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The map label for this gene is moeA [H]

Identifier: 37523308

GI number: 37523308

Start: 3950515

End: 3951723

Strand: Direct

Name: moeA [H]

Synonym: glr3739

Alternate gene names: 37523308

Gene position: 3950515-3951723 (Clockwise)

Preceding gene: 37523303

Following gene: 37523310

Centisome position: 84.79

GC content: 66.75

Gene sequence:

>1209_bases
ATGATTTCCGTCGAAGAAGCACAAGCGCTCATCCTCGAAGCGGTGGAGGTCGGCGCCCCCGAGCGGGTCGATCTGCTGGC
TGCCTGCAGCCGGGTGCTCGCCGAGACCATCCTGGCGCGCACAGATTTTCCGCCCTACGACAACTCGGCGATGGACGGTT
ACGCGGTGCGCTCCGCCGATACCGGTTTTGGGAAGCTGCAAGTGGTTGAAACGATCGCGGCGGGCCGGATGCCCACCCAT
CCCCTCGCCGAGGGGCAGGCCGCCCGGATCATGACCGGGGCGGTGCTCCCTGAGGGCTCCGACGCGGTTCTCATTCAAGA
AGAAGCCCGCCTGGAGGGAGACACCCTCACGTTTGAAAAGCTCCCTGCCCCCGGAGCGAACGTGCGCTACCGCGGCGCCT
TTCACAAAGCGGGCTCACCCCTGATGCCGCCGGGTACAGTCCTGCAGCCGGGCGAAATTGCCCTTTTGGCGGCGGCCCAG
CGCGCCTTCGTACTCACCCACCGCCCGCCCGCAGTGGCGATCGTCTCGACGGGGGACGAACTGGTGGGTATCGACGGGGT
GCTCGCAGGGGCGCGCATCGTTGATTCCAACCAGTACGGCCTCGTCGCCCAGGTGCGCGAGGCGGGGGGCGATCCCCGGG
CGTTGGGCATCGCCCCCGACGATCCCGAGGCAATCCGCATGCGCTTGCTGGCTGCCCTGGATGCCGATTTTGTGCTGCTC
TCGGGCGGGGCGAGCGTCGGGCAATTTGACTACACCCCACAGGTGCTCGAAGCGTTGGGTGCGCAGGTGGTGCTCTACAA
GATCAACATGAAGCCGGGCAAACCGCTGATGTTCGCCCGGCTGGGCAGCCGACTCATCTGGGGCCTGCCCGGCAACCCGG
TCTCGTCGCTGTTTTGCTTCTGGCAGTTTGTGCGGCCCGCCATCCGCAAATTCATGGGCTACCCGCCCGAGCGCTGGCGT
TACCCGGTGGTAACGGCGCAACTGAAAGCGCCGGTGCGCTCGAAGGGCGACCGGCGCGCCTACCTGCGCGGCCAATTGGC
CCTCGAAGCCGGTGTCTGGCGCTTTGCTCCGTACCGCACCGACAACTCCGGCGACCTGGTGAGCCTGCTTGGCATCAACG
CCTTTGCCTGGCTGGAAGCCGGGGTGACGGGTGCCTGCGAAGGGGAGACGGTGCCGGTTTTGGTGGTAGGCGAACTGGTG
AACCGCTGA

Upstream 100 bases:

>100_bases
GCGAGGGCGGAGAGCCAGCCTGTAGGAGGGCGTGAAACCAGTTCCATGGTGTGGATTGGGGTTGGCGCTAGGCTAGAAGG
CAGCGCCTTACATCATATTT

Downstream 100 bases:

>100_bases
AAGCTCTAGCCCAGGTGGCTGCTCAAAAATGTGAGGGTACGGCCGTTGGCCAGCTCGGCGGCTTCCTTTTGATAGGTGGT
GCCGTCCACGCGGGCAAAGG

Product: molybdopterin biosynthesis protein MoaA-like protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSADTGFGKLQVVETIAAGRMPTH
PLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEKLPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQ
RAFVLTHRPPAVAIVSTGDELVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLL
SGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCFWQFVRPAIRKFMGYPPERWR
YPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRTDNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELV
NR

Sequences:

>Translated_402_residues
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSADTGFGKLQVVETIAAGRMPTH
PLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEKLPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQ
RAFVLTHRPPAVAIVSTGDELVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLL
SGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCFWQFVRPAIRKFMGYPPERWR
YPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRTDNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELV
NR
>Mature_402_residues
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSADTGFGKLQVVETIAAGRMPTH
PLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEKLPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQ
RAFVLTHRPPAVAIVSTGDELVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLL
SGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCFWQFVRPAIRKFMGYPPERWR
YPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRTDNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELV
NR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=428, Percent_Identity=35.0467289719626, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI10880983, Length=428, Percent_Identity=35.0467289719626, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1787049, Length=340, Percent_Identity=37.0588235294118, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=30.3303303303303, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17136978, Length=412, Percent_Identity=31.3106796116505, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24638841, Length=412, Percent_Identity=31.3106796116505, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42907; Mature: 42907

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSAD
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
TGFGKLQVVETIAAGRMPTHPLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCEEEEECCCCCCCCEEEHCC
LPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQRAFVLTHRPPAVAIVSTGDE
CCCCCCCEEEECCCCCCCCCCCCCCCEECCCCEEEEEECCEEEEEECCCCEEEEEECCCC
LVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLL
EEECCHHEECCEEEECCCCCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCEEEE
SGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCF
ECCCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCEEEECCCCCHHHHHHHH
WQFVRPAIRKFMGYPPERWRYPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRT
HHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCEEECCCCC
DNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELVNR
CCCCCEEEEHHCCHHHHHHCCCCCCCCCCCEEEEEECHHHCC
>Mature Secondary Structure
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSAD
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
TGFGKLQVVETIAAGRMPTHPLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCEEEEECCCCCCCCEEEHCC
LPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQRAFVLTHRPPAVAIVSTGDE
CCCCCCCEEEECCCCCCCCCCCCCCCEECCCCEEEEEECCEEEEEECCCCEEEEEECCCC
LVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLL
EEECCHHEECCEEEECCCCCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCEEEE
SGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCF
ECCCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCEEEECCCCCHHHHHHHH
WQFVRPAIRKFMGYPPERWRYPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRT
HHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCEEECCCCC
DNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELVNR
CCCCCEEEEHHCCHHHHHHCCCCCCCCCCCEEEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]