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The map label for this gene is fabF [H]

Identifier: 37523583

GI number: 37523583

Start: 4216316

End: 4217563

Strand: Reverse

Name: fabF [H]

Synonym: gll4014

Alternate gene names: 37523583

Gene position: 4217563-4216316 (Counterclockwise)

Preceding gene: 37523588

Following gene: 37523582

Centisome position: 90.52

GC content: 64.66

Gene sequence:

>1248_bases
ATGGAAAAAAAGCGGGTGGTGGTGACCGGCGTCGGCGCGGTGACGCCTCTTGGCAACACGGCGGCCGACTTCTGGGAAGG
CTTGCTCGCAGGCCGTTCCGGTGTGGCACCTATCAGTCTGTTTGACCCGAGCCGCCACGACGCGCGCATCGCGGCCGAGG
TCAAAAATTTTGATCCCCACCAGTACCTCGAGAAAAAAGAAGTCAAGCGCACGGTGCGCTTTACCCAGATGGCGGTGGCC
GCGAGCAAGCAGGCGGTCGCCGACGCGGCTCTTGCCATCAACGAGTTCAACAGCGAACAGGTCGGGGTGATTATCGGCAA
CGGCACCGGCGGCATGGAGTGGCTGGAGCAGCAGGACGGCATCCTGCGCGAGCAGGGACCCAACCGCGTTTCACCCTTTA
TGGTGCCGCTGTTTATCGCCAATATGGCCGCCGGCTTCACCGCCATTCAGCTGGGCGCCAAAGGCCCCAATTCCTGCACC
GTCACCGCCTGCGCCGCCGGCTCCAACGCCATCGGCGACGCTTTTCGGCTTATCCAGTACGGCGAAGCCCAGGCGGTGAT
CTGCGGCGGCACCGAGGCGTGCATCACCCCGCTGGTGGTGGCGGGCTTCGCCGCGTCGCGCGCCCTTTCGACCCGCAACG
ACGAACCTGAAACAGCGAGCCGGCCTTTCGATTTAAACCGCGACGGCTTTGTGATTGGCGAGGGGGCGGGCATTCTGGTG
CTCGAAGAACTCAGCCACGCCCTGGCGCGCGGCGCGCGCATCTACGCCGAAATCTGCGGCTACGCGATGACCTGCGACGC
TTATCACATGACCTCGCCCGCACCGGCCGGCGAAGGGGCCGCTCGGGCCATCCGGCTGGCGCTCAAGGATGCAGGCGTGT
TCCCGGACCAGGTGAGCTACATCAACGCCCACGGCACCAGTACGCCCCTCAACGACACCAACGAGACCCAGGCGATTAAG
ACCGTGCTGGGAGAGGCTGCCTACAGCGTGGCGGTCAGTTCCACCAAATCGATGACCGGTCACCTGCTGGGCGGATCCGG
GGGCATCGAGGCGGTGGCCACGGCTCTGGCTGTTTACCACGACATCGCGCCGCCCACCATCAACCTTGAGACCCCCGACC
CGAGCTGCGACCTCGACTACGTGCCGGGGGTCGCCCGGACGATGCCTATCGAGGTGGCTCTATCCAATTCCTTCGGCTTC
GGCGGCCACAACGTCACCCTGGTATTTAGAAAGTTCCGCGAAGCCTAG

Upstream 100 bases:

>100_bases
GGGCGGGTTGCGGACACCCTCCAGGCTACTACTTTCATCGGCCGACTGCCCAAGCCTGTTATTCTTGAAAGGATCAGCCT
ACGCGAGGTACAGGGTCTCG

Downstream 100 bases:

>100_bases
GAAAGCCTCCCGAACCGGTCGTTCCAGACATTACAATGGCGGCAATTCCCAGATGGGGAGCGTACTGTGGTGATGCCCGT
TGCTTCCGAATTTTCAGGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MEKKRVVVTGVGAVTPLGNTAADFWEGLLAGRSGVAPISLFDPSRHDARIAAEVKNFDPHQYLEKKEVKRTVRFTQMAVA
ASKQAVADAALAINEFNSEQVGVIIGNGTGGMEWLEQQDGILREQGPNRVSPFMVPLFIANMAAGFTAIQLGAKGPNSCT
VTACAAGSNAIGDAFRLIQYGEAQAVICGGTEACITPLVVAGFAASRALSTRNDEPETASRPFDLNRDGFVIGEGAGILV
LEELSHALARGARIYAEICGYAMTCDAYHMTSPAPAGEGAARAIRLALKDAGVFPDQVSYINAHGTSTPLNDTNETQAIK
TVLGEAAYSVAVSSTKSMTGHLLGGSGGIEAVATALAVYHDIAPPTINLETPDPSCDLDYVPGVARTMPIEVALSNSFGF
GGHNVTLVFRKFREA

Sequences:

>Translated_415_residues
MEKKRVVVTGVGAVTPLGNTAADFWEGLLAGRSGVAPISLFDPSRHDARIAAEVKNFDPHQYLEKKEVKRTVRFTQMAVA
ASKQAVADAALAINEFNSEQVGVIIGNGTGGMEWLEQQDGILREQGPNRVSPFMVPLFIANMAAGFTAIQLGAKGPNSCT
VTACAAGSNAIGDAFRLIQYGEAQAVICGGTEACITPLVVAGFAASRALSTRNDEPETASRPFDLNRDGFVIGEGAGILV
LEELSHALARGARIYAEICGYAMTCDAYHMTSPAPAGEGAARAIRLALKDAGVFPDQVSYINAHGTSTPLNDTNETQAIK
TVLGEAAYSVAVSSTKSMTGHLLGGSGGIEAVATALAVYHDIAPPTINLETPDPSCDLDYVPGVARTMPIEVALSNSFGF
GGHNVTLVFRKFREA
>Mature_415_residues
MEKKRVVVTGVGAVTPLGNTAADFWEGLLAGRSGVAPISLFDPSRHDARIAAEVKNFDPHQYLEKKEVKRTVRFTQMAVA
ASKQAVADAALAINEFNSEQVGVIIGNGTGGMEWLEQQDGILREQGPNRVSPFMVPLFIANMAAGFTAIQLGAKGPNSCT
VTACAAGSNAIGDAFRLIQYGEAQAVICGGTEACITPLVVAGFAASRALSTRNDEPETASRPFDLNRDGFVIGEGAGILV
LEELSHALARGARIYAEICGYAMTCDAYHMTSPAPAGEGAARAIRLALKDAGVFPDQVSYINAHGTSTPLNDTNETQAIK
TVLGEAAYSVAVSSTKSMTGHLLGGSGGIEAVATALAVYHDIAPPTINLETPDPSCDLDYVPGVARTMPIEVALSNSFGF
GGHNVTLVFRKFREA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=46.1352657004831, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=55.1724137931034, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=25.7683215130024, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=50.8474576271186, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=38.1642512077295, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.0119904076739, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=39.7727272727273, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=429, Percent_Identity=24.2424242424242, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=293, Percent_Identity=29.3515358361775, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=35.0446428571429, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24644341, Length=427, Percent_Identity=44.9648711943794, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI221330659, Length=427, Percent_Identity=24.3559718969555, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19920632, Length=427, Percent_Identity=24.3559718969555, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24581345, Length=439, Percent_Identity=22.5512528473804, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43460; Mature: 43460

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKRVVVTGVGAVTPLGNTAADFWEGLLAGRSGVAPISLFDPSRHDARIAAEVKNFDPH
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHCCCCHH
QYLEKKEVKRTVRFTQMAVAASKQAVADAALAINEFNSEQVGVIIGNGTGGMEWLEQQDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCC
ILREQGPNRVSPFMVPLFIANMAAGFTAIQLGAKGPNSCTVTACAAGSNAIGDAFRLIQY
CHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHC
GEAQAVICGGTEACITPLVVAGFAASRALSTRNDEPETASRPFDLNRDGFVIGEGAGILV
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEELSHALARGARIYAEICGYAMTCDAYHMTSPAPAGEGAARAIRLALKDAGVFPDQVSY
HHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHEE
INAHGTSTPLNDTNETQAIKTVLGEAAYSVAVSSTKSMTGHLLGGSGGIEAVATALAVYH
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHECCCCCCCEEEECCCCCHHHHHHHHHHHH
DIAPPTINLETPDPSCDLDYVPGVARTMPIEVALSNSFGFGGHNVTLVFRKFREA
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCC
>Mature Secondary Structure
MEKKRVVVTGVGAVTPLGNTAADFWEGLLAGRSGVAPISLFDPSRHDARIAAEVKNFDPH
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHCCCCHH
QYLEKKEVKRTVRFTQMAVAASKQAVADAALAINEFNSEQVGVIIGNGTGGMEWLEQQDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCC
ILREQGPNRVSPFMVPLFIANMAAGFTAIQLGAKGPNSCTVTACAAGSNAIGDAFRLIQY
CHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHC
GEAQAVICGGTEACITPLVVAGFAASRALSTRNDEPETASRPFDLNRDGFVIGEGAGILV
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEELSHALARGARIYAEICGYAMTCDAYHMTSPAPAGEGAARAIRLALKDAGVFPDQVSY
HHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHEE
INAHGTSTPLNDTNETQAIKTVLGEAAYSVAVSSTKSMTGHLLGGSGGIEAVATALAVYH
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHECCCCCCCEEEECCCCCHHHHHHHHHHHH
DIAPPTINLETPDPSCDLDYVPGVARTMPIEVALSNSFGFGGHNVTLVFRKFREA
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]