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The map label for this gene is wzc [H]

Identifier: 37523879

GI number: 37523879

Start: 4542641

End: 4544917

Strand: Direct

Name: wzc [H]

Synonym: glr4310

Alternate gene names: 37523879

Gene position: 4542641-4544917 (Clockwise)

Preceding gene: 37523878

Following gene: 37523880

Centisome position: 97.5

GC content: 67.15

Gene sequence:

>2277_bases
GTGGGACTGCGCGAGTACTTGCGGATTTTGAACCGCCACTGGCCCTACGCCGCGGGGACGGCCCTGGCGGTGGTGACGGT
TGTTACCGTCTGGACTTTTGCGCTGCCACCGGTCTGGGAAGCCCAGGGCCGTTTATTGTTCAAACAGAAAGACACGGCGA
TTGACAACCCTACGGCCGTGGGCTTGCGCGGTGCTCTTGGACAGATGGGCTCGGTCGCCTACGGCAATCCCCTCGACACC
CAGGCGGAGATCCTCCAATCGCGGCCGGTGGCAGCCGGGGTGATCCGCGATCTGCAACTGGGCGATCCGCGTCGGCCGGG
GGAGTTGCTCGCCACCACCGACTTTTTGCGCGCCCTCAAAGTGGAGGCATTGCGCCGCACCGACTTATTGGTCATCAAAT
ACCGCGACCGCGACCCGGCGGTGGCGACAAGGGTGGTCAACACCCTCGCCCGCCATTACATCGACCTCAACATGCAGCAA
AATCGGGCGGAGGCCGCCTCGACCCGCGGCTTCGTCGAAGCGCAGCTGCCGGCGATGGAGCAGCGCCTGCGCGCCTCGGA
GCGCAAACTGCGTTCTTTCAAAGAACAGTACGGCAGCGTCGCCCTCGCCGAGGAGCAGCAGGCGGCGGTGCGTCTTTTGT
CCGAATTTAGAAGCCAGCAGGCCCAGGCCGATGTCGCCCTTTCGGAGGCCGGGGCGCGGGTGCGGGCGATCGACGCCCGT
ATGGGCGGTCTTTCTGAACCAGAGGCGCTCGTGGCCGGCGCCCTGAGCGGCAGCGACGGGATGCGCGATTTGCGCAAGAC
CTTGCTTGAGATCGAATCGAAGCTGGCGGTGGCCCGCGCCCAGTACCAGGACAGCTATCCCGAAGTCGAGCAACTTATCA
AGCGGCGGGGTGCCTTGCGGGCGCTGCTGGCGAGCGAGGCGGACCGGCTTTTGGGCCGCCGGGGACTGCCCGATTCGCTG
CTCGATGCGAATCTGGGGACCGGGAGGACCGAGCCAGCGGCGGTCCCCGACGATCTGCCGCGCCTCGACGCGGTGCGCCA
GCAACTGCTCAAAGATCTGATCGCCGCCCGGGTCGAAGAACTGGCCGCCCGCACCCGCACCGAGGCGCTCGCCCGGGTGA
GTGCCGAGTACGACGCGCGGGTGGCCGCTTTGCCCCGGCTGGAGGAGTCCCAGCGCCGGCTGGCCCGGCAGGTGGAGGCC
GACCAGGAAGCCTACCGGCTACTTCAGAAAAAATTCTACGAATACCGGATTCTCGAAGCGCAGAACATCGGCAACGCCAC
GCTCATCGAACCGGCCGAGGTGCCGGAGATACCAGCCTGGCCGAAGCCGCTGCTCAATCTGGCTGCGGGCGGAGTGCTCG
CCCTGATTCTCGCAGCGCTAGCCGCCTACACGCGCGAATTTTTTGACGACTCGCTGCGCAGCGTCGAGGAAGCGCGGGGG
CTTCTGGGCACATCGCTTCTGGGAAGCGTGCCGCGCTGGAACGCCCAGAGCGTCCGGGGTCCGCTCATGGCGCTTCGCGA
CCCGCTCTCGCCGGTGAGCGAGGCCTACCGTTCGATCCGCACCCACCTCAAATTTTTAAGTAGCGAGCGGGGTCTGCGCG
CCTTCGTGCTCACCAGCGCCAGCCCCCAGGAGGGAAAATCGACCACCGCCGCCAATCTTGCGGCGGTGAGCGCCCAGGCA
GGGGCGCGGGTGTTGCTGGTGGACGGCGACCTGCGCAAACCCCGCCAGCACGCCCTCTGGGATCTCGACAACCGCCAGGG
GCTCTCGACGCTGCTGGTGGGTGAAGCCGACTGGCAAACGGCAGTCCGCCCCACCCCCCAACCCGGTCTCGTGGTGCTCA
CCGCCGGACCGCCACCGCCCAACCCGGTAGTCCTGCTCGAATCGAGGCGATTGGGCGAACTGCTTGGCCTGTGGAGCGAG
CAGTTCGACCTCGTCATCTTCGACGCCCCGCCGCTCACCGCCGCCTCCGATGCACTGGTACTGGGGGCGCTCGGTGGCGG
ACTGGTGCTGGTGGTGCGTCCCGGCGTCACCAACAAGCGCGTGCTCGCCAAGGTGCGCGACAGCCTCAAGCGGCCCGGCA
TCGAGCTGTTGGGTCATATCGTCAATGGCACAATCGCCGCCAACGAAGGCCACGACGAGTACTACTACTACAACCGCTAC
GGGGCCGACCCCGTCCCAGGGCAGCCCGAAGCTGCGGCCCACACCAACGGCAACGGCACCGCCCGCCGTTGGTTCCAATC
CCTCTCCACCCGGCGCTCCAGCAAGCCCCGCTCCTGA

Upstream 100 bases:

>100_bases
AGTCAACTGCAGCAAGTTATACGGATAGGTCGCGTGTTTGACTGCATACATTGCGCATGGTGTAAATTCTTGGTTGCAGG
TGCATGGATGAGGAGAGTGC

Downstream 100 bases:

>100_bases
AGATGTCTGCCATCGCCGTCAACGGCCGGTTCCTGCACAAAGCGCGCATCTGTGGCGTCGAGCGCTACGGCCGGGAGGTG
GTTGCCCGGCTGCCGGAGTA

Product: hypothetical protein

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MGLREYLRILNRHWPYAAGTALAVVTVVTVWTFALPPVWEAQGRLLFKQKDTAIDNPTAVGLRGALGQMGSVAYGNPLDT
QAEILQSRPVAAGVIRDLQLGDPRRPGELLATTDFLRALKVEALRRTDLLVIKYRDRDPAVATRVVNTLARHYIDLNMQQ
NRAEAASTRGFVEAQLPAMEQRLRASERKLRSFKEQYGSVALAEEQQAAVRLLSEFRSQQAQADVALSEAGARVRAIDAR
MGGLSEPEALVAGALSGSDGMRDLRKTLLEIESKLAVARAQYQDSYPEVEQLIKRRGALRALLASEADRLLGRRGLPDSL
LDANLGTGRTEPAAVPDDLPRLDAVRQQLLKDLIAARVEELAARTRTEALARVSAEYDARVAALPRLEESQRRLARQVEA
DQEAYRLLQKKFYEYRILEAQNIGNATLIEPAEVPEIPAWPKPLLNLAAGGVLALILAALAAYTREFFDDSLRSVEEARG
LLGTSLLGSVPRWNAQSVRGPLMALRDPLSPVSEAYRSIRTHLKFLSSERGLRAFVLTSASPQEGKSTTAANLAAVSAQA
GARVLLVDGDLRKPRQHALWDLDNRQGLSTLLVGEADWQTAVRPTPQPGLVVLTAGPPPPNPVVLLESRRLGELLGLWSE
QFDLVIFDAPPLTAASDALVLGALGGGLVLVVRPGVTNKRVLAKVRDSLKRPGIELLGHIVNGTIAANEGHDEYYYYNRY
GADPVPGQPEAAAHTNGNGTARRWFQSLSTRRSSKPRS

Sequences:

>Translated_758_residues
MGLREYLRILNRHWPYAAGTALAVVTVVTVWTFALPPVWEAQGRLLFKQKDTAIDNPTAVGLRGALGQMGSVAYGNPLDT
QAEILQSRPVAAGVIRDLQLGDPRRPGELLATTDFLRALKVEALRRTDLLVIKYRDRDPAVATRVVNTLARHYIDLNMQQ
NRAEAASTRGFVEAQLPAMEQRLRASERKLRSFKEQYGSVALAEEQQAAVRLLSEFRSQQAQADVALSEAGARVRAIDAR
MGGLSEPEALVAGALSGSDGMRDLRKTLLEIESKLAVARAQYQDSYPEVEQLIKRRGALRALLASEADRLLGRRGLPDSL
LDANLGTGRTEPAAVPDDLPRLDAVRQQLLKDLIAARVEELAARTRTEALARVSAEYDARVAALPRLEESQRRLARQVEA
DQEAYRLLQKKFYEYRILEAQNIGNATLIEPAEVPEIPAWPKPLLNLAAGGVLALILAALAAYTREFFDDSLRSVEEARG
LLGTSLLGSVPRWNAQSVRGPLMALRDPLSPVSEAYRSIRTHLKFLSSERGLRAFVLTSASPQEGKSTTAANLAAVSAQA
GARVLLVDGDLRKPRQHALWDLDNRQGLSTLLVGEADWQTAVRPTPQPGLVVLTAGPPPPNPVVLLESRRLGELLGLWSE
QFDLVIFDAPPLTAASDALVLGALGGGLVLVVRPGVTNKRVLAKVRDSLKRPGIELLGHIVNGTIAANEGHDEYYYYNRY
GADPVPGQPEAAAHTNGNGTARRWFQSLSTRRSSKPRS
>Mature_757_residues
GLREYLRILNRHWPYAAGTALAVVTVVTVWTFALPPVWEAQGRLLFKQKDTAIDNPTAVGLRGALGQMGSVAYGNPLDTQ
AEILQSRPVAAGVIRDLQLGDPRRPGELLATTDFLRALKVEALRRTDLLVIKYRDRDPAVATRVVNTLARHYIDLNMQQN
RAEAASTRGFVEAQLPAMEQRLRASERKLRSFKEQYGSVALAEEQQAAVRLLSEFRSQQAQADVALSEAGARVRAIDARM
GGLSEPEALVAGALSGSDGMRDLRKTLLEIESKLAVARAQYQDSYPEVEQLIKRRGALRALLASEADRLLGRRGLPDSLL
DANLGTGRTEPAAVPDDLPRLDAVRQQLLKDLIAARVEELAARTRTEALARVSAEYDARVAALPRLEESQRRLARQVEAD
QEAYRLLQKKFYEYRILEAQNIGNATLIEPAEVPEIPAWPKPLLNLAAGGVLALILAALAAYTREFFDDSLRSVEEARGL
LGTSLLGSVPRWNAQSVRGPLMALRDPLSPVSEAYRSIRTHLKFLSSERGLRAFVLTSASPQEGKSTTAANLAAVSAQAG
ARVLLVDGDLRKPRQHALWDLDNRQGLSTLLVGEADWQTAVRPTPQPGLVVLTAGPPPPNPVVLLESRRLGELLGLWSEQ
FDLVIFDAPPLTAASDALVLGALGGGLVLVVRPGVTNKRVLAKVRDSLKRPGIELLGHIVNGTIAANEGHDEYYYYNRYG
ADPVPGQPEAAAHTNGNGTARRWFQSLSTRRSSKPRS

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=422, Percent_Identity=32.4644549763033, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1787216, Length=349, Percent_Identity=32.9512893982808, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 82798; Mature: 82666

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLREYLRILNRHWPYAAGTALAVVTVVTVWTFALPPVWEAQGRLLFKQKDTAIDNPTAV
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHH
GLRGALGQMGSVAYGNPLDTQAEILQSRPVAAGVIRDLQLGDPRRPGELLATTDFLRALK
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VEALRRTDLLVIKYRDRDPAVATRVVNTLARHYIDLNMQQNRAEAASTRGFVEAQLPAME
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
QRLRASERKLRSFKEQYGSVALAEEQQAAVRLLSEFRSQQAQADVALSEAGARVRAIDAR
HHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
MGGLSEPEALVAGALSGSDGMRDLRKTLLEIESKLAVARAQYQDSYPEVEQLIKRRGALR
HCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ALLASEADRLLGRRGLPDSLLDANLGTGRTEPAAVPDDLPRLDAVRQQLLKDLIAARVEE
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAARTRTEALARVSAEYDARVAALPRLEESQRRLARQVEADQEAYRLLQKKFYEYRILEA
HHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEC
QNIGNATLIEPAEVPEIPAWPKPLLNLAAGGVLALILAALAAYTREFFDDSLRSVEEARG
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGTSLLGSVPRWNAQSVRGPLMALRDPLSPVSEAYRSIRTHLKFLSSERGLRAFVLTSA
HHHHHHHCCCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
SPQEGKSTTAANLAAVSAQAGARVLLVDGDLRKPRQHALWDLDNRQGLSTLLVGEADWQT
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCC
AVRPTPQPGLVVLTAGPPPPNPVVLLESRRLGELLGLWSEQFDLVIFDAPPLTAASDALV
CCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHE
LGALGGGLVLVVRPGVTNKRVLAKVRDSLKRPGIELLGHIVNGTIAANEGHDEYYYYNRY
EEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCEEEECC
GADPVPGQPEAAAHTNGNGTARRWFQSLSTRRSSKPRS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GLREYLRILNRHWPYAAGTALAVVTVVTVWTFALPPVWEAQGRLLFKQKDTAIDNPTAV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHH
GLRGALGQMGSVAYGNPLDTQAEILQSRPVAAGVIRDLQLGDPRRPGELLATTDFLRALK
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VEALRRTDLLVIKYRDRDPAVATRVVNTLARHYIDLNMQQNRAEAASTRGFVEAQLPAME
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
QRLRASERKLRSFKEQYGSVALAEEQQAAVRLLSEFRSQQAQADVALSEAGARVRAIDAR
HHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
MGGLSEPEALVAGALSGSDGMRDLRKTLLEIESKLAVARAQYQDSYPEVEQLIKRRGALR
HCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ALLASEADRLLGRRGLPDSLLDANLGTGRTEPAAVPDDLPRLDAVRQQLLKDLIAARVEE
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAARTRTEALARVSAEYDARVAALPRLEESQRRLARQVEADQEAYRLLQKKFYEYRILEA
HHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEC
QNIGNATLIEPAEVPEIPAWPKPLLNLAAGGVLALILAALAAYTREFFDDSLRSVEEARG
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGTSLLGSVPRWNAQSVRGPLMALRDPLSPVSEAYRSIRTHLKFLSSERGLRAFVLTSA
HHHHHHHCCCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
SPQEGKSTTAANLAAVSAQAGARVLLVDGDLRKPRQHALWDLDNRQGLSTLLVGEADWQT
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCC
AVRPTPQPGLVVLTAGPPPPNPVVLLESRRLGELLGLWSEQFDLVIFDAPPLTAASDALV
CCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHE
LGALGGGLVLVVRPGVTNKRVLAKVRDSLKRPGIELLGHIVNGTIAANEGHDEYYYYNRY
EEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCEEEECC
GADPVPGQPEAAAHTNGNGTARRWFQSLSTRRSSKPRS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]