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The map label for this gene is zraR [H]

Identifier: 37678854

GI number: 37678854

Start: 667503

End: 668852

Strand: Direct

Name: zraR [H]

Synonym: VV0670

Alternate gene names: 37678854

Gene position: 667503-668852 (Clockwise)

Preceding gene: 37678853

Following gene: 37678855

Centisome position: 19.9

GC content: 46.52

Gene sequence:

>1350_bases
GTGAAAGGGTTGTATATGGCTACTCAGTTTAAGATGGATTCTGTACCGGGGTCATTGGTAGTGGTTGGTGGTACTTATGA
GCCTTGGTTGTCCGTTTTGGAGCAGGTGGGCTGGAAGTGCCATCAATGTGCGGATTTACGCAAAGTGGACGCGCTGTTAG
AAGATATTGGGCCATGCATCGGCATTGTTGACCTTAGCCATGATGAGTTCAGTCTCAATGGCATCGCTAATCTTGTGAGT
ACACACAAGCACGTGCGCTGGCTCGCCTTTATTCGTGAACAGCAACTCAGCTCTGACACGATTTGCCAGTTTATCGTTAA
CTTTTGTATCGACTTTTTCACCGCACCTATCCCTGATGCGCAACTGCTCAGTACGATAGGCCATCAATTGGGCATGTTAA
AGCTTGAGAAGAAGGTTTGGCCGACGTTTGGCAATAATCAAGATATGGGACTGATTGGGGAATCGGTTCCTTTGAAGCGC
CTACGCGATCAAATTAAACGCATTGGTCCTACCGATGTGAGCATTCTGATCAATGGGGAAAATGGCTCAGGAAAAGAAAC
GGTCGCTCGAGCCATTCATAAAATCTCATCGCGTGCGATGAAGCCATTCTTTTCTGTCAAATGTCGTGCAATGAGCGAGC
AACGTTTTCAAGCGGATGTTTTTGGCATTGGGGCTGACGCAAATGCAGGGCCGTCAATACTAGAGCAGGCTGATGGTGGC
ACGGTGCTGTTTAATGACATTCTAACCATTTCCAAAACTCAGCAACTGCACCTTCTTCGTTTCTTGCAAGAAGGAACGAT
AGAAACCAGCGATGGTATGAAGAAGGTCAATGTCCGCATTTTGACGGCGAATGCTTCCGATATTGAAAAAGCATTGATCG
ATGGGGATTTTAGTGAAGAGCTTTACCACTACATCAATGTGCTGCGGATTAATGTGCCAAGTCTCAAAGAGCGTGCCAGT
GACATCACCTTGTTGGCTCGTTACTACCTGCAAGAGTACTCAAAAGAGTATAACGCGCAGGCAAAAGGCTATTCTGAAGA
AGCGCTGAGAGCTTTGATGCGTTATTACTGGCCTGGCAATGTACGCGAGCTGATGAATCAAATTAAGCGTGCTGTCTTGA
TGTCAGATAGCGTGATCATCGATGTGCCGCAATTGGATCTTCCTAAACGTGGCGATAGTAAACGCAGCTTAAAAAATATC
CGTGAGAAAAGTGAGCGCGATGCGCTATTGCTGGTACTGGAATCTCATTCTGGTCAGGTCTCTAATGCCGCCAAAGAATT
GGGGGTTTCACGTGCGACGATGTATCGACTGCTAAACAAACACAATTTGATTTCCGAACAAACGGTGTAG

Upstream 100 bases:

>100_bases
TCCAAGTATTAGTAATTGAGTCTAGAATTAATTAACTGTCTCATATTTGAAACAGACTTATGAATCATTAGTCTCGATAA
TGTAACTAACGATCGAAATA

Downstream 100 bases:

>100_bases
CGGAATATCCTGTTTAAATCACCCAAAGCTTGAGGCCATTCTATTGAATGGCCTTTTTACATTCAGATAATCATCTAACA
ACCTCATATTGCTAAGGTGA

Product: sigma-54 dependent transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKGLYMATQFKMDSVPGSLVVVGGTYEPWLSVLEQVGWKCHQCADLRKVDALLEDIGPCIGIVDLSHDEFSLNGIANLVS
THKHVRWLAFIREQQLSSDTICQFIVNFCIDFFTAPIPDAQLLSTIGHQLGMLKLEKKVWPTFGNNQDMGLIGESVPLKR
LRDQIKRIGPTDVSILINGENGSGKETVARAIHKISSRAMKPFFSVKCRAMSEQRFQADVFGIGADANAGPSILEQADGG
TVLFNDILTISKTQQLHLLRFLQEGTIETSDGMKKVNVRILTANASDIEKALIDGDFSEELYHYINVLRINVPSLKERAS
DITLLARYYLQEYSKEYNAQAKGYSEEALRALMRYYWPGNVRELMNQIKRAVLMSDSVIIDVPQLDLPKRGDSKRSLKNI
REKSERDALLLVLESHSGQVSNAAKELGVSRATMYRLLNKHNLISEQTV

Sequences:

>Translated_449_residues
MKGLYMATQFKMDSVPGSLVVVGGTYEPWLSVLEQVGWKCHQCADLRKVDALLEDIGPCIGIVDLSHDEFSLNGIANLVS
THKHVRWLAFIREQQLSSDTICQFIVNFCIDFFTAPIPDAQLLSTIGHQLGMLKLEKKVWPTFGNNQDMGLIGESVPLKR
LRDQIKRIGPTDVSILINGENGSGKETVARAIHKISSRAMKPFFSVKCRAMSEQRFQADVFGIGADANAGPSILEQADGG
TVLFNDILTISKTQQLHLLRFLQEGTIETSDGMKKVNVRILTANASDIEKALIDGDFSEELYHYINVLRINVPSLKERAS
DITLLARYYLQEYSKEYNAQAKGYSEEALRALMRYYWPGNVRELMNQIKRAVLMSDSVIIDVPQLDLPKRGDSKRSLKNI
REKSERDALLLVLESHSGQVSNAAKELGVSRATMYRLLNKHNLISEQTV
>Mature_449_residues
MKGLYMATQFKMDSVPGSLVVVGGTYEPWLSVLEQVGWKCHQCADLRKVDALLEDIGPCIGIVDLSHDEFSLNGIANLVS
THKHVRWLAFIREQQLSSDTICQFIVNFCIDFFTAPIPDAQLLSTIGHQLGMLKLEKKVWPTFGNNQDMGLIGESVPLKR
LRDQIKRIGPTDVSILINGENGSGKETVARAIHKISSRAMKPFFSVKCRAMSEQRFQADVFGIGADANAGPSILEQADGG
TVLFNDILTISKTQQLHLLRFLQEGTIETSDGMKKVNVRILTANASDIEKALIDGDFSEELYHYINVLRINVPSLKERAS
DITLLARYYLQEYSKEYNAQAKGYSEEALRALMRYYWPGNVRELMNQIKRAVLMSDSVIIDVPQLDLPKRGDSKRSLKNI
REKSERDALLLVLESHSGQVSNAAKELGVSRATMYRLLNKHNLISEQTV

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=357, Percent_Identity=31.6526610644258, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788905, Length=344, Percent_Identity=31.6860465116279, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788550, Length=426, Percent_Identity=31.2206572769953, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=30.5295950155763, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1790299, Length=332, Percent_Identity=31.9277108433735, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87082117, Length=309, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=30.8176100628931, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=31.5457413249211, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789087, Length=297, Percent_Identity=31.6498316498317, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787583, Length=304, Percent_Identity=29.6052631578947, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786524, Length=314, Percent_Identity=29.9363057324841, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081858, Length=289, Percent_Identity=26.9896193771626, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789828, Length=252, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50304; Mature: 50304

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLYMATQFKMDSVPGSLVVVGGTYEPWLSVLEQVGWKCHQCADLRKVDALLEDIGPCI
CCCCEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCE
GIVDLSHDEFSLNGIANLVSTHKHVRWLAFIREQQLSSDTICQFIVNFCIDFFTAPIPDA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCH
QLLSTIGHQLGMLKLEKKVWPTFGNNQDMGLIGESVPLKRLRDQIKRIGPTDVSILINGE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
NGSGKETVARAIHKISSRAMKPFFSVKCRAMSEQRFQADVFGIGADANAGPSILEQADGG
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCC
TVLFNDILTISKTQQLHLLRFLQEGTIETSDGMKKVNVRILTANASDIEKALIDGDFSEE
EEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHH
LYHYINVLRINVPSLKERASDITLLARYYLQEYSKEYNAQAKGYSEEALRALMRYYWPGN
HHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
VRELMNQIKRAVLMSDSVIIDVPQLDLPKRGDSKRSLKNIREKSERDALLLVLESHSGQV
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCH
SNAAKELGVSRATMYRLLNKHNLISEQTV
HHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKGLYMATQFKMDSVPGSLVVVGGTYEPWLSVLEQVGWKCHQCADLRKVDALLEDIGPCI
CCCCEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCE
GIVDLSHDEFSLNGIANLVSTHKHVRWLAFIREQQLSSDTICQFIVNFCIDFFTAPIPDA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCH
QLLSTIGHQLGMLKLEKKVWPTFGNNQDMGLIGESVPLKRLRDQIKRIGPTDVSILINGE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
NGSGKETVARAIHKISSRAMKPFFSVKCRAMSEQRFQADVFGIGADANAGPSILEQADGG
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCC
TVLFNDILTISKTQQLHLLRFLQEGTIETSDGMKKVNVRILTANASDIEKALIDGDFSEE
EEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHH
LYHYINVLRINVPSLKERASDITLLARYYLQEYSKEYNAQAKGYSEEALRALMRYYWPGN
HHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
VRELMNQIKRAVLMSDSVIIDVPQLDLPKRGDSKRSLKNIREKSERDALLLVLESHSGQV
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCH
SNAAKELGVSRATMYRLLNKHNLISEQTV
HHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]