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The map label for this gene is gcvT [H]

Identifier: 37523099

GI number: 37523099

Start: 3729583

End: 3730686

Strand: Direct

Name: gcvT [H]

Synonym: glr3530

Alternate gene names: 37523099

Gene position: 3729583-3730686 (Clockwise)

Preceding gene: 37523097

Following gene: 37523100

Centisome position: 80.05

GC content: 65.13

Gene sequence:

>1104_bases
ATGGTGGCCCGTAGTCTGGGTTTGATGAGCGACCTCAAGCGTACCCCTCTTTGCGCGCAGCACCTGCAACTTGGTGCGCG
CCTCGTTCCCTTCGGCGGCTGGGAGATGCCCCTGCAGTACAGCACCCTCACCCGCGAACACCGGGCCGTGCGCACCGCTG
TGGGTCTTTTCGACATCTCCCACATGGGCAAGTACACCCTCTCGGGGCCGGACGTGCTGGCCCAGATCCAGAGGCTGGTG
CCCTCGGATCTGGCTCGATTGCAACCCGGGCAAGCCCAGTACACCGTCCTGCTCAATGAGCAAGCCGGGATCATCGACGA
TCTCATTTTTTACTGCCGCAGCCCAGAGCATTGGGTGGTGATCGTCAACGGCGCCACCAACGACAAAGACCGCCGCTGGC
TCGCAGAACACCTGCAGGGCGTTCACTTCGACGACCTGACCGGCACCCACACGCTGCTGGCGCTGCAGGGACCGGCGGCG
GTCGAGACGCTGCAACCGCTGGTGGACATAGACCTTGCCCGGTTGGGCCGCTTTGAGCACGCCCAGGTCTCGCTGGCGGG
CAAACCGGCTTTTCTGGCCAGGACCGGCTATACCGGCGAGGACGGTTTTGAGATCATGAGTCTCGAGCCCGAAGGCATCG
CGCTGTGGCAATCCCTCACCGCAGCCGGTGTGCCGCCCTGCGGCCTCGGTGCCCGCGATACCTTGCGCCTCGAGGCGGCG
ATGCACCTGTACGGCCAGGATATGGACGAATCGACCACGCCGCTCGAGGCGTCCCTGGGTTGGGTGATCGATTGGGACAA
GCCCGATTACTTCGGCCGGGAGATTTTGCTGGCCCAAAAGGCCCAGGGCACCGAGCGGCGGCTGGTCGGGCTCACCGTCG
AAGGCCGGCAGATTGCCCGCCATGGCTACGGCCTTTTTGACGGTGAGCAGCAGGTGGGGGTTGTCACCAGCGGCACCCTC
ACCCCGACGGTCGACCGGCCCATTGCGCTTGCCTACGTGGGCAAACCTTTTGCCCCCATCGGTTCTAGGCTCGAAGTCGA
CATTCGCGGCCGCCGGGCCATGGCCACCGTCGTCAAGCGTCCCTTCTACCGCCGCGCGCTGTAA

Upstream 100 bases:

>100_bases
CGGACTCGGGCACAGCGCGGCAGCCTCGCGGCAGTGATAAACAGAAGCCAGTGTACCAGCAGCCGTACTCGCGCCCGCGT
CCGCCCGCGTACTAGGATGC

Downstream 100 bases:

>100_bases
GATCCCTGTGTGACAAAAATGCAGAGGTAGACGAACCATGGCCCTGGAATACCCGGAGGAACTAAAATATCTCGACTCCC
ACGAGTACCTGCGCGTCGAG

Product: glycine cleavage system protein T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MVARSLGLMSDLKRTPLCAQHLQLGARLVPFGGWEMPLQYSTLTREHRAVRTAVGLFDISHMGKYTLSGPDVLAQIQRLV
PSDLARLQPGQAQYTVLLNEQAGIIDDLIFYCRSPEHWVVIVNGATNDKDRRWLAEHLQGVHFDDLTGTHTLLALQGPAA
VETLQPLVDIDLARLGRFEHAQVSLAGKPAFLARTGYTGEDGFEIMSLEPEGIALWQSLTAAGVPPCGLGARDTLRLEAA
MHLYGQDMDESTTPLEASLGWVIDWDKPDYFGREILLAQKAQGTERRLVGLTVEGRQIARHGYGLFDGEQQVGVVTSGTL
TPTVDRPIALAYVGKPFAPIGSRLEVDIRGRRAMATVVKRPFYRRAL

Sequences:

>Translated_367_residues
MVARSLGLMSDLKRTPLCAQHLQLGARLVPFGGWEMPLQYSTLTREHRAVRTAVGLFDISHMGKYTLSGPDVLAQIQRLV
PSDLARLQPGQAQYTVLLNEQAGIIDDLIFYCRSPEHWVVIVNGATNDKDRRWLAEHLQGVHFDDLTGTHTLLALQGPAA
VETLQPLVDIDLARLGRFEHAQVSLAGKPAFLARTGYTGEDGFEIMSLEPEGIALWQSLTAAGVPPCGLGARDTLRLEAA
MHLYGQDMDESTTPLEASLGWVIDWDKPDYFGREILLAQKAQGTERRLVGLTVEGRQIARHGYGLFDGEQQVGVVTSGTL
TPTVDRPIALAYVGKPFAPIGSRLEVDIRGRRAMATVVKRPFYRRAL
>Mature_367_residues
MVARSLGLMSDLKRTPLCAQHLQLGARLVPFGGWEMPLQYSTLTREHRAVRTAVGLFDISHMGKYTLSGPDVLAQIQRLV
PSDLARLQPGQAQYTVLLNEQAGIIDDLIFYCRSPEHWVVIVNGATNDKDRRWLAEHLQGVHFDDLTGTHTLLALQGPAA
VETLQPLVDIDLARLGRFEHAQVSLAGKPAFLARTGYTGEDGFEIMSLEPEGIALWQSLTAAGVPPCGLGARDTLRLEAA
MHLYGQDMDESTTPLEASLGWVIDWDKPDYFGREILLAQKAQGTERRLVGLTVEGRQIARHGYGLFDGEQQVGVVTSGTL
TPTVDRPIALAYVGKPFAPIGSRLEVDIRGRRAMATVVKRPFYRRAL

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=362, Percent_Identity=36.4640883977901, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI257796258, Length=348, Percent_Identity=35.9195402298851, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI257796254, Length=357, Percent_Identity=33.6134453781513, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI257796256, Length=304, Percent_Identity=35.5263157894737, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI24797151, Length=335, Percent_Identity=26.5671641791045, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI197927446, Length=327, Percent_Identity=26.605504587156, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI21361378, Length=327, Percent_Identity=26.605504587156, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1789272, Length=380, Percent_Identity=39.4736842105263, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=35.230352303523, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71994052, Length=375, Percent_Identity=25.0666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994045, Length=375, Percent_Identity=25.0666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32563613, Length=340, Percent_Identity=22.9411764705882, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=379, Percent_Identity=36.4116094986807, Blast_Score=206, Evalue=6e-54,
Organism=Drosophila melanogaster, GI20129441, Length=371, Percent_Identity=36.1185983827493, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20130091, Length=369, Percent_Identity=25.7452574525745, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28571104, Length=271, Percent_Identity=27.6752767527675, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40398; Mature: 40398

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARSLGLMSDLKRTPLCAQHLQLGARLVPFGGWEMPLQYSTLTREHRAVRTAVGLFDIS
CCCCHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
HMGKYTLSGPDVLAQIQRLVPSDLARLQPGQAQYTVLLNEQAGIIDDLIFYCRSPEHWVV
HCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEE
IVNGATNDKDRRWLAEHLQGVHFDDLTGTHTLLALQGPAAVETLQPLVDIDLARLGRFEH
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCC
AQVSLAGKPAFLARTGYTGEDGFEIMSLEPEGIALWQSLTAAGVPPCGLGARDTLRLEAA
EEEEECCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MHLYGQDMDESTTPLEASLGWVIDWDKPDYFGREILLAQKAQGTERRLVGLTVEGRQIAR
HHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHH
HGYGLFDGEQQVGVVTSGTLTPTVDRPIALAYVGKPFAPIGSRLEVDIRGRRAMATVVKR
CCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHC
PFYRRAL
CHHHHCC
>Mature Secondary Structure
MVARSLGLMSDLKRTPLCAQHLQLGARLVPFGGWEMPLQYSTLTREHRAVRTAVGLFDIS
CCCCHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
HMGKYTLSGPDVLAQIQRLVPSDLARLQPGQAQYTVLLNEQAGIIDDLIFYCRSPEHWVV
HCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEE
IVNGATNDKDRRWLAEHLQGVHFDDLTGTHTLLALQGPAAVETLQPLVDIDLARLGRFEH
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCC
AQVSLAGKPAFLARTGYTGEDGFEIMSLEPEGIALWQSLTAAGVPPCGLGARDTLRLEAA
EEEEECCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MHLYGQDMDESTTPLEASLGWVIDWDKPDYFGREILLAQKAQGTERRLVGLTVEGRQIAR
HHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHH
HGYGLFDGEQQVGVVTSGTLTPTVDRPIALAYVGKPFAPIGSRLEVDIRGRRAMATVVKR
CCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHC
PFYRRAL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]