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The map label for this gene is iscS [H]

Identifier: 37523953

GI number: 37523953

Start: 4613360

End: 4614637

Strand: Reverse

Name: iscS [H]

Synonym: gll4384

Alternate gene names: 37523953

Gene position: 4614637-4613360 (Counterclockwise)

Preceding gene: 37523955

Following gene: 37523952

Centisome position: 99.05

GC content: 61.19

Gene sequence:

>1278_bases
ATGATCACTAGAGCTATCTATATGGACAACAACGCCACCACCCCGGTCGATCCGGTGGTGCTGGAGGTGATGTTGCCGTA
CTTCACCGAGAAATTCGGCAACGCGGCCAGCCGCAACCACGCCTATGGCTGGGAAGCGGAGGAAGCGGTCGAAAACGCCC
GCGCCCAGATTGCTGCGGCGGTAGGGGCCGACCCGAAGGAAATCATCTTCACCAGCGGCGCCACTGAATCGAACAACCTC
GCCCTCAAGGGTGTGGCCGAGGTGTACCGCGAGAAGGGCAACCACATCATCACCGTGGTCACCGAGCACAAGTGCATCCT
GGATAGCGCCAAGTACCTCGAGCAGCACGGCTGCCGCATCACTTATCTGCCGGTCAAGCCCGACGGTCTCATAGATCTGG
CCGAGTTGGAAGCGGCGATTACCCCTGAGACCGTTTTGATCTCGGTGATGTTCGCCAACAACGAAATCGGCGTCATTCAG
CCTGTCGCCGAAATCGCCAAGATTGCCAAATCCCACGGCGTGCTCTTTCACACCGACGCTGCCCAGGCCCTGGGCAAAGT
GCCCATCGACGTGCAGGCCCTAGGCATCGACTTGATGTCGATGTCAGGCCACAAGCTCTACGGCCCCAAGGGCATCGGTG
CTCTCTACGTGCGGCGCAAGAACCCGCGTGTGCGCCTCGAAGCGCAGTTGCACGGCGGTGGCCATGAGCGGGGCATGCGC
TCCGGTACCCTCTATGTGCCCCTGATTGTCGGCATGGGTGCCGCGGCCGAGCGGGCGGTGCAAAACCTCGAAGTCGAAGC
GGCCCGGACGCGCAAACTGCGCGAGCGGCTCTTAGAACAAATTACCGGTCGGTTGAGCGAGGTTTATGTCAACGGCTCGC
TGGAACATCGCCTGTCCGGCAACCTCAACTTGAGCTTCGCCTTTGTCGAAGGGGAAGCCCTGCTGATGGGCCTCAACGAC
ACGGTGGCACTCTCCTCCGGGTCGGCGTGCACTTCGGCGTCGCTGGAGCCCAGTTACGTGCTCAAGGCCCTGGGGGTGGG
CGACGAATTGGCTCACTCCTCGCTGCGCTTCGGGATCGGCCGCTTTAATACTGAAGAAGACATCGACCGCACCAGCGCCA
AAATTGTCGAGGTGGTCAACCGCCTGCGCGAGATGTCGCCTCTGTGGGAGATGCACCAGGAAGGCATCGACCTGAAGCAG
ATGGCCTGGCCGCCCACTGACTTTCTTTTGCCCACCGCACACCCTGAAAGGATCCCAGGCCATGCCGTACAGCGATAA

Upstream 100 bases:

>100_bases
ACCACCGTAAAGTACAATGAAGCCAGCGAAACAGTACCAAGTTAGTGCGGTATCCGTTCGAGTCCGGCGAGACGTTTAGC
ACCCGAAGGGAACAGGCAGG

Downstream 100 bases:

>100_bases
AGTCATCGACCACTACAACAATCTCCTGAGCCTGCCGCCGGTCAAGATCCACTGCTCGGTGCCGGCTGAGGATGCCATGC
GGGCTGCCGTTGCCGACTAC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MITRAIYMDNNATTPVDPVVLEVMLPYFTEKFGNAASRNHAYGWEAEEAVENARAQIAAAVGADPKEIIFTSGATESNNL
ALKGVAEVYREKGNHIITVVTEHKCILDSAKYLEQHGCRITYLPVKPDGLIDLAELEAAITPETVLISVMFANNEIGVIQ
PVAEIAKIAKSHGVLFHTDAAQALGKVPIDVQALGIDLMSMSGHKLYGPKGIGALYVRRKNPRVRLEAQLHGGGHERGMR
SGTLYVPLIVGMGAAAERAVQNLEVEAARTRKLRERLLEQITGRLSEVYVNGSLEHRLSGNLNLSFAFVEGEALLMGLND
TVALSSGSACTSASLEPSYVLKALGVGDELAHSSLRFGIGRFNTEEDIDRTSAKIVEVVNRLREMSPLWEMHQEGIDLKQ
MAWPPTDFLLPTAHPERIPGHAVQR

Sequences:

>Translated_425_residues
MITRAIYMDNNATTPVDPVVLEVMLPYFTEKFGNAASRNHAYGWEAEEAVENARAQIAAAVGADPKEIIFTSGATESNNL
ALKGVAEVYREKGNHIITVVTEHKCILDSAKYLEQHGCRITYLPVKPDGLIDLAELEAAITPETVLISVMFANNEIGVIQ
PVAEIAKIAKSHGVLFHTDAAQALGKVPIDVQALGIDLMSMSGHKLYGPKGIGALYVRRKNPRVRLEAQLHGGGHERGMR
SGTLYVPLIVGMGAAAERAVQNLEVEAARTRKLRERLLEQITGRLSEVYVNGSLEHRLSGNLNLSFAFVEGEALLMGLND
TVALSSGSACTSASLEPSYVLKALGVGDELAHSSLRFGIGRFNTEEDIDRTSAKIVEVVNRLREMSPLWEMHQEGIDLKQ
MAWPPTDFLLPTAHPERIPGHAVQR
>Mature_425_residues
MITRAIYMDNNATTPVDPVVLEVMLPYFTEKFGNAASRNHAYGWEAEEAVENARAQIAAAVGADPKEIIFTSGATESNNL
ALKGVAEVYREKGNHIITVVTEHKCILDSAKYLEQHGCRITYLPVKPDGLIDLAELEAAITPETVLISVMFANNEIGVIQ
PVAEIAKIAKSHGVLFHTDAAQALGKVPIDVQALGIDLMSMSGHKLYGPKGIGALYVRRKNPRVRLEAQLHGGGHERGMR
SGTLYVPLIVGMGAAAERAVQNLEVEAARTRKLRERLLEQITGRLSEVYVNGSLEHRLSGNLNLSFAFVEGEALLMGLND
TVALSSGSACTSASLEPSYVLKALGVGDELAHSSLRFGIGRFNTEEDIDRTSAKIVEVVNRLREMSPLWEMHQEGIDLKQ
MAWPPTDFLLPTAHPERIPGHAVQR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=402, Percent_Identity=62.6865671641791, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI156713448, Length=419, Percent_Identity=35.3221957040573, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI48994898, Length=400, Percent_Identity=59.25, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1789175, Length=402, Percent_Identity=28.3582089552239, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787970, Length=214, Percent_Identity=30.8411214953271, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=399, Percent_Identity=57.8947368421053, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17533177, Length=329, Percent_Identity=33.1306990881459, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=58.0645161290323, Blast_Score=471, Evalue=1e-134,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=62.75, Blast_Score=514, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46299; Mature: 46299

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRAIYMDNNATTPVDPVVLEVMLPYFTEKFGNAASRNHAYGWEAEEAVENARAQIAAA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VGADPKEIIFTSGATESNNLALKGVAEVYREKGNHIITVVTEHKCILDSAKYLEQHGCRI
CCCCCHHEEEECCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCEE
TYLPVKPDGLIDLAELEAAITPETVLISVMFANNEIGVIQPVAEIAKIAKSHGVLFHTDA
EEEECCCCCCEEHHHHHHHCCCCEEEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEECH
AQALGKVPIDVQALGIDLMSMSGHKLYGPKGIGALYVRRKNPRVRLEAQLHGGGHERGMR
HHHHCCCCCEEEEECEEEEECCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCC
SGTLYVPLIVGMGAAAERAVQNLEVEAARTRKLRERLLEQITGRLSEVYVNGSLEHRLSG
CCCEEEEHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCEEEECCC
NLNLSFAFVEGEALLMGLNDTVALSSGSACTSASLEPSYVLKALGVGDELAHSSLRFGIG
CCEEEEEEEECCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCC
RFNTEEDIDRTSAKIVEVVNRLREMSPLWEMHQEGIDLKQMAWPPTDFLLPTAHPERIPG
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCC
HAVQR
HHCCC
>Mature Secondary Structure
MITRAIYMDNNATTPVDPVVLEVMLPYFTEKFGNAASRNHAYGWEAEEAVENARAQIAAA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VGADPKEIIFTSGATESNNLALKGVAEVYREKGNHIITVVTEHKCILDSAKYLEQHGCRI
CCCCCHHEEEECCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCEE
TYLPVKPDGLIDLAELEAAITPETVLISVMFANNEIGVIQPVAEIAKIAKSHGVLFHTDA
EEEECCCCCCEEHHHHHHHCCCCEEEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEECH
AQALGKVPIDVQALGIDLMSMSGHKLYGPKGIGALYVRRKNPRVRLEAQLHGGGHERGMR
HHHHCCCCCEEEEECEEEEECCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCC
SGTLYVPLIVGMGAAAERAVQNLEVEAARTRKLRERLLEQITGRLSEVYVNGSLEHRLSG
CCCEEEEHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCEEEECCC
NLNLSFAFVEGEALLMGLNDTVALSSGSACTSASLEPSYVLKALGVGDELAHSSLRFGIG
CCEEEEEEEECCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCC
RFNTEEDIDRTSAKIVEVVNRLREMSPLWEMHQEGIDLKQMAWPPTDFLLPTAHPERIPG
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCC
HAVQR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA