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The map label for this gene is hemN [H]

Identifier: 37678377

GI number: 37678377

Start: 203662

End: 205053

Strand: Direct

Name: hemN [H]

Synonym: VV0193

Alternate gene names: 37678377

Gene position: 203662-205053 (Clockwise)

Preceding gene: 37678376

Following gene: 37678379

Centisome position: 6.07

GC content: 47.63

Gene sequence:

>1392_bases
ATGTCGAATCAGAACCTTGAATCGAACCAACAAATTGTTTGGGACCAAGCGGTATTAGACAAATATAACTATTCAGGTCC
GCGTTATACGTCTTACCCAACGGCGCTTGAGTTTCATGAAGCATTTACCATTTCTGACTACGATATGGCTTGCACGCAAT
ACCCTGAGCGACCGCTGTCCCTGTACATTCACATCCCGTTTTGCCATAAGCTGTGCTACTACTGTGGCTGTAATAAGGTG
ATAACACGCCATTCGCACAAAGCGGATGAGTATTTGGATGTGTTGGAGCATGAGATTCGCCAACGTGCGTCTTTACTGCA
AGGTCGTCGCGTAACGCAATTGCATTTTGGTGGTGGTACACCAACATTTCTTAGTGCTAAGCAAATCACCCGCTTGATGA
CACTGCTGCGTGAAGAGTTCACCTTCACAGCGGAAGCCGAAATCAGTATTGAAGTTGACCCACGAGAAATTGCGTTGGAA
ATGCTGGATCACCTACGTGCAGAAGGCTTTAACCGCCTGAGTATCGGTGTGCAAGACTTCAACAAAGAAGTGCAAAAGCT
GGTCAATCGCGAGCAAGATGAAGCATTTATTTTCGCGATGGTTGAGCGCGCGAAGCAGCTCGGTTTCCGTTCGACCAACC
TTGACTTGATTTACGGTTTGCCTAAGCAAGATCGAGATTCTTTTGCCAAAACGTTGGAACAAGTCCTCAGCATGCAGCCA
GGCCGATTGTCGGTGTTTAACTACGCTCACATGCCTCAGCTTTTTGCTGCGCAGCGCAAAATTAAAGATGAAGATTTGCC
GAAAGCGGAAGAGAAAATGGCGATTCTGCAAAACACCATCGCGACGTTGACCGATGCGGGCTATCAATTCATCGGCATGG
ACCACTTTGCGTTGCCTGACGATGAACTGGCGGTGGCTCAGCGTAATGGCGTGCTGCATCGCAACTTTCAAGGCTACACA
ACGCAAGGGGAGTGTGACTTGGTTGGCTTTGGTGTATCGGCCATTTCCATGATTGGCGATGCCTATGCGCAAAACCAAAA
AGAGCTGAAAAAGTACTACGCACAAGTGAATGATTTACGTCATGCGCTGTGGAAGGGTGTTGCGCTGGATGGTGACGATT
TATTGCGTCGAGAAGTGATCAAACAGCTGATTTGTAACTTCAAACTCGACAAAGTGGCGATTGAGAAGCAGTTCGCCGTG
ACGTTCAATCAGTACTTTAAAGAAGACTTACAATTGCTACAGACCTTCATTGACGATGCGCTGGTGGAAGTGGATGAACA
AGTGATCCGCGTGACACTTCGTGGCCGTCTGCTCATTCGCAATATCTGTATGTGCTTTGATAAGTACTTGAGAGCCAAAG
CGCGTCAGCAGCAGTTTTCTCGCGTGATCTAA

Upstream 100 bases:

>100_bases
ACTTCTAAAAATTGGCGATAAAAAAGCCATATCACAGCGCCATGAGCGTCTCATTGATGTGGCAAAATAGCGCCCCACAG
CATTTTATGGAAGTACCACC

Downstream 100 bases:

>100_bases
ACACAGCATCGATGTCTCTTTAAATACAAATGCCAGCGGAAATGCTGGCATTTTTAATATATCTCAACGGTTTGTGCTTA
TAGCGATGGCCACTCATCAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSNQNLESNQQIVWDQAVLDKYNYSGPRYTSYPTALEFHEAFTISDYDMACTQYPERPLSLYIHIPFCHKLCYYCGCNKV
ITRHSHKADEYLDVLEHEIRQRASLLQGRRVTQLHFGGGTPTFLSAKQITRLMTLLREEFTFTAEAEISIEVDPREIALE
MLDHLRAEGFNRLSIGVQDFNKEVQKLVNREQDEAFIFAMVERAKQLGFRSTNLDLIYGLPKQDRDSFAKTLEQVLSMQP
GRLSVFNYAHMPQLFAAQRKIKDEDLPKAEEKMAILQNTIATLTDAGYQFIGMDHFALPDDELAVAQRNGVLHRNFQGYT
TQGECDLVGFGVSAISMIGDAYAQNQKELKKYYAQVNDLRHALWKGVALDGDDLLRREVIKQLICNFKLDKVAIEKQFAV
TFNQYFKEDLQLLQTFIDDALVEVDEQVIRVTLRGRLLIRNICMCFDKYLRAKARQQQFSRVI

Sequences:

>Translated_463_residues
MSNQNLESNQQIVWDQAVLDKYNYSGPRYTSYPTALEFHEAFTISDYDMACTQYPERPLSLYIHIPFCHKLCYYCGCNKV
ITRHSHKADEYLDVLEHEIRQRASLLQGRRVTQLHFGGGTPTFLSAKQITRLMTLLREEFTFTAEAEISIEVDPREIALE
MLDHLRAEGFNRLSIGVQDFNKEVQKLVNREQDEAFIFAMVERAKQLGFRSTNLDLIYGLPKQDRDSFAKTLEQVLSMQP
GRLSVFNYAHMPQLFAAQRKIKDEDLPKAEEKMAILQNTIATLTDAGYQFIGMDHFALPDDELAVAQRNGVLHRNFQGYT
TQGECDLVGFGVSAISMIGDAYAQNQKELKKYYAQVNDLRHALWKGVALDGDDLLRREVIKQLICNFKLDKVAIEKQFAV
TFNQYFKEDLQLLQTFIDDALVEVDEQVIRVTLRGRLLIRNICMCFDKYLRAKARQQQFSRVI
>Mature_462_residues
SNQNLESNQQIVWDQAVLDKYNYSGPRYTSYPTALEFHEAFTISDYDMACTQYPERPLSLYIHIPFCHKLCYYCGCNKVI
TRHSHKADEYLDVLEHEIRQRASLLQGRRVTQLHFGGGTPTFLSAKQITRLMTLLREEFTFTAEAEISIEVDPREIALEM
LDHLRAEGFNRLSIGVQDFNKEVQKLVNREQDEAFIFAMVERAKQLGFRSTNLDLIYGLPKQDRDSFAKTLEQVLSMQPG
RLSVFNYAHMPQLFAAQRKIKDEDLPKAEEKMAILQNTIATLTDAGYQFIGMDHFALPDDELAVAQRNGVLHRNFQGYTT
QGECDLVGFGVSAISMIGDAYAQNQKELKKYYAQVNDLRHALWKGVALDGDDLLRREVIKQLICNFKLDKVAIEKQFAVT
FNQYFKEDLQLLQTFIDDALVEVDEQVIRVTLRGRLLIRNICMCFDKYLRAKARQQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=396, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082341, Length=456, Percent_Identity=70.6140350877193, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=244, Percent_Identity=34.4262295081967, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53509; Mature: 53378

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQNLESNQQIVWDQAVLDKYNYSGPRYTSYPTALEFHEAFTISDYDMACTQYPERPLS
CCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCHHHHHHCCCCCEE
LYIHIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRASLLQGRRVTQLHFGGGT
EEEECHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PTFLSAKQITRLMTLLREEFTFTAEAEISIEVDPREIALEMLDHLRAEGFNRLSIGVQDF
CCHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHHHHCCCCEEECCHHHH
NKEVQKLVNREQDEAFIFAMVERAKQLGFRSTNLDLIYGLPKQDRDSFAKTLEQVLSMQP
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC
GRLSVFNYAHMPQLFAAQRKIKDEDLPKAEEKMAILQNTIATLTDAGYQFIGMDHFALPD
CCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
DELAVAQRNGVLHRNFQGYTTQGECDLVGFGVSAISMIGDAYAQNQKELKKYYAQVNDLR
CHHHHHHHCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HALWKGVALDGDDLLRREVIKQLICNFKLDKVAIEKQFAVTFNQYFKEDLQLLQTFIDDA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVEVDEQVIRVTLRGRLLIRNICMCFDKYLRAKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNQNLESNQQIVWDQAVLDKYNYSGPRYTSYPTALEFHEAFTISDYDMACTQYPERPLS
CCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCHHHHHHCCCCCEE
LYIHIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRASLLQGRRVTQLHFGGGT
EEEECHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PTFLSAKQITRLMTLLREEFTFTAEAEISIEVDPREIALEMLDHLRAEGFNRLSIGVQDF
CCHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHHHHCCCCEEECCHHHH
NKEVQKLVNREQDEAFIFAMVERAKQLGFRSTNLDLIYGLPKQDRDSFAKTLEQVLSMQP
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC
GRLSVFNYAHMPQLFAAQRKIKDEDLPKAEEKMAILQNTIATLTDAGYQFIGMDHFALPD
CCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
DELAVAQRNGVLHRNFQGYTTQGECDLVGFGVSAISMIGDAYAQNQKELKKYYAQVNDLR
CHHHHHHHCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HALWKGVALDGDDLLRREVIKQLICNFKLDKVAIEKQFAVTFNQYFKEDLQLLQTFIDDA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVEVDEQVIRVTLRGRLLIRNICMCFDKYLRAKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]