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The map label for this gene is cysC

Identifier: 37678598

GI number: 37678598

Start: 409584

End: 410207

Strand: Direct

Name: cysC

Synonym: VV0414

Alternate gene names: 37678598

Gene position: 409584-410207 (Clockwise)

Preceding gene: 37678597

Following gene: 37678600

Centisome position: 12.21

GC content: 48.24

Gene sequence:

>624_bases
ATGAGCAGCGTTATCGCGCAAAAAGATGAAAATGTCGTTTGGCATCAACATGCTGTGACTAAAACGCAGCGCGCAGATTT
AAAACAGCAAAAGCCAGCCGTGCTTTGGTTTACGGGATTGTCTGGTGCGGGCAAATCGACAGTGGCTGGTGCGCTGGAAA
ATCGGCTTGCTGAACAAGGTTTTCATACTTATCTATTGGATGGAGACAACGTACGTCACGGCTTGTGCAGTGATCTTGGT
TTTTCGACGCAAGATCGTCGTGAAAACATTCGCCGTATCGGTGAGTTAGCTAAGTTGATGGCTGATGCGGGATTGATCGT
GTTGACGGCATTTATTTCTCCTCACCGCGCTGAGCGTCAGTTGGTGCGTGATTTATTGCCGGAAGGGGAGTTTATTGAAG
TTTTCGTCAATACGTCATTAGAAGTGTGCGAACAACGCGATCCAAAAGGTTTGTATAAAAAAGCACGTGCAGGCGAAATT
GCCAACTTCACAGGAATCGACTCTGAATATGAGGTACCACTCAATCCAGAGATTGACCTGCCTGCGGGAGAAAAAGGCAT
CGAAGCGCTGGTGGATTTGCTGGTGGAGCAGCTCACTCTGCGTGGTGTGATTTCCCCACGTTAG

Upstream 100 bases:

>100_bases
TTGGATTATTTGAAAATTGGTGTGCCGATCTCTTTGGTGTATTCGGTGCTGGTGTTGACTCTGATTCCGATTTTCTTCCC
GTTTTAAAAAAGGATTTTCT

Downstream 100 bases:

>100_bases
TACTGTTAACTGAATTTTTGTATGACAAGAAGTGAGTGTCGCAGCGCGAGACTCACTTTTTTATTGTGATTCATTTTATG
TGGATAGCTTGACGTTATTG

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSSVIAQKDENVVWHQHAVTKTQRADLKQQKPAVLWFTGLSGAGKSTVAGALENRLAEQGFHTYLLDGDNVRHGLCSDLG
FSTQDRRENIRRIGELAKLMADAGLIVLTAFISPHRAERQLVRDLLPEGEFIEVFVNTSLEVCEQRDPKGLYKKARAGEI
ANFTGIDSEYEVPLNPEIDLPAGEKGIEALVDLLVEQLTLRGVISPR

Sequences:

>Translated_207_residues
MSSVIAQKDENVVWHQHAVTKTQRADLKQQKPAVLWFTGLSGAGKSTVAGALENRLAEQGFHTYLLDGDNVRHGLCSDLG
FSTQDRRENIRRIGELAKLMADAGLIVLTAFISPHRAERQLVRDLLPEGEFIEVFVNTSLEVCEQRDPKGLYKKARAGEI
ANFTGIDSEYEVPLNPEIDLPAGEKGIEALVDLLVEQLTLRGVISPR
>Mature_206_residues
SSVIAQKDENVVWHQHAVTKTQRADLKQQKPAVLWFTGLSGAGKSTVAGALENRLAEQGFHTYLLDGDNVRHGLCSDLGF
STQDRRENIRRIGELAKLMADAGLIVLTAFISPHRAERQLVRDLLPEGEFIEVFVNTSLEVCEQRDPKGLYKKARAGEIA
NFTGIDSEYEVPLNPEIDLPAGEKGIEALVDLLVEQLTLRGVISPR

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=207, Percent_Identity=49.2753623188406, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI34447231, Length=204, Percent_Identity=49.0196078431373, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI62912492, Length=204, Percent_Identity=49.0196078431373, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1789107, Length=194, Percent_Identity=67.5257731958763, Blast_Score=259, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17542422, Length=209, Percent_Identity=50.2392344497608, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322852, Length=196, Percent_Identity=49.4897959183673, Blast_Score=194, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24667032, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24667028, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24667036, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI116007838, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24667044, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24667040, Length=203, Percent_Identity=44.3349753694581, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_VIBVU (Q8DE75)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759705.1
- ProteinModelPortal:   Q8DE75
- SMR:   Q8DE75
- GeneID:   1177668
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0723
- HOGENOM:   HBG309946
- OMA:   ITITAFV
- ProtClustDB:   PRK03846
- BioCyc:   VVUL216895:VV1_0723-MONOMER
- BRENDA:   2.7.1.25
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 22886; Mature: 22755

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: ACT_SITE 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVIAQKDENVVWHQHAVTKTQRADLKQQKPAVLWFTGLSGAGKSTVAGALENRLAEQG
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCC
FHTYLLDGDNVRHGLCSDLGFSTQDRRENIRRIGELAKLMADAGLIVLTAFISPHRAERQ
CEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
LVRDLLPEGEFIEVFVNTSLEVCEQRDPKGLYKKARAGEIANFTGIDSEYEVPLNPEIDL
HHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PAGEKGIEALVDLLVEQLTLRGVISPR
CCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSVIAQKDENVVWHQHAVTKTQRADLKQQKPAVLWFTGLSGAGKSTVAGALENRLAEQG
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCC
FHTYLLDGDNVRHGLCSDLGFSTQDRRENIRRIGELAKLMADAGLIVLTAFISPHRAERQ
CEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
LVRDLLPEGEFIEVFVNTSLEVCEQRDPKGLYKKARAGEIANFTGIDSEYEVPLNPEIDL
HHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PAGEKGIEALVDLLVEQLTLRGVISPR
CCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA