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The map label for this gene is desA [H]

Identifier: 37523304

GI number: 37523304

Start: 3944843

End: 3945910

Strand: Reverse

Name: desA [H]

Synonym: gvip506

Alternate gene names: 37523304

Gene position: 3945910-3944843 (Counterclockwise)

Preceding gene: 37523305

Following gene: 37523301

Centisome position: 84.69

GC content: 62.36

Gene sequence:

>1068_bases
TTGACGATCGATACGCCGGCGGCGGGCATCCGCACGCACAACCGCAAGTTACTGCGCCAACTGGAGCGGGTGACCTACCG
CGAGGTGCTCAGTACCATTCCCAAAAAATGCTTCGAGCGCGACACCCTGCGCGGCCTGGGGGCGGTGGTCCTGCACCTGG
GGGTTCTGGCCGGTTCTTACGCGCTTTTTGCCGTCTCTCCGATCTGGCTGGCGCCGCTCTTTTGGGTGTGGATCGGCACG
GTGCTGTGGGGCAACTTCGTGCTGGCCCACGACTGTGGTCACCAGTCCTTCTCGCCCTACCGCAGGCTCAATGCGCTGGT
GGGCCATGGGCTGCTGCTGCCGACGCTCTACCCGTTTCACAGCTGGCGGATCATGCACAACCGCCACCACGCCTGGACCA
ACCACCAGGACAACGACAACAGCTGGCGGACGATCGCCCCCGAGACTTACGCGGGTATGAACGACTTCAACCGGTTTTTT
TATCGGCATGTCCACACCTGGGCCTGGTGGTTCGCCTCGGTCATTCATCTGTTCATCTTCCACTACGACCAAAAGAAATT
CCTCCCCCAGGAGCGGCCCGAGGCGCGCTTTTCGATTGCAGTGAACGTCGTGTTTGCAGCGGTCGCCCTACCGGGCTTGT
TCTGGCTCACCGGTTTTGGGGGGGTGCTCAGTTACTGGGTGCTGCCGTGGCTGGTCTTTCACTTCTGGCTGAGCACCTTC
ACCCTTATCCACCACAACCATCCGGACATTCCCTACTTCCCGGAGGGCGAGTGGACGCCGCTGAAGGCGCAACTGTTCGG
CACGGTCCACTGCGAGTACCCCTGGTGGGTCGAACTGGTGGCCTACCGCATTGGCGTGCACATCCCCCACCACCTCTCGA
CGGCGATCCCGTACTATCACCTCGACGAGGCCCACGCCGCCCTCAAAGCCCGCTGGCCGGAGTACGTGCACGAGGCGCGC
TTCACCTGGCCGTATCTCAAATCGATCGTCACCACCTGCCACCTGAGCGGTCCGGAGGGCTATCATCTGCCCATCAAACG
CGCCCGGGTCGTAAGGGGCCGCAAATAA

Upstream 100 bases:

>100_bases
TGAACGTTCGGGTTCGTGGCGCTTTCGCCGCTTCGGCGGCCGGAGGCTCACTGCGCTGTGCCCAGCTTTCGGGGTCAAGC
AACCGCAAGAGGAGTGAGCG

Downstream 100 bases:

>100_bases
AAGCCCCGGCGGCTCAAAGCCACCGGGACCAACAGAAGAGGTGTAGCTATCGAATGGGGGGTTAACCCTGGCGGACCGCT
TCGAGGGCGTCAAGGTAGCG

Product: delta 12 acyl-lipid desaturase

Products: NA

Alternate protein names: Delta(12) desaturase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTIDTPAAGIRTHNRKLLRQLERVTYREVLSTIPKKCFERDTLRGLGAVVLHLGVLAGSYALFAVSPIWLAPLFWVWIGT
VLWGNFVLAHDCGHQSFSPYRRLNALVGHGLLLPTLYPFHSWRIMHNRHHAWTNHQDNDNSWRTIAPETYAGMNDFNRFF
YRHVHTWAWWFASVIHLFIFHYDQKKFLPQERPEARFSIAVNVVFAAVALPGLFWLTGFGGVLSYWVLPWLVFHFWLSTF
TLIHHNHPDIPYFPEGEWTPLKAQLFGTVHCEYPWWVELVAYRIGVHIPHHLSTAIPYYHLDEAHAALKARWPEYVHEAR
FTWPYLKSIVTTCHLSGPEGYHLPIKRARVVRGRK

