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The map label for this gene is mutSB [H]

Identifier: 37523206

GI number: 37523206

Start: 3833787

End: 3836159

Strand: Direct

Name: mutSB [H]

Synonym: glr3637

Alternate gene names: 37523206

Gene position: 3833787-3836159 (Clockwise)

Preceding gene: 37523202

Following gene: 37523207

Centisome position: 82.29

GC content: 67.68

Gene sequence:

>2373_bases
GTGTTGTTAGCGGATCTCGGTGCTGAAACGCGCGGACTGCTGGGCTGGGCGCGCCTTTGCGCTCAGCTGGCTTCCTTCGC
CCAGACCAAGGCGGCCAAAGGTGAATGCGAGACATTGTTGCCCTTCGAGGCGCGCAGCGAAGCCGAACGCTGGCTGCAGC
GCGCCGAGGAGGCCCTGCGCTTGGCCGAGAGCGTCCCGGGCGGCCTCGCCTTTGACGGGGTGCACGACATTGCCTCCGAC
GTTGAGCGCGCCGGGCGCGGGGGTCTGCTCACCGGTGAAGCGCTGCTGGCCGTCGCCTCGACCCTGGCGGCTGCCCGCCG
CCTGCGCCGGGCGATCGAAGAGCATTCCGGCCAGGCGGAGGAACTGGCGTTGTTGGTGGCCGAAGTGCGCACTTTTCCGG
AACTGGAACAAGAAATTTACCGTTGCATCGACGATACCGGTGAAGTGGCCGACCGGGCGAGCGAGAAGTTGCGCGATCTG
CGTTCGGGCCACCGGCGGTTGCGCGCCGAGATCCAGCGCACGCTGTTGCAACTGTTGCAGCGGCGGGCCAACTGCTTTCA
GGAAAGTCTGATCACCCAGCGGGGCGAGCGATTTGTCGTCCCGGTCAAAGTCAGCCACCGCGATCAGGTACCGGGGATCG
TCCATGATTCTTCCGCAAGCGGCCAGACGCTGTTTGTCGAACCGATGGCGGTGATCGATACCACCAATCGGTTGGTCGAA
GGGATGCGCGCCGAGCAAGTCGAAATCGAGCGCATTCTTGCCGAACTCGCGGCCCTGGTGGCCGAGCGCGCTACGGAGCT
GCTGCATCTGCATCGGGTGCTGGTGGATCTCGACCTGGCGGCGGCTCGCGCCCGCTACGCAAGCTGGCTGGGGGCGGTGC
GCCCCCGCTTTGGCGAGCGCGGCTGCGGGCTGGTACAGGTGCGCCATCCGCTCCTGGTCTGGCAGGAGCGCCACGAGCAG
GGTACCCCGGTGGTGCCTGTCGATCTGCCCGTTGACCCGGCGGTGCGGGCGGTCGTGATCACCGGCCCCAACACCGGCGG
CAAGACGGTGACCCTCAAGACCCTCGGCCTGGTGGTGCTGATGGCCCAGGCGGGGCTATTCGTGCCCGCCCGCGATCCGG
CGGTGCTGCCCTGGTTCGACCGGGTGCTGGCCGACATCGGCGACGAGCAATCGATCGAGCAAAATTTGTCCACCTTCTCC
GGCCATATCCGCCGCATCGTGCGGATTCTGGCGGCCCTCACCCCCGATGCGCTGGTGTTGCTCGATGAGGTGGGGGCAGG
CACCGACCCCCAGGAAGGTGCCGCCCTCGCCCGCGCCCTGTTGGTGCACCTGGCCGAGCGGGCGGGTCTGGTGCTCGCCA
CCACCCACTACGGCGAACTCAAAGCGCTCAAATACACCCAGTCCCACTTCGAAAACGCCTCGGTCGAATTCGATCTGGCC
ACACTCTCGCCCACCTATCGTCTGCTGTGGGGCATACCGGGGCGCTCGAACGCCCTGACGATCGCCGAGCGGCTCGGGCT
CGACGCGCAGGTGGTGGCGGTGGCCCAGGCGAGTCTGAGCGAGGGCGACGTCGAACTCGACCGGGTGATCGGCGCTCTGC
AGGAGCAGTTGCAGATCCAGGAGGAGCAGGTGCGCTCCACCACCCGATTGCGGGGCGAAGTCGAGCGGCTGCAATCGGAT
TTGCTCAGGCAGCAGGTGCTTCTCGACGCGCGCGAGGCGGCCCTACGCGCCCGCCAGGACCAGCAGGTGCGCGAGGTGGT
GGCCGAGGCCCGCGCTGAAGTAGCCCAGGTGATCCGCACCCTCCAGCGCGGCGATGCCACCGCCCAGCAGGCCCAGCAGG
CTTCCGAGGCGCTCAAAGCCGTTGGCGAAGCGTACCTGGGCGAGGAGTCCGCCGCCCCGGCCGAGTACCGCCCCCAACCG
GGAGACAAAGTCGAGATCGTTCCGCTCGGCCAGATGGGTGAAGTGCTGAGCCCTCCCGACAACGGCGATCAGGTGCGTGT
GCAGGTGGGTATATTAAAGCTCACCGTACCGGCAAGCCAACTGCGTCGCCCCGGTAGCCCGGCGACCCGGCCCAAACCGC
GGCCCCAGGCTGAAGTTCCCCGTCCGCCTTCACCGCCCAAGCAAGAACCGCTGGTGCGCACCGAAGCGCAGACGATCGAT
CTCAGGGGGCGGCGCGTCGCCGAGGCGGAAGCGCTCCTGGAGCCGGAACTGAACCGCCAAAGCGGGCCGCTCTGGATCAT
CCACGGCCACGGCACCGGCAAGCTGCGCGACGGCATCCACGAAATCCTCGAACGCCACCCGCGCGTCGCCCGCTTCGAAT
TTGCCGATCGCACCGAGGGCGGCAACGGGGTGACGGTGGTGTTTTTGAAGTAG

Upstream 100 bases:

>100_bases
ACGGCATAGCCGCCCGGCGGCCAAAAGCAAGGGCCTGTACTACGATCGATCAAGTGGGTGCGGCTGCATCATCTTTCACG
GCTCACCCGATTTGCTCATT

Downstream 100 bases:

>100_bases
TCCAGGCAGGCGGATAAAATGGGCGCAATCCTTCAGGCCCTGCCATGCCTTCGGTCGAAACACCCGTCGTTTATCCGGAC
TCGGACGGCCTGCCCATGGC

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALRLAESVPGGLAFDGVHDIASD
VERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAEELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDL
RSGHRRLRAEIQRTLLQLLQRRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVE
GMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGERGCGLVQVRHPLLVWQERHEQ
GTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVLMAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFS
GHIRRIVRILAALTPDALVLLDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLA
TLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQEEQVRSTTRLRGEVERLQSD
LLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRTLQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQP
GDKVEIVPLGQMGEVLSPPDNGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTID
LRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEGGNGVTVVFLK

Sequences:

>Translated_790_residues
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALRLAESVPGGLAFDGVHDIASD
VERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAEELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDL
RSGHRRLRAEIQRTLLQLLQRRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVE
GMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGERGCGLVQVRHPLLVWQERHEQ
GTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVLMAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFS
GHIRRIVRILAALTPDALVLLDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLA
TLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQEEQVRSTTRLRGEVERLQSD
LLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRTLQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQP
GDKVEIVPLGQMGEVLSPPDNGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTID
LRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEGGNGVTVVFLK
>Mature_790_residues
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALRLAESVPGGLAFDGVHDIASD
VERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAEELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDL
RSGHRRLRAEIQRTLLQLLQRRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVE
GMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGERGCGLVQVRHPLLVWQERHEQ
GTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVLMAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFS
GHIRRIVRILAALTPDALVLLDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLA
TLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQEEQVRSTTRLRGEVERLQSD
LLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRTLQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQP
GDKVEIVPLGQMGEVLSPPDNGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTID
LRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEGGNGVTVVFLK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=305, Percent_Identity=25.9016393442623, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI4557761, Length=365, Percent_Identity=27.1232876712329, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI284813531, Length=342, Percent_Identity=28.0701754385965, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI4504191, Length=224, Percent_Identity=29.9107142857143, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI26638666, Length=201, Percent_Identity=33.8308457711443, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4505253, Length=201, Percent_Identity=33.8308457711443, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI26638664, Length=202, Percent_Identity=33.6633663366337, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI262231786, Length=202, Percent_Identity=33.6633663366337, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789089, Length=254, Percent_Identity=31.496062992126, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=291, Percent_Identity=25.7731958762887, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508445, Length=403, Percent_Identity=24.5657568238213, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17539736, Length=130, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=223, Percent_Identity=29.1479820627803, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=291, Percent_Identity=30.2405498281787, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324482, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320302, Length=349, Percent_Identity=26.647564469914, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321912, Length=180, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=127, Percent_Identity=33.8582677165354, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=233, Percent_Identity=26.1802575107296, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24584320, Length=296, Percent_Identity=29.3918918918919, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664545, Length=122, Percent_Identity=37.7049180327869, Blast_Score=80, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86435; Mature: 86435

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LAESVPGGLAFDGVHDIASDVERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAE
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDLRSGHRRLRAEIQRTLLQLLQ
HHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVE
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCEEEECCHHHHHHHHHHHH
GMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GCGLVQVRHPLLVWQERHEQGTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVL
CCCEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
MAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFSGHIRRIVRILAALTPDALVL
HHHCCCEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLA
EHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
TLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQ
ECCCHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
EEQVRSTTRLRGEVERLQSDLLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQPGDKVEIVPLGQMGEVLSPPD
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
NGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTID
CCCEEEEEEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEC
LRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEG
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
GNGVTVVFLK
CCCEEEEEEC
>Mature Secondary Structure
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LAESVPGGLAFDGVHDIASDVERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAE
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDLRSGHRRLRAEIQRTLLQLLQ
HHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVE
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCEEEECCHHHHHHHHHHHH
GMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GCGLVQVRHPLLVWQERHEQGTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVL
CCCEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
MAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFSGHIRRIVRILAALTPDALVL
HHHCCCEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLA
EHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
TLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQ
ECCCHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
EEQVRSTTRLRGEVERLQSDLLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQPGDKVEIVPLGQMGEVLSPPD
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
NGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTID
CCCEEEEEEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEC
LRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEG
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
GNGVTVVFLK
CCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]