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The map label for this gene is betC [H]

Identifier: 37523000

GI number: 37523000

Start: 3631121

End: 3632686

Strand: Reverse

Name: betC [H]

Synonym: gll3431

Alternate gene names: 37523000

Gene position: 3632686-3631121 (Counterclockwise)

Preceding gene: 37523004

Following gene: 37522999

Centisome position: 77.97

GC content: 65.96

Gene sequence:

>1566_bases
ATGAAAAAAATTGCCCCCCTTCCGGTAAAACTCGGCACCCTCGCCCTGGTGGGTTTGGTACTCGCCGCCGCCTTGCTCCC
GACGCCGGGGGGCTTTGCCCGGCGCGGCCAGGCCGCGGCGGCGGTGAAGCCCAGCATCGTCGTGGTCACCGCCGACGATC
TCTCGACGATGGAATTGAACGACGGCCTCGAGCGGGGCCTGCTGCCGGCTATCCAAAACCGCCTGGTGGAAGAAGGCACC
GTCTTCGCCAACTCCTTCGTCTCCTATTCGCTGTGCTGCCCTTCGCGCTCCACCTTTCTGACCGGGCAGTACAGCCATAA
CCACGGCGTGCAGGGCAACGGCCCGCCCATCGGCGGCGCGGTGGCTTTGCGGGACGATTCGACTTTGGCGACCTGGCTTG
ACGATGCAGGCTACGTCACGGGTTTTCTGGGCAAGTACCTCAATGGCTACGGGGCGAACAAAGACAAAAGTTCGCCCCGC
GACGACGCGACCTACGTTCCGCCGGGTTGGGATGTCTGGCAGGGTCTGGTCGATCCGACCACCTACCAGGTCTACAACTT
CAAAATCAACGAGAACGGCCGGGTGGCCAACTACGGCACCGACCAGGCTGAGCCGCCCGAGGAGTATCAGACCGATGTGC
TGAGCGCGCGGGCGGTGAACTTCGTCGAGCAGTACGGCAGTGGCGACGCGCCGTTTTTTCTGTGGGTCAACCCGATCGCC
CCCCACTTCGAACTGCGCGGTACCCGGCGCTGCACCGTCAACCCGCGACCGCAAAACAGCATTCGCCCTGCTCCCCGCCA
CGCCGGCAGCGCCGCCGCCGTTCCCCTGCCGCGCGGCCCCGCCTTCAACGAGCAGGATGTCTCAGACAAACCCACCTGGG
TGCAGCAAAATCCGGCGATGAGCGAGCGGACTATCGACTGTCTGCAAAACCTTTACCGCAACCGCCTGGAGGCGATGCGC
GCCGTGGACGATCTGGTGGCGGCGCTGTTCGACGCCCTGGAACGCACCGGCGCGCTGGGCGACACGATCGTGCTGTTGAC
CTCCGACAACGGTTATCTGCTCGGGCAGCACCGGCTGACCGCCAAAGTCCTGCCCTACGAGGAGTCGATCCGGGTGCCGC
TTCTGGTGCGGGTGCCCGATGCCGGTGCCCCCGGGCGCGTCGATGAACTGGTGATCAACAACGACCTTGCCCCGACGATT
GCCGCGTGGGCGGGAGTCACCCCGGATCTGGCCGTCGACGGCCGCTCGCTGGTGCCGCTGTTGGCCGATTCCACCCCGGC
GCAGTGGCGCAAACGCTTGCTGGTCGGGCACATCGGTACCACCAACGCCAACGAACCGTCCAACCACGCAGTACTGCGCA
CCGGCGCGCGCGACAGCGCCCGCCCCAACCGCGCCTACGTCGAATACACGGCCCATTCGCCGGAACTCTACGACCTCAAC
AGCGATCCCGCACAGCTGACCAGTTTGCACGCCCAGCGCCCCGAGGAGGTTGGCGCGCTGAGCGCCCAGCTTGCAGGACT
GAAAACCTGCGCCGGGAGCACCTGCCGGACCCTCGAAGACCAGTAG

Upstream 100 bases:

>100_bases
TGTGTTCATGGGTTCTTCCGCACGGTTGTGCGGAGCATATTTTCGCGGCTGCCGGAAGCTGTTATGCTCCCCCGGCGGCG
ATGCGAACGAGGAGTCAATC

Downstream 100 bases:

>100_bases
TTTCCACCCCAACGCCCCGGCGGCCCTTCGCCGGGGCACTTTAAACAAATACTTGAGCAATCGTTTGTTTTCAGTTACGA
TAGGGCCATTGCGATAGGGA

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MKKIAPLPVKLGTLALVGLVLAAALLPTPGGFARRGQAAAAVKPSIVVVTADDLSTMELNDGLERGLLPAIQNRLVEEGT
VFANSFVSYSLCCPSRSTFLTGQYSHNHGVQGNGPPIGGAVALRDDSTLATWLDDAGYVTGFLGKYLNGYGANKDKSSPR
DDATYVPPGWDVWQGLVDPTTYQVYNFKINENGRVANYGTDQAEPPEEYQTDVLSARAVNFVEQYGSGDAPFFLWVNPIA
PHFELRGTRRCTVNPRPQNSIRPAPRHAGSAAAVPLPRGPAFNEQDVSDKPTWVQQNPAMSERTIDCLQNLYRNRLEAMR
AVDDLVAALFDALERTGALGDTIVLLTSDNGYLLGQHRLTAKVLPYEESIRVPLLVRVPDAGAPGRVDELVINNDLAPTI
AAWAGVTPDLAVDGRSLVPLLADSTPAQWRKRLLVGHIGTTNANEPSNHAVLRTGARDSARPNRAYVEYTAHSPELYDLN
SDPAQLTSLHAQRPEEVGALSAQLAGLKTCAGSTCRTLEDQ

Sequences:

>Translated_521_residues
MKKIAPLPVKLGTLALVGLVLAAALLPTPGGFARRGQAAAAVKPSIVVVTADDLSTMELNDGLERGLLPAIQNRLVEEGT
VFANSFVSYSLCCPSRSTFLTGQYSHNHGVQGNGPPIGGAVALRDDSTLATWLDDAGYVTGFLGKYLNGYGANKDKSSPR
DDATYVPPGWDVWQGLVDPTTYQVYNFKINENGRVANYGTDQAEPPEEYQTDVLSARAVNFVEQYGSGDAPFFLWVNPIA
PHFELRGTRRCTVNPRPQNSIRPAPRHAGSAAAVPLPRGPAFNEQDVSDKPTWVQQNPAMSERTIDCLQNLYRNRLEAMR
AVDDLVAALFDALERTGALGDTIVLLTSDNGYLLGQHRLTAKVLPYEESIRVPLLVRVPDAGAPGRVDELVINNDLAPTI
AAWAGVTPDLAVDGRSLVPLLADSTPAQWRKRLLVGHIGTTNANEPSNHAVLRTGARDSARPNRAYVEYTAHSPELYDLN
SDPAQLTSLHAQRPEEVGALSAQLAGLKTCAGSTCRTLEDQ
>Mature_521_residues
MKKIAPLPVKLGTLALVGLVLAAALLPTPGGFARRGQAAAAVKPSIVVVTADDLSTMELNDGLERGLLPAIQNRLVEEGT
VFANSFVSYSLCCPSRSTFLTGQYSHNHGVQGNGPPIGGAVALRDDSTLATWLDDAGYVTGFLGKYLNGYGANKDKSSPR
DDATYVPPGWDVWQGLVDPTTYQVYNFKINENGRVANYGTDQAEPPEEYQTDVLSARAVNFVEQYGSGDAPFFLWVNPIA
PHFELRGTRRCTVNPRPQNSIRPAPRHAGSAAAVPLPRGPAFNEQDVSDKPTWVQQNPAMSERTIDCLQNLYRNRLEAMR
AVDDLVAALFDALERTGALGDTIVLLTSDNGYLLGQHRLTAKVLPYEESIRVPLLVRVPDAGAPGRVDELVINNDLAPTI
AAWAGVTPDLAVDGRSLVPLLADSTPAQWRKRLLVGHIGTTNANEPSNHAVLRTGARDSARPNRAYVEYTAHSPELYDLN
SDPAQLTSLHAQRPEEVGALSAQLAGLKTCAGSTCRTLEDQ

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4504061, Length=521, Percent_Identity=31.8618042226488, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI189571643, Length=443, Percent_Identity=31.1512415349887, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI189571641, Length=443, Percent_Identity=31.1512415349887, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI189571638, Length=443, Percent_Identity=31.1512415349887, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI189571636, Length=443, Percent_Identity=31.1512415349887, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI240255478, Length=453, Percent_Identity=29.5805739514349, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI240255483, Length=453, Percent_Identity=29.5805739514349, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI29789100, Length=453, Percent_Identity=29.5805739514349, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI39930577, Length=516, Percent_Identity=23.8372093023256, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4557659, Length=381, Percent_Identity=24.6719160104987, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568795, Length=385, Percent_Identity=33.2467532467532, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24653364, Length=523, Percent_Identity=31.1663479923518, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19922168, Length=523, Percent_Identity=30.9751434034417, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24647401, Length=395, Percent_Identity=31.3924050632911, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281366397, Length=430, Percent_Identity=27.2093023255814, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281366395, Length=430, Percent_Identity=27.2093023255814, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24666163, Length=430, Percent_Identity=27.2093023255814, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 56119; Mature: 56119

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAPLPVKLGTLALVGLVLAAALLPTPGGFARRGQAAAAVKPSIVVVTADDLSTMELN
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCEEEEEECCCCCEEEHH
DGLERGLLPAIQNRLVEEGTVFANSFVSYSLCCPSRSTFLTGQYSHNHGVQGNGPPIGGA
CCHHHCHHHHHHHHHHHCCCEEEHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCE
VALRDDSTLATWLDDAGYVTGFLGKYLNGYGANKDKSSPRDDATYVPPGWDVWQGLVDPT
EEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
TYQVYNFKINENGRVANYGTDQAEPPEEYQTDVLSARAVNFVEQYGSGDAPFFLWVNPIA
EEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
PHFELRGTRRCTVNPRPQNSIRPAPRHAGSAAAVPLPRGPAFNEQDVSDKPTWVQQNPAM
CCEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
SERTIDCLQNLYRNRLEAMRAVDDLVAALFDALERTGALGDTIVLLTSDNGYLLGQHRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEE
AKVLPYEESIRVPLLVRVPDAGAPGRVDELVINNDLAPTIAAWAGVTPDLAVDGRSLVPL
EEECCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEECCCCEEHE
LADSTPAQWRKRLLVGHIGTTNANEPSNHAVLRTGARDSARPNRAYVEYTAHSPELYDLN
ECCCCHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEECC
SDPAQLTSLHAQRPEEVGALSAQLAGLKTCAGSTCRTLEDQ
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKIAPLPVKLGTLALVGLVLAAALLPTPGGFARRGQAAAAVKPSIVVVTADDLSTMELN
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCEEEEEECCCCCEEEHH
DGLERGLLPAIQNRLVEEGTVFANSFVSYSLCCPSRSTFLTGQYSHNHGVQGNGPPIGGA
CCHHHCHHHHHHHHHHHCCCEEEHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCE
VALRDDSTLATWLDDAGYVTGFLGKYLNGYGANKDKSSPRDDATYVPPGWDVWQGLVDPT
EEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
TYQVYNFKINENGRVANYGTDQAEPPEEYQTDVLSARAVNFVEQYGSGDAPFFLWVNPIA
EEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
PHFELRGTRRCTVNPRPQNSIRPAPRHAGSAAAVPLPRGPAFNEQDVSDKPTWVQQNPAM
CCEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
SERTIDCLQNLYRNRLEAMRAVDDLVAALFDALERTGALGDTIVLLTSDNGYLLGQHRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEE
AKVLPYEESIRVPLLVRVPDAGAPGRVDELVINNDLAPTIAAWAGVTPDLAVDGRSLVPL
EEECCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEECCCCEEHE
LADSTPAQWRKRLLVGHIGTTNANEPSNHAVLRTGARDSARPNRAYVEYTAHSPELYDLN
ECCCCHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEECC
SDPAQLTSLHAQRPEEVGALSAQLAGLKTCAGSTCRTLEDQ
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]