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The map label for this gene is qor [C]

Identifier: 37523160

GI number: 37523160

Start: 3784299

End: 3784970

Strand: Direct

Name: qor [C]

Synonym: glr3591

Alternate gene names: 37523160

Gene position: 3784299-3784970 (Clockwise)

Preceding gene: 37523158

Following gene: 37523168

Centisome position: 81.23

GC content: 62.5

Gene sequence:

>672_bases
ATGCAAGCTGCAGTGATCGAGTCGTTCGGGGGACCACAGGTGTTTGAATACCGACACTTGCCAGTACCGGTTCCCAAAGG
CCGCGAGTTGCTCATTCGGGTCAAAGCCACCTCCGTCAACCCCCTCGACTGCCAGATCCGGCGGGGGAATTACAAGGAGC
AGGTGAGCCTGCCCGCCATCCTTGGCCACGATGTCTCCGGCGTGGTGGAAGCTGTGGGTGACGCCGTACGGGACTTTGCC
GAGGGCGACGAAGTCTTCTACGTTCCGCGCATTTTCGGTGGTCCGGGCAGCTACGCGCAATACCATGTTGTGGAGGAAGC
CATCGTTGCCCATAAACCCGCCAACCTCTCGCACGCTCAAGCAGCAGCACTTCCTCTGGCGGGTGGAACCGCCTGGGATG
CCCTGGTGGTGCGGGCTGCCCTGCGCGTGGGGGAGTCGATTCTCATCCATGCCGGTGCCGGTGGTGTCGGGTCGCTCGCG
GTCCAACTGGCCAGGGCGATGGGGGCACAAAAAAGCCGAGTGGCACGCTTATCTGCGGCAGCCCATTTCAGCAACCGGCA
GATACACGAACAAGCGTACCGCCGCAGTGTTCCAGGGTGCTTGGGGCACCGGAATCAATTGGCAGCTTGCTCGGCTTCCA
GTGCCCTTGCCACTGCTTCCGGCTCGCCGTGA

Upstream 100 bases:

>100_bases
ATTTCGAGCCTACCCCACCAAAAAGTGCTTACTTGTGTTGATTGATCAGGACACCTAATTTTAGGTCATGACTGAGCACA
ACGTTCTTCAGGAGGGCAGC

Downstream 100 bases:

>100_bases
AAGTACGTGTGAATCACTTGCGCTAGACGCGAGCCGATGCCGGGGGTCTTGGCAATTTCCTCGAAGCTCGCCTTTTCGAG
TACCGGCACCGAGCGGAACG

Product: hypothetical protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MQAAVIESFGGPQVFEYRHLPVPVPKGRELLIRVKATSVNPLDCQIRRGNYKEQVSLPAILGHDVSGVVEAVGDAVRDFA
EGDEVFYVPRIFGGPGSYAQYHVVEEAIVAHKPANLSHAQAAALPLAGGTAWDALVVRAALRVGESILIHAGAGGVGSLA
VQLARAMGAQKSRVARLSAAAHFSNRQIHEQAYRRSVPGCLGHRNQLAACSASSALATASGSP

Sequences:

>Translated_223_residues
MQAAVIESFGGPQVFEYRHLPVPVPKGRELLIRVKATSVNPLDCQIRRGNYKEQVSLPAILGHDVSGVVEAVGDAVRDFA
EGDEVFYVPRIFGGPGSYAQYHVVEEAIVAHKPANLSHAQAAALPLAGGTAWDALVVRAALRVGESILIHAGAGGVGSLA
VQLARAMGAQKSRVARLSAAAHFSNRQIHEQAYRRSVPGCLGHRNQLAACSASSALATASGSP
>Mature_223_residues
MQAAVIESFGGPQVFEYRHLPVPVPKGRELLIRVKATSVNPLDCQIRRGNYKEQVSLPAILGHDVSGVVEAVGDAVRDFA
EGDEVFYVPRIFGGPGSYAQYHVVEEAIVAHKPANLSHAQAAALPLAGGTAWDALVVRAALRVGESILIHAGAGGVGSLA
VQLARAMGAQKSRVARLSAAAHFSNRQIHEQAYRRSVPGCLGHRNQLAACSASSALATASGSP

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239676, Length=171, Percent_Identity=42.1052631578947, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI194239674, Length=171, Percent_Identity=42.1052631578947, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI13236495, Length=171, Percent_Identity=42.1052631578947, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI47519420, Length=201, Percent_Identity=34.3283582089552, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI24308257, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI22538446, Length=199, Percent_Identity=32.6633165829146, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22538444, Length=199, Percent_Identity=32.6633165829146, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28557745, Length=149, Percent_Identity=32.8859060402685, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI18379349, Length=139, Percent_Identity=34.5323741007194, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI67078404, Length=164, Percent_Identity=28.6585365853659, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=161, Percent_Identity=36.0248447204969, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=190, Percent_Identity=38.9473684210526, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17507255, Length=164, Percent_Identity=36.5853658536585, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=178, Percent_Identity=30.8988764044944, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=210, Percent_Identity=28.0952380952381, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=179, Percent_Identity=30.7262569832402, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 23372; Mature: 23372

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAAVIESFGGPQVFEYRHLPVPVPKGRELLIRVKATSVNPLDCQIRRGNYKEQVSLPAI
CCCCEECCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCHHHCCCCHH
LGHDVSGVVEAVGDAVRDFAEGDEVFYVPRIFGGPGSYAQYHVVEEAIVAHKPANLSHAQ
HCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHH
AAALPLAGGTAWDALVVRAALRVGESILIHAGAGGVGSLAVQLARAMGAQKSRVARLSAA
HHHEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHH
AHFSNRQIHEQAYRRSVPGCLGHRNQLAACSASSALATASGSP
HHHCCHHHHHHHHHHCCCCHHCCCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAAVIESFGGPQVFEYRHLPVPVPKGRELLIRVKATSVNPLDCQIRRGNYKEQVSLPAI
CCCCEECCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCHHHCCCCHH
LGHDVSGVVEAVGDAVRDFAEGDEVFYVPRIFGGPGSYAQYHVVEEAIVAHKPANLSHAQ
HCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHH
AAALPLAGGTAWDALVVRAALRVGESILIHAGAGGVGSLAVQLARAMGAQKSRVARLSAA
HHHEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHH
AHFSNRQIHEQAYRRSVPGCLGHRNQLAACSASSALATASGSP
HHHCCHHHHHHHHHHCCCCHHCCCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA