Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 37522651

GI number: 37522651

Start: 3282307

End: 3284829

Strand: Reverse

Name: gyrA [H]

Synonym: gvip425

Alternate gene names: 37522651

Gene position: 3284829-3282307 (Counterclockwise)

Preceding gene: 37522652

Following gene: 37522650

Centisome position: 70.5

GC content: 64.76

Gene sequence:

>2523_bases
ATGACGACGATCATCCCGACCAACTTGCGCAACGAGATGCAGCGCTCCTACCTCGAATATGCGATGAGCGTGATTGTCGG
GCGGGCGCTGCCCGATGCCCGCGACGGGCTCAAACCGGTGCACCGGCGCATTCTCTTTGCGATGCACGAACTGGGTCTGG
GACCGGACCGTCCTTACCGCAAATGCGCCCGCGTCGTGGGCGACGTGCTGGGCAAGTACCACCCCCACGGCGACTCGGCG
GTCTACGACGCGCTGGTGCGCCTGGCACAAGATTTTTCGACCCGCTATCTGCTCATCGACGGCCACGGCAACTTTGGCTC
GGTAGACAACGACCCGCCCGCGGCGATGCGCTACACCGAGTGCCGCCTGACCCCCCTTACCCGCGACACGCTGCTGGCCG
ATCTCGAAGCGGAGACGGTCGATTTTAGCGACAACTTCGACGGTTCGCAGCAGGAGCCCACGGTGCTCCCCTCGCGCCTG
CCGCAGCTGTTGCTCAACGGCAGCGCCGGAATCGCCGTCGGCATGGCCACGAATATTCCCCCCCACCAGCTGGGCGAACT
GGTCGACGGGGTCACCGCGCTGCTCGCCAACCCCAATTTGGGCATTCCCGAGTTGATGCGCTATATCCCCGGCCCCGATT
TTCCGACCGGCGGCACGATCTTGGGCCAGTCGGGCATTCGCGAAGCCTACACCACCGGCCGCGGCTCGATCACGATGCGC
GGCGTGGCGGCCATCGAGACGATCCAGGTGCGCGGCCGGCCGGACCGCGAGGCGATCGTGATCACCGAATTGCCCTATCA
AGTCTGCAAGGCGGCCCTCATCGAAAAGATCGCCGAACTGGTCAACGACAAGCGCATCGACGGCATCAGCGACATCCGCG
ACGAATCGGACCGCGACGGCTTGCGGGCGGTCATCGAACTGAAGCGCGACGCCTACCCGCGGGTGGTGCTCAACAACCTT
TTCAAACTGACACCCCTGCAGACCAACTTCGGCTGCAACATGCTGGCCTTGGTCAACGGCGAGCCGCGGCTGCTGAATTT
AAAAGAGTTCCTGCAGACTTTTATCGATTTTCGCGCCGAGGTGATCACCCGCCGCACCCACTACGAGCTGCGCAAGGCCC
GCGAGCGCGACCACATTTTGATGGGGATGCTGGTGGCGCTTGCCAACCTCGAATCGGTGATCGCCTTGATTCGCGCCGCT
GACGACACGGCCTCCGCGCGCGCCGAACTGGTGAACCGCTTCGAGCTGAGCGAGGCCCAGGCAGAAGCGATTTTGCAAAT
GCAGCTTCGGCGGCTCACCGGCATGGAGGCGGGGCGCATCGAGGCGGAACACCGCGAATTGATCGCCAAAATCGCCGATC
TCAGCGATGTGCTGGAGCGGCGCGAGCGCATCGACCAGATCATCCGCGACGAGTTGCTGACAGCCAAGCAGCGCCTGAAT
GACCCACGCCGCACGATCATCGAAAAAGCCGAGGGCGAGATCGACGACGCCGACCTCATCGCCAATCAGGAGATGGTGGT
GCTGGTGACGGAGCAAGGCTATATCAAGCGTTTGCCCGTCGACACTTTTGATCGCCAGCGGCGGGCCACCCGCGGCAAAT
CCGGCGCCCGCATGCGCGAGGACGACGCGGTCGAGCACTTTATCACCTGCTGCAACCACGACACGGTGCTGTTTTTCACC
AACCGCGGCGTCGTCTACGCCCTGCGCGGCTACCAGATCCCGGCCGGTTCGCGCACCGCCAAGGGCACGCCCGTCGTGCA
GCTTTTGCCCATTCCGATCGAGGAGAAGGTGACTTCAATTGTGCCGGTGCAGGAATTTGCGAGCGACGAATTTCTGGTGA
TGCTCACCCGCACGGGCTTTATCAAGAAAACGGCCCTGGCCGCTTTTGCCAACCTGCGGGCCAACGGCCTCATCGCCATC
GGCCTCGAAGAGGGCGACGAGTTGCGCTGGGTGCGCCGGGCGCGCGCCGAGGACGACATCCTGGTCGGTTCGCGCGCCGG
GATGGCGATTCGCTTTCGCGCCGACGAAGAGCAGCTGCGGCCCCTGGGTCGCACCGCCCGCGGGGTCAAGTCGATGGAAC
TGCGCAAGGGCGACGAGCTGGTCAGCATGGACATCTTGAGCTGCGAGCAGCGCGAGCGGGCCGAGGCGAACGGCGAGTGC
GGCCCCTGGGTGTTGGTGGTCACCGCCGACGGCTTCGGCAAGCGCGTGCCCTTCAGCGAGTTTCGTGCCCAGAACCGGGG
CGGCATGGGGGTGATCGCCACCAAGTTCCGCGACCAGGGGGACGAACTGGCGGCCTTGCGCGTGGTGAGCTGCGAGGATG
AGCTGATGATCGTCACCGCCCGGGGGGTGATCATCCGTCAACAGAGCGAAGAAATCTCCCAGCAGTCGCGGGCGGCCACC
GGGGTGCGGGTGCAGCGCCTCGACGAAGACGATACGATCGTGGGCGTCGCCGTGGTGCCGGAGTCGGCGGAAGACGGCGG
CAGTGCCTTTGCCGCCGAAGAAGAAGAGGAAGCGGAAGCATAA

Upstream 100 bases:

>100_bases
GTAATGCATTGGACATTTTGAGCCGCATTGATCGCCCGTTTCACTGACGCCATGAGCGCAGGGGAGCGGGCGGTCATCTT
ATCTGGGAGCCCACAGGTAC

Downstream 100 bases:

>100_bases
ATGGCCACCCACGTCTCGGGCCTGTTCGTCTATCCGGTCAAATCTTGCCGGGGGATCGCCCTGGAGGCGGCCGAACTGGG
TACCCGGGGCATCCGGTTGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 840; Mature: 839

Protein sequence:

>840_residues
MTTIIPTNLRNEMQRSYLEYAMSVIVGRALPDARDGLKPVHRRILFAMHELGLGPDRPYRKCARVVGDVLGKYHPHGDSA
VYDALVRLAQDFSTRYLLIDGHGNFGSVDNDPPAAMRYTECRLTPLTRDTLLADLEAETVDFSDNFDGSQQEPTVLPSRL
PQLLLNGSAGIAVGMATNIPPHQLGELVDGVTALLANPNLGIPELMRYIPGPDFPTGGTILGQSGIREAYTTGRGSITMR
GVAAIETIQVRGRPDREAIVITELPYQVCKAALIEKIAELVNDKRIDGISDIRDESDRDGLRAVIELKRDAYPRVVLNNL
FKLTPLQTNFGCNMLALVNGEPRLLNLKEFLQTFIDFRAEVITRRTHYELRKARERDHILMGMLVALANLESVIALIRAA
DDTASARAELVNRFELSEAQAEAILQMQLRRLTGMEAGRIEAEHRELIAKIADLSDVLERRERIDQIIRDELLTAKQRLN
DPRRTIIEKAEGEIDDADLIANQEMVVLVTEQGYIKRLPVDTFDRQRRATRGKSGARMREDDAVEHFITCCNHDTVLFFT
NRGVVYALRGYQIPAGSRTAKGTPVVQLLPIPIEEKVTSIVPVQEFASDEFLVMLTRTGFIKKTALAAFANLRANGLIAI
GLEEGDELRWVRRARAEDDILVGSRAGMAIRFRADEEQLRPLGRTARGVKSMELRKGDELVSMDILSCEQRERAEANGEC
GPWVLVVTADGFGKRVPFSEFRAQNRGGMGVIATKFRDQGDELAALRVVSCEDELMIVTARGVIIRQQSEEISQQSRAAT
GVRVQRLDEDDTIVGVAVVPESAEDGGSAFAAEEEEEAEA

Sequences:

>Translated_840_residues
MTTIIPTNLRNEMQRSYLEYAMSVIVGRALPDARDGLKPVHRRILFAMHELGLGPDRPYRKCARVVGDVLGKYHPHGDSA
VYDALVRLAQDFSTRYLLIDGHGNFGSVDNDPPAAMRYTECRLTPLTRDTLLADLEAETVDFSDNFDGSQQEPTVLPSRL
PQLLLNGSAGIAVGMATNIPPHQLGELVDGVTALLANPNLGIPELMRYIPGPDFPTGGTILGQSGIