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The map label for this gene is liaR [H]

Identifier: 37523311

GI number: 37523311

Start: 3953559

End: 3954224

Strand: Direct

Name: liaR [H]

Synonym: glr3742

Alternate gene names: 37523311

Gene position: 3953559-3954224 (Clockwise)

Preceding gene: 37523310

Following gene: 37523314

Centisome position: 84.86

GC content: 65.77

Gene sequence:

>666_bases
ATGATTCGGGTGGCGGTGGCGGCCGATGCTGCTGTCGTGCGCGCCGGGCTGGCCGCCCTGGTTGCGGCCAGCCCGGATCT
GACTGTTGTCGGTCACCCCGTTTCCCTCGCCGAGCTGCCGCAACTCTTGGAGGAACTGCAGCCCGAGGTCGTGCTGGTCG
ACCTCGAAGATGACGCCGACGATGCAGTGCTCGACTGGCTTCCCGGTCTTGTCCCATCTCCAATCGAAGGAGAGGGCGTC
CCGGCTGTCTCTTTGGTCATCCTCACCGAGGAAACCGCAGGAAGCTGGATGGCCGAGGTGCTGCGCTCCGGCGTGCGTGC
CCTGCTGCCGCGCACCGCCACCGCCGGTGAGATCACCGCCGCAATCACAGCGGCAGCGGGTGCGCTGGTGGCGATTCATC
CCGACTTGCTGGGTGCGATGCTTTGCGCTCTACCCGGCCAGCCGCGCCCACCCACCGAAGCGCCCGAACAGCCCCTCACA
CCGCGCGAAGTGGAGGTGCTCTCGATGCTCGCCGAGGGCCTCGGCAACAAAACCATCGCCCGCCGCCTGCAAATTTCCGA
ACACACCGTCAAATTTCACATCGGCTCGATTTTCGGCAAGCTCGAGGCCACAAGCCGCACCGAAGCTGTCACCCTGGGCG
TCAGGCGGGGACTGATTATGCTCTAG

Upstream 100 bases:

>100_bases
GGCGAACGGCTGCGGAGAGGGACGTGAATACCCGGCACCCAGAGCAAGCAGAAAGTCTGGAGGCGGCAGGATTTTGGATC
GCCTGCGGGCGGAGTGCGGC

Downstream 100 bases:

>100_bases
CGGGTCGGTTGGGTCGTTCCCTGGGCGTTGGTCGGCGCGAGCGTACCGCCGCTGGTGGCGGTGAAGTTGAAGTTTGGTGT
CGGGGCGGGCAGGCCCGAGT

Product: LuxR family transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MIRVAVAADAAVVRAGLAALVAASPDLTVVGHPVSLAELPQLLEELQPEVVLVDLEDDADDAVLDWLPGLVPSPIEGEGV
PAVSLVILTEETAGSWMAEVLRSGVRALLPRTATAGEITAAITAAAGALVAIHPDLLGAMLCALPGQPRPPTEAPEQPLT
PREVEVLSMLAEGLGNKTIARRLQISEHTVKFHIGSIFGKLEATSRTEAVTLGVRRGLIML

Sequences:

>Translated_221_residues
MIRVAVAADAAVVRAGLAALVAASPDLTVVGHPVSLAELPQLLEELQPEVVLVDLEDDADDAVLDWLPGLVPSPIEGEGV
PAVSLVILTEETAGSWMAEVLRSGVRALLPRTATAGEITAAITAAAGALVAIHPDLLGAMLCALPGQPRPPTEAPEQPLT
PREVEVLSMLAEGLGNKTIARRLQISEHTVKFHIGSIFGKLEATSRTEAVTLGVRRGLIML
>Mature_221_residues
MIRVAVAADAAVVRAGLAALVAASPDLTVVGHPVSLAELPQLLEELQPEVVLVDLEDDADDAVLDWLPGLVPSPIEGEGV
PAVSLVILTEETAGSWMAEVLRSGVRALLPRTATAGEITAAITAAAGALVAIHPDLLGAMLCALPGQPRPPTEAPEQPLT
PREVEVLSMLAEGLGNKTIARRLQISEHTVKFHIGSIFGKLEATSRTEAVTLGVRRGLIML

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789937, Length=178, Percent_Identity=34.2696629213483, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788521, Length=215, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787473, Length=202, Percent_Identity=31.6831683168317, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22993; Mature: 22993

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAVAADAAVVRAGLAALVAASPDLTVVGHPVSLAELPQLLEELQPEVVLVDLEDDAD
CEEEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCC
DAVLDWLPGLVPSPIEGEGVPAVSLVILTEETAGSWMAEVLRSGVRALLPRTATAGEITA
HHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
AITAAAGALVAIHPDLLGAMLCALPGQPRPPTEAPEQPLTPREVEVLSMLAEGLGNKTIA
HHHHHCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
RRLQISEHTVKFHIGSIFGKLEATSRTEAVTLGVRRGLIML
HHHHHCHHEEEEEHHHHHHHHCCCCCHHHEEHHHHCCEECC
>Mature Secondary Structure
MIRVAVAADAAVVRAGLAALVAASPDLTVVGHPVSLAELPQLLEELQPEVVLVDLEDDAD
CEEEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCC
DAVLDWLPGLVPSPIEGEGVPAVSLVILTEETAGSWMAEVLRSGVRALLPRTATAGEITA
HHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
AITAAAGALVAIHPDLLGAMLCALPGQPRPPTEAPEQPLTPREVEVLSMLAEGLGNKTIA
HHHHHCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
RRLQISEHTVKFHIGSIFGKLEATSRTEAVTLGVRRGLIML
HHHHHCHHEEEEEHHHHHHHHCCCCCHHHEEHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]