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The map label for this gene is lspA

Identifier: 37678872

GI number: 37678872

Start: 688143

End: 688649

Strand: Direct

Name: lspA

Synonym: VV0688

Alternate gene names: 37678872

Gene position: 688143-688649 (Clockwise)

Preceding gene: 37678871

Following gene: 37678873

Centisome position: 20.51

GC content: 46.35

Gene sequence:

>507_bases
ATGAGCGGTAAAGCGCAAATATTCAAACAAACGGGTGTACGTTGGTTATGGCTGGCACTGGTGGTGTTTTTAGCCGATAT
CGGTATTAAATTCATTGTGATGGAAAACATGGGGTATGGCTGGGCAAATCGCATTGAGGTTTTGCCTTTCTTTAATCTGC
TCTATGTGCATAACTACGGTGCCGCATTTAGCTTTTTGAGCGATCAAGCCGGTTGGCAACGCTGGTTATTTACTGGTATT
GCGTTTGTGGTCACGGGTCTATTGACCTACTGGATGAGCAAGCTACCAGCGGCAGAGAAATGGAATAATGTCGCTTATGC
CATGATCATTGGTGGTGCGATTGGCAACGTGTTTGATCGCATGGTGCATGGCTTTGTTGTGGATTACCTCGACTTTTATT
GGGGTACTTACCATTGGCCTGCGTTCAACTTAGCCGACACGGCAATTTGTCTTGGCGCGGCGATGATCATTCTCGATGGC
TTCCGGAAAAAGGAAGAAGAGAAGTAA

Upstream 100 bases:

>100_bases
CGAAGCGCGTAAGTTCGCTTAATCGGTCTCTTTAATACGATTGAACTTTTTTTAAATTTTATAGCCCCAGTATCGACTGG
GGTTATTTTTAGGAAGAAAG

Downstream 100 bases:

>100_bases
TCTTTGCGAGATCGCGAATAACCCTAAGCGTCGTCGGTTGATTCTGGCGACGCTTTTTAGTATACCCGTCATATTTGAAG
CAGCAGCGTTGTTGACTGCG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGI
AFVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDRMVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDG
FRKKEEEK

Sequences:

>Translated_168_residues
MSGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGI
AFVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDRMVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDG
FRKKEEEK
>Mature_167_residues
SGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGIA
FVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDRMVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDGF
RKKEEEK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=51.8292682926829, Blast_Score=181, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_VIBVU (Q8DES8)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759498.1
- GeneID:   1177460
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0506
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK00376
- BioCyc:   VVUL216895:VV1_0506-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19201; Mature: 19069

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 119-119 ACT_SITE 146-146

Signals:

None

Transmembrane regions:

HASH(0x163608ec)-; HASH(0x157f175c)-; HASH(0x14e493a4)-; HASH(0x15b48a68)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYG
CCCHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
AAFSFLSDQAGWQRWLFTGIAFVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHHHHHHHHHHH
MVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDGFRKKEEEK
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYG
CCHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
AAFSFLSDQAGWQRWLFTGIAFVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHHHHHHHHHHH
MVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDGFRKKEEEK
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA