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The map label for this gene is envZ

Identifier: 37678421

GI number: 37678421

Start: 244169

End: 245467

Strand: Direct

Name: envZ

Synonym: VV0237

Alternate gene names: 37678421

Gene position: 244169-245467 (Clockwise)

Preceding gene: 37678420

Following gene: 37678435

Centisome position: 7.28

GC content: 51.89

Gene sequence:

>1299_bases
ATGCGTTTTCGTAGTTCCTTTACCCAATCGATATTTATCTTCATTACGTTGCTGCTCGCCAGTCAGGTGTTCTCCTATTA
CGCGGTGTTCAACTACGCGCTATTGCCGAGTTTGCAGCAGTTCAACAAAATCCTCGCCCATGAGCTGAATTTGGTGCTCG
ATGACGACAGCGCTCTGATGGCGGATGCGCCGTTGCGTCGGCAGGTTTTGGAGCAACTTGGTGTGACGGTGCACGCGGCC
GATAGTGAACAAGCCAAAGAGTTTGACCATGCGATGACCATCGATTTGATGAGTGAAGAGATGACTCACGAGCTTGGTTC
GCCAACCGAAGTGCGTCTGCTGTTGGGCAGCGAAAGCTACATTTTGTGGATGAAAATTGACGCGCTTCCAGGTTCACTGA
TCCGCATTCCGCTCTCTGAACTGCAAGAAGAAGATTTCGCTCCACTGTTTCGCAACAGTTTGATTGTGGCGCTGTTGATC
ATCGCTGGTGGTTGGCTGTTTATCCGTTTACAAAACCGGCCACTCATCGCGCTGGAGAAGGCGGCCAAGGAAGTCGGTCG
AGGGGAAATCCCGCCACCGCTGCCAGAAAAAGGGGCCACAGAGATCCGTGCAGTGACGCGCGCGTTCAATCAAATGTCTC
GCGGCATTCAAGAGTTGGAAGCTGACCGCGCGTTGTTGATGGCGGGTATTAGCCATGATTTAAGAACGCCGTTAACACGA
ATTCGCCTTGCGACTGAAATGATGTCACCAGAAGACAGCTATTTAGCGGAAGGGATCATCAGTGATACTGAAGAGTGTAA
TGAGATCATCAGCCAGTTTATGGACTACCTCAAACCAGTGAATACGCAAAGTTTCACCGAGGTCGACATCAATGGTATTT
CTGGGGATGTAGCGAGCTCCGAAGGGGGTTACGAAGTACAGATTGAGACCGCCTTCCAGCCTTCGATTCGCACCGCTTTT
GGCAGCCCGATCGCAATTAAGCGTGCCGTGAGCAACTTAGTGGTCAATGCACTGCGTTACGGTAATGGATGGGTGAAAAT
CAGCACGGGGATGACCGCAGACAGCAAGTTGGTGTGGGTGTGTGTGGAAGATAACGGCCCAGGGATTGAAAAATCACAAG
TGGCGAAGTTGTTTGAACCTTTCACCCGTGGCGATACGGCTCGTGGTAGCGAAGGAACCGGCTTAGGGCTGGCCATTGTC
AAACGTATTGTCAGCCAGCATCACGGCTCGGTGGTGGTGAACAACCGCAGCGAAGGTGGGCTCAAAGTACAGTTGAGCTT
TCCGACCAGCGAACGTTAG

Upstream 100 bases:

>100_bases
CAGCATAATCTCACATGACGATTCTTCTACAATCCCTGGCTTTGACCAGGGATTGTTGTTTATTCTACCTTCGTACTCTA
CCTAGCTGCCGAGGTCTTTG

Downstream 100 bases:

>100_bases
TCGTAACCCTATTTAGGACGGGGCAGAGTCAATTGGGTTAAAAAGGGTTGCCACAGTCGGCAACCCTTTTTCTTTGTGTA
GATTAGCGCTTTACAGTCGC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRFRSSFTQSIFIFITLLLASQVFSYYAVFNYALLPSLQQFNKILAHELNLVLDDDSALMADAPLRRQVLEQLGVTVHAA
DSEQAKEFDHAMTIDLMSEEMTHELGSPTEVRLLLGSESYILWMKIDALPGSLIRIPLSELQEEDFAPLFRNSLIVALLI
IAGGWLFIRLQNRPLIALEKAAKEVGRGEIPPPLPEKGATEIRAVTRAFNQMSRGIQELEADRALLMAGISHDLRTPLTR
IRLATEMMSPEDSYLAEGIISDTEECNEIISQFMDYLKPVNTQSFTEVDINGISGDVASSEGGYEVQIETAFQPSIRTAF
GSPIAIKRAVSNLVVNALRYGNGWVKISTGMTADSKLVWVCVEDNGPGIEKSQVAKLFEPFTRGDTARGSEGTGLGLAIV
KRIVSQHHGSVVVNNRSEGGLKVQLSFPTSER

