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The map label for this gene is ugd [H]

Identifier: 37678549

GI number: 37678549

Start: 375513

End: 376694

Strand: Direct

Name: ugd [H]

Synonym: VV0365

Alternate gene names: 37678549

Gene position: 375513-376694 (Clockwise)

Preceding gene: 37678548

Following gene: 37678550

Centisome position: 11.19

GC content: 44.84

Gene sequence:

>1182_bases
ATGACAGGAAATGTTATGCGAATCACCGTCGTTGGGGCTGGCTACGTCGGCCTGGCTAACGCTGCACTTTTGGCACAGTA
CCATTCCATTACTCTGCTCGATGTAGACTCTAAAAGAGTCGAACAAATCAATGCCCAAAGTAGCCCAATCGTAGATGCGG
ATATTGAGCGGTTCTTATCGTCGGGGGCGCTTCAGCTTACGGCCACCACATCACCACAAATTGCCTACCACGATGCGCAG
CTGATTATTGTTGCTACTCCTACAAACTACGATCCCATTACCAATGGTTTTGATACTGCTTCTGTTGAACAGGTGATTAA
GGATGCGATTCAGATTAGCCCGAATGCTACGATTCTTATCCGTTCGACTGTGCCAGTCGGGTTTACAGAAAGAATGCGTG
CTCAAGCGAAAAGGTGCAATATTCTCTTTGCTCCTGAGTTTCTGCGTGAGGGTAAGGCGCTGTACGACAATCTCTTTCCT
TCTCGTATTGTCATCGGAGAACAAAGTGAACGTGGGCAAAAAATTGCGGAATTATTTGCCAACGCTGCCGAGAAAAGGGA
TGTGCCCATTCTACTGACTAACCCAACCGAAGCTGAAGCGATCAAGTTGTTTTCAAACACTTATTTGGCGATGCGTATCG
CTTACTTCAACGAGTTGGACTCCTATGCAGAAGCGCATGGCTTAGATGCTCGTCAGATTATTCAAGGGGTTGGCTTAGAC
CCTCGTATTGGCAATCACTACAACAACCCATCATTTGGTTATGGCGGTTACTGCTTGCCAAAAGATACCAAGCAACTGTT
GGCGAACTACCAAGATGTACCGAATAACATCATTGGTGCCATTGTTGATGCGAACCGTACCCGTAAAGATTTTGTTGCTG
AGTCGATTTTGAAGCGCAACCCCAAAGTCGTGGGTATTTATCGTTTAATCATGAAAGCGGGTTCGGATAATTTTCGCGCT
TCCTCGATTCAAGGAATCATGAAACGTATCAAGGCCAAAGACATTGAAGTTGTGGTTTATGAGCCTGTTTTAAAAGAGGC
TGAATTTTTCCATTCTCGTGTAATCAAAGATTTGAATGAATTTAAGCAAACAGCGGACGTGATAGTCTCAAATCGCATGG
TGGAAGAATTAGTTGACGTTGCAGATAAAGTTTACACCCGCGATTTGTTTGGTAGTGATTAA

Upstream 100 bases:

>100_bases
TATTTATCTTCTGCCATATCGGCCTTTCTCTTCCTTTCTTGTTACCTTAGCTTCTTAGAGGTGTAACATTCAGTTGTTGA
TATAGCGTGTAACGTTGTCA

Downstream 100 bases:

>100_bases
GGTAGGTTAAGAGAAGGTTGCTAGGGACTAAGTACTAGGGAAGAGCAGGAAGTAAGGTTTCTTTCGCTCTTGCTCTTTCT
AGTAATCTAGCTCCTAGTAG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTGNVMRITVVGAGYVGLANAALLAQYHSITLLDVDSKRVEQINAQSSPIVDADIERFLSSGALQLTATTSPQIAYHDAQ
LIIVATPTNYDPITNGFDTASVEQVIKDAIQISPNATILIRSTVPVGFTERMRAQAKRCNILFAPEFLREGKALYDNLFP
SRIVIGEQSERGQKIAELFANAAEKRDVPILLTNPTEAEAIKLFSNTYLAMRIAYFNELDSYAEAHGLDARQIIQGVGLD
PRIGNHYNNPSFGYGGYCLPKDTKQLLANYQDVPNNIIGAIVDANRTRKDFVAESILKRNPKVVGIYRLIMKAGSDNFRA
SSIQGIMKRIKAKDIEVVVYEPVLKEAEFFHSRVIKDLNEFKQTADVIVSNRMVEELVDVADKVYTRDLFGSD