Sequences:

>Translated_355_residues
MTIDTPAAGIRTHNRKLLRQLERVTYREVLSTIPKKCFERDTLRGLGAVVLHLGVLAGSYALFAVSPIWLAPLFWVWIGT
VLWGNFVLAHDCGHQSFSPYRRLNALVGHGLLLPTLYPFHSWRIMHNRHHAWTNHQDNDNSWRTIAPETYAGMNDFNRFF
YRHVHTWAWWFASVIHLFIFHYDQKKFLPQERPEARFSIAVNVVFAAVALPGLFWLTGFGGVLSYWVLPWLVFHFWLSTF
TLIHHNHPDIPYFPEGEWTPLKAQLFGTVHCEYPWWVELVAYRIGVHIPHHLSTAIPYYHLDEAHAALKARWPEYVHEAR
FTWPYLKSIVTTCHLSGPEGYHLPIKRARVVRGRK
>Mature_354_residues
TIDTPAAGIRTHNRKLLRQLERVTYREVLSTIPKKCFERDTLRGLGAVVLHLGVLAGSYALFAVSPIWLAPLFWVWIGTV
LWGNFVLAHDCGHQSFSPYRRLNALVGHGLLLPTLYPFHSWRIMHNRHHAWTNHQDNDNSWRTIAPETYAGMNDFNRFFY
RHVHTWAWWFASVIHLFIFHYDQKKFLPQERPEARFSIAVNVVFAAVALPGLFWLTGFGGVLSYWVLPWLVFHFWLSTFT
LIHHNHPDIPYFPEGEWTPLKAQLFGTVHCEYPWWVELVAYRIGVHIPHHLSTAIPYYHLDEAHAALKARWPEYVHEARF
TWPYLKSIVTTCHLSGPEGYHLPIKRARVVRGRK

Specific function: Can introduce a second cis double bond at the Delta(12) position of fatty acid bound to membranes glycerolipids. This enzyme is involved in chilling tolerance because the phase transition temperature of lipids of cellular membranes depends on the degree o

COG id: COG3239

COG function: function code I; Fatty acid desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fatty acid desaturase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17542730, Length=322, Percent_Identity=29.8136645962733, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71999459, Length=290, Percent_Identity=28.6206896551724, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005804
- InterPro:   IPR005803 [H]

Pfam domain/function: PF00487 FA_desaturase [H]

EC number: NA

Molecular weight: Translated: 41580; Mature: 41449

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDTPAAGIRTHNRKLLRQLERVTYREVLSTIPKKCFERDTLRGLGAVVLHLGVLAGSY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALFAVSPIWLAPLFWVWIGTVLWGNFVLAHDCGHQSFSPYRRLNALVGHGLLLPTLYPFH
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHCCHH
SWRIMHNRHHAWTNHQDNDNSWRTIAPETYAGMNDFNRFFYRHVHTWAWWFASVIHLFIF
HHHHHHCCCCCCCCCCCCCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYDQKKFLPQERPEARFSIAVNVVFAAVALPGLFWLTGFGGVLSYWVLPWLVFHFWLSTF
HCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIHHNHPDIPYFPEGEWTPLKAQLFGTVHCEYPWWVELVAYRIGVHIPHHLSTAIPYYH
HHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCEE
LDEAHAALKARWPEYVHEARFTWPYLKSIVTTCHLSGPEGYHLPIKRARVVRGRK
CHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TIDTPAAGIRTHNRKLLRQLERVTYREVLSTIPKKCFERDTLRGLGAVVLHLGVLAGSY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALFAVSPIWLAPLFWVWIGTVLWGNFVLAHDCGHQSFSPYRRLNALVGHGLLLPTLYPFH
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHCCHH
SWRIMHNRHHAWTNHQDNDNSWRTIAPETYAGMNDFNRFFYRHVHTWAWWFASVIHLFIF
HHHHHHCCCCCCCCCCCCCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYDQKKFLPQERPEARFSIAVNVVFAAVALPGLFWLTGFGGVLSYWVLPWLVFHFWLSTF
HCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIHHNHPDIPYFPEGEWTPLKAQLFGTVHCEYPWWVELVAYRIGVHIPHHLSTAIPYYH
HHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCEE
LDEAHAALKARWPEYVHEARFTWPYLKSIVTTCHLSGPEGYHLPIKRARVVRGRK
CHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118597; 8905231 [H]