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The map label for this gene is zwf [H]

Identifier: 37522747

GI number: 37522747

Start: 3386664

End: 3388202

Strand: Direct

Name: zwf [H]

Synonym: gvip438

Alternate gene names: 37522747

Gene position: 3386664-3388202 (Clockwise)

Preceding gene: 37522746

Following gene: 37522748

Centisome position: 72.69

GC content: 61.21

Gene sequence:

>1539_bases
ATGACCGCATCGTTGACTGGAGGATTGAGCGCCAATCCGTTGCGCCAGGGGCTGCGCCTGGAGCGCACGCCCAAGCCTGC
CATTTTGACTATCTTCGGGGCCTCCGGAGATTTGACCGTCCGCAAGCTGATCCCAGCCCTTTACGACCTGGCCCGCGACC
GGCGATTGCCCCCTGAATTCACGGTCGTGGGCTATGCCCGTCGCCCCTACAGCCACGAAGAATTTCGCGAAATGATGAAG
GAAGGGGTAGCCAAGTATTCGCGCAGCAAGCTGGGCAACCTCTGGGAAAGTTTCTCCAAGGGCATCTATTACTTCCAGGG
GGACCTCGACAATCTCCAGAATTTTAAGGACCTCGGCGAATTTTTGCAGACTCTAGATAGCGAGCGCGGCACCCTCGGCA
ACCGGGCCTTCTACATGGCTACCGCCCCGAGTTTCTTTGCGCCCATCATCGAGAATCTGGGCGGAGCGGGCCTGGCGGGC
GACGTGCGCAACACGCGCCTGGTGATCGAAAAACCCTTCGGCCACGACCTGGAGTCGGCTCAAAATCTCAACAAAGTCGT
CCAGCAAGTCTTTCACGAAAAGCAGGTCTACCGCATCGATCACTACCTGGGCAAAGAGACCGTTCAGAATATCCTGGTCT
TCCGCTTTGCCAATTCGATCTGGGAACCGCTCTGGAACAACCGCTACGTCGATCACGTGCAGATCACGGTAGCAGAGACG
GTGGGGGTCGAAAACCGCGGGCCGTACTACGACGAAGCCGGCGGCGCGCTGCGCGACATGATCCAGAATCACCTGGTACA
GCTGTTGGCTCTCACCGCCATGGAGCCGCCCTCCGCCTTCGAGGCCGACACCGTGCGCGACGAAAAAGTGAAAGTCCTGC
GCGCCACCCAGGTCGGCCAGGGGCCGAACGGCCTTGCGGCAGTCCGCGCCCAGTACGCCAACGGCTGGATTTCAGGCGAA
CCGGTGCACGCCTACCGCGACGAACCCCGGGTCAACCCCGACGTTCAGACTGCGAGCTATATTGCCGCCAAATTCATGAT
CAACAATTGGCGCTGGAAGGGCGTGCCGTTTTTGCTGCGCACCGGCAAACGCCTCGCCAAGCGCGTCACCGAAATTGCCC
TGCAATTTCGGGAAGTGCCGCACCTGCTCTTTCCGTCGAGCAGCGCGGGCCAGCTCAGCCCGAACATGCTGGTGCTGCGC
ATCCAACCGGACGAAGGCATTTCGCTGCGCTTCGAGGCCAAGCGGCCGGTGGCCGACATCGCCATGCGCTCGGTGAACAT
GGACTTTCACTACGGCGGCACCTTCGAGGTCGCCTCGCCCGAAGCCTACGAGCGGTTGCTGCTCGATTTTCTGCTCGGGG
ATCAGACGCTGTTTACCCGCGCGGACGAAGTCGAGGCGGCCTGGAAGATCGTCACACCGCTCATCGAGCGCTGGGAAATC
CAGAAAGCCGGCGATCTCAATTACTACGACGCCGGTTCCTGGGGGCCGAGTGCCGCGAGTAAGCTGATGGACAACGGCCG
CCGCTGGCGGCGCCTATAG

Upstream 100 bases:

>100_bases
TCCGACGATTTTGCGCGGCGACAAAGCGAAGCCGCCTAGTCTGGGGTAACACCCGGCGGTGTTGCACAGATCCTTGCTTG
AGTTTCGAGGCCGCTACCGT

Downstream 100 bases:

>100_bases
CCTGTGTTTTCTTCTTAACTGGTGAGTGAATCATGACCGAGAATGCCTCCGTCGTCGCGATTGCCGAGCCCTTCCGGGTG
CAAGTCAGCCAGATCGACAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MTASLTGGLSANPLRQGLRLERTPKPAILTIFGASGDLTVRKLIPALYDLARDRRLPPEFTVVGYARRPYSHEEFREMMK
EGVAKYSRSKLGNLWESFSKGIYYFQGDLDNLQNFKDLGEFLQTLDSERGTLGNRAFYMATAPSFFAPIIENLGGAGLAG
DVRNTRLVIEKPFGHDLESAQNLNKVVQQVFHEKQVYRIDHYLGKETVQNILVFRFANSIWEPLWNNRYVDHVQITVAET
VGVENRGPYYDEAGGALRDMIQNHLVQLLALTAMEPPSAFEADTVRDEKVKVLRATQVGQGPNGLAAVRAQYANGWISGE
PVHAYRDEPRVNPDVQTASYIAAKFMINNWRWKGVPFLLRTGKRLAKRVTEIALQFREVPHLLFPSSSAGQLSPNMLVLR
IQPDEGISLRFEAKRPVADIAMRSVNMDFHYGGTFEVASPEAYERLLLDFLLGDQTLFTRADEVEAAWKIVTPLIERWEI
QKAGDLNYYDAGSWGPSAASKLMDNGRRWRRL

Sequences:

>Translated_512_residues
MTASLTGGLSANPLRQGLRLERTPKPAILTIFGASGDLTVRKLIPALYDLARDRRLPPEFTVVGYARRPYSHEEFREMMK
EGVAKYSRSKLGNLWESFSKGIYYFQGDLDNLQNFKDLGEFLQTLDSERGTLGNRAFYMATAPSFFAPIIENLGGAGLAG
DVRNTRLVIEKPFGHDLESAQNLNKVVQQVFHEKQVYRIDHYLGKETVQNILVFRFANSIWEPLWNNRYVDHVQITVAET
VGVENRGPYYDEAGGALRDMIQNHLVQLLALTAMEPPSAFEADTVRDEKVKVLRATQVGQGPNGLAAVRAQYANGWISGE
PVHAYRDEPRVNPDVQTASYIAAKFMINNWRWKGVPFLLRTGKRLAKRVTEIALQFREVPHLLFPSSSAGQLSPNMLVLR
IQPDEGISLRFEAKRPVADIAMRSVNMDFHYGGTFEVASPEAYERLLLDFLLGDQTLFTRADEVEAAWKIVTPLIERWEI
QKAGDLNYYDAGSWGPSAASKLMDNGRRWRRL
>Mature_511_residues
TASLTGGLSANPLRQGLRLERTPKPAILTIFGASGDLTVRKLIPALYDLARDRRLPPEFTVVGYARRPYSHEEFREMMKE
GVAKYSRSKLGNLWESFSKGIYYFQGDLDNLQNFKDLGEFLQTLDSERGTLGNRAFYMATAPSFFAPIIENLGGAGLAGD
VRNTRLVIEKPFGHDLESAQNLNKVVQQVFHEKQVYRIDHYLGKETVQNILVFRFANSIWEPLWNNRYVDHVQITVAETV
GVENRGPYYDEAGGALRDMIQNHLVQLLALTAMEPPSAFEADTVRDEKVKVLRATQVGQGPNGLAAVRAQYANGWISGEP
VHAYRDEPRVNPDVQTASYIAAKFMINNWRWKGVPFLLRTGKRLAKRVTEIALQFREVPHLLFPSSSAGQLSPNMLVLRI
QPDEGISLRFEAKRPVADIAMRSVNMDFHYGGTFEVASPEAYERLLLDFLLGDQTLFTRADEVEAAWKIVTPLIERWEIQ
KAGDLNYYDAGSWGPSAASKLMDNGRRWRRL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=478, Percent_Identity=38.7029288702929, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI108773793, Length=478, Percent_Identity=38.7029288702929, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI52145310, Length=507, Percent_Identity=28.9940828402367, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1788158, Length=498, Percent_Identity=39.9598393574297, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=482, Percent_Identity=38.5892116182573, Blast_Score=335, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324088, Length=485, Percent_Identity=36.9072164948454, Blast_Score=297, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=36.4389233954451, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=36.4389233954451, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221513548, Length=481, Percent_Identity=32.016632016632, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57858; Mature: 57726

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00069 G6P_DEHYDROGENASE ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASLTGGLSANPLRQGLRLERTPKPAILTIFGASGDLTVRKLIPALYDLARDRRLPPEF
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCE
TVVGYARRPYSHEEFREMMKEGVAKYSRSKLGNLWESFSKGIYYFQGDLDNLQNFKDLGE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
FLQTLDSERGTLGNRAFYMATAPSFFAPIIENLGGAGLAGDVRNTRLVIEKPFGHDLESA
HHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHH
QNLNKVVQQVFHEKQVYRIDHYLGKETVQNILVFRFANSIWEPLWNNRYVDHVQITVAET
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHH
VGVENRGPYYDEAGGALRDMIQNHLVQLLALTAMEPPSAFEADTVRDEKVKVLRATQVGQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC
GPNGLAAVRAQYANGWISGEPVHAYRDEPRVNPDVQTASYIAAKFMINNWRWKGVPFLLR
CCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCHHHHH
TGKRLAKRVTEIALQFREVPHLLFPSSSAGQLSPNMLVLRIQPDEGISLRFEAKRPVADI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHH
AMRSVNMDFHYGGTFEVASPEAYERLLLDFLLGDQTLFTRADEVEAAWKIVTPLIERWEI
HHHHCCCEEECCCEEECCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCC
QKAGDLNYYDAGSWGPSAASKLMDNGRRWRRL
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TASLTGGLSANPLRQGLRLERTPKPAILTIFGASGDLTVRKLIPALYDLARDRRLPPEF
CCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCE
TVVGYARRPYSHEEFREMMKEGVAKYSRSKLGNLWESFSKGIYYFQGDLDNLQNFKDLGE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
FLQTLDSERGTLGNRAFYMATAPSFFAPIIENLGGAGLAGDVRNTRLVIEKPFGHDLESA
HHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHH
QNLNKVVQQVFHEKQVYRIDHYLGKETVQNILVFRFANSIWEPLWNNRYVDHVQITVAET
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHH
VGVENRGPYYDEAGGALRDMIQNHLVQLLALTAMEPPSAFEADTVRDEKVKVLRATQVGQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC
GPNGLAAVRAQYANGWISGEPVHAYRDEPRVNPDVQTASYIAAKFMINNWRWKGVPFLLR
CCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCHHHHH
TGKRLAKRVTEIALQFREVPHLLFPSSSAGQLSPNMLVLRIQPDEGISLRFEAKRPVADI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHH
AMRSVNMDFHYGGTFEVASPEAYERLLLDFLLGDQTLFTRADEVEAAWKIVTPLIERWEI
HHHHCCCEEECCCEEECCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCC
QKAGDLNYYDAGSWGPSAASKLMDNGRRWRRL
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]