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The map label for this gene is arlS [H]

Identifier: 37523244

GI number: 37523244

Start: 3880658

End: 3882214

Strand: Direct

Name: arlS [H]

Synonym: glr3675

Alternate gene names: 37523244

Gene position: 3880658-3882214 (Clockwise)

Preceding gene: 37523243

Following gene: 37523247

Centisome position: 83.29

GC content: 63.97

Gene sequence:

>1557_bases
ATGCTTAAAAATCGACCCGTCCATCACCGAGACCGCTCATTTCAGGTGTCGGGCGCAGTGCAAAGAGCCGGCCGGCCGAT
GCCCTCTTGGGGGTACAGTCTTGGGGGCTTCAAGCTCTCTCGCCCGCGGGGCCTATTCGGCCGATTCGGGGTGCGTTTGC
GGCTACTTGCATGGTGCATATTGCTGATGATCCTCTTTGGGGCAGCCTCCGGTCTGCTTATTGACCAGGTGCTTTTTTTC
TATCTGGAAGATCGTATTGAAGCGTCCCTCACCCAGGAAGCGGCTGAATTTCGAGCGCTGGCCACCAGAAGCAAACCCGG
AGGCCGGCTTCTGGTGGCCAGGGAGACTTTTACGGGAGTTCTCGATGAATTTCTGACCCACAATATTCCACCCCAGAATA
CGTTTTATCTCACGTTTGCCGATGGAGCGTTTCATAAAGCCAGCCCGCGGGCGTTGCCGCCCTTGCTCGCACCGGATTCT
CCCCTCACCAGGCGGCTTGCGGGGGTGAGCCTGCCGCAGCGCAGCGAAGTGGTGACCGCCGACGGGCAGCGCTATGTCTA
TCTGAGCGAGCCGCTGAATGCGGCGGGCCGGACGCGCGGCGGGTTGGTTCTGGCCCACTGCGTTTCCTGCGAGCGCCAGT
TTCTCGATCAGTGCCTCGCCGTCATCGGGGTCATCTTCCTCTTGGCGCTCGCCCTCGCCTCGGTGATTGTCTGGGTCGGG
ACCGGGCGCGTGCTTGCTCCCCTACAACAGCTGCTGCGCACCGTGCGCGCCATCGACGAGTTGGATCTCACCCGGCGGGT
GCACTTGCACGAACAGAGCAACGAATGGAGCGAATTGGCCTGTGCCTTCAATGCCATGCTCGGCCGCCTGGAGGGGGCCT
TTCAAACGCAGCGCCACTTTGTCAACGAAGTCAGCCACGAACTGCGCACACCGCTCACGATCATCCGTGGGCACCTCGAA
CTCATCGGCGACGACCCCCACGAGCGCGCCGAGACGATGCACATCGTCCACGACGAATTGGGCCGCATGCACCGCTTTGT
CGAAAGTTTGTTGCTGCTGGACCGCCTGGAGCGGCACGATGGCTTGCATCTGGAGCCACTTGAAGTGGACGCTCTGACGC
GCGAGTGTTTCGCCAAGGCCCGCGGGCTGGGGCGGCGCCAGTGGCATTTGCCCTCCGCCGCTTCCGGCTGCCGCGTCCAC
GCCGATCGCCAGTGCCTGACCCAGGCGGTGCTCAATCTCGCCCACAACGCCGTCAAATTCACCACCCACCAGGACCGCAT
CGCCATCGGCTCCAGCCTGGTAGACGGCCGGGTGCACCTGTGGGTGAGCGACAGCGGACCCGGCGTGCCCCTCGAAGCCC
AGGGGCGCATCTTCGAGTGCTTCGAGCGGGGAAGCTGCCATCGTCAGACCGAAGGCAACGGCCTGGGTCTGGCCATCGTG
CGCTCGATCGCCCTGGCCCACGGCGGCGAAGTGCGCCTGCAGAGCACCCCAGGCCACGGCGCCACGTTCACGCTCGTGCT
GCCCCTCGCGCCGCAAACCCACCGGCAAGACGGCTGA

