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The map label for this gene is gltT [H]

Identifier: 37523293

GI number: 37523293

Start: 3935894

End: 3937219

Strand: Reverse

Name: gltT [H]

Synonym: gll3724

Alternate gene names: 37523293

Gene position: 3937219-3935894 (Counterclockwise)

Preceding gene: 37523294

Following gene: 37523292

Centisome position: 84.51

GC content: 58.14

Gene sequence:

>1326_bases
ATGAACCGCGAAGCCGGAATGCCTCTGCATACGCGTATATTTATCGGTCTGGCCGTCGGGCTGGGGCTGGGGCTGCTGTG
CAACATTGTGCTGCCCGGTGACCCGCGCGTGCAGTGGGTGGTGGCCAACGTCGCCTACCCGGCGGGCCAGATCTTTTTGC
GCTCGATCTTTATGATCGTTATCCCTTTGATTTTCACCGCCATCGTGCTGGGAATAGCCGATCTCGGCGACATCAAAAAA
ATCGGCCGCATCGGCCTCAAGACACTGCTGTTTACGGTCGTGATTACCGGCATCTCGGTGCTCATCGGCCTGACGTTGGT
CAATACCGTCAAGCCGGGTGTGGGTCTATCTGAACAGAGCCGCACCGCGCTGATTGGTGCCCTTAGCAATAACGAAAAAG
TTTCGGGAATCGTCACCTCCGCAGGCGAGGCGAAGACACCGATCCAGACGCTGGTCGAAATTATTCCCCGCAACCCGCTT
GCCGATGCGGTCTACGCCTTTGATCCCGAATACCGCGGCGGCGGGTTGCTGTCGGTGATGTTCTTTTCGGTAGTCTTCGG
TGTGGCGCTTGCCGTGAGCGATCCCCGGCGCACCGCACCCCTGGTGCAAGGGTTACAGGGGCTCTACGACGTGATCATGA
AGATCATCGAATTTGCCATGAACCTCGCACCCTACGGCGTGGCGGCCCTTATCTTCACAACAGCCTCCCAGCTCGGTTTT
GAAGTCATCCTGGTGTTGCTCAAGTACGTGCTGGTGGTGATCGCTGCCCTTGCCATCCACCAGTTTGTCACCTACGGTCT
TATCGTTCGTTTTTTCGCTCGCCTCAATCCGCTCAAATTCTTTCAAAGCATCCGCGAGGTGATGCTGACGGCTTTCTCCA
CCAGCTCCTCCAATGCCACGCTGCCCACGGCCATCCGCGTCAGTTCCAACGAACTCAAACTCAACCGCGACATCGCCAAC
TTCGTGCTGACCGTCGGCTCGACCGCCAACCAAAATGGTACAGCTTTGTACGAAGGAATCACGGTTTTGTTTCTTGCCCA
GTTCTACGGTGTGGAATTGACCATTGGCCAACAATTGACCGTCGTGCTCTTGTCTATCCTGGCCGGGGTGGGCACGGCGG
GCGTTCCCGGCGGCTCGCTGCCCCTGGTGGTTCTGGTGCTGCAGACAGTCGGAGTGCCTGCCGAAGGCATCGGCATCATT
CTGGGGGTGGACCGCATTCTCGACATGTGCAGAACCGTGGTCAACGTCACCGGCGACATTACCCTGGCCGCCTGTGTCGA
TGCCAGTGAGAACAGGGCCTCCGCCAAAGATACCGGTGTGGCCTGA

Upstream 100 bases:

>100_bases
TGTTGCACAAGATCGTCGGCTACAAGTTTTACGGCGGCCGAGGCTGACTTGACGGCGGCTATCCGCGGACGCCATGCTGT
GCCCAGCATTGGGATGACCT

Downstream 100 bases:

>100_bases
GAGCCGCGCGTATCGGTCGCGTCCGCCGTACGCACCTCCCCCACGATCGCCTCCCCCGGGTGTTCCCTCTTACTTTAAAA
ACAGAAAATGGTATTGGCCT

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNREAGMPLHTRIFIGLAVGLGLGLLCNIVLPGDPRVQWVVANVAYPAGQIFLRSIFMIVIPLIFTAIVLGIADLGDIKK
IGRIGLKTLLFTVVITGISVLIGLTLVNTVKPGVGLSEQSRTALIGALSNNEKVSGIVTSAGEAKTPIQTLVEIIPRNPL
ADAVYAFDPEYRGGGLLSVMFFSVVFGVALAVSDPRRTAPLVQGLQGLYDVIMKIIEFAMNLAPYGVAALIFTTASQLGF
EVILVLLKYVLVVIAALAIHQFVTYGLIVRFFARLNPLKFFQSIREVMLTAFSTSSSNATLPTAIRVSSNELKLNRDIAN
FVLTVGSTANQNGTALYEGITVLFLAQFYGVELTIGQQLTVVLLSILAGVGTAGVPGGSLPLVVLVLQTVGVPAEGIGII
LGVDRILDMCRTVVNVTGDITLAACVDASENRASAKDTGVA

Sequences:

>Translated_441_residues
MNREAGMPLHTRIFIGLAVGLGLGLLCNIVLPGDPRVQWVVANVAYPAGQIFLRSIFMIVIPLIFTAIVLGIADLGDIKK
IGRIGLKTLLFTVVITGISVLIGLTLVNTVKPGVGLSEQSRTALIGALSNNEKVSGIVTSAGEAKTPIQTLVEIIPRNPL
ADAVYAFDPEYRGGGLLSVMFFSVVFGVALAVSDPRRTAPLVQGLQGLYDVIMKIIEFAMNLAPYGVAALIFTTASQLGF
EVILVLLKYVLVVIAALAIHQFVTYGLIVRFFARLNPLKFFQSIREVMLTAFSTSSSNATLPTAIRVSSNELKLNRDIAN
FVLTVGSTANQNGTALYEGITVLFLAQFYGVELTIGQQLTVVLLSILAGVGTAGVPGGSLPLVVLVLQTVGVPAEGIGII
LGVDRILDMCRTVVNVTGDITLAACVDASENRASAKDTGVA
>Mature_441_residues
MNREAGMPLHTRIFIGLAVGLGLGLLCNIVLPGDPRVQWVVANVAYPAGQIFLRSIFMIVIPLIFTAIVLGIADLGDIKK
IGRIGLKTLLFTVVITGISVLIGLTLVNTVKPGVGLSEQSRTALIGALSNNEKVSGIVTSAGEAKTPIQTLVEIIPRNPL
ADAVYAFDPEYRGGGLLSVMFFSVVFGVALAVSDPRRTAPLVQGLQGLYDVIMKIIEFAMNLAPYGVAALIFTTASQLGF
EVILVLLKYVLVVIAALAIHQFVTYGLIVRFFARLNPLKFFQSIREVMLTAFSTSSSNATLPTAIRVSSNELKLNRDIAN
FVLTVGSTANQNGTALYEGITVLFLAQFYGVELTIGQQLTVVLLSILAGVGTAGVPGGSLPLVVLVLQTVGVPAEGIGII
LGVDRILDMCRTVVNVTGDITLAACVDASENRASAKDTGVA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=445, Percent_Identity=30.561797752809, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI66773030, Length=406, Percent_Identity=32.512315270936, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI40254478, Length=454, Percent_Identity=29.7356828193833, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI21314632, Length=428, Percent_Identity=26.8691588785047, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI169790839, Length=444, Percent_Identity=28.1531531531532, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4827012, Length=258, Percent_Identity=35.6589147286822, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI5032093, Length=408, Percent_Identity=27.6960784313726, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=30.9352517985612, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=30.8823529411765, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI301601644, Length=159, Percent_Identity=32.7044025157233, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI262359914, Length=365, Percent_Identity=26.3013698630137, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1790514, Length=429, Percent_Identity=33.1002331002331, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1789947, Length=382, Percent_Identity=29.0575916230367, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788024, Length=403, Percent_Identity=27.7915632754342, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789473, Length=311, Percent_Identity=27.0096463022508, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996953, Length=476, Percent_Identity=28.9915966386555, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71983106, Length=422, Percent_Identity=29.6208530805687, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71983099, Length=422, Percent_Identity=29.6208530805687, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI193206505, Length=450, Percent_Identity=28.4444444444444, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=415, Percent_Identity=31.566265060241, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=398, Percent_Identity=28.643216080402, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193206654, Length=446, Percent_Identity=24.8878923766816, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24583025, Length=404, Percent_Identity=29.4554455445545, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17137668, Length=404, Percent_Identity=29.4554455445545, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24583023, Length=404, Percent_Identity=29.4554455445545, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI281360483, Length=428, Percent_Identity=29.2056074766355, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137666, Length=428, Percent_Identity=29.2056074766355, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281360481, Length=428, Percent_Identity=29.2056074766355, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46536; Mature: 46536

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREAGMPLHTRIFIGLAVGLGLGLLCNIVLPGDPRVQWVVANVAYPAGQIFLRSIFMIV
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHH
IPLIFTAIVLGIADLGDIKKIGRIGLKTLLFTVVITGISVLIGLTLVNTVKPGVGLSEQS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RTALIGALSNNEKVSGIVTSAGEAKTPIQTLVEIIPRNPLADAVYAFDPEYRGGGLLSVM
CCEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHH
FFSVVFGVALAVSDPRRTAPLVQGLQGLYDVIMKIIEFAMNLAPYGVAALIFTTASQLGF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EVILVLLKYVLVVIAALAIHQFVTYGLIVRFFARLNPLKFFQSIREVMLTAFSTSSSNAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
LPTAIRVSSNELKLNRDIANFVLTVGSTANQNGTALYEGITVLFLAQFYGVELTIGQQLT
CCEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCHHH
VVLLSILAGVGTAGVPGGSLPLVVLVLQTVGVPAEGIGIILGVDRILDMCRTVVNVTGDI
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCE
TLAACVDASENRASAKDTGVA
EEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MNREAGMPLHTRIFIGLAVGLGLGLLCNIVLPGDPRVQWVVANVAYPAGQIFLRSIFMIV
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHH
IPLIFTAIVLGIADLGDIKKIGRIGLKTLLFTVVITGISVLIGLTLVNTVKPGVGLSEQS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RTALIGALSNNEKVSGIVTSAGEAKTPIQTLVEIIPRNPLADAVYAFDPEYRGGGLLSVM
CCEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHH
FFSVVFGVALAVSDPRRTAPLVQGLQGLYDVIMKIIEFAMNLAPYGVAALIFTTASQLGF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EVILVLLKYVLVVIAALAIHQFVTYGLIVRFFARLNPLKFFQSIREVMLTAFSTSSSNAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
LPTAIRVSSNELKLNRDIANFVLTVGSTANQNGTALYEGITVLFLAQFYGVELTIGQQLT
CCEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCHHH
VVLLSILAGVGTAGVPGGSLPLVVLVLQTVGVPAEGIGIILGVDRILDMCRTVVNVTGDI
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCE
TLAACVDASENRASAKDTGVA
EEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]