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The map label for this gene is gloA [C]

Identifier: 37523477

GI number: 37523477

Start: 4110410

End: 4110772

Strand: Direct

Name: gloA [C]

Synonym: glr3908

Alternate gene names: 37523477

Gene position: 4110410-4110772 (Clockwise)

Preceding gene: 37523476

Following gene: 37523494

Centisome position: 88.22

GC content: 60.61

Gene sequence:

>363_bases
GTGCAGATCGTTCGGGCTTTGCACACAGCGCTCCTGGTCAGCGACCTGGAGCGCGCCGAATATTTCTACGGAAGCGTTCT
GGGTCTTGCCAAAGTCGAGCGCCCATCGCACTTTGCCGGAGCCTGGTACCAGGTGGCCGACTACCAGATTCACCTGATTA
CCGCCACGCAGCGTGTGGACGACCGCGTCGACCACGAGCGCTGGGGGCGCAACCGCCACATTGCCTTTGCGGTTGCCGAT
GTGCAAGCTGCCAAAGACCAACTGCTGCGACACGGCTACGCACTCCAGATGAGTGCTTCGGGCCGGACGGCACTGTTTAC
CGAAGATCCCGACGGCAATCTCGTCGAATTGAGTGAGATGTGA

Upstream 100 bases:

>100_bases
ACCCCCCGCGGCCAGGGATCGCCCCGATGCCCCCACGACCCAACCCACCGCGACCCTGAACTCGCGCTTGCATAATGAAA
CTAGCATTGGAAGATTTGCC

Downstream 100 bases:

>100_bases
ACTTAAAATGATCCCCGTCACTGGGGAGGCAACGGGGATTCGCCTTCGGATCGCAAAGCGAAGCAGTTACGCTTCGACCG
TGCAGGTACCCCCGGCCGCT

Product: hypothetical protein

Products: (R)-S-Lactoylglutathione [C]

Alternate protein names: Glyoxalase Family Protein; Glyoxalase Family Protein Superfamily

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MQIVRALHTALLVSDLERAEYFYGSVLGLAKVERPSHFAGAWYQVADYQIHLITATQRVDDRVDHERWGRNRHIAFAVAD
VQAAKDQLLRHGYALQMSASGRTALFTEDPDGNLVELSEM

Sequences:

>Translated_120_residues
MQIVRALHTALLVSDLERAEYFYGSVLGLAKVERPSHFAGAWYQVADYQIHLITATQRVDDRVDHERWGRNRHIAFAVAD
VQAAKDQLLRHGYALQMSASGRTALFTEDPDGNLVELSEM
>Mature_120_residues
MQIVRALHTALLVSDLERAEYFYGSVLGLAKVERPSHFAGAWYQVADYQIHLITATQRVDDRVDHERWGRNRHIAFAVAD
VQAAKDQLLRHGYALQMSASGRTALFTEDPDGNLVELSEM

Specific function: Catalyzes The Conversion Of Hemimercaptal, Formed From Methylglyoxal And Glutathione, To S-Lactoylglutathione. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.4.1.5 [C]

Molecular weight: Translated: 13568; Mature: 13568

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVRALHTALLVSDLERAEYFYGSVLGLAKVERPSHFAGAWYQVADYQIHLITATQRVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECEEEEEEEECCHHH
DRVDHERWGRNRHIAFAVADVQAAKDQLLRHGYALQMSASGRTALFTEDPDGNLVELSEM
HHHHHHHCCCCCEEEEEEEHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCEEEEECC
>Mature Secondary Structure
MQIVRALHTALLVSDLERAEYFYGSVLGLAKVERPSHFAGAWYQVADYQIHLITATQRVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECEEEEEEEECCHHH
DRVDHERWGRNRHIAFAVADVQAAKDQLLRHGYALQMSASGRTALFTEDPDGNLVELSEM
HHHHHHHCCCCCEEEEEEEHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): 20280 [C]

Specific activity: NA

Km value (mM): 0.0272 {methylglyoxal/glutathione} [C]

Substrates: Reduced glutathione; Methylglyoxal [C]

Specific reaction: Reduced glutathione + Methylglyoxal --> (R)-S-Lactoylglutathione [C]

General reaction: addition of RSH [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA