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The map label for this gene is sppA [H]

Identifier: 37523775

GI number: 37523775

Start: 4403579

End: 4405477

Strand: Direct

Name: sppA [H]

Synonym: glr4206

Alternate gene names: 37523775

Gene position: 4403579-4405477 (Clockwise)

Preceding gene: 37523773

Following gene: 37523776

Centisome position: 94.52

GC content: 62.3

Gene sequence:

>1899_bases
GTGGTCGTGTCACCAACAACGTCGACGCTGCCCCGCGGCACGATTATGGTTCACTCACGATCTGGCAATGGCCGGGATAC
TGCGTCGCTTTGTTACGATCGCCCTGTTGGTCCTGGCGGGAAGAACGTGGGTACCCTCAAAAAAATCGGGGTCTGGCTGG
GGCGCATCCTCGCGGTGATTGGCGCTCTTGTGGTGGTGCTGGTGGTTGTGGCCGTGCTGGGGTTGCTGCTGTTGGGCCGT
GGGCCGCAGATTGCCGACAACTCGGTACTGGAAATCAAACTTTCCGGCGATCTGCCGGAAAAAGCCTCCGAAGACCCGAT
CGCCGGGCTGTTGGGTACCCCTGCCCTGACTTTTAAAGATGCGCTCGACAACCTCAAAAAAGCGGCAATAGACACGCGCA
TCAAGGGGGTGGTGCTGCGCCTCGACGGCACCAGCTTGGGTTGGGCGAGAGTTGAAGAATTGCGAGAGGCGTTGATGCAA
TTTCGCCAAACCGGCAAATTTGCCGTGGGCTACGCCGAGGGAATAAGCGAGCGGGGGTATTACCTGGCGCTTGCCCTCGA
CCGCTTTTACCTGCCGCCCACGGGCGGCTTCGAGATGAACGGCCTAGTCAGTTCCAACTCCCACCTGCCGGGATTGCTTG
CCAAAATTGGCATCGGCGTGCAGTACTTTCGCTACGGCAAATATAAATCCGTCAGCGGCGAGACCTTCGGCCAGCCGGCA
TTCAGCGAGCCGGTCAAAGAGATGATCAACTTCAACCTCACCGAGCAGTACGAGACTTTCGTGGGCGCCGTGGCTACCGC
CCGCAAGCTCCCCGCATCCGAAGTGCGCCGGCTCATCGACACCAACCGGCCCACCGCTGAATGGGCACTCGCCAACAAGC
TCATCGACGGCATCGCTTACTGGGACGAGGTAGAGGCGGGCCTCAAAAAGCAGGCGGGCATCGCAGCGGATAAAGATCTG
CCGAAAGTGAGCGCCACCGAGTACGCGCGTGTGAGCCTGGAGGAACTGGGTCTCAACCGGGGGCCGAACAAAATTGGCTA
TATCGTCGCCGAGGGCTTGGTGGTCTCCGGGGGCAGCGGCCCTGTCAATCCGCTTTCCGGAGGGCCGGTGCAGGGGTCTG
AACCGCTCATCAAGGCTCTGCGCGAAGCGGGCCGGCGCGAGGACATCAAGGCGGTGGTGATGCGGGTCAACTCCCCCGGT
GGGGCGGGTCTGGGGTGCGACCTGGTGCGCCGGGAAGTCGAACGGTTGCGCGCCAAAAAGCCCGTCGTCGTCTCGATGGG
CGATTCGGCCGCGAGCGGCGGCTACTGGATCGCAATGGACGCCAGTGCGATCGTCGCCCAGCCTTCCACCCAGACGGGAT
CGATCGGCATCTTCGCGGTAATCCCTAACGTCGAGCAATTGAACCGCGACCTCACCCTCACCCCGGAAGTGTTCAAGCGC
GGGGCACGCGCCGACGTTTTAAGCGGCAACCGGCCGCTCAACCCCGAAGAGGCAAAGATCTTCGATCAGGAATTGCTCTC
AAGCTACCGCCGCTTCGTGGCCCTTGCCGCCAAGGGCCGCAACAAAACGGTCCCCCAGATGGAAGCACTCGCCCAGGGCC
GTACCTGGCTGGGTCGCAAAGCCCTCGAATTAGGGCTGGTGGACCGATTGGGCGGCATCGATACGGCCATTGCCCTGGCG
GCGGAAAAAGCGAAAGTTGCTCCCGACACGGTAGCCCTTGAGCGACTCGAAGGCGAGCAGAGCACGCTCGCAAGCCTACT
TGGCGCCGAAGCCACCCGCATGGCGCTGCGCAGCCTGGGCATCGAGCGGACGGTAAGCCGCCTGGCGCCGCCGTTCAGCC
TCGATGTGCTCCTGAGTGAGCATCTCTATCCGCTTGCATTGCCGCAGCGTTTCGAGTAA

Upstream 100 bases:

>100_bases
TAGATCTTTTCGGGGACGTTCATGCCAGCTCGAACTCATTCAACCCTTCTATCTTCGCATCGGCTCAGGTAAACTCGGGC
CTGTCGAAAAATCCGCCAAA

Downstream 100 bases:

>100_bases
GGACTGCTTCAAAACCCTGTGATAGCGTTGAGGCAGTCGAAAGACGGAGGTGATGTATGGTGCCGGTGATCTCCGAACAC
ATCGAAATTACGCCGGGGGT

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MVVSPTTSTLPRGTIMVHSRSGNGRDTASLCYDRPVGPGGKNVGTLKKIGVWLGRILAVIGALVVVLVVVAVLGLLLLGR
GPQIADNSVLEIKLSGDLPEKASEDPIAGLLGTPALTFKDALDNLKKAAIDTRIKGVVLRLDGTSLGWARVEELREALMQ
FRQTGKFAVGYAEGISERGYYLALALDRFYLPPTGGFEMNGLVSSNSHLPGLLAKIGIGVQYFRYGKYKSVSGETFGQPA
FSEPVKEMINFNLTEQYETFVGAVATARKLPASEVRRLIDTNRPTAEWALANKLIDGIAYWDEVEAGLKKQAGIAADKDL
PKVSATEYARVSLEELGLNRGPNKIGYIVAEGLVVSGGSGPVNPLSGGPVQGSEPLIKALREAGRREDIKAVVMRVNSPG
GAGLGCDLVRREVERLRAKKPVVVSMGDSAASGGYWIAMDASAIVAQPSTQTGSIGIFAVIPNVEQLNRDLTLTPEVFKR
GARADVLSGNRPLNPEEAKIFDQELLSSYRRFVALAAKGRNKTVPQMEALAQGRTWLGRKALELGLVDRLGGIDTAIALA
AEKAKVAPDTVALERLEGEQSTLASLLGAEATRMALRSLGIERTVSRLAPPFSLDVLLSEHLYPLALPQRFE

Sequences:

>Translated_632_residues
MVVSPTTSTLPRGTIMVHSRSGNGRDTASLCYDRPVGPGGKNVGTLKKIGVWLGRILAVIGALVVVLVVVAVLGLLLLGR
GPQIADNSVLEIKLSGDLPEKASEDPIAGLLGTPALTFKDALDNLKKAAIDTRIKGVVLRLDGTSLGWARVEELREALMQ
FRQTGKFAVGYAEGISERGYYLALALDRFYLPPTGGFEMNGLVSSNSHLPGLLAKIGIGVQYFRYGKYKSVSGETFGQPA
FSEPVKEMINFNLTEQYETFVGAVATARKLPASEVRRLIDTNRPTAEWALANKLIDGIAYWDEVEAGLKKQAGIAADKDL
PKVSATEYARVSLEELGLNRGPNKIGYIVAEGLVVSGGSGPVNPLSGGPVQGSEPLIKALREAGRREDIKAVVMRVNSPG
GAGLGCDLVRREVERLRAKKPVVVSMGDSAASGGYWIAMDASAIVAQPSTQTGSIGIFAVIPNVEQLNRDLTLTPEVFKR
GARADVLSGNRPLNPEEAKIFDQELLSSYRRFVALAAKGRNKTVPQMEALAQGRTWLGRKALELGLVDRLGGIDTAIALA
AEKAKVAPDTVALERLEGEQSTLASLLGAEATRMALRSLGIERTVSRLAPPFSLDVLLSEHLYPLALPQRFE
>Mature_632_residues
MVVSPTTSTLPRGTIMVHSRSGNGRDTASLCYDRPVGPGGKNVGTLKKIGVWLGRILAVIGALVVVLVVVAVLGLLLLGR
GPQIADNSVLEIKLSGDLPEKASEDPIAGLLGTPALTFKDALDNLKKAAIDTRIKGVVLRLDGTSLGWARVEELREALMQ
FRQTGKFAVGYAEGISERGYYLALALDRFYLPPTGGFEMNGLVSSNSHLPGLLAKIGIGVQYFRYGKYKSVSGETFGQPA
FSEPVKEMINFNLTEQYETFVGAVATARKLPASEVRRLIDTNRPTAEWALANKLIDGIAYWDEVEAGLKKQAGIAADKDL
PKVSATEYARVSLEELGLNRGPNKIGYIVAEGLVVSGGSGPVNPLSGGPVQGSEPLIKALREAGRREDIKAVVMRVNSPG
GAGLGCDLVRREVERLRAKKPVVVSMGDSAASGGYWIAMDASAIVAQPSTQTGSIGIFAVIPNVEQLNRDLTLTPEVFKR
GARADVLSGNRPLNPEEAKIFDQELLSSYRRFVALAAKGRNKTVPQMEALAQGRTWLGRKALELGLVDRLGGIDTAIALA
AEKAKVAPDTVALERLEGEQSTLASLLGAEATRMALRSLGIERTVSRLAPPFSLDVLLSEHLYPLALPQRFE

