVAPRGIVAASISSLFAIKLESLGMSEA
HHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
ALLVPLTFMVIIGTVVLQSATARPVAVALGVSEPAPKGFLIIGANDVARTLAQAINKYDC
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCC
RVVLTDSNWDYIRQARMAGLDNYFGNPVSSHADEYLNLIGIGHVVALSPDRYFNIMACMH
EEEEECCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHH
FLNDFSDKRIFCLYDKSNGNGSGDKHSVSDGYKGLPFLDEAISYKKLASLINQGAEVRHT
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
KISENYTYADYRETHANNYVLPLFVVDTNGRVQICHNSANFSPKEGETIVSLIKVQEA
ECCCCCCCCCHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]