Sequences:

>Translated_432_residues
MRFRSSFTQSIFIFITLLLASQVFSYYAVFNYALLPSLQQFNKILAHELNLVLDDDSALMADAPLRRQVLEQLGVTVHAA
DSEQAKEFDHAMTIDLMSEEMTHELGSPTEVRLLLGSESYILWMKIDALPGSLIRIPLSELQEEDFAPLFRNSLIVALLI
IAGGWLFIRLQNRPLIALEKAAKEVGRGEIPPPLPEKGATEIRAVTRAFNQMSRGIQELEADRALLMAGISHDLRTPLTR
IRLATEMMSPEDSYLAEGIISDTEECNEIISQFMDYLKPVNTQSFTEVDINGISGDVASSEGGYEVQIETAFQPSIRTAF
GSPIAIKRAVSNLVVNALRYGNGWVKISTGMTADSKLVWVCVEDNGPGIEKSQVAKLFEPFTRGDTARGSEGTGLGLAIV
KRIVSQHHGSVVVNNRSEGGLKVQLSFPTSER
>Mature_432_residues
MRFRSSFTQSIFIFITLLLASQVFSYYAVFNYALLPSLQQFNKILAHELNLVLDDDSALMADAPLRRQVLEQLGVTVHAA
DSEQAKEFDHAMTIDLMSEEMTHELGSPTEVRLLLGSESYILWMKIDALPGSLIRIPLSELQEEDFAPLFRNSLIVALLI
IAGGWLFIRLQNRPLIALEKAAKEVGRGEIPPPLPEKGATEIRAVTRAFNQMSRGIQELEADRALLMAGISHDLRTPLTR
IRLATEMMSPEDSYLAEGIISDTEECNEIISQFMDYLKPVNTQSFTEVDINGISGDVASSEGGYEVQIETAFQPSIRTAF
GSPIAIKRAVSNLVVNALRYGNGWVKISTGMTADSKLVWVCVEDNGPGIEKSQVAKLFEPFTRGDTARGSEGTGLGLAIV
KRIVSQHHGSVVVNNRSEGGLKVQLSFPTSER

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=436, Percent_Identity=48.8532110091743, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=31.6176470588235, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=29.3040293040293, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=30.1754385964912, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=27.0175438596491, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=28.8321167883212, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=27.4900398406374, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=22.7891156462585, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=25.9786476868327, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=25.5813953488372, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=333, Percent_Identity=25.2252252252252, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=29.4605809128631, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787374, Length=290, Percent_Identity=25.1724137931034, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=222, Percent_Identity=24.3243243243243, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=25, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47645; Mature: 47645

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRSSFTQSIFIFITLLLASQVFSYYAVFNYALLPSLQQFNKILAHELNLVLDDDSALM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEE
ADAPLRRQVLEQLGVTVHAADSEQAKEFDHAMTIDLMSEEMTHELGSPTEVRLLLGSESY
CCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
ILWMKIDALPGSLIRIPLSELQEEDFAPLFRNSLIVALLIIAGGWLFIRLQNRPLIALEK
EEEEEEECCCCCEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEHHHH
AAKEVGRGEIPPPLPEKGATEIRAVTRAFNQMSRGIQELEADRALLMAGISHDLRTPLTR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IRLATEMMSPEDSYLAEGIISDTEECNEIISQFMDYLKPVNTQSFTEVDINGISGDVASS
HHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
EGGYEVQIETAFQPSIRTAFGSPIAIKRAVSNLVVNALRYGNGWVKISTGMTADSKLVWV
CCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
CVEDNGPGIEKSQVAKLFEPFTRGDTARGSEGTGLGLAIVKRIVSQHHGSVVVNNRSEGG
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
LKVQLSFPTSER
EEEEEECCCCCC
>Mature Secondary Structure
MRFRSSFTQSIFIFITLLLASQVFSYYAVFNYALLPSLQQFNKILAHELNLVLDDDSALM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEE
ADAPLRRQVLEQLGVTVHAADSEQAKEFDHAMTIDLMSEEMTHELGSPTEVRLLLGSESY
CCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
ILWMKIDALPGSLIRIPLSELQEEDFAPLFRNSLIVALLIIAGGWLFIRLQNRPLIALEK
EEEEEEECCCCCEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEHHHH
AAKEVGRGEIPPPLPEKGATEIRAVTRAFNQMSRGIQELEADRALLMAGISHDLRTPLTR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IRLATEMMSPEDSYLAEGIISDTEECNEIISQFMDYLKPVNTQSFTEVDINGISGDVASS
HHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
EGGYEVQIETAFQPSIRTAFGSPIAIKRAVSNLVVNALRYGNGWVKISTGMTADSKLVWV
CCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
CVEDNGPGIEKSQVAKLFEPFTRGDTARGSEGTGLGLAIVKRIVSQHHGSVVVNNRSEGG
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
LKVQLSFPTSER
EEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]