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The map label for this gene is ubiB

Identifier: 37678363

GI number: 37678363

Start: 189822

End: 191456

Strand: Direct

Name: ubiB

Synonym: VV0179

Alternate gene names: 37678363

Gene position: 189822-191456 (Clockwise)

Preceding gene: 37678362

Following gene: 37678364

Centisome position: 5.66

GC content: 46.67

Gene sequence:

>1635_bases
ATGACCCCGACAGAGCTAAAGCGCCTTTATCGCATCATTAAAGTTCAGCTTGAATATGGTTTGGATGACCTACTGCCAGA
CCATCAACTTGCCAAAGCACCACGTTGGATGCGCAAAAGCTTGTTTTGGCTTAAAAATCAGCATCCAGAAAAACCGTTAG
GGGATCGTCTACGTCTTGCCCTGCAAGAGCTAGGGCCTGTTTGGATTAAATTTGGCCAGATGTTGTCTACTCGTCGCGAT
CTGTTTCCTCCTCACATTGCAGACCCGCTTGCACTGCTGCAAGATCAAGTCTCGCCTTTTGATGGTGCATTGGCGAAAGC
ACAAATGGAGCAAGCGCTCGGTGGGCCTTTAGAAACCTGGTTTAGTGATTTTGACCTAGTTCCTTTAGCGTCGGCCTCCA
TTGCGCAGGTGCATACCGCCAAGCTGAAAACGACTAACCAAGAAGTGGTATTAAAGGTCATTCGCCCAGATATTCGTCCC
ATCATTGATGCAGATCTAAAACTGATGCGACGTATGGCGAGTATAGTCGCCAAAGCAATGCCTGAAGCACGTCGTCTTAA
ACCGATCGAAGTGGTTCGAGAGTATGAGAAAACCTTACTGGATGAGCTTGATTTGCGTCGCGAAGCGGCCAATGCGATAC
AGCTAAGACGTAATTTTACCGACAGCGAAGAGTTATACGTTCCTGAAGTTTATCCGGACTTTAGTAATGAAACTGTCATG
GTTTCTGAGCGAATATACGGCATCCAAGTGTCGGATATTACAGGCTTGAAAGCGAATGGCACCAACATGAAGTTGTTGGC
GGAAAGAGGGGTGAGTGTATTCTTTACCCAAGTTTTTCGCGACAGCTTCTTCCATGCAGACATGCATCCAGGGAACGTGT
TTGTTAACCCTGAACATCCCGAGAACCCACAATGGATTGGTTTGGATTGTGGCATTGTTGGCACATTAAATAGCGAAGAT
AAACGCTATTTAGCGGAAAACTTTTTGGCGTTTTTTAATCGTGATTATCGACGTGTGGCAGAGCTGCATGTGGACTCTGG
CTGGGTACCGGCAGACACCAATATTGATGAATTTGAATTTGCGATTCGTATTGTCTGTGAGCCGATTTTTGCCAAACCGT
TGTGTGAAATCTCCTTTGGTCATGTGTTATTGAACCTATTCAATACCGCAAGGCGATTCAATATGGAAGTTCAGCCGCAA
CTGGTGTTATTGCAAAAAACCTTGCTGTATGTGGAAGGATTAGGGCGCCAGCTTTATCCTCAGCTTGATCTCTGGGAAAC
CGCAAAACCCTTCCTTGAAGAGTGGATGATGAATCAAGTTGGTCCTAAAGCGTTGATCAATGCAATAAAAGACCGCGCGC
CTTATTGGGCGGAAAAATTACCTGAACTGCCGGAATTGCTGTATGACAGCCTCAAACAGGGCAAAGCGATGAACCAGAGA
ATGGATCAGCTTTACCAAGGCTATCGAGCCAGCAAGCGCCAGCAGGCAACAGGAAAGTTTTTATTTGGCGTTGGGGCCAC
ATTAGTCGTATGCTCGGCAATATTGGTGGACCACACTTATGAACAGCTTTCACTGGCGACGGCTATTGCAGGCGTCACAT
TTTGGCTGTTCAGTTGGCGAGCTTATCGTCGTTAG

Upstream 100 bases:

>100_bases
CTGGACCATTGGAAGTGGCTTACTTCTGTGACCAAGTGGACGATGCCAAAAGTGATCTCGCCAGACTAGAAGCTCGTCTG
CAAAAACTGTTGGAGAAAGC

Downstream 100 bases:

>100_bases
ACGTTAAACTCTTGATCTAATTTTTGTTACAAAAGACCCGAGGTAAAAAGAATGGGTGGTATCAGTATCTGGCAACTGTT
GATTATTGCTGTCATCGTTG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MTPTELKRLYRIIKVQLEYGLDDLLPDHQLAKAPRWMRKSLFWLKNQHPEKPLGDRLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADPLALLQDQVSPFDGALAKAQMEQALGGPLETWFSDFDLVPLASASIAQVHTAKLKTTNQEVVLKVIRPDIRP
IIDADLKLMRRMASIVAKAMPEARRLKPIEVVREYEKTLLDELDLRREAANAIQLRRNFTDSEELYVPEVYPDFSNETVM
VSERIYGIQVSDITGLKANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPEHPENPQWIGLDCGIVGTLNSED
KRYLAENFLAFFNRDYRRVAELHVDSGWVPADTNIDEFEFAIRIVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWETAKPFLEEWMMNQVGPKALINAIKDRAPYWAEKLPELPELLYDSLKQGKAMNQR
MDQLYQGYRASKRQQATGKFLFGVGATLVVCSAILVDHTYEQLSLATAIAGVTFWLFSWRAYRR