Upstream 100 bases:

>100_bases
GTAGTCTCAAGACGGTGGCCCCAGGTCGTGGTTGCTGTTCAACCCGGCCCGGTCATAGGCGATGCCTGATGCTCATCAGA
CTTCTTAGGTACTGAGAACC

Downstream 100 bases:

>100_bases
CCTCGGGGGGCTGCCTCATCCCAACAGACTGGTAATTGCCCAGGTGAAGACCGCCCCGGCCGCCAGAGCGCTACCCAGGC
CGAGGGTTTGGGCGGGCGAA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MLKNRPVHHRDRSFQVSGAVQRAGRPMPSWGYSLGGFKLSRPRGLFGRFGVRLRLLAWCILLMILFGAASGLLIDQVLFF
YLEDRIEASLTQEAAEFRALATRSKPGGRLLVARETFTGVLDEFLTHNIPPQNTFYLTFADGAFHKASPRALPPLLAPDS
PLTRRLAGVSLPQRSEVVTADGQRYVYLSEPLNAAGRTRGGLVLAHCVSCERQFLDQCLAVIGVIFLLALALASVIVWVG
TGRVLAPLQQLLRTVRAIDELDLTRRVHLHEQSNEWSELACAFNAMLGRLEGAFQTQRHFVNEVSHELRTPLTIIRGHLE
LIGDDPHERAETMHIVHDELGRMHRFVESLLLLDRLERHDGLHLEPLEVDALTRECFAKARGLGRRQWHLPSAASGCRVH
ADRQCLTQAVLNLAHNAVKFTTHQDRIAIGSSLVDGRVHLWVSDSGPGVPLEAQGRIFECFERGSCHRQTEGNGLGLAIV
RSIALAHGGEVRLQSTPGHGATFTLVLPLAPQTHRQDG

Sequences:

>Translated_518_residues
MLKNRPVHHRDRSFQVSGAVQRAGRPMPSWGYSLGGFKLSRPRGLFGRFGVRLRLLAWCILLMILFGAASGLLIDQVLFF
YLEDRIEASLTQEAAEFRALATRSKPGGRLLVARETFTGVLDEFLTHNIPPQNTFYLTFADGAFHKASPRALPPLLAPDS
PLTRRLAGVSLPQRSEVVTADGQRYVYLSEPLNAAGRTRGGLVLAHCVSCERQFLDQCLAVIGVIFLLALALASVIVWVG
TGRVLAPLQQLLRTVRAIDELDLTRRVHLHEQSNEWSELACAFNAMLGRLEGAFQTQRHFVNEVSHELRTPLTIIRGHLE
LIGDDPHERAETMHIVHDELGRMHRFVESLLLLDRLERHDGLHLEPLEVDALTRECFAKARGLGRRQWHLPSAASGCRVH
ADRQCLTQAVLNLAHNAVKFTTHQDRIAIGSSLVDGRVHLWVSDSGPGVPLEAQGRIFECFERGSCHRQTEGNGLGLAIV
RSIALAHGGEVRLQSTPGHGATFTLVLPLAPQTHRQDG
>Mature_518_residues
MLKNRPVHHRDRSFQVSGAVQRAGRPMPSWGYSLGGFKLSRPRGLFGRFGVRLRLLAWCILLMILFGAASGLLIDQVLFF
YLEDRIEASLTQEAAEFRALATRSKPGGRLLVARETFTGVLDEFLTHNIPPQNTFYLTFADGAFHKASPRALPPLLAPDS
PLTRRLAGVSLPQRSEVVTADGQRYVYLSEPLNAAGRTRGGLVLAHCVSCERQFLDQCLAVIGVIFLLALALASVIVWVG
TGRVLAPLQQLLRTVRAIDELDLTRRVHLHEQSNEWSELACAFNAMLGRLEGAFQTQRHFVNEVSHELRTPLTIIRGHLE
LIGDDPHERAETMHIVHDELGRMHRFVESLLLLDRLERHDGLHLEPLEVDALTRECFAKARGLGRRQWHLPSAASGCRVH
ADRQCLTQAVLNLAHNAVKFTTHQDRIAIGSSLVDGRVHLWVSDSGPGVPLEAQGRIFECFERGSCHRQTEGNGLGLAIV
RSIALAHGGEVRLQSTPGHGATFTLVLPLAPQTHRQDG

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=34.6491228070175, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=325, Percent_Identity=26.7692307692308, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=31.9634703196347, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=31.4685314685315, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787894, Length=296, Percent_Identity=29.7297297297297, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788279, Length=313, Percent_Identity=25.2396166134185, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=337, Percent_Identity=29.9703264094956, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=28.5140562248996, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=26.2962962962963, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=28.6184210526316, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=30.2491103202847, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.4545454545455, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=29.7413793103448, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=264, Percent_Identity=28.4090909090909, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=26.6393442622951, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=32.4, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57427; Mature: 57427

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNRPVHHRDRSFQVSGAVQRAGRPMPSWGYSLGGFKLSRPRGLFGRFGVRLRLLAWCI
CCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LLMILFGAASGLLIDQVLFFYLEDRIEASLTQEAAEFRALATRSKPGGRLLVARETFTGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHH
LDEFLTHNIPPQNTFYLTFADGAFHKASPRALPPLLAPDSPLTRRLAGVSLPQRSEVVTA
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
DGQRYVYLSEPLNAAGRTRGGLVLAHCVSCERQFLDQCLAVIGVIFLLALALASVIVWVG
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGRVLAPLQQLLRTVRAIDELDLTRRVHLHEQSNEWSELACAFNAMLGRLEGAFQTQRHF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNEVSHELRTPLTIIRGHLELIGDDPHERAETMHIVHDELGRMHRFVESLLLLDRLERHD
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLHLEPLEVDALTRECFAKARGLGRRQWHLPSAASGCRVHADRQCLTQAVLNLAHNAVKF
CCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEECCHHHHHHHHHHHHHHHHEEE
TTHQDRIAIGSSLVDGRVHLWVSDSGPGVPLEAQGRIFECFERGSCHRQTEGNGLGLAIV
ECCCCHHHHCCCEECCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHH
RSIALAHGGEVRLQSTPGHGATFTLVLPLAPQTHRQDG
HHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLKNRPVHHRDRSFQVSGAVQRAGRPMPSWGYSLGGFKLSRPRGLFGRFGVRLRLLAWCI
CCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LLMILFGAASGLLIDQVLFFYLEDRIEASLTQEAAEFRALATRSKPGGRLLVARETFTGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHH
LDEFLTHNIPPQNTFYLTFADGAFHKASPRALPPLLAPDSPLTRRLAGVSLPQRSEVVTA
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
DGQRYVYLSEPLNAAGRTRGGLVLAHCVSCERQFLDQCLAVIGVIFLLALALASVIVWVG
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGRVLAPLQQLLRTVRAIDELDLTRRVHLHEQSNEWSELACAFNAMLGRLEGAFQTQRHF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNEVSHELRTPLTIIRGHLELIGDDPHERAETMHIVHDELGRMHRFVESLLLLDRLERHD
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLHLEPLEVDALTRECFAKARGLGRRQWHLPSAASGCRVHADRQCLTQAVLNLAHNAVKF
CCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEECCHHHHHHHHHHHHHHHHEEE
TTHQDRIAIGSSLVDGRVHLWVSDSGPGVPLEAQGRIFECFERGSCHRQTEGNGLGLAIV
ECCCCHHHHCCCEECCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHH
RSIALAHGGEVRLQSTPGHGATFTLVLPLAPQTHRQDG
HHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA