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The map label for this gene is kdgA [H]

Identifier: 37523840

GI number: 37523840

Start: 4493081

End: 4493746

Strand: Reverse

Name: kdgA [H]

Synonym: gll4271

Alternate gene names: 37523840

Gene position: 4493746-4493081 (Counterclockwise)

Preceding gene: 37523843

Following gene: 37523839

Centisome position: 96.45

GC content: 70.72

Gene sequence:

>666_bases
GTGTCCCACGCCCTATGCCACCGCTTTATTGAGCACCGTCTGCTTGCCATCGTGCGCGCCGACTCGGCCCCGGCCGCCCT
GGCCATCGGCCGGGCGGTGGTCACTGGCGGCTTCCGGTTGGTGGAGGTGACCCTCACCACCCCCGGCGCCGAGCAGGTGG
TGGGCGAGTTGCGCGGCTCGGGCGGCGAGGTGTTGGTCGGCTGCGGCACAGTCCTGACCCCCGAGGCAGCCCGCCGGGCG
ATCGGATGGGGGGCACACTTTGTGGTCAGTCCCCACACGGACCCGGAAATTATCGCCACCGCCCATCAACTGGGCGCGCT
CGCCATCGGCGGCGCCCTCACCCCGAATGAGATCGTGGCGGCCTGGCAGGCAGGAGCGGATCTGATCAAGGTGTTTCCGG
TCGCCCAGGTGGGAGGGCTTGCCTACTTAAAGGCTCTGCGCGGGCCGTTTCCCGACCTGCCGCTCTTGCCCACCGGGGGC
ATCGGCGAGGATGACTATCTGGACTACCTGGCCGCCGGGGCGACCGCCGTCGGGGTCGGCCAGGCCCTCGCCCCCCAGGG
TGAAGTGCGCGAGGGACGCTGGGGAACCGTCGCCGGTCGGGCCAGCGACTGGGTGATGCGTTTGGCCGAGGGCAACGGCT
GTCTGGTTCCGGGGGAGCGCCGGTAA

Upstream 100 bases:

>100_bases
ACGCTCCTCATCAGTGTATCCAGACCGGACGTTTGTGGCTGATCCCCTTGTGGGTGGATCCGCTATGCTGGGAGGCTGAT
CGCCCGAAAGCGTCACGCGC

Downstream 100 bases:

>100_bases
AATGGCGTTGGACACCTCGGCGGACTGGACATGCTTGGCAAGTTTTTCAAAAAGCCCGACGCGGAGCGCAACGACCGCGT
GCCCCCCGGACAGTATCTGA

Product: KHG-KDPG bifunctional aldolase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSHALCHRFIEHRLLAIVRADSAPAALAIGRAVVTGGFRLVEVTLTTPGAEQVVGELRGSGGEVLVGCGTVLTPEAARRA
IGWGAHFVVSPHTDPEIIATAHQLGALAIGGALTPNEIVAAWQAGADLIKVFPVAQVGGLAYLKALRGPFPDLPLLPTGG
IGEDDYLDYLAAGATAVGVGQALAPQGEVREGRWGTVAGRASDWVMRLAEGNGCLVPGERR

Sequences:

>Translated_221_residues
MSHALCHRFIEHRLLAIVRADSAPAALAIGRAVVTGGFRLVEVTLTTPGAEQVVGELRGSGGEVLVGCGTVLTPEAARRA
IGWGAHFVVSPHTDPEIIATAHQLGALAIGGALTPNEIVAAWQAGADLIKVFPVAQVGGLAYLKALRGPFPDLPLLPTGG
IGEDDYLDYLAAGATAVGVGQALAPQGEVREGRWGTVAGRASDWVMRLAEGNGCLVPGERR
>Mature_220_residues
SHALCHRFIEHRLLAIVRADSAPAALAIGRAVVTGGFRLVEVTLTTPGAEQVVGELRGSGGEVLVGCGTVLTPEAARRAI
GWGAHFVVSPHTDPEIIATAHQLGALAIGGALTPNEIVAAWQAGADLIKVFPVAQVGGLAYLKALRGPFPDLPLLPTGGI
GEDDYLDYLAAGATAVGVGQALAPQGEVREGRWGTVAGRASDWVMRLAEGNGCLVPGERR

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0800

COG function: function code G; 2-keto-3-deoxy-6-phosphogluconate aldolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788156, Length=180, Percent_Identity=31.6666666666667, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI48994954, Length=180, Percent_Identity=32.7777777777778, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 22760; Mature: 22629

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHALCHRFIEHRLLAIVRADSAPAALAIGRAVVTGGFRLVEVTLTTPGAEQVVGELRGS
CCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHCCC
GGEVLVGCGTVLTPEAARRAIGWGAHFVVSPHTDPEIIATAHQLGALAIGGALTPNEIVA
CCCEEEECCCEECHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHH
AWQAGADLIKVFPVAQVGGLAYLKALRGPFPDLPLLPTGGIGEDDYLDYLAAGATAVGVG
HHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCC
QALAPQGEVREGRWGTVAGRASDWVMRLAEGNGCLVPGERR
CCCCCCCCCCCCCCCEECCCHHHHHHEEECCCCEECCCCCC
>Mature Secondary Structure 
SHALCHRFIEHRLLAIVRADSAPAALAIGRAVVTGGFRLVEVTLTTPGAEQVVGELRGS
CHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHCCC
GGEVLVGCGTVLTPEAARRAIGWGAHFVVSPHTDPEIIATAHQLGALAIGGALTPNEIVA
CCCEEEECCCEECHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHH
AWQAGADLIKVFPVAQVGGLAYLKALRGPFPDLPLLPTGGIGEDDYLDYLAAGATAVGVG
HHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCC
QALAPQGEVREGRWGTVAGRASDWVMRLAEGNGCLVPGERR
CCCCCCCCCCCCCCCEECCCHHHHHHEEECCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]