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The map label for this gene is rpoC1

Identifier: 37523846

GI number: 37523846

Start: 4498067

End: 4499893

Strand: Direct

Name: rpoC1

Synonym: gvip556

Alternate gene names: 37523846

Gene position: 4498067-4499893 (Clockwise)

Preceding gene: 37523842

Following gene: 37523847

Centisome position: 96.55

GC content: 62.94

Gene sequence:

>1827_bases
ATGCCCAGGATGGAACAGCGTTTCGACTACATCAAGATCTCTATTGCCTCCCCGGAGCGGGTCATGGCCTGGGGGCAGCG
CACCCTCCCCAACGGCCAGGTCGTCGGGGAGGTGACCAAGCCCGAGACGATCAACTACCGCACCCTCAAGCCCGAGATGG
ACGGGCTTTTTTGTGAGCGCATCTTCGGGCCTTCCAAAGATTGGGAGTGCTACTGCGGCAAATACAAACGCGTGCGCCAC
CGGGGCATCGTCTGCGAGCGCTGCGGCGTCGAAGTCACCGAATCGAAGGTGCGCCGCCACCGCATGGGCTATATCAAGCT
CGCCGCCCCGGTCACCCACGTCTGGTACCTGAAGGGCATTCCTTCTTATATTTCGACGCTGCTCGACATGCCCCTGCGCG
ACGTCGAGCAGGTGGTCTATTTCAACGCCTACGTGGTGCTCAACCCGGGCAACGCCGAGAACCTCTACTACAAACAGCTG
CTCACCGAGGACCAGTATATCGAGGTCGAAGATCAGATCTTCGCCGAGGATTCGAGCCTGGAACTGCCCGAAGGTTGGGC
GAAGATGGGGGCCGAAGCGATCCACGAACTGCTCGCGGCCATCGAAATGGAGTCCGAAGCCGAGCGGCTGCGCGCAGATC
TGGGCGAGTCGAAGGGGCAGAAGCGCACCAAACTGATCAAGCGCCTGCGGGTGCTCGACAACTTCATCGCCACCGGTTCG
CGGCCGGAGTGGATGGTACTGACCGCCATCCCGGTCATCCCGCCGGATCTGAGACCGATGGTGCAGCTCGACGGCGGCCG
TTTTGCCACCAGCGACCTCAACGACCTCTACCGCCGGGTGATCAACCGCAACAACCGCCTCGCGCGTCTGCAGGAGATCC
TGGCGCCCGAGATCATCGTGCGCAACGAAAAGCGTATGCTCCAGGAGGCGGTGGACGCGCTCATCGACAACGGCCGGCGC
GGCCGGACGGTGGTCGGCGCCAACAACCGGCCCCTCAAGTCGCTCTCGGACATCATCGAGGGCAAGCAGGGGCGCTTTCG
CCAGAACCTGCTCGGTAAGCGCGTCGACTACTCGGGCCGCTCGGTGATCGTGGTCGGCCCCAAGCTCAAGCTCCACCAGT
GCGGCCTGCCCAAGGAGATGGCCATCGAGCTGTTTCAGCCGTTTGTCATCCACAAGCTCATCCAGCGCGGACTGGTCAAC
AACATCAAAGCCGCCAAAAAGATGATCCAGCGCAACGACGCGCGCATCTGGAGCGTGCTCGACGAGGTGATCACCGGCCA
CCCGGTGCTCCTCAACCGCGCGCCCACGCTCCACCGCCTGGGTATCCAGGCGTTCGAACCGATCCTGGTCTCCGGTCGTG
CCATTCAGCTCCATCCGCTGGTGTGCACGGCCTTCAACGCCGACTTCGACGGCGATCAGATGGCGGTGCACGTGCCGCTG
TCGCTGGAGTCGCAGGCGGAGGCGCGCCTGTTGATGCTCGCTTCCAACAACGTGCTTTCGCCTGCCACCGGTCGGCCGAT
CATCACCCCTACCCAGGACATGGTGCTCGGGTGCTACTACCTGACGGTCGACAACCCCGACGCCACCAAAGGCTCCGGTA
AATACTTCGGCAGCAGCGAAGACGCCGTGATCGCCTACAACCAGGGCATGATCGACCTGCACGCCAAGATCTGGCTGCGC
TTTGAGGGCGAGGTCGAAACCGACAACCCCGAGGATTTGCGCGTGCGCCGTGACGAGCAGGGCAACGCGCTCTCGCAGTT
CGTGCGCACCACCGTCGGGCGCATCATCTTCAACCAGGTCATTCAAGAAACGCTTGTCGCCAGCTAG

Upstream 100 bases:

>100_bases
GTTCGTGCATAAGGTTTGATCCAAAGCCGGTGTGGGGTGCCTTTTGCTTTTGGCTGGGCTCCTTGCCTCCGGCAGCGCAT
TGATTCGGGAGTAGAAGCTC

Downstream 100 bases:

>100_bases
CGAAGGGAAAAGCCATGACGCAAGAACCGCAACCCAAGTTCATCAACCGCAAAATCGACAAGAAGGGTCTGGGCAAGCTC
ATCTCCTGGGCTTTCTCCCA

Product: DNA-directed RNA polymerase subunit gamma

Products: NA

Alternate protein names: RNAP subunit gamma; RNA polymerase subunit gamma; Transcriptase subunit gamma

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPRMEQRFDYIKISIASPERVMAWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCERIFGPSKDWECYCGKYKRVRH
RGIVCERCGVEVTESKVRRHRMGYIKLAAPVTHVWYLKGIPSYISTLLDMPLRDVEQVVYFNAYVVLNPGNAENLYYKQL
LTEDQYIEVEDQIFAEDSSLELPEGWAKMGAEAIHELLAAIEMESEAERLRADLGESKGQKRTKLIKRLRVLDNFIATGS
RPEWMVLTAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRR
GRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKEMAIELFQPFVIHKLIQRGLVN
NIKAAKKMIQRNDARIWSVLDEVITGHPVLLNRAPTLHRLGIQAFEPILVSGRAIQLHPLVCTAFNADFDGDQMAVHVPL
SLESQAEARLLMLASNNVLSPATGRPIITPTQDMVLGCYYLTVDNPDATKGSGKYFGSSEDAVIAYNQGMIDLHAKIWLR
FEGEVETDNPEDLRVRRDEQGNALSQFVRTTVGRIIFNQVIQETLVAS

Sequences:

>Translated_608_residues
MPRMEQRFDYIKISIASPERVMAWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCERIFGPSKDWECYCGKYKRVRH
RGIVCERCGVEVTESKVRRHRMGYIKLAAPVTHVWYLKGIPSYISTLLDMPLRDVEQVVYFNAYVVLNPGNAENLYYKQL
LTEDQYIEVEDQIFAEDSSLELPEGWAKMGAEAIHELLAAIEMESEAERLRADLGESKGQKRTKLIKRLRVLDNFIATGS
RPEWMVLTAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRR
GRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKEMAIELFQPFVIHKLIQRGLVN
NIKAAKKMIQRNDARIWSVLDEVITGHPVLLNRAPTLHRLGIQAFEPILVSGRAIQLHPLVCTAFNADFDGDQMAVHVPL
SLESQAEARLLMLASNNVLSPATGRPIITPTQDMVLGCYYLTVDNPDATKGSGKYFGSSEDAVIAYNQGMIDLHAKIWLR
FEGEVETDNPEDLRVRRDEQGNALSQFVRTTVGRIIFNQVIQETLVAS
>Mature_607_residues
PRMEQRFDYIKISIASPERVMAWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCERIFGPSKDWECYCGKYKRVRHR
GIVCERCGVEVTESKVRRHRMGYIKLAAPVTHVWYLKGIPSYISTLLDMPLRDVEQVVYFNAYVVLNPGNAENLYYKQLL
TEDQYIEVEDQIFAEDSSLELPEGWAKMGAEAIHELLAAIEMESEAERLRADLGESKGQKRTKLIKRLRVLDNFIATGSR
PEWMVLTAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRG
RTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKEMAIELFQPFVIHKLIQRGLVNN
IKAAKKMIQRNDARIWSVLDEVITGHPVLLNRAPTLHRLGIQAFEPILVSGRAIQLHPLVCTAFNADFDGDQMAVHVPLS
LESQAEARLLMLASNNVLSPATGRPIITPTQDMVLGCYYLTVDNPDATKGSGKYFGSSEDAVIAYNQGMIDLHAKIWLRF
EGEVETDNPEDLRVRRDEQGNALSQFVRTTVGRIIFNQVIQETLVAS

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG0086

COG function: function code K; DNA-directed RNA polymerase, beta' subunit/160 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily

Homologues:

Organism=Homo sapiens, GI4505939, Length=494, Percent_Identity=27.3279352226721, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI39725938, Length=325, Percent_Identity=30.1538461538462, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI103471997, Length=230, Percent_Identity=31.304347826087, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI2367335, Length=601, Percent_Identity=60.2329450915141, Blast_Score=754, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987878, Length=305, Percent_Identity=31.1475409836066, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25145495, Length=494, Percent_Identity=27.9352226720648, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320061, Length=328, Percent_Identity=33.2317073170732, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324690, Length=360, Percent_Identity=33.0555555555556, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17530899, Length=491, Percent_Identity=25.6619144602851, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281360912, Length=503, Percent_Identity=26.8389662027833, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17647875, Length=374, Percent_Identity=27.0053475935829, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPOC1_GLOVI (Q7NDF8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927223.1
- ProteinModelPortal:   Q7NDF8
- SMR:   Q7NDF8
- GeneID:   2602680
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.4277
- HOGENOM:   HBG285548
- OMA:   HVWYLKG
- ProtClustDB:   PRK02625
- BioCyc:   GVIO251221:GLR4277-MONOMER
- BRENDA:   2.7.7.6
- HAMAP:   MF_01323
- InterPro:   IPR000722
- InterPro:   IPR006592
- InterPro:   IPR007080
- InterPro:   IPR007066
- InterPro:   IPR012755
- SMART:   SM00663
- TIGRFAMs:   TIGR02387

Pfam domain/function: PF04997 RNA_pol_Rpb1_1; PF00623 RNA_pol_Rpb1_2; PF04983 RNA_pol_Rpb1_3

EC number: =2.7.7.6

Molecular weight: Translated: 68865; Mature: 68733

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRMEQRFDYIKISIASPERVMAWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCER
CCCHHHCCCEEEEEECCCHHHHHCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHH
IFGPSKDWECYCGKYKRVRHRGIVCERCGVEVTESKVRRHRMGYIKLAAPVTHVWYLKGI
HCCCCCCCHHHHHHHHHHHHCCCEEHHCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHCH
PSYISTLLDMPLRDVEQVVYFNAYVVLNPGNAENLYYKQLLTEDQYIEVEDQIFAEDSSL
HHHHHHHHCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCEEEECHHHEECCCCC
ELPEGWAKMGAEAIHELLAAIEMESEAERLRADLGESKGQKRTKLIKRLRVLDNFIATGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
RPEWMVLTAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIV
CCCEEEEEEECCCCCCCCCEEEECCCEEECCHHHHHHHHHHCCCCHHHHHHHHHCCHHEE
RNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGR
CCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCC
SVIVVGPKLKLHQCGLPKEMAIELFQPFVIHKLIQRGLVNNIKAAKKMIQRNDARIWSVL
EEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DEVITGHPVLLNRAPTLHRLGIQAFEPILVSGRAIQLHPLVCTAFNADFDGDQMAVHVPL
HHHHCCCCEEECCCCCHHHHCHHHHCHHHCCCCEEEEEEEEEEEECCCCCCCCEEEEEEC
SLESQAEARLLMLASNNVLSPATGRPIITPTQDMVLGCYYLTVDNPDATKGSGKYFGSSE
CCCCCCCEEEEEEECCCEECCCCCCCCCCCCHHHEEEEEEEEECCCCCCCCCCCCCCCCC
DAVIAYNQGMIDLHAKIWLRFEGEVETDNPEDLRVRRDEQGNALSQFVRTTVGRIIFNQV
CEEEEECCCEEEEEEEEEEEEECEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
IQETLVAS
HHHHHCCC
>Mature Secondary Structure 
PRMEQRFDYIKISIASPERVMAWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCER
CCHHHCCCEEEEEECCCHHHHHCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHH
IFGPSKDWECYCGKYKRVRHRGIVCERCGVEVTESKVRRHRMGYIKLAAPVTHVWYLKGI
HCCCCCCCHHHHHHHHHHHHCCCEEHHCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHCH
PSYISTLLDMPLRDVEQVVYFNAYVVLNPGNAENLYYKQLLTEDQYIEVEDQIFAEDSSL
HHHHHHHHCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCEEEECHHHEECCCCC
ELPEGWAKMGAEAIHELLAAIEMESEAERLRADLGESKGQKRTKLIKRLRVLDNFIATGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
RPEWMVLTAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIV
CCCEEEEEEECCCCCCCCCEEEECCCEEECCHHHHHHHHHHCCCCHHHHHHHHHCCHHEE
RNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGR
CCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCC
SVIVVGPKLKLHQCGLPKEMAIELFQPFVIHKLIQRGLVNNIKAAKKMIQRNDARIWSVL
EEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DEVITGHPVLLNRAPTLHRLGIQAFEPILVSGRAIQLHPLVCTAFNADFDGDQMAVHVPL
HHHHCCCCEEECCCCCHHHHCHHHHCHHHCCCCEEEEEEEEEEEECCCCCCCCEEEEEEC
SLESQAEARLLMLASNNVLSPATGRPIITPTQDMVLGCYYLTVDNPDATKGSGKYFGSSE
CCCCCCCEEEEEEECCCEECCCCCCCCCCCCHHHEEEEEEEEECCCCCCCCCCCCCCCCC
DAVIAYNQGMIDLHAKIWLRFEGEVETDNPEDLRVRRDEQGNALSQFVRTTVGRIIFNQV
CEEEEECCCEEEEEEEEEEEEECEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
IQETLVAS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292