Sequences:

>Translated_393_residues
MTGNVMRITVVGAGYVGLANAALLAQYHSITLLDVDSKRVEQINAQSSPIVDADIERFLSSGALQLTATTSPQIAYHDAQ
LIIVATPTNYDPITNGFDTASVEQVIKDAIQISPNATILIRSTVPVGFTERMRAQAKRCNILFAPEFLREGKALYDNLFP
SRIVIGEQSERGQKIAELFANAAEKRDVPILLTNPTEAEAIKLFSNTYLAMRIAYFNELDSYAEAHGLDARQIIQGVGLD
PRIGNHYNNPSFGYGGYCLPKDTKQLLANYQDVPNNIIGAIVDANRTRKDFVAESILKRNPKVVGIYRLIMKAGSDNFRA
SSIQGIMKRIKAKDIEVVVYEPVLKEAEFFHSRVIKDLNEFKQTADVIVSNRMVEELVDVADKVYTRDLFGSD
>Mature_392_residues
TGNVMRITVVGAGYVGLANAALLAQYHSITLLDVDSKRVEQINAQSSPIVDADIERFLSSGALQLTATTSPQIAYHDAQL
IIVATPTNYDPITNGFDTASVEQVIKDAIQISPNATILIRSTVPVGFTERMRAQAKRCNILFAPEFLREGKALYDNLFPS
RIVIGEQSERGQKIAELFANAAEKRDVPILLTNPTEAEAIKLFSNTYLAMRIAYFNELDSYAEAHGLDARQIIQGVGLDP
RIGNHYNNPSFGYGGYCLPKDTKQLLANYQDVPNNIIGAIVDANRTRKDFVAESILKRNPKVVGIYRLIMKAGSDNFRAS
SIQGIMKRIKAKDIEVVVYEPVLKEAEFFHSRVIKDLNEFKQTADVIVSNRMVEELVDVADKVYTRDLFGSD

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=367, Percent_Identity=28.3378746594005, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI296040443, Length=354, Percent_Identity=24.5762711864407, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI296040438, Length=266, Percent_Identity=29.6992481203008, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=68.0412371134021, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI48994968, Length=399, Percent_Identity=24.812030075188, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=397, Percent_Identity=29.2191435768262, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136908, Length=367, Percent_Identity=27.7929155313352, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43552; Mature: 43421

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNVMRITVVGAGYVGLANAALLAQYHSITLLDVDSKRVEQINAQSSPIVDADIERFLS
CCCCEEEEEEEECCHHHHHHHHHHHHHHEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHC
SGALQLTATTSPQIAYHDAQLIIVATPTNYDPITNGFDTASVEQVIKDAIQISPNATILI
CCCEEEEECCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
RSTVPVGFTERMRAQAKRCNILFAPEFLREGKALYDNLFPSRIVIGEQSERGQKIAELFA
EECCCCCHHHHHHHHHHHCCEEECHHHHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHHH
NAAEKRDVPILLTNPTEAEAIKLFSNTYLAMRIAYFNELDSYAEAHGLDARQIIQGVGLD
HHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
PRIGNHYNNPSFGYGGYCLPKDTKQLLANYQDVPNNIIGAIVDANRTRKDFVAESILKRN
CCCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHHCC
PKVVGIYRLIMKAGSDNFRASSIQGIMKRIKAKDIEVVVYEPVLKEAEFFHSRVIKDLNE
CCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
FKQTADVIVSNRMVEELVDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGNVMRITVVGAGYVGLANAALLAQYHSITLLDVDSKRVEQINAQSSPIVDADIERFLS
CCCEEEEEEEECCHHHHHHHHHHHHHHEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHC
SGALQLTATTSPQIAYHDAQLIIVATPTNYDPITNGFDTASVEQVIKDAIQISPNATILI
CCCEEEEECCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
RSTVPVGFTERMRAQAKRCNILFAPEFLREGKALYDNLFPSRIVIGEQSERGQKIAELFA
EECCCCCHHHHHHHHHHHCCEEECHHHHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHHH
NAAEKRDVPILLTNPTEAEAIKLFSNTYLAMRIAYFNELDSYAEAHGLDARQIIQGVGLD
HHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
PRIGNHYNNPSFGYGGYCLPKDTKQLLANYQDVPNNIIGAIVDANRTRKDFVAESILKRN
CCCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHHCC
PKVVGIYRLIMKAGSDNFRASSIQGIMKRIKAKDIEVVVYEPVLKEAEFFHSRVIKDLNE
CCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
FKQTADVIVSNRMVEELVDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]