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The map label for this gene is glpD

Identifier: 37523236

GI number: 37523236

Start: 3872517

End: 3873434

Strand: Direct

Name: glpD

Synonym: gvip496

Alternate gene names: 37523236

Gene position: 3872517-3873434 (Clockwise)

Preceding gene: 37523235

Following gene: 37523237

Centisome position: 83.12

GC content: 67.43

Gene sequence:

>918_bases
ATGCGCATTGCCGTACTCGGGGGCGGCGCCTGGGGAACGACCCTGGCGGACCTTGCTGCGGCCCAGGATCATCAGGTGCG
GGTGTGGTCGCGTTCGGGAGCATTGGCCCTGGGTGAAGTTCTGGCCCAGGCGGAGGCAGTGTTCAGTTGTCTGCCGATGG
CGGCGGTGGCCGGGGTGATCGATCAGGTAATAGCCCTTGGGCTGCCTGCGGGGGTGATCGTGGTCAACGCCACCAAGGGG
CTCGATCGCCGCACGGCCCGCCCCGCCTCCAGCCTCTGGCAGGCCCGCTTTGCCGACCATCCGCTGGTGGTGCTGTCCGG
ACCGAATTTGGCTGCTGAAATTCGCGCCGGGCTGCCGGCGGCCACCGTGGTGGCAAGCGCCGACGGCCAGGCGGCCGGAC
GCATCCAGCAATGCCTGGCCTCCGAACGCTTCCGGGTCTACACCAGTGCCGACTGGCGCGGTGTGGAGTTGGGGGGCGTG
CTCAAAAACGTAATCGCCATCGCCGCCGGGGTCAGCGACGGCCTGGGCCTGGGCGCCAACGCCAAGGCCGCCCTTATCAC
CCGCGGTCTGGCCGAGATGATCCGGGTAGGCACCCACTGGGGGGGACTTGCCGAGACTTTTTACGGTCTGTCGGGTCTGG
GGGACTTGCTCACTACCTGCAACAGTCCCCTGAGCCGCAACTACCAGGTGGGTTTTGGCCTGGGCAAAGGCCAATCTCTA
GAAGCTGTTCTTGAGCGTCTCGAAGGGACCGCCGAGGGGGTGGCAACCGCCGCCATCCTCGCCGAATACGCCCAGCGCAG
CGCGCTTGAAGTGCCGATTACCGATCAAATCTGCGCCGTCCTGGGCGGCCTGCGCCCCCCCACCGAAGCGCTCGCAGCCC
TGATGACCCGCCGACTGCGCGAAGAGGACGGTGGTTAG

Upstream 100 bases:

>100_bases
ACGATGCGATCAACAATTTCCGGCGCACCGACGTGCGCATCACCCCGAAGATTATCAGCCCCGCTCCTGCCGGCGAGACG
GTTCCATCCGAAAAACCCTG

Downstream 100 bases:

>100_bases
GAAATACATTCAACCGAAATCTACGAATGTCTCCCACTCCGGAACAATTGCCGGCTTTTTTCTTGCGATGCCGGGAACTG
ACGGAACGCTACAATCGCCC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRIAVLGGGAWGTTLADLAAAQDHQVRVWSRSGALALGEVLAQAEAVFSCLPMAAVAGVIDQVIALGLPAGVIVVNATKG
LDRRTARPASSLWQARFADHPLVVLSGPNLAAEIRAGLPAATVVASADGQAAGRIQQCLASERFRVYTSADWRGVELGGV
LKNVIAIAAGVSDGLGLGANAKAALITRGLAEMIRVGTHWGGLAETFYGLSGLGDLLTTCNSPLSRNYQVGFGLGKGQSL
EAVLERLEGTAEGVATAAILAEYAQRSALEVPITDQICAVLGGLRPPTEALAALMTRRLREEDGG

Sequences:

>Translated_305_residues
MRIAVLGGGAWGTTLADLAAAQDHQVRVWSRSGALALGEVLAQAEAVFSCLPMAAVAGVIDQVIALGLPAGVIVVNATKG
LDRRTARPASSLWQARFADHPLVVLSGPNLAAEIRAGLPAATVVASADGQAAGRIQQCLASERFRVYTSADWRGVELGGV
LKNVIAIAAGVSDGLGLGANAKAALITRGLAEMIRVGTHWGGLAETFYGLSGLGDLLTTCNSPLSRNYQVGFGLGKGQSL
EAVLERLEGTAEGVATAAILAEYAQRSALEVPITDQICAVLGGLRPPTEALAALMTRRLREEDGG
>Mature_305_residues
MRIAVLGGGAWGTTLADLAAAQDHQVRVWSRSGALALGEVLAQAEAVFSCLPMAAVAGVIDQVIALGLPAGVIVVNATKG
LDRRTARPASSLWQARFADHPLVVLSGPNLAAEIRAGLPAATVVASADGQAAGRIQQCLASERFRVYTSADWRGVELGGV
LKNVIAIAAGVSDGLGLGANAKAALITRGLAEMIRVGTHWGGLAETFYGLSGLGDLLTTCNSPLSRNYQVGFGLGKGQSL
EAVLERLEGTAEGVATAAILAEYAQRSALEVPITDQICAVLGGLRPPTEALAALMTRRLREEDGG

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=290, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI24307999, Length=271, Percent_Identity=27.3062730627306, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=37.9939209726444, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI32564399, Length=342, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI193210134, Length=311, Percent_Identity=27.0096463022508, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193210136, Length=351, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32564403, Length=351, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17507425, Length=201, Percent_Identity=29.8507462686567, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324513, Length=340, Percent_Identity=26.7647058823529, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320181, Length=343, Percent_Identity=25.3644314868805, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI22026922, Length=205, Percent_Identity=31.219512195122, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17136204, Length=273, Percent_Identity=28.9377289377289, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136202, Length=273, Percent_Identity=28.9377289377289, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136200, Length=273, Percent_Identity=28.9377289377289, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_GLOVI (Q7NF59)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926613.1
- ProteinModelPortal:   Q7NF59
- SMR:   Q7NF59
- GeneID:   2602071
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3667
- HOGENOM:   HBG586392
- OMA:   AKGIEHG
- ProtClustDB:   PRK14619
- BioCyc:   GVIO251221:GLR3667-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 31325; Mature: 31325

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 162-162 BINDING 79-79 BINDING 79-79 BINDING 111-111 BINDING 226-226 BINDING 252-252

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVLGGGAWGTTLADLAAAQDHQVRVWSRSGALALGEVLAQAEAVFSCLPMAAVAGVI
CEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQVIALGLPAGVIVVNATKGLDRRTARPASSLWQARFADHPLVVLSGPNLAAEIRAGLPA
HHHHHHCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCH
ATVVASADGQAAGRIQQCLASERFRVYTSADWRGVELGGVLKNVIAIAAGVSDGLGLGAN
HHEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
AKAALITRGLAEMIRVGTHWGGLAETFYGLSGLGDLLTTCNSPLSRNYQVGFGLGKGQSL
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCH
EAVLERLEGTAEGVATAAILAEYAQRSALEVPITDQICAVLGGLRPPTEALAALMTRRLR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
EEDGG
HCCCC
>Mature Secondary Structure
MRIAVLGGGAWGTTLADLAAAQDHQVRVWSRSGALALGEVLAQAEAVFSCLPMAAVAGVI
CEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQVIALGLPAGVIVVNATKGLDRRTARPASSLWQARFADHPLVVLSGPNLAAEIRAGLPA
HHHHHHCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCH
ATVVASADGQAAGRIQQCLASERFRVYTSADWRGVELGGVLKNVIAIAAGVSDGLGLGAN
HHEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
AKAALITRGLAEMIRVGTHWGGLAETFYGLSGLGDLLTTCNSPLSRNYQVGFGLGKGQSL
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCH
EAVLERLEGTAEGVATAAILAEYAQRSALEVPITDQICAVLGGLRPPTEALAALMTRRLR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
EEDGG
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292