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The map label for this gene is ygcA [C]

Identifier: 37522703

GI number: 37522703

Start: 3337150

End: 3338523

Strand: Reverse

Name: ygcA [C]

Synonym: gll3134

Alternate gene names: 37522703

Gene position: 3338523-3337150 (Counterclockwise)

Preceding gene: 37522704

Following gene: 37522699

Centisome position: 71.66

GC content: 66.08

Gene sequence:

>1374_bases
ATGGTGGGGCGCCCAGTAGAACCCGGTGCCCTCCTGCAGGGGCAAACCGTAACTGTCCCCATCACGGCCCTGGCTGCGGG
GGGCGACGGGATCGCCCGGCTCACCGACGGCAGGGTGCTCTTTGTGGCAGGGGCGGTACCCGGTGACACCGTCGAAGCGC
GGCTGGTACATCTCAAAAAGGACCACGGCTTCGGCAAGATCCTGCAGATTGTGCAAGCCTCGCCCCACCGCATCGAAGCC
CCTTGCCCGGTGGCAGAACGCTGCGGCAGTTGCCAGTGGCAATGGATCGATTACCCGTTTCAACTGGAGGCCAAGCAGCG
GCAGGTGCGCGAGGCGCTCGAACACCTGGGCGGGTTCGCAGAGCCGCCGGTGGAGCCGGTCATTGCCCAGCCGCGCCCTT
TTGGCTACCGCAACAAATCGACTTTCCCGATCGGCCGGGATGCCCGCGGTGAACCCGTCATCGGCTACTACCAGAAAGAT
TCGCACCGGATCGTGCCTCTCGATGCTTGTCCGGTGCAGGATAGCCGCCTTGACCCGTTGCTGGCGGCGGCGCGCGAATT
GATCCGCACCCAGGGCTGGAGCATCTACGACGAAAAACACCACCGCGGCGCCCTGCGCCATCTGGGCCTGCGCATCGGCG
AGCGCACGGGCCAGAGACTGCTCACCTTTGTGGTGAACGGCCAGACCCTCTCGGGGATCAAGCCCGCCGCCCAGGCGCTC
ATGGACCGCTTTGCCGACCTGGTGGGGGTCTGCCTCAATACCCACACCGAGCGCGGCAATACGATCTTTGGTCCCCAGAC
CCGCTGCCTGGCGGGCCAGGACTTTATCGAAGAGGTGCTGGACGGCTTTCGCTTTCGCATCGAGCCCACGACGTTTTTTC
AGATCTGCACCTCCCAGGCGGAAATCCTCGCCCGCCTGGTGGCCCGGGGAGCGGACGCTACTGCCGAGCAGACCGTCGTC
GACGCCTACTGCGGCATCGGCACGCTGAGCCTGCCCCTGGCGCGCGCCGCCCGCGCCGTGGTGGGTATCGAAAGCCACGT
CCGTTCTGTGGAACAGGCCAGGCAGAATGCCCGGATCAACGGCATCGAAAATTGTCGGTTTCTGGCTGGAACCGTCGAGG
CGCTGCTGCCGGATCTGCGGGCCGACATCGTCGTCGTCGATCCGCCGCGCAAGGGTTGCGATCCGGAAGTGCTCGAAGCC
ATCCTGCACGCGGTGCCGATGCGGGTGGTCTACGTCAGTTGCAATCCCGCCACGCTCGCCCGCGACCTGAAGCGGCTGGT
GGCAGGAGGCTATTGCCTGGTGGGCGTGCAGCCGGTGGACCTGTTTGCCCAGACCCACCACGTCGAGTGCGTGGCGACGC
TGGAGCGGTCGTAG

Upstream 100 bases:

>100_bases
AGAGCCGCTACTGGTACAAATTCACCGTCACCGGCACCTGGATCTGCATCGGGGTGATCGCGCTTATCTGGGTGGTCGTC
AACTTTGGCCACTATATGAA

Downstream 100 bases:

>100_bases
GGCTCGACTCAGTTGCCGGTTGTCGAAAAACGCGAGGCCCAGGGCTGGAGCCCTCGTTTTTCAAAGCGGCAGGTTCTCCG
CGGCATCAGGTGAGTCCGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVGRPVEPGALLQGQTVTVPITALAAGGDGIARLTDGRVLFVAGAVPGDTVEARLVHLKKDHGFGKILQIVQASPHRIEA
PCPVAERCGSCQWQWIDYPFQLEAKQRQVREALEHLGGFAEPPVEPVIAQPRPFGYRNKSTFPIGRDARGEPVIGYYQKD
SHRIVPLDACPVQDSRLDPLLAAARELIRTQGWSIYDEKHHRGALRHLGLRIGERTGQRLLTFVVNGQTLSGIKPAAQAL
MDRFADLVGVCLNTHTERGNTIFGPQTRCLAGQDFIEEVLDGFRFRIEPTTFFQICTSQAEILARLVARGADATAEQTVV
DAYCGIGTLSLPLARAARAVVGIESHVRSVEQARQNARINGIENCRFLAGTVEALLPDLRADIVVVDPPRKGCDPEVLEA
ILHAVPMRVVYVSCNPATLARDLKRLVAGGYCLVGVQPVDLFAQTHHVECVATLERS

Sequences:

>Translated_457_residues
MVGRPVEPGALLQGQTVTVPITALAAGGDGIARLTDGRVLFVAGAVPGDTVEARLVHLKKDHGFGKILQIVQASPHRIEA
PCPVAERCGSCQWQWIDYPFQLEAKQRQVREALEHLGGFAEPPVEPVIAQPRPFGYRNKSTFPIGRDARGEPVIGYYQKD
SHRIVPLDACPVQDSRLDPLLAAARELIRTQGWSIYDEKHHRGALRHLGLRIGERTGQRLLTFVVNGQTLSGIKPAAQAL
MDRFADLVGVCLNTHTERGNTIFGPQTRCLAGQDFIEEVLDGFRFRIEPTTFFQICTSQAEILARLVARGADATAEQTVV
DAYCGIGTLSLPLARAARAVVGIESHVRSVEQARQNARINGIENCRFLAGTVEALLPDLRADIVVVDPPRKGCDPEVLEA
ILHAVPMRVVYVSCNPATLARDLKRLVAGGYCLVGVQPVDLFAQTHHVECVATLERS
>Mature_457_residues
MVGRPVEPGALLQGQTVTVPITALAAGGDGIARLTDGRVLFVAGAVPGDTVEARLVHLKKDHGFGKILQIVQASPHRIEA
PCPVAERCGSCQWQWIDYPFQLEAKQRQVREALEHLGGFAEPPVEPVIAQPRPFGYRNKSTFPIGRDARGEPVIGYYQKD
SHRIVPLDACPVQDSRLDPLLAAARELIRTQGWSIYDEKHHRGALRHLGLRIGERTGQRLLTFVVNGQTLSGIKPAAQAL
MDRFADLVGVCLNTHTERGNTIFGPQTRCLAGQDFIEEVLDGFRFRIEPTTFFQICTSQAEILARLVARGADATAEQTVV
DAYCGIGTLSLPLARAARAVVGIESHVRSVEQARQNARINGIENCRFLAGTVEALLPDLRADIVVVDPPRKGCDPEVLEA
ILHAVPMRVVYVSCNPATLARDLKRLVAGGYCLVGVQPVDLFAQTHHVECVATLERS

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=364, Percent_Identity=31.043956043956, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI51173878, Length=364, Percent_Identity=31.043956043956, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI269784680, Length=381, Percent_Identity=28.8713910761155, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI269784676, Length=381, Percent_Identity=28.8713910761155, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI20149688, Length=381, Percent_Identity=28.8713910761155, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI269784678, Length=384, Percent_Identity=28.90625, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1789148, Length=454, Percent_Identity=28.8546255506608, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1787083, Length=386, Percent_Identity=26.9430051813472, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790403, Length=343, Percent_Identity=25.9475218658892, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997438, Length=165, Percent_Identity=34.5454545454545, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322909, Length=432, Percent_Identity=24.537037037037, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24666579, Length=429, Percent_Identity=26.8065268065268, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y3134_GLOVI (Q7NGN4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926080.1
- ProteinModelPortal:   Q7NGN4
- SMR:   Q7NGN4
- GeneID:   2601535
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll3134
- NMPDR:   fig|251221.1.peg.3134
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- BioCyc:   GVIO251221:GLL3134-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 49843; Mature: 49843

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 414-414 BINDING 294-294 BINDING 323-323 BINDING 344-344 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGRPVEPGALLQGQTVTVPITALAAGGDGIARLTDGRVLFVAGAVPGDTVEARLVHLKK
CCCCCCCCCCEECCCEEEEEEEEEECCCCCCEEEECCEEEEEECCCCCCCHHHEEEEEEC
DHGFGKILQIVQASPHRIEAPCPVAERCGSCQWQWIDYPFQLEAKQRQVREALEHLGGFA
CCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCEEECHHHHHHHHHHHHHCCCC
EPPVEPVIAQPRPFGYRNKSTFPIGRDARGEPVIGYYQKDSHRIVPLDACPVQDSRLDPL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCHH
LAAARELIRTQGWSIYDEKHHRGALRHLGLRIGERTGQRLLTFVVNGQTLSGIKPAAQAL
HHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHH
MDRFADLVGVCLNTHTERGNTIFGPQTRCLAGQDFIEEVLDGFRFRIEPTTFFQICTSQA
HHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHH
EILARLVARGADATAEQTVVDAYCGIGTLSLPLARAARAVVGIESHVRSVEQARQNARIN
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIENCRFLAGTVEALLPDLRADIVVVDPPRKGCDPEVLEAILHAVPMRVVYVSCNPATLA
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEEECCHHHHH
RDLKRLVAGGYCLVGVQPVDLFAQTHHVECVATLERS
HHHHHHHCCCEEEEECCHHHHHHHHCCEEEEEEECCC
>Mature Secondary Structure
MVGRPVEPGALLQGQTVTVPITALAAGGDGIARLTDGRVLFVAGAVPGDTVEARLVHLKK
CCCCCCCCCCEECCCEEEEEEEEEECCCCCCEEEECCEEEEEECCCCCCCHHHEEEEEEC
DHGFGKILQIVQASPHRIEAPCPVAERCGSCQWQWIDYPFQLEAKQRQVREALEHLGGFA
CCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCEEECHHHHHHHHHHHHHCCCC
EPPVEPVIAQPRPFGYRNKSTFPIGRDARGEPVIGYYQKDSHRIVPLDACPVQDSRLDPL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCHH
LAAARELIRTQGWSIYDEKHHRGALRHLGLRIGERTGQRLLTFVVNGQTLSGIKPAAQAL
HHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHH
MDRFADLVGVCLNTHTERGNTIFGPQTRCLAGQDFIEEVLDGFRFRIEPTTFFQICTSQA
HHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHH
EILARLVARGADATAEQTVVDAYCGIGTLSLPLARAARAVVGIESHVRSVEQARQNARIN
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIENCRFLAGTVEALLPDLRADIVVVDPPRKGCDPEVLEAILHAVPMRVVYVSCNPATLA
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEEECCHHHHH
RDLKRLVAGGYCLVGVQPVDLFAQTHHVECVATLERS
HHHHHHHCCCEEEEECCHHHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292