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The map label for this gene is gloA [H]

Identifier: 37523130

GI number: 37523130

Start: 3753802

End: 3754236

Strand: Reverse

Name: gloA [H]

Synonym: gll3561

Alternate gene names: 37523130

Gene position: 3754236-3753802 (Counterclockwise)

Preceding gene: 37523135

Following gene: 37523126

Centisome position: 80.58

GC content: 60.23

Gene sequence:

>435_bases
GTGCGGATTCTTCACACGATGCTGCGGGTGCGCGATCTGGAGGCTTCCAAGGCTTTCTACTGCGATGTATTGGGCATGAA
ACTGCTGCGCCAAAAAGACTACCCCGACGGCAAATTTACCCTCGCCTTCGTGGGCTACGGCAGCGAGGCGGACAGCGCGG
TGATCGAACTGACCCACAACTGGGAGCGCGACCATTACGACCTGGGCGACGCCTTCGGCCACATCGCCCTCGGTGTCGAG
GACATTTACCGGACCTGCAGCGAACTGACCGCCCGGGGCGGCAAAGTCGTGCGCCAACCCGGCCCGATGCAGCACGGCAG
CACGGTGATTGCATTTCTGGAAGATCCCGACGGCTACAAGATCGAACTCATCCAGAAAAGTGCATCGCCGCAGACTGCAG
AAGAGGTCGCAATGGCCAGAGCCGGCAATTCTTGA

Upstream 100 bases:

>100_bases
AAGAAAATACCCTGTGCTTCCGGAGGCGCAGGTTGCCTTGAGCGCCTGCCCGCTTGGGGCCGGAAGGTACACTGGAGGGG
CCTTTGAAGGAGGAACGACC

Downstream 100 bases:

>100_bases
AGATAGCTGGCCTCGCAATTATTGCGGCCGGAGGACTACCATGCCTGAACATCTTCGCCGAGGCCCGCGCTGCTCTCTGC
GGCAGGCGTACCACCGGGCA

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MRILHTMLRVRDLEASKAFYCDVLGMKLLRQKDYPDGKFTLAFVGYGSEADSAVIELTHNWERDHYDLGDAFGHIALGVE
DIYRTCSELTARGGKVVRQPGPMQHGSTVIAFLEDPDGYKIELIQKSASPQTAEEVAMARAGNS

Sequences:

>Translated_144_residues
MRILHTMLRVRDLEASKAFYCDVLGMKLLRQKDYPDGKFTLAFVGYGSEADSAVIELTHNWERDHYDLGDAFGHIALGVE
DIYRTCSELTARGGKVVRQPGPMQHGSTVIAFLEDPDGYKIELIQKSASPQTAEEVAMARAGNS
>Mature_144_residues
MRILHTMLRVRDLEASKAFYCDVLGMKLLRQKDYPDGKFTLAFVGYGSEADSAVIELTHNWERDHYDLGDAFGHIALGVE
DIYRTCSELTARGGKVVRQPGPMQHGSTVIAFLEDPDGYKIELIQKSASPQTAEEVAMARAGNS

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=149, Percent_Identity=36.9127516778523, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1787940, Length=126, Percent_Identity=59.5238095238095, Blast_Score=162, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323639, Length=139, Percent_Identity=41.726618705036, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129743, Length=147, Percent_Identity=38.7755102040816, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920404, Length=149, Percent_Identity=28.8590604026846, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 15978; Mature: 15978

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILHTMLRVRDLEASKAFYCDVLGMKLLRQKDYPDGKFTLAFVGYGSEADSAVIELTHN
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECC
WERDHYDLGDAFGHIALGVEDIYRTCSELTARGGKVVRQPGPMQHGSTVIAFLEDPDGYK
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCE
IELIQKSASPQTAEEVAMARAGNS
EEEEECCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRILHTMLRVRDLEASKAFYCDVLGMKLLRQKDYPDGKFTLAFVGYGSEADSAVIELTHN
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECC
WERDHYDLGDAFGHIALGVEDIYRTCSELTARGGKVVRQPGPMQHGSTVIAFLEDPDGYK
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCE
IELIQKSASPQTAEEVAMARAGNS
EEEEECCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]