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The map label for this gene is prlC [H]

Identifier: 37678251

GI number: 37678251

Start: 78071

End: 80179

Strand: Direct

Name: prlC [H]

Synonym: VV0067

Alternate gene names: 37678251

Gene position: 78071-80179 (Clockwise)

Preceding gene: 37678248

Following gene: 37678252

Centisome position: 2.33

GC content: 52.39

Gene sequence:

>2109_bases
GTGAATAAGCGAGCCATCGATGGACAGTTGGCCACGATACTGAAGAGTCAAACAAAAGGAATTTATATGTCTAATCCACT
CCTTACTTTTACGGATCTGCCTCCGTTTTCTCAAATCAAGCCAGAGCATGTGTTTCCTGCGGTGGAACAGGCGATTGCCG
ATTGTCGTGCCAAGATTGAACAGGTGCTTGAAGGCAATAATACCCCTAGCTGGGAAACGGTGATTGCGCCGATCGAAGAA
GTGGATGATCGTCTCAGCCGTATTTGGTCACCCGTGAGCCACATGAACTCTGTTGTCAACAGCGACGAGCTGCGCGACGC
GTATGAAAGCTGCCTGCCAATGTTGTCGGAATACGGCACTTGGGTCGGCCAGCACAAAGGTCTGTTTGAAGCGTACAAAG
CGATTAAAGCCAGCGAAGCGTTTGCCAAGTTGACCACAGCACAACAGAAAACCATTACCGATGCATTGCGTGATTTTGAG
CTATCAGGCATCGGTCTGCCTGCGGATGAGCAAAAGCGCTATGGCGAAATCAGCAAGCGTATGTCAGAGCTGAGCTCTAA
GTTTTCCAACAACACGCTAGACGCCACCATGGGCTGGACCAAGCACATCACCGATGAGAAAGAGTTGGCAGGCATGCCGG
AATCGGCGTTGGCGGCCGCGAAAGCCGCCGCTGAAGCCAAAGAGCTCGACGGTTATTTGATCACGCTGGATGTGCCGTCT
TACCTGCCAGTGATGACTTACTGTGACAACCAAGCGCTGCGCCGTGAAGTGTACGAAGCGTACGTGACTCGCGCGTCGGA
TCGCGGTCCAAATGCCGGTAAGTGGGACAACACCGAGATCATCAATGAGCAGTTGAAACTGCGTCATGAAATTGCTCGCA
TGCTTGGCTTTAACACCTACAGCGAAAAGTCTCTGGCGACCAAAATGGCGGAAAACCCAGCGCAAGTGTTGGGCTTCCTC
AATGACTTAGCCACCAAAGCCAAACCACAAGGTGAGCGTGAAGTGGCAGAGTTGCGTCAGTTTGCCGAGCAAGAGTTTGG
TGTGTCTGAACTCAATGTTTGGGATATCGCTTACTACAGCGAAAAACAAAAGCAGCACCTGTTCCAAATTTCGGATGAAG
AACTGCGTCCGTACTTCCCTGAGTCGAAAGCCGTCAGCGGTTTGTTTGAAGTGCTCAAACGTGTGTTTGGCATGAGCGTG
AAAGAGCGCGAAGGCATTGACGTTTGGCACAACTCAGTGCGTTTCTTCGATATTTTCGATGCGCAGGGCGAGCTGCGTGG
CAGCTTCTACCTCGATCTCTATGCGCGTGAACACAAACGTGGCGGCGCTTGGATGGATGAATGCCGCGTGCGCCGTATTA
ACGCACAAGGCGAGCTGCAAACCCCAGTGGCGTACCTGACGTGTAACTTCAACCGCCCAATCGGCGACAAACCAGCGCTG
TTTACGCACGATGAAGTGGTCACCTTGTTCCACGAATTTGGCCACGGTATTCATCATATGCTGACTCAAGTCACCACGGG
TGCGGTGTCTGGTATTAATGGTGTGCCTTGGGATGCGGTGGAGCTGCCAAGTCAGTTCCTAGAAAACTGGTGTTGGGAAG
AAGAAGCGCTGGCGTTTATCTCTGGCCACTACGAAACGGGTGAGCCGCTGCCAAAAGCGATGCTAGAGAAGATGTTGGCG
GCGAAGAACTTCCAATCGGCGATGGGCATTTTGCGCCAGCTTGAGTTCGGTCTGTTTGACTTCACGCTGCACACCGAGTT
TGATCCTGAAATTGGCCCACGCGTGCTCGAAACCTTGGCGCAAGTGAAGCAGAAAGTCGCGGTACTTCCAGCGGTTGAGT
GGGCGCGTTTCTCACACAGCTTTGGCCACATTTTTGCGGGCGGTTACTGTGCGGGTTACTACAGCTACCTATGGGCAGAA
GTGCTCTCTTCTGACGCTTTCTCGCGTTTTGAGGAAGAAGGTATTTTCAACGCTGAGACGGGTCAGAGCTTCCTCAACCA
TATTCTTGAGATGGGCGGCAGCGAAGAGCCAATGGAGCTGTTCAAACGCTTCCGTGGCCGTGAACCACAAATCGATGCTT
TGCTGCGCCATTCTGGAATTGCGGCTTAA

Upstream 100 bases:

>100_bases
TAATCGTCAATTCGTATTGAAATGTGAACCTTTAACCCTCATTTAGTATCAAAATGTAAGACCAGTTGGCGACAGTCGAG
GAAAATCGCGTATTATTATT

Downstream 100 bases:

>100_bases
CTCGATGAAGTAAACCCAGCATCACAAGGTCAGCCCAACGGCTGGCCTTGTTTTTTTGCGGTACGCTAAGTTTGTTGTCG
CAAGTTAAGTTTTGTCGCGA

Product: Zn-dependent oligopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MNKRAIDGQLATILKSQTKGIYMSNPLLTFTDLPPFSQIKPEHVFPAVEQAIADCRAKIEQVLEGNNTPSWETVIAPIEE
VDDRLSRIWSPVSHMNSVVNSDELRDAYESCLPMLSEYGTWVGQHKGLFEAYKAIKASEAFAKLTTAQQKTITDALRDFE
LSGIGLPADEQKRYGEISKRMSELSSKFSNNTLDATMGWTKHITDEKELAGMPESALAAAKAAAEAKELDGYLITLDVPS
YLPVMTYCDNQALRREVYEAYVTRASDRGPNAGKWDNTEIINEQLKLRHEIARMLGFNTYSEKSLATKMAENPAQVLGFL
NDLATKAKPQGEREVAELRQFAEQEFGVSELNVWDIAYYSEKQKQHLFQISDEELRPYFPESKAVSGLFEVLKRVFGMSV
KEREGIDVWHNSVRFFDIFDAQGELRGSFYLDLYAREHKRGGAWMDECRVRRINAQGELQTPVAYLTCNFNRPIGDKPAL
FTHDEVVTLFHEFGHGIHHMLTQVTTGAVSGINGVPWDAVELPSQFLENWCWEEEALAFISGHYETGEPLPKAMLEKMLA
AKNFQSAMGILRQLEFGLFDFTLHTEFDPEIGPRVLETLAQVKQKVAVLPAVEWARFSHSFGHIFAGGYCAGYYSYLWAE
VLSSDAFSRFEEEGIFNAETGQSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHSGIAA

Sequences:

>Translated_702_residues
MNKRAIDGQLATILKSQTKGIYMSNPLLTFTDLPPFSQIKPEHVFPAVEQAIADCRAKIEQVLEGNNTPSWETVIAPIEE
VDDRLSRIWSPVSHMNSVVNSDELRDAYESCLPMLSEYGTWVGQHKGLFEAYKAIKASEAFAKLTTAQQKTITDALRDFE
LSGIGLPADEQKRYGEISKRMSELSSKFSNNTLDATMGWTKHITDEKELAGMPESALAAAKAAAEAKELDGYLITLDVPS
YLPVMTYCDNQALRREVYEAYVTRASDRGPNAGKWDNTEIINEQLKLRHEIARMLGFNTYSEKSLATKMAENPAQVLGFL
NDLATKAKPQGEREVAELRQFAEQEFGVSELNVWDIAYYSEKQKQHLFQISDEELRPYFPESKAVSGLFEVLKRVFGMSV
KEREGIDVWHNSVRFFDIFDAQGELRGSFYLDLYAREHKRGGAWMDECRVRRINAQGELQTPVAYLTCNFNRPIGDKPAL
FTHDEVVTLFHEFGHGIHHMLTQVTTGAVSGINGVPWDAVELPSQFLENWCWEEEALAFISGHYETGEPLPKAMLEKMLA
AKNFQSAMGILRQLEFGLFDFTLHTEFDPEIGPRVLETLAQVKQKVAVLPAVEWARFSHSFGHIFAGGYCAGYYSYLWAE
VLSSDAFSRFEEEGIFNAETGQSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHSGIAA
>Mature_702_residues
MNKRAIDGQLATILKSQTKGIYMSNPLLTFTDLPPFSQIKPEHVFPAVEQAIADCRAKIEQVLEGNNTPSWETVIAPIEE
VDDRLSRIWSPVSHMNSVVNSDELRDAYESCLPMLSEYGTWVGQHKGLFEAYKAIKASEAFAKLTTAQQKTITDALRDFE
LSGIGLPADEQKRYGEISKRMSELSSKFSNNTLDATMGWTKHITDEKELAGMPESALAAAKAAAEAKELDGYLITLDVPS
YLPVMTYCDNQALRREVYEAYVTRASDRGPNAGKWDNTEIINEQLKLRHEIARMLGFNTYSEKSLATKMAENPAQVLGFL
NDLATKAKPQGEREVAELRQFAEQEFGVSELNVWDIAYYSEKQKQHLFQISDEELRPYFPESKAVSGLFEVLKRVFGMSV
KEREGIDVWHNSVRFFDIFDAQGELRGSFYLDLYAREHKRGGAWMDECRVRRINAQGELQTPVAYLTCNFNRPIGDKPAL
FTHDEVVTLFHEFGHGIHHMLTQVTTGAVSGINGVPWDAVELPSQFLENWCWEEEALAFISGHYETGEPLPKAMLEKMLA
AKNFQSAMGILRQLEFGLFDFTLHTEFDPEIGPRVLETLAQVKQKVAVLPAVEWARFSHSFGHIFAGGYCAGYYSYLWAE
VLSSDAFSRFEEEGIFNAETGQSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHSGIAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=32.03125, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI14149738, Length=673, Percent_Identity=30.7578008915305, Blast_Score=296, Evalue=7e-80,
Organism=Homo sapiens, GI156105687, Length=659, Percent_Identity=24.4309559939302, Blast_Score=186, Evalue=8e-47,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=70.6489675516224, Blast_Score=1021, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=30.6122448979592, Blast_Score=292, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71999758, Length=574, Percent_Identity=25.7839721254355, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI32565901, Length=680, Percent_Identity=21.0294117647059, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=697, Percent_Identity=29.6987087517934, Blast_Score=304, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=735, Percent_Identity=24.0816326530612, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21356111, Length=579, Percent_Identity=27.979274611399, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI20129717, Length=546, Percent_Identity=25.4578754578755, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79254; Mature: 79254

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRAIDGQLATILKSQTKGIYMSNPLLTFTDLPPFSQIKPEHVFPAVEQAIADCRAKIE
CCCCCCCHHHHHHHHHHCCCEEECCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHH
QVLEGNNTPSWETVIAPIEEVDDRLSRIWSPVSHMNSVVNSDELRDAYESCLPMLSEYGT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
WVGQHKGLFEAYKAIKASEAFAKLTTAQQKTITDALRDFELSGIGLPADEQKRYGEISKR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
MSELSSKFSNNTLDATMGWTKHITDEKELAGMPESALAAAKAAAEAKELDGYLITLDVPS
HHHHHHHHCCCCCHHHCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
YLPVMTYCDNQALRREVYEAYVTRASDRGPNAGKWDNTEIINEQLKLRHEIARMLGFNTY
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SEKSLATKMAENPAQVLGFLNDLATKAKPQGEREVAELRQFAEQEFGVSELNVWDIAYYS
CHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
EKQKQHLFQISDEELRPYFPESKAVSGLFEVLKRVFGMSVKEREGIDVWHNSVRFFDIFD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEEEC
AQGELRGSFYLDLYAREHKRGGAWMDECRVRRINAQGELQTPVAYLTCNFNRPIGDKPAL
CCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHEECCCCCCCCCEEEEEEECCCCCCCCCCE
FTHDEVVTLFHEFGHGIHHMLTQVTTGAVSGINGVPWDAVELPSQFLENWCWEEEALAFI
ECHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SGHYETGEPLPKAMLEKMLAAKNFQSAMGILRQLEFGLFDFTLHTEFDPEIGPRVLETLA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
QVKQKVAVLPAVEWARFSHSFGHIFAGGYCAGYYSYLWAEVLSSDAFSRFEEEGIFNAET
HHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GQSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHSGIAA
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNKRAIDGQLATILKSQTKGIYMSNPLLTFTDLPPFSQIKPEHVFPAVEQAIADCRAKIE
CCCCCCCHHHHHHHHHHCCCEEECCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHH
QVLEGNNTPSWETVIAPIEEVDDRLSRIWSPVSHMNSVVNSDELRDAYESCLPMLSEYGT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
WVGQHKGLFEAYKAIKASEAFAKLTTAQQKTITDALRDFELSGIGLPADEQKRYGEISKR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
MSELSSKFSNNTLDATMGWTKHITDEKELAGMPESALAAAKAAAEAKELDGYLITLDVPS
HHHHHHHHCCCCCHHHCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
YLPVMTYCDNQALRREVYEAYVTRASDRGPNAGKWDNTEIINEQLKLRHEIARMLGFNTY
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SEKSLATKMAENPAQVLGFLNDLATKAKPQGEREVAELRQFAEQEFGVSELNVWDIAYYS
CHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
EKQKQHLFQISDEELRPYFPESKAVSGLFEVLKRVFGMSVKEREGIDVWHNSVRFFDIFD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEEEC
AQGELRGSFYLDLYAREHKRGGAWMDECRVRRINAQGELQTPVAYLTCNFNRPIGDKPAL
CCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHEECCCCCCCCCEEEEEEECCCCCCCCCCE
FTHDEVVTLFHEFGHGIHHMLTQVTTGAVSGINGVPWDAVELPSQFLENWCWEEEALAFI
ECHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SGHYETGEPLPKAMLEKMLAAKNFQSAMGILRQLEFGLFDFTLHTEFDPEIGPRVLETLA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
QVKQKVAVLPAVEWARFSHSFGHIFAGGYCAGYYSYLWAEVLSSDAFSRFEEEGIFNAET
HHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GQSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHSGIAA
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]