Sequences:

>Translated_544_residues
MTPTELKRLYRIIKVQLEYGLDDLLPDHQLAKAPRWMRKSLFWLKNQHPEKPLGDRLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADPLALLQDQVSPFDGALAKAQMEQALGGPLETWFSDFDLVPLASASIAQVHTAKLKTTNQEVVLKVIRPDIRP
IIDADLKLMRRMASIVAKAMPEARRLKPIEVVREYEKTLLDELDLRREAANAIQLRRNFTDSEELYVPEVYPDFSNETVM
VSERIYGIQVSDITGLKANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPEHPENPQWIGLDCGIVGTLNSED
KRYLAENFLAFFNRDYRRVAELHVDSGWVPADTNIDEFEFAIRIVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWETAKPFLEEWMMNQVGPKALINAIKDRAPYWAEKLPELPELLYDSLKQGKAMNQR
MDQLYQGYRASKRQQATGKFLFGVGATLVVCSAILVDHTYEQLSLATAIAGVTFWLFSWRAYRR
>Mature_543_residues
TPTELKRLYRIIKVQLEYGLDDLLPDHQLAKAPRWMRKSLFWLKNQHPEKPLGDRLRLALQELGPVWIKFGQMLSTRRDL
FPPHIADPLALLQDQVSPFDGALAKAQMEQALGGPLETWFSDFDLVPLASASIAQVHTAKLKTTNQEVVLKVIRPDIRPI
IDADLKLMRRMASIVAKAMPEARRLKPIEVVREYEKTLLDELDLRREAANAIQLRRNFTDSEELYVPEVYPDFSNETVMV
SERIYGIQVSDITGLKANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPEHPENPQWIGLDCGIVGTLNSEDK
RYLAENFLAFFNRDYRRVAELHVDSGWVPADTNIDEFEFAIRIVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQL
VLLQKTLLYVEGLGRQLYPQLDLWETAKPFLEEWMMNQVGPKALINAIKDRAPYWAEKLPELPELLYDSLKQGKAMNQRM
DQLYQGYRASKRQQATGKFLFGVGATLVVCSAILVDHTYEQLSLATAIAGVTFWLFSWRAYRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=280, Percent_Identity=30, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI32261307, Length=332, Percent_Identity=26.2048192771084, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI40254938, Length=277, Percent_Identity=28.8808664259928, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=29.8701298701299, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI34147522, Length=250, Percent_Identity=27.2, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=67.948717948718, Blast_Score=774, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=26.8551236749117, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=270, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=26.530612244898, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6323282, Length=296, Percent_Identity=24.6621621621622, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=243, Percent_Identity=24.6913580246914, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI22024280, Length=289, Percent_Identity=29.4117647058824, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24662575, Length=231, Percent_Identity=28.1385281385281, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62509; Mature: 62378

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTELKRLYRIIKVQLEYGLDDLLPDHQLAKAPRWMRKSLFWLKNQHPEKPLGDRLRLA
CCHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADPLALLQDQVSPFDGALAKAQMEQALGGPLETW
HHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
FSDFDLVPLASASIAQVHTAKLKTTNQEVVLKVIRPDIRPIIDADLKLMRRMASIVAKAM
HCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPIEVVREYEKTLLDELDLRREAANAIQLRRNFTDSEELYVPEVYPDFSNETVM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEE
VSERIYGIQVSDITGLKANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPEHP
EECCEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
ENPQWIGLDCGIVGTLNSEDKRYLAENFLAFFNRDYRRVAELHVDSGWVPADTNIDEFEF
CCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AIRIVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWETAKPFLEEWMMNQVGPKALINAIKDRAPYWAEKLPELPELLYDSLKQGKAMNQR
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCHHHHHH
MDQLYQGYRASKRQQATGKFLFGVGATLVVCSAILVDHTYEQLSLATAIAGVTFWLFSWR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYRR
HHCC
>Mature Secondary Structure 
TPTELKRLYRIIKVQLEYGLDDLLPDHQLAKAPRWMRKSLFWLKNQHPEKPLGDRLRLA
CHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADPLALLQDQVSPFDGALAKAQMEQALGGPLETW
HHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
FSDFDLVPLASASIAQVHTAKLKTTNQEVVLKVIRPDIRPIIDADLKLMRRMASIVAKAM
HCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPIEVVREYEKTLLDELDLRREAANAIQLRRNFTDSEELYVPEVYPDFSNETVM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEE
VSERIYGIQVSDITGLKANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPEHP
EECCEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
ENPQWIGLDCGIVGTLNSEDKRYLAENFLAFFNRDYRRVAELHVDSGWVPADTNIDEFEF
CCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AIRIVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWETAKPFLEEWMMNQVGPKALINAIKDRAPYWAEKLPELPELLYDSLKQGKAMNQR
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCHHHHHH
MDQLYQGYRASKRQQATGKFLFGVGATLVVCSAILVDHTYEQLSLATAIAGVTFWLFSWR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYRR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA