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The map label for this gene is mdtA [H]

Identifier: 37523596

GI number: 37523596

Start: 4225324

End: 4226772

Strand: Direct

Name: mdtA [H]

Synonym: glr4027

Alternate gene names: 37523596

Gene position: 4225324-4226772 (Clockwise)

Preceding gene: 37523590

Following gene: 37523597

Centisome position: 90.69

GC content: 67.84

Gene sequence:

>1449_bases
GTGCCCGGTGATGCAGACGACAGCGCCGTAGGTAAGGCGTTGTTCTCCTCACAGGCTTTTCGTGCGGCCGGTCCGCATAT
TTTTCAGCATCCCGGCATCACCTTTCAGACCACCGCACGCGAACCCCCGCTCACCATGGCCGATTCTACCCGCGAATCCC
GCGCTCCCCAACGCGCCGACCTCCCCCCGGTTTCCGAGCGCGAACGGCGCAACTGGGTGCCGATCGTCGTGGGCCTCGCG
CTCATCGTACTGGGGATTGTCCTGTTTCGGTTCTTTGCAGGGGACAAACCGGCGGAGTCGCCCGCAGCCCAGGCGGGACG
CAAAGCGGTGCCGGCGGCCACAGCGGTAGCGACCCAAAAAGCAGTGCCGATCGCGATTGCCGCCATCGGCGCCGTCGAAG
CCTACAACACCGTCGCCGTGCGCTCCCAGGTCGAAGGTACCCTCACCCGCGTCGTCTTCGAGCAGGGCCAGTACGTCCAG
AAAGGTGCTCTGCTCTTTACGGTGGATGCCCGTCCGAACGCGGCGGCCTTTGCCCAGGCCGAGGCGCAACTGAGCCGCGA
CCAGGCGGGAGTCGCCCAGGCGGAAGCGGCGGTGGCGCGCGATCGCGCCCAATTGCGCACCGCCCGGACCCAGGTGCAGC
GCTACCGGTCGCTGGTGGCCCAGGGGGCGGTCTCCCAGGAGCAGTTCGACCAGGTGCAGACCAACGCCGAGGCCCTCGCC
GCCACCGTGCGCGCGAGCGAAGCGGCCGTGGCCAACGCCCGCTCGGTGGTGCGCGCGAGCCGTGCCGCCGTCGAGAGCGC
CCGCGTTCAGTTGGGCTACACCGAGATTCGTGCCCCGATTGCCGGACGCACCGGCAGCCTCGCGGTCTACGCCGGCAACC
TGGTGCGCGCCAACGACACTACACCGCTGGTGGTGATCAATCGGGTGAGCCCGATCTATGTGAGCTTTACGGTCCCTGAG
CGGGAACTGCCCGCCATCAAGCGCTACCAGGCCCAGGCCCGCCTCAAAGTCGTCGCCGTGCCGCCCAGCGGAGCCGGTCG
CGCCGTGACGGGGTACTTGAGCTTTATCGACAACGCCGTCGACAGCACCACAGGCACCATTCGCCTGCGCGGCACGTTCG
AGAACCAGGACAACTACCTGGTTCCCGGCCAGTTCATGAACGTCACCCTCACCCTCACCACCCAGCCGAACGCGGTGGTG
GTGCCCACCCAGGCGGTACAGACCGGTCAGCAGGGTACCTACGTCTATGTGGTCAAGCCCGACCGGACGGTGGACCTGCG
GGTGGTGACGAGCAGCCGTACCGTAGGCGGCGACGCGCTCATCGACCGGGGAGTCGCACCTGGGGAGACCGTCGTCACCG
ACGGCCAGCTGCAACTGAAGCCGGGCGACACCATTAAAACCGCGTCCACCGCCTCTACCCCGTCCACCACCCAGGAGCCG
CGTCCGTGA

Upstream 100 bases:

>100_bases
GCTCGTCATCTTCGATGTTCAACCCGCCAAGCGCGCTTCCGAGTCGGGGTAGAGGCGCTCAGCAGCTGCCCCCTGGTAAG
ATCCAAAGGCAGGTCGCCGC

Downstream 100 bases:

>100_bases
ACTTCTCGGCAGTGTTCATCCGCCGCCCCGTCGCCACGACGCTGGTGATGCTCGGGGTGTTGTTCTTCGGCCTGATTGCC
TACCGGCTCCTGCCGGTCAA

Product: RND efflux membrane fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MPGDADDSAVGKALFSSQAFRAAGPHIFQHPGITFQTTAREPPLTMADSTRESRAPQRADLPPVSERERRNWVPIVVGLA
LIVLGIVLFRFFAGDKPAESPAAQAGRKAVPAATAVATQKAVPIAIAAIGAVEAYNTVAVRSQVEGTLTRVVFEQGQYVQ
KGALLFTVDARPNAAAFAQAEAQLSRDQAGVAQAEAAVARDRAQLRTARTQVQRYRSLVAQGAVSQEQFDQVQTNAEALA
ATVRASEAAVANARSVVRASRAAVESARVQLGYTEIRAPIAGRTGSLAVYAGNLVRANDTTPLVVINRVSPIYVSFTVPE
RELPAIKRYQAQARLKVVAVPPSGAGRAVTGYLSFIDNAVDSTTGTIRLRGTFENQDNYLVPGQFMNVTLTLTTQPNAVV
VPTQAVQTGQQGTYVYVVKPDRTVDLRVVTSSRTVGGDALIDRGVAPGETVVTDGQLQLKPGDTIKTASTASTPSTTQEP
RP

Sequences:

>Translated_482_residues
MPGDADDSAVGKALFSSQAFRAAGPHIFQHPGITFQTTAREPPLTMADSTRESRAPQRADLPPVSERERRNWVPIVVGLA
LIVLGIVLFRFFAGDKPAESPAAQAGRKAVPAATAVATQKAVPIAIAAIGAVEAYNTVAVRSQVEGTLTRVVFEQGQYVQ
KGALLFTVDARPNAAAFAQAEAQLSRDQAGVAQAEAAVARDRAQLRTARTQVQRYRSLVAQGAVSQEQFDQVQTNAEALA
ATVRASEAAVANARSVVRASRAAVESARVQLGYTEIRAPIAGRTGSLAVYAGNLVRANDTTPLVVINRVSPIYVSFTVPE
RELPAIKRYQAQARLKVVAVPPSGAGRAVTGYLSFIDNAVDSTTGTIRLRGTFENQDNYLVPGQFMNVTLTLTTQPNAVV
VPTQAVQTGQQGTYVYVVKPDRTVDLRVVTSSRTVGGDALIDRGVAPGETVVTDGQLQLKPGDTIKTASTASTPSTTQEP
RP
>Mature_481_residues
PGDADDSAVGKALFSSQAFRAAGPHIFQHPGITFQTTAREPPLTMADSTRESRAPQRADLPPVSERERRNWVPIVVGLAL
IVLGIVLFRFFAGDKPAESPAAQAGRKAVPAATAVATQKAVPIAIAAIGAVEAYNTVAVRSQVEGTLTRVVFEQGQYVQK
GALLFTVDARPNAAAFAQAEAQLSRDQAGVAQAEAAVARDRAQLRTARTQVQRYRSLVAQGAVSQEQFDQVQTNAEALAA
TVRASEAAVANARSVVRASRAAVESARVQLGYTEIRAPIAGRTGSLAVYAGNLVRANDTTPLVVINRVSPIYVSFTVPER
ELPAIKRYQAQARLKVVAVPPSGAGRAVTGYLSFIDNAVDSTTGTIRLRGTFENQDNYLVPGQFMNVTLTLTTQPNAVVV
PTQAVQTGQQGTYVYVVKPDRTVDLRVVTSSRTVGGDALIDRGVAPGETVVTDGQLQLKPGDTIKTASTASTPSTTQEPR
P

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=385, Percent_Identity=34.2857142857143, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789665, Length=359, Percent_Identity=31.1977715877437, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1786668, Length=379, Percent_Identity=30.3430079155673, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789929, Length=424, Percent_Identity=25.9433962264151, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081796, Length=356, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081951, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790519, Length=216, Percent_Identity=28.2407407407407, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 51035; Mature: 50904

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGDADDSAVGKALFSSQAFRAAGPHIFQHPGITFQTTAREPPLTMADSTRESRAPQRAD
CCCCCCHHHHHHHHHHCCHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCHHHCCCCCCC
LPPVSERERRNWVPIVVGLALIVLGIVLFRFFAGDKPAESPAAQAGRKAVPAATAVATQK
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCC
AVPIAIAAIGAVEAYNTVAVRSQVEGTLTRVVFEQGQYVQKGALLFTVDARPNAAAFAQA
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCCCHHHHHH
EAQLSRDQAGVAQAEAAVARDRAQLRTARTQVQRYRSLVAQGAVSQEQFDQVQTNAEALA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ATVRASEAAVANARSVVRASRAAVESARVQLGYTEIRAPIAGRTGSLAVYAGNLVRANDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCEEEEECCEEEECCC
TPLVVINRVSPIYVSFTVPERELPAIKRYQAQARLKVVAVPPSGAGRAVTGYLSFIDNAV
CCEEEEECCCEEEEEEECCCHHCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
DSTTGTIRLRGTFENQDNYLVPGQFMNVTLTLTTQPNAVVVPTQAVQTGQQGTYVYVVKP
CCCCCEEEEEEEECCCCCEECCCCEEEEEEEEEECCCEEEEECHHHHCCCCCCEEEEECC
DRTVDLRVVTSSRTVGGDALIDRGVAPGETVVTDGQLQLKPGDTIKTASTASTPSTTQEP
CCEEEEEEEECCCCCCCHHHHHCCCCCCCEEEECCEEEECCCCCEECCCCCCCCCCCCCC
RP
CC
>Mature Secondary Structure 
PGDADDSAVGKALFSSQAFRAAGPHIFQHPGITFQTTAREPPLTMADSTRESRAPQRAD
CCCCCHHHHHHHHHHCCHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCHHHCCCCCCC
LPPVSERERRNWVPIVVGLALIVLGIVLFRFFAGDKPAESPAAQAGRKAVPAATAVATQK
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCC
AVPIAIAAIGAVEAYNTVAVRSQVEGTLTRVVFEQGQYVQKGALLFTVDARPNAAAFAQA
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCCCHHHHHH
EAQLSRDQAGVAQAEAAVARDRAQLRTARTQVQRYRSLVAQGAVSQEQFDQVQTNAEALA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ATVRASEAAVANARSVVRASRAAVESARVQLGYTEIRAPIAGRTGSLAVYAGNLVRANDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCEEEEECCEEEECCC
TPLVVINRVSPIYVSFTVPERELPAIKRYQAQARLKVVAVPPSGAGRAVTGYLSFIDNAV
CCEEEEECCCEEEEEEECCCHHCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
DSTTGTIRLRGTFENQDNYLVPGQFMNVTLTLTTQPNAVVVPTQAVQTGQQGTYVYVVKP
CCCCCEEEEEEEECCCCCEECCCCEEEEEEEEEECCCEEEEECHHHHCCCCCCEEEEECC
DRTVDLRVVTSSRTVGGDALIDRGVAPGETVVTDGQLQLKPGDTIKTASTASTPSTTQEP
CCEEEEEEEECCCCCCCHHHHHCCCCCCCEEEECCEEEECCCCCEECCCCCCCCCCCCCC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA