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The map label for this gene is uvrC

Identifier: 37523161

GI number: 37523161

Start: 3784913

End: 3786799

Strand: Reverse

Name: uvrC

Synonym: gvip488

Alternate gene names: 37523161

Gene position: 3786799-3784913 (Counterclockwise)

Preceding gene: 37523162

Following gene: 37523159

Centisome position: 81.28

GC content: 64.18

Gene sequence:

>1887_bases
ATGCCCAACCTCATCGCCGACCCCGAACGCCTCAAAGAGCGGCTCGAACTGCTGCCCACCTCGGCGGGCGTCTACCTGAT
GCGCGACGAGGCCGGGGAGATTCTCTACGTCGGCAAGGCCAAGAATCTCAGAAACCGGGTGCGCTCGTACTTCCAGCCCG
GACACGACCACTCGCCGCGCATCGCGATCATGGTGGGCAAGGTCCACGACTTCGAACTGATTCTCACCGACACCGAGGCG
GAGGCGCTCGTCCTCGAAGACAACCTGATCAAGACCCACAAGCCGCGCTACAACGTCCTGCTCAAAGACGACAAGCAGTA
CCCCTACCTGTGCATTACTTGGTCGGAGGAGTACCCGCGCATCTTCGTCACCCGCCGCCGCGGCAGCGGCCACCCGGAAG
ACCGCTACTTCGGTCCCTACACCGACGCGGGGGCGTTGCACAGCACCCTGGGCCTGCTCAAAAAACTCTTTCCCCTGCGC
CAGCGCAATACCCCCGTCTTTAAGGACCGCCCCTGCATCAACTACGAGATGGGCCGCTGTCCGGGCCTCTGCCAGCGGTT
GATTTCGCCCCAGGAGTATCGCGCCACCATCCGTCAGATCCAGATGATCCTCCAGGGGCGCACCGCAGAACTCCTCGCCC
AACTCGAAGACCAGATGCAAACGGCCGCCGCCGCGATGAACTTCGAGCATGCCGCCCGACTGCGCGACCGCATCACCGGC
CTCAACCAGTTGGGTGCCCACCAGAAGATCACCGTTCCCGACAGTTCGGTCTCCCGCGACGCGGTCGCCCTGGCCGCCGA
CGCCGCCCTCGTCTCGATTCAGCTTTTTCAGGTGCGCTCGGGCAAGCTCATCGGCCGGCTCGGTTTTTCGGCCGCCGCTT
CCGGCGAGGATCCTGGCCACATCCTCCAGCGCGTGCTCGAAGAGCATTACCGCGCCTCGGCTTCCGAGGAGATTCCCCTC
GAAGTGCTCACCCAGCATCCGCTGCCAGAGGCAGATATTCTGGCTACCTGGCTTGCCGAGAAAAAAGGCCGCAAAGTCGA
AATCCATGCCCCCCAGCGTCAAATCAAAGCCGAACTCGTCGAGATGGTGGCCCGCAACGCCGAGGCCGAGTTGCAGCGCT
TGGAGCGCTTCTCCCGCCGCCAGGAAAAGGGGCTGCTCAACCTGGCGGAGGCTCTAGAATTGCCGAGCGTTCCCCGGCGC
ATGGAGTGCTACGACATCTCCCACATCCAGGGCACCGACACCGTCGCCTCGCGGGTGGTGTTCGTGGACGGAGCGCCCGC
CAAGCAGTACTACCGCCACTACAAAATCCGCGATCCGCGCATCGTGGCGGGCCGTCCGGACGACTTTGCCTCGATGGCCG
AGGTGATCTCCCGCCGCTTTGCGCGTGCCGAGAGCGAACCGGAGGGAGACCTGCCGGATCTGGTGGTAATCGACGGCGGC
AAAGGACAGCTTTCGGCCGCCCGCGCCGTTATGGAAGAGCTGTCCTACGGCGATGTGCCCACGATTGGCCTGGCCAAGCG
CCTCGAAGAAGTCTTCCTGCCGGGGCGTTCGGACCCGGTGCTGATTGCGCAGGGCGACCCGGCTTTGCACCTGCTGCAGC
GCATCCGCGACGAGGCCCACCGCTTTGCGGTGAGCTTCCACCGCGAGCAGCGCGGCAAGCGGATGACCCGCTCCAGCCTG
GATGATATCCCCGGCATCGGCCCTGCCAAGCGCAAGATCCTTCTCGATACGTTCCGCTCGGTGCCGGTACTCGAAAAGGC
GAGCTTCGAGGAAATTGCCAAGACCCCCGGCATCGGCTCGCGTCTAGCGCAAGTGATTCACACGTACTTTCACGGCGAGC
CGGAAGCAGTGGCAAGGGCACTGGAAGCCGAGCAAGCTGCCAATTGA

Upstream 100 bases:

>100_bases
GACCCGCTGCGCGTGCAGATCAAGGGCGACTTCAACCCGCGCGGCAACGTGCACATGGTGGTCGAAGCCCGCCATACCCG
ACCCGGCACCTGACACCTGC

Downstream 100 bases:

>100_bases
TTCCGGTGCCCCAAGCACCCTGGAACACTGCGGCGGTACGCTTGTTCGTGTATCTGCCGGTTGCTGAAATGGGCTGCCGC
AGATAAGCGTGCCACTCGGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MPNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPRIAIMVGKVHDFELILTDTEA
EALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPRIFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLR
QRNTPVFKDRPCINYEMGRCPGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITG
LNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGHILQRVLEEHYRASASEEIPL
EVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELVEMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRR
MECYDISHIQGTDTVASRVVFVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGG
KGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAHRFAVSFHREQRGKRMTRSSL
DDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGSRLAQVIHTYFHGEPEAVARALEAEQAAN

Sequences:

>Translated_628_residues
MPNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPRIAIMVGKVHDFELILTDTEA
EALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPRIFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLR
QRNTPVFKDRPCINYEMGRCPGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITG
LNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGHILQRVLEEHYRASASEEIPL
EVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELVEMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRR
MECYDISHIQGTDTVASRVVFVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGG
KGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAHRFAVSFHREQRGKRMTRSSL
DDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGSRLAQVIHTYFHGEPEAVARALEAEQAAN
>Mature_627_residues
PNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPRIAIMVGKVHDFELILTDTEAE
ALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPRIFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLRQ
RNTPVFKDRPCINYEMGRCPGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITGL
NQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGHILQRVLEEHYRASASEEIPLE
VLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELVEMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRRM
ECYDISHIQGTDTVASRVVFVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGGK
GQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAHRFAVSFHREQRGKRMTRSSLD
DIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGSRLAQVIHTYFHGEPEAVARALEAEQAAN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=621, Percent_Identity=36.3929146537842, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1788037, Length=196, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_GLOVI (Q7NFD4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926538.1
- ProteinModelPortal:   Q7NFD4
- GeneID:   2601996
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3592
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   GVIO251221:GLL3592-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70536; Mature: 70405

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPR
CCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCCCE
IAIMVGKVHDFELILTDTEAEALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPR
EEEEEECEECEEEEEECCCCCEEEEECCCHHCCCCCEEEEEECCCCCCEEEEEECCCCCE
IFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLRQRNTPVFKDRPCINYEMGRC
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITG
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGH
HHHHCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCCHHH
ILQRVLEEHYRASASEEIPLEVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELV
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHH
EMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRRMECYDISHIQGTDTVASRVV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHCEEE
FVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGG
EECCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
KGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAH
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
RFAVSFHREQRGKRMTRSSLDDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCHHH
RLAQVIHTYFHGEPEAVARALEAEQAAN
HHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPR
CCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCCCE
IAIMVGKVHDFELILTDTEAEALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPR
EEEEEECEECEEEEEECCCCCEEEEECCCHHCCCCCEEEEEECCCCCCEEEEEECCCCCE
IFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLRQRNTPVFKDRPCINYEMGRC
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITG
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGH
HHHHCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCCHHH
ILQRVLEEHYRASASEEIPLEVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELV
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHH
EMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRRMECYDISHIQGTDTVASRVV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHCEEE
FVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGG
EECCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
KGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAH
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
RFAVSFHREQRGKRMTRSSLDDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCHHH
RLAQVIHTYFHGEPEAVARALEAEQAAN
HHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292