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The map label for this gene is rnhA [H]

Identifier: 37523181

GI number: 37523181

Start: 3808044

End: 3808685

Strand: Reverse

Name: rnhA [H]

Synonym: gvip491

Alternate gene names: 37523181

Gene position: 3808685-3808044 (Counterclockwise)

Preceding gene: 37523183

Following gene: 37523180

Centisome position: 81.75

GC content: 66.51

Gene sequence:

>642_bases
ATGTTTCGGATAGCGACCGACGGGGCCTGCAGCGGCAATCCCGGTCCGGGGGGATGGGCGGCCCTGGTCGTGGGGGAGGG
CACCTACGAAGAAGTGTTCGGTTTCGAGCCGCACACCACCAATAACCGCATGGAGATGCGCGCCGTCATCGAAGGTTTGA
CGCGCGTACCCGCGGACGCCAAGGTGAAAGTGCTCACCGACAGCCAGTACGTGATCAAAGGGATGAGCGAGTGGCTGCCC
GGCTGGAAGCGGCGCGGCTGGATCACTTCCACCGGCAAACCCGTCGAGAACCGGGATCTGTGGGAAGCGCTGGAGCGGGC
GGTAGGGGGGCGCGTGCTCTGGGAGCATGTGCGCGGCCACACCGGCCACCCCGAGAATGAGCGGGCCAACACGCTCGCCC
AGACGGCAGCCCGCGGCGGTGCTCCGGCCGTTGGCGCCCGGACTGTGCCCACCAATGGAACGACCTATCTGAGTCTGGTG
GACGGGCACCTCAGCCGCTCGACCGGCTGGAGCGCCTGCCAGGCGCTGGTGCAGGGCGTATCCGGGGCGCGATACAAAAA
ATGCCGCAACCGGGCGGAGGAATTGGACACGATTTCTGCCTGGGGACTGCCTCCCGAGTCGCTTGTGCAGCTGGAAGGTT
AA

Upstream 100 bases:

>100_bases
TTATCCAGATTTGATCAGATTCTACTGTGCGCCCTGGCCGTCCCACCGTCAACCGGCCCGATCCGGTATGGTGTGAAATG
TTTGTCAGTGGAAAGTACGG

Downstream 100 bases:

>100_bases
GATCTGCGGCATCCCGGAAATTTTGCATGCCCGACAGCCTGACCATCCACCTGCCCGACATTCCAAGTACGCTCAACCTG
GTCGGTCCCGCCGAAGAAAA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MFRIATDGACSGNPGPGGWAALVVGEGTYEEVFGFEPHTTNNRMEMRAVIEGLTRVPADAKVKVLTDSQYVIKGMSEWLP
GWKRRGWITSTGKPVENRDLWEALERAVGGRVLWEHVRGHTGHPENERANTLAQTAARGGAPAVGARTVPTNGTTYLSLV
DGHLSRSTGWSACQALVQGVSGARYKKCRNRAEELDTISAWGLPPESLVQLEG

Sequences:

>Translated_213_residues
MFRIATDGACSGNPGPGGWAALVVGEGTYEEVFGFEPHTTNNRMEMRAVIEGLTRVPADAKVKVLTDSQYVIKGMSEWLP
GWKRRGWITSTGKPVENRDLWEALERAVGGRVLWEHVRGHTGHPENERANTLAQTAARGGAPAVGARTVPTNGTTYLSLV
DGHLSRSTGWSACQALVQGVSGARYKKCRNRAEELDTISAWGLPPESLVQLEG
>Mature_213_residues
MFRIATDGACSGNPGPGGWAALVVGEGTYEEVFGFEPHTTNNRMEMRAVIEGLTRVPADAKVKVLTDSQYVIKGMSEWLP
GWKRRGWITSTGKPVENRDLWEALERAVGGRVLWEHVRGHTGHPENERANTLAQTAARGGAPAVGARTVPTNGTTYLSLV
DGHLSRSTGWSACQALVQGVSGARYKKCRNRAEELDTISAWGLPPESLVQLEG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=141, Percent_Identity=36.1702127659575, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786408, Length=135, Percent_Identity=48.1481481481481, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI115532542, Length=145, Percent_Identity=37.2413793103448, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=34.8484848484849, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552509, Length=140, Percent_Identity=31.4285714285714, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137476, Length=140, Percent_Identity=31.4285714285714, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 23052; Mature: 23052

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRIATDGACSGNPGPGGWAALVVGEGTYEEVFGFEPHTTNNRMEMRAVIEGLTRVPADA
CEEECCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
KVKVLTDSQYVIKGMSEWLPGWKRRGWITSTGKPVENRDLWEALERAVGGRVLWEHVRGH
EEEEEECCHHHHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
TGHPENERANTLAQTAARGGAPAVGARTVPTNGTTYLSLVDGHLSRSTGWSACQALVQGV
CCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCHHCCCCCHHHHHHHHHCC
SGARYKKCRNRAEELDTISAWGLPPESLVQLEG
CCHHHHHHHHHHHHHHHHHHCCCCHHHHEEECC
>Mature Secondary Structure
MFRIATDGACSGNPGPGGWAALVVGEGTYEEVFGFEPHTTNNRMEMRAVIEGLTRVPADA
CEEECCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
KVKVLTDSQYVIKGMSEWLPGWKRRGWITSTGKPVENRDLWEALERAVGGRVLWEHVRGH
EEEEEECCHHHHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
TGHPENERANTLAQTAARGGAPAVGARTVPTNGTTYLSLVDGHLSRSTGWSACQALVQGV
CCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCHHCCCCCHHHHHHHHHCC
SGARYKKCRNRAEELDTISAWGLPPESLVQLEG
CCHHHHHHHHHHHHHHHHHHCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA