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The map label for this gene is alsR [H]

Identifier: 37522929

GI number: 37522929

Start: 3568953

End: 3569858

Strand: Direct

Name: alsR [H]

Synonym: glr3360

Alternate gene names: 37522929

Gene position: 3568953-3569858 (Clockwise)

Preceding gene: 37522924

Following gene: 37522930

Centisome position: 76.6

GC content: 65.56

Gene sequence:

>906_bases
GTGGAACTTCGACACCTGAAATATTTCCTGGCAGTCGCAGAGGAACTGCATTTCAGCCGGGCCGCCGAGAAGCTGCACAT
GGCCCAACCGCCCTTGAGTCAGCAAATCCGGGCGCTGGAAACGGAACTGGGGGTGCAGTTGTTCGAGCGCACCCGCCGCA
AGGTGCAGTTGACCGAGGCTGGGCGGGTGTTGCTCGAAGAAGGGCAGCTGGTGATGGCGCAACTGGAGCAGGCGGTGAGA
TCCACACAACGGGCCGCCCGCGGCGAGAGCGGTCGGCTTGCGGTCGGATTCAACAGTTCTGCGGCCTACAGCGTGCTGCC
TGCGATATTGCGCGCCTACCGGCAACGCTTCGCAGCAGTCGAACTGGTGTTGCGCGAATTGACCACCGACCGGCAACTGT
CGGAACTGCGCGACGGGCGGATCGACGTCGGTTTTCTCTATCTGCCCGTCGAGGATCCCGCCCTGCGCTGCGAGGTGCTG
TTGAGCGAGCCGCTGGTGGTTGCCGTGGGCGAATTTCATCCGTTTGCGGGCGAGCAGAGCCTGGGACTGGAAGCTTTGGC
GGGCGAGCCGCTGATTATCAACCCGCGCGCGGACGGTCGCCGCTTCTACGACCTGGTGACGGGAATTTTCGAGCAGGCGG
GCTTCAAGCCGCGCGTCGCCCAGGAGGCGGTGCTCACCCAGACGATCGTGAGCCTGGTGGCGGGTGGTGTCGGCATTGCC
CTGCTGCCCGCCTCCGCGCGCCAGTTTCAACGAGCGGGGGTAGTCTACAGACCGCTTCGTGAGCAGACCCCTCATCTGGA
AGTGGCCGTCGCCTGGCGGGCGGAGCCCCCGGCGGTGGTGCGCGAGTTCGTGCGGGTGGCCCGGGAGATTGCCTTTGCCG
CTGTCGCCGCCGGACAGTCTGTCTGA

Upstream 100 bases:

>100_bases
GCCTTGCAACGATATCCTCAGCCTAGAAAGCTAGCTTTGATACGTCCAATACCTGTTGAATGGCTAATTTATATCTACGA
CATATCAATTTCTAACTCCC

Downstream 100 bases:

>100_bases
CGGCAGGACGTTTTTCTGAGGCGGGTTCGGCCTGTGGCGCACAATAGGAGGAGCAAGGGAGGCGGCAATCGGAATGTACA
GCCCCTTTAGGAGTGCTGCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MELRHLKYFLAVAEELHFSRAAEKLHMAQPPLSQQIRALETELGVQLFERTRRKVQLTEAGRVLLEEGQLVMAQLEQAVR
STQRAARGESGRLAVGFNSSAAYSVLPAILRAYRQRFAAVELVLRELTTDRQLSELRDGRIDVGFLYLPVEDPALRCEVL
LSEPLVVAVGEFHPFAGEQSLGLEALAGEPLIINPRADGRRFYDLVTGIFEQAGFKPRVAQEAVLTQTIVSLVAGGVGIA
LLPASARQFQRAGVVYRPLREQTPHLEVAVAWRAEPPAVVREFVRVAREIAFAAVAAGQSV

Sequences:

>Translated_301_residues
MELRHLKYFLAVAEELHFSRAAEKLHMAQPPLSQQIRALETELGVQLFERTRRKVQLTEAGRVLLEEGQLVMAQLEQAVR
STQRAARGESGRLAVGFNSSAAYSVLPAILRAYRQRFAAVELVLRELTTDRQLSELRDGRIDVGFLYLPVEDPALRCEVL
LSEPLVVAVGEFHPFAGEQSLGLEALAGEPLIINPRADGRRFYDLVTGIFEQAGFKPRVAQEAVLTQTIVSLVAGGVGIA
LLPASARQFQRAGVVYRPLREQTPHLEVAVAWRAEPPAVVREFVRVAREIAFAAVAAGQSV
>Mature_301_residues
MELRHLKYFLAVAEELHFSRAAEKLHMAQPPLSQQIRALETELGVQLFERTRRKVQLTEAGRVLLEEGQLVMAQLEQAVR
STQRAARGESGRLAVGFNSSAAYSVLPAILRAYRQRFAAVELVLRELTTDRQLSELRDGRIDVGFLYLPVEDPALRCEVL
LSEPLVVAVGEFHPFAGEQSLGLEALAGEPLIINPRADGRRFYDLVTGIFEQAGFKPRVAQEAVLTQTIVSLVAGGVGIA
LLPASARQFQRAGVVYRPLREQTPHLEVAVAWRAEPPAVVREFVRVAREIAFAAVAAGQSV

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=273, Percent_Identity=36.6300366300366, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1788887, Length=292, Percent_Identity=36.6438356164384, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI2367136, Length=264, Percent_Identity=34.8484848484849, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1790399, Length=279, Percent_Identity=35.4838709677419, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=32.6446280991736, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788748, Length=244, Percent_Identity=30.327868852459, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=27.7551020408163, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=30.7317073170732, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790208, Length=246, Percent_Identity=31.3008130081301, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787806, Length=277, Percent_Identity=27.7978339350181, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788481, Length=242, Percent_Identity=28.9256198347107, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790262, Length=266, Percent_Identity=27.8195488721804, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789204, Length=262, Percent_Identity=28.6259541984733, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789173, Length=164, Percent_Identity=34.7560975609756, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787601, Length=268, Percent_Identity=24.2537313432836, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082132, Length=290, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=256, Percent_Identity=26.953125, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082024, Length=286, Percent_Identity=24.8251748251748, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789506, Length=273, Percent_Identity=22.7106227106227, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787589, Length=143, Percent_Identity=33.5664335664336, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787949, Length=170, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994962, Length=158, Percent_Identity=31.6455696202532, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI145693193, Length=138, Percent_Identity=32.6086956521739, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33209; Mature: 33209

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLKYFLAVAEELHFSRAAEKLHMAQPPLSQQIRALETELGVQLFERTRRKVQLTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
GRVLLEEGQLVMAQLEQAVRSTQRAARGESGRLAVGFNSSAAYSVLPAILRAYRQRFAAV
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ELVLRELTTDRQLSELRDGRIDVGFLYLPVEDPALRCEVLLSEPLVVAVGEFHPFAGEQS
HHHHHHHCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCC
LGLEALAGEPLIINPRADGRRFYDLVTGIFEQAGFKPRVAQEAVLTQTIVSLVAGGVGIA
CCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
LLPASARQFQRAGVVYRPLREQTPHLEVAVAWRAEPPAVVREFVRVAREIAFAAVAAGQS
EECHHHHHHHHCCCCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
V
C
>Mature Secondary Structure
MELRHLKYFLAVAEELHFSRAAEKLHMAQPPLSQQIRALETELGVQLFERTRRKVQLTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
GRVLLEEGQLVMAQLEQAVRSTQRAARGESGRLAVGFNSSAAYSVLPAILRAYRQRFAAV
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ELVLRELTTDRQLSELRDGRIDVGFLYLPVEDPALRCEVLLSEPLVVAVGEFHPFAGEQS
HHHHHHHCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCC
LGLEALAGEPLIINPRADGRRFYDLVTGIFEQAGFKPRVAQEAVLTQTIVSLVAGGVGIA
CCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
LLPASARQFQRAGVVYRPLREQTPHLEVAVAWRAEPPAVVREFVRVAREIAFAAVAAGQS
EECHHHHHHHHCCCCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]