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The map label for this gene is lysS

Identifier: 37522925

GI number: 37522925

Start: 3565377

End: 3566870

Strand: Reverse

Name: lysS

Synonym: gvip461

Alternate gene names: 37522925

Gene position: 3566870-3565377 (Counterclockwise)

Preceding gene: 37522926

Following gene: 37522918

Centisome position: 76.56

GC content: 62.85

Gene sequence:

>1494_bases
ATGGCCGAGGAAGATTTGCGCCGCACGCGCCTGGAGAAGGCCGAGCAGTGGCGCGTCCACAACCAAAACCCCTACCCGTA
CCGCTACGAGCGCACGCACATGGCAGGGGATTTGCAGGCGAAATACAAAGATCTCGAAAACGGCCAGGAAGTCGAAGATG
CCGTCTCGGTGGCGGGCCGCATCGTCGCCCGGCGCGTGCTGGGCAGCGTCGCCTTTTTTGGCCTCCAGGACGATTCGGGT
ACCATCCAGCTTTATTTCGACAAAAAGCGCATCCGCGAGAGCATGGGAGCCGACGCCTTCAAGTGGCTCGACAAGCTCAC
CGACACCGGCGATTTTATCGGGGCGCACGGTACCATCCGCCGCACCGAGCGCGGCGAACTGTCGGTCTACGTCCACGAGT
ACGAGCTGTTGTGCAAGTCGATTTTGCCCTTGCCCTCTGAGTACTACGGCCTCACCGACGTCCAGAAGCGCTACCGTCAG
CGCTATCTCGATCTGATCGCCAACCCCGGCGTGCGTGAGACCTTCCGCAAGCGCGCCCTGATTGTGCGGGAAATTCGCCG
CTTTCTCGATGAGCGGGGCTTTCTTGAAATCGAGACCCCCGTGCTGCAGACCGAGGCCGGGGGCGCGGCGGCGCGGCCCT
TTACCACCCACCACAACGCCCTGGGCCTCGATATGTTCTTGCGCATCGCCACCGAATTGCACCTGAAGCGGCTGGTGGTG
GGCGGGTTCGAAAAGGTCTACGAACTGGGGCGGATCTTTCGCAACGAGGGCATCTCGACGCGCCACAACCCGGAATTTAC
CACCGTCGAAATCTACGAAGCCTACAGCGATTACTTCGACATCATGGATCTGGTGGAAACCCTGCTGCGCGCGGTGGCCC
ACATTGTCCTCGGCTCCACCGAACTGGTCTGCGAGGGCAATACGATCGACCTGGGCGCCCCGTTTCGGCGGATCACCATG
TTCGATCTGGTCGCACAGATGACCGGGGTGGCCCTGGCCGGATTGCGCGACGGCGAGAAGGCGGCCCGCCTTGCCGAAGC
AGTCGGTGTCGAGGTAACCGCGGGAGCCTCGGTCGGCCAGATTCTCTACCAGCTATTCGAAGAAAAGTGCGAGGCGAAGC
TCACCCAACCTACCTTCGTGCTCGACTATCCGGTCGAAATTTCGCCGCTTGCCAAGGCCCACCGCTCGGTGCCGAACATG
GTCGAGCGCTTCGAGCTATATATCAACGGTCGTGAGACCGCCGACGGTTTTTCAGAACTCAACGACCCGGTCGATCAGCG
CGCCCGCCTGGAGGCCCAGGCCAAAGCGAAGGCGGCGGGAGACCTGGAGGCGCACCCCTTCGACGAGGATTTTCTGACCG
CCATCGAGCACGGCCTGCCTCCCACCGGCGGCGTCGGCATCGGCATCGACCGGCTGGTGATGCTGCTCACCGACAGCCCG
AGCATCCGCGATGTGATCGCCTTTCCGACCCTCCGGCCGGAGGCGGGGGAATAG

Upstream 100 bases:

>100_bases
CCTGGCTCACAGACCGACGGCATAACATTCGGGGCGTAGCCCGACCGGCAGCTCCGGCGGAAGACGCTACGATAAGTCTC
TGGGAACGCCGGAGAGAAGC

Downstream 100 bases:

>100_bases
TCTTCAACAGCACCCGCCGCCCTGGTAGTGGTAGGTCGGGGCGGTGATCACCAGATCGCTGTGGTGTAGGCGGGCGAGCT
TGTCGGCGGTCTTATCGCAC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAEEDLRRTRLEKAEQWRVHNQNPYPYRYERTHMAGDLQAKYKDLENGQEVEDAVSVAGRIVARRVLGSVAFFGLQDDSG
TIQLYFDKKRIRESMGADAFKWLDKLTDTGDFIGAHGTIRRTERGELSVYVHEYELLCKSILPLPSEYYGLTDVQKRYRQ
RYLDLIANPGVRETFRKRALIVREIRRFLDERGFLEIETPVLQTEAGGAAARPFTTHHNALGLDMFLRIATELHLKRLVV
GGFEKVYELGRIFRNEGISTRHNPEFTTVEIYEAYSDYFDIMDLVETLLRAVAHIVLGSTELVCEGNTIDLGAPFRRITM
FDLVAQMTGVALAGLRDGEKAARLAEAVGVEVTAGASVGQILYQLFEEKCEAKLTQPTFVLDYPVEISPLAKAHRSVPNM
VERFELYINGRETADGFSELNDPVDQRARLEAQAKAKAAGDLEAHPFDEDFLTAIEHGLPPTGGVGIGIDRLVMLLTDSP
SIRDVIAFPTLRPEAGE

Sequences:

>Translated_497_residues
MAEEDLRRTRLEKAEQWRVHNQNPYPYRYERTHMAGDLQAKYKDLENGQEVEDAVSVAGRIVARRVLGSVAFFGLQDDSG
TIQLYFDKKRIRESMGADAFKWLDKLTDTGDFIGAHGTIRRTERGELSVYVHEYELLCKSILPLPSEYYGLTDVQKRYRQ
RYLDLIANPGVRETFRKRALIVREIRRFLDERGFLEIETPVLQTEAGGAAARPFTTHHNALGLDMFLRIATELHLKRLVV
GGFEKVYELGRIFRNEGISTRHNPEFTTVEIYEAYSDYFDIMDLVETLLRAVAHIVLGSTELVCEGNTIDLGAPFRRITM
FDLVAQMTGVALAGLRDGEKAARLAEAVGVEVTAGASVGQILYQLFEEKCEAKLTQPTFVLDYPVEISPLAKAHRSVPNM
VERFELYINGRETADGFSELNDPVDQRARLEAQAKAKAAGDLEAHPFDEDFLTAIEHGLPPTGGVGIGIDRLVMLLTDSP
SIRDVIAFPTLRPEAGE
>Mature_496_residues
AEEDLRRTRLEKAEQWRVHNQNPYPYRYERTHMAGDLQAKYKDLENGQEVEDAVSVAGRIVARRVLGSVAFFGLQDDSGT
IQLYFDKKRIRESMGADAFKWLDKLTDTGDFIGAHGTIRRTERGELSVYVHEYELLCKSILPLPSEYYGLTDVQKRYRQR
YLDLIANPGVRETFRKRALIVREIRRFLDERGFLEIETPVLQTEAGGAAARPFTTHHNALGLDMFLRIATELHLKRLVVG
GFEKVYELGRIFRNEGISTRHNPEFTTVEIYEAYSDYFDIMDLVETLLRAVAHIVLGSTELVCEGNTIDLGAPFRRITMF
DLVAQMTGVALAGLRDGEKAARLAEAVGVEVTAGASVGQILYQLFEEKCEAKLTQPTFVLDYPVEISPLAKAHRSVPNMV
ERFELYINGRETADGFSELNDPVDQRARLEAQAKAKAAGDLEAHPFDEDFLTAIEHGLPPTGGVGIGIDRLVMLLTDSPS
IRDVIAFPTLRPEAGE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI194272210, Length=502, Percent_Identity=41.4342629482072, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI5031815, Length=502, Percent_Identity=41.4342629482072, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI45439306, Length=470, Percent_Identity=22.1276595744681, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI40789249, Length=272, Percent_Identity=27.2058823529412, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790571, Length=493, Percent_Identity=49.0872210953347, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1789256, Length=491, Percent_Identity=49.0835030549898, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI87082379, Length=323, Percent_Identity=34.6749226006192, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788173, Length=275, Percent_Identity=30.1818181818182, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17535925, Length=502, Percent_Identity=43.0278884462151, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535927, Length=502, Percent_Identity=43.0278884462151, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71994340, Length=502, Percent_Identity=43.0278884462151, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17551876, Length=489, Percent_Identity=23.3128834355828, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32566633, Length=299, Percent_Identity=25.752508361204, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=509, Percent_Identity=41.0609037328094, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324256, Length=475, Percent_Identity=31.7894736842105, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=504, Percent_Identity=24.6031746031746, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325153, Length=137, Percent_Identity=32.1167883211679, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640849, Length=496, Percent_Identity=43.5483870967742, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640851, Length=488, Percent_Identity=43.8524590163934, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI17136276, Length=343, Percent_Identity=25.6559766763848, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24584738, Length=306, Percent_Identity=24.5098039215686, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_GLOVI (Q7NG18)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926302.1
- ProteinModelPortal:   Q7NG18
- SMR:   Q7NG18
- GeneID:   2601759
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3356
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- ProtClustDB:   PRK00484
- BioCyc:   GVIO251221:GLL3356-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 55958; Mature: 55827

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEEDLRRTRLEKAEQWRVHNQNPYPYRYERTHMAGDLQAKYKDLENGQEVEDAVSVAGR
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
IVARRVLGSVAFFGLQDDSGTIQLYFDKKRIRESMGADAFKWLDKLTDTGDFIGAHGTIR
HHHHHHHHHHHHEEEECCCCEEEEEECHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEE
RTERGELSVYVHEYELLCKSILPLPSEYYGLTDVQKRYRQRYLDLIANPGVRETFRKRAL
ECCCCCEEEEEHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IVREIRRFLDERGFLEIETPVLQTEAGGAAARPFTTHHNALGLDMFLRIATELHLKRLVV
HHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GGFEKVYELGRIFRNEGISTRHNPEFTTVEIYEAYSDYFDIMDLVETLLRAVAHIVLGST
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ELVCEGNTIDLGAPFRRITMFDLVAQMTGVALAGLRDGEKAARLAEAVGVEVTAGASVGQ
EEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCHHHH
ILYQLFEEKCEAKLTQPTFVLDYPVEISPLAKAHRSVPNMVERFELYINGRETADGFSEL
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
NDPVDQRARLEAQAKAKAAGDLEAHPFDEDFLTAIEHGLPPTGGVGIGIDRLVMLLTDSP
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
SIRDVIAFPTLRPEAGE
CHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AEEDLRRTRLEKAEQWRVHNQNPYPYRYERTHMAGDLQAKYKDLENGQEVEDAVSVAGR
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
IVARRVLGSVAFFGLQDDSGTIQLYFDKKRIRESMGADAFKWLDKLTDTGDFIGAHGTIR
HHHHHHHHHHHHEEEECCCCEEEEEECHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEE
RTERGELSVYVHEYELLCKSILPLPSEYYGLTDVQKRYRQRYLDLIANPGVRETFRKRAL
ECCCCCEEEEEHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IVREIRRFLDERGFLEIETPVLQTEAGGAAARPFTTHHNALGLDMFLRIATELHLKRLVV
HHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GGFEKVYELGRIFRNEGISTRHNPEFTTVEIYEAYSDYFDIMDLVETLLRAVAHIVLGST
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ELVCEGNTIDLGAPFRRITMFDLVAQMTGVALAGLRDGEKAARLAEAVGVEVTAGASVGQ
EEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCHHHH
ILYQLFEEKCEAKLTQPTFVLDYPVEISPLAKAHRSVPNMVERFELYINGRETADGFSEL
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
NDPVDQRARLEAQAKAKAAGDLEAHPFDEDFLTAIEHGLPPTGGVGIGIDRLVMLLTDSP
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
SIRDVIAFPTLRPEAGE
CHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292