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=543, Percent_Identity=32.5966850828729, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI1787527, Length=170, Percent_Identity=34.1176470588235, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 67550; Mature: 67550

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVSPTTSTLPRGTIMVHSRSGNGRDTASLCYDRPVGPGGKNVGTLKKIGVWLGRILAVI
CEECCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GALVVVLVVVAVLGLLLLGRGPQIADNSVLEIKLSGDLPEKASEDPIAGLLGTPALTFKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCHHHHH
ALDNLKKAAIDTRIKGVVLRLDGTSLGWARVEELREALMQFRQTGKFAVGYAEGISERGY
HHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCE
YLALALDRFYLPPTGGFEMNGLVSSNSHLPGLLAKIGIGVQYFRYGKYKSVSGETFGQPA
EEEEEEEEEECCCCCCCEECCEECCCCCCCHHHHHHCCCHHEEECCCCCCCCCCCCCCCC
FSEPVKEMINFNLTEQYETFVGAVATARKLPASEVRRLIDTNRPTAEWALANKLIDGIAY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WDEVEAGLKKQAGIAADKDLPKVSATEYARVSLEELGLNRGPNKIGYIVAEGLVVSGGSG
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCC
PVNPLSGGPVQGSEPLIKALREAGRREDIKAVVMRVNSPGGAGLGCDLVRREVERLRAKK
CCCCCCCCCCCCCCHHHHHHHHCCCHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCC
PVVVSMGDSAASGGYWIAMDASAIVAQPSTQTGSIGIFAVIPNVEQLNRDLTLTPEVFKR
CEEEEECCCCCCCCEEEEECCCEEEECCCCCCCCEEEEEEECCHHHHCCCCEECHHHHHC
GARADVLSGNRPLNPEEAKIFDQELLSSYRRFVALAAKGRNKTVPQMEALAQGRTWLGRK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
ALELGLVDRLGGIDTAIALAAEKAKVAPDTVALERLEGEQSTLASLLGAEATRMALRSLG
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
IERTVSRLAPPFSLDVLLSEHLYPLALPQRFE
HHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVVSPTTSTLPRGTIMVHSRSGNGRDTASLCYDRPVGPGGKNVGTLKKIGVWLGRILAVI
CEECCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GALVVVLVVVAVLGLLLLGRGPQIADNSVLEIKLSGDLPEKASEDPIAGLLGTPALTFKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCHHHHH
ALDNLKKAAIDTRIKGVVLRLDGTSLGWARVEELREALMQFRQTGKFAVGYAEGISERGY
HHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCE
YLALALDRFYLPPTGGFEMNGLVSSNSHLPGLLAKIGIGVQYFRYGKYKSVSGETFGQPA
EEEEEEEEEECCCCCCCEECCEECCCCCCCHHHHHHCCCHHEEECCCCCCCCCCCCCCCC
FSEPVKEMINFNLTEQYETFVGAVATARKLPASEVRRLIDTNRPTAEWALANKLIDGIAY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WDEVEAGLKKQAGIAADKDLPKVSATEYARVSLEELGLNRGPNKIGYIVAEGLVVSGGSG
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCC
PVNPLSGGPVQGSEPLIKALREAGRREDIKAVVMRVNSPGGAGLGCDLVRREVERLRAKK
CCCCCCCCCCCCCCHHHHHHHHCCCHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCC
PVVVSMGDSAASGGYWIAMDASAIVAQPSTQTGSIGIFAVIPNVEQLNRDLTLTPEVFKR
CEEEEECCCCCCCCEEEEECCCEEEECCCCCCCCEEEEEEECCHHHHCCCCEECHHHHHC
GARADVLSGNRPLNPEEAKIFDQELLSSYRRFVALAAKGRNKTVPQMEALAQGRTWLGRK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
ALELGLVDRLGGIDTAIALAAEKAKVAPDTVALERLEGEQSTLASLLGAEATRMALRSLG
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
IERTVSRLAPPFSLDVLLSEHLYPLALPQRFE
HHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]