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The map label for this gene is 37678556

Identifier: 37678556

GI number: 37678556

Start: 381384

End: 382724

Strand: Direct

Name: 37678556

Synonym: VV0372

Alternate gene names: NA

Gene position: 381384-382724 (Clockwise)

Preceding gene: 37678555

Following gene: 37678557

Centisome position: 11.37

GC content: 47.13

Gene sequence:

>1341_bases
ATGCAAGTCATTCACCATGGGGGAAAGGATACCGTCACAGGTTCTTGTCATGAGTTTCGCGCTGCGGGTATCGCACTCTT
AATCGATTGTGGGCTTTTCCAAGGGAAAGATGCGCGGCCTCCGGAAGTGGATTTCCCTGTCAAACATATTGATGCTTTAG
TGCTGACTCATGCGCACATCGATCATATTGGTCGTATTCCTTGGCTACTTGCTGCAGGATTTTCTGGTTCTATCTACTGT
ACGGAAGCGACTGCTGAACTCGTTCCACTGATGTTGGAGGATGGGTTAAGGTTACAGTTAGGCTTAAACCAAAAACAGTT
ACACCAAGTGCTCGATTTGGTCAAAAAACGCTTAAAACCTGTGAAGTATGGAGAATGGCTAAGGCTGACTCCTCGCATAA
AAAATGGCAATCGGGCTTCGCGCTTTGTTTCTCATGCTTTAGAAAACTACCTCTATCTGCGTTTTAATCCTGCAGGTCAT
ATACTGGGCTCGGCATATTTGGAGTTTAAGCTACCAAACGACGAAGTTGTGGTGTTCTCGGGGGACTTAGGGCCTCGAAA
TACGCCACTACTGCCAGATCCCATTTCTCCTCCTCGAGCCGATTATCTGTATATAGAAAGCACTTATGGCGATAAATTGC
ATGAAAGTGTTGAAGAAAGAGGAGAGCGCCTCAAGTCGATCATCAATCGCTCATTGCAAGACGGTGGCACCATCTTGATT
CCTGCGTTTAGTGTCGGCCGCACACAAGAGTTGTTGTTTGATATTGAGCAGTTGATATTTGAGCATAATATCGGCACCGA
CATCCCTATTATTCTCGACTCGCCATTAGACAAAAGAGTAACTCAATCGTATCGCCGTTTTAAAAAACTATGGGGAAGGG
AGGCGAGGCGGCGGCTGGAGGTTCATCGCCATCCGTTGGCCTTTAAACAGTGCATAACGATAGATGATTATCGTCAACAT
AAAGCATTAGTGAATCGTCTCGCATCAACGGGGGAGCCAGCGATTGTGGTTGCTGCATCTGGCATGTGCCAAGGTGGCCG
GATTATGGACTATCTCCAAGCGTTGTTGCCAGATGAGCGTACGGATGTGTTGTTTGCTGGATATCAGGCTAACGGTACTT
TGGGGCGTGAGATTCAGTCTGGTGAGAAAACGGTACAAATTGAGCAGAAAATGGTGGAGGTTCGCGCTCAGATACATACG
ATGTCTGGCTACTCGGCCCATGCAGACCAAGCAGATCTACTGGCGTTTATTCAAGGTATTGCGCAAAAGCCGAAGGAGAT
TCATTGGATCCATGGTGAAGACGATGCAAAGCAAAGTCTGCTTCGAGCCATGCAGTTTTAG

Upstream 100 bases:

>100_bases
GGATCTGTATAAAAATCTCCGTACTACGATCCGATAAGTGCGTTATTAGCTTTGTGCCGTTTCGTTGTGAAGGGGTGCTT
TAGGGGAGCAAGGAGTAAGC

Downstream 100 bases:

>100_bases
GTTTCTCGTTTCTTTTGTTGCTACTCTCCATTTCTGTCTTTTACTTGCTTTAGTCCCTAGTCCCTAGTCCCTAGTCCCTA
GTCCTTTATCTCTTATCTTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNQKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRFVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEVVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLDKRVTQSYRRFKKLWGREARRRLEVHRHPLAFKQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQANGTLGREIQSGEKTVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHWIHGEDDAKQSLLRAMQF

Sequences:

>Translated_446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNQKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRFVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEVVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLDKRVTQSYRRFKKLWGREARRRLEVHRHPLAFKQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQANGTLGREIQSGEKTVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHWIHGEDDAKQSLLRAMQF
>Mature_446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNQKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRFVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEVVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLDKRVTQSYRRFKKLWGREARRRLEVHRHPLAFKQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQANGTLGREIQSGEKTVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHWIHGEDDAKQSLLRAMQF

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=443, Percent_Identity=26.86230248307, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI7706427, Length=446, Percent_Identity=26.6816143497758, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=29.0909090909091, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32564696, Length=449, Percent_Identity=26.5033407572383, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323307, Length=460, Percent_Identity=24.7826086956522, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24648013, Length=453, Percent_Identity=26.2693156732892, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI21358523, Length=456, Percent_Identity=28.2894736842105, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50174; Mature: 50174

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHI
CCCEECCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DHIGRIPWLLAAGFSGSIYCTEATAELVPLMLEDGLRLQLGLNQKQLHQVLDLVKKRLKP
HHHCCCHHHEECCCCCCEEEECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC
VKYGEWLRLTPRIKNGNRASRFVSHALENYLYLRFNPAGHILGSAYLEFKLPNDEVVVFS
CCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCHHCCCEEEEEECCCCCEEEEE
GDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLDKRVTQSYRRFKKLWGREARRRLE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHRHPLAFKQCITIDDYRQHKALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDER
HHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
TDVLFAGYQANGTLGREIQSGEKTVQIEQKMVEVRAQIHTMSGYSAHADQADLLAFIQGI
CCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AQKPKEIHWIHGEDDAKQSLLRAMQF
HCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHI
CCCEECCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DHIGRIPWLLAAGFSGSIYCTEATAELVPLMLEDGLRLQLGLNQKQLHQVLDLVKKRLKP
HHHCCCHHHEECCCCCCEEEECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC
VKYGEWLRLTPRIKNGNRASRFVSHALENYLYLRFNPAGHILGSAYLEFKLPNDEVVVFS
CCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCHHCCCEEEEEECCCCCEEEEE
GDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLDKRVTQSYRRFKKLWGREARRRLE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHRHPLAFKQCITIDDYRQHKALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDER
HHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
TDVLFAGYQANGTLGREIQSGEKTVQIEQKMVEVRAQIHTMSGYSAHADQADLLAFIQGI
CCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AQKPKEIHWIHGEDDAKQSLLRAMQF
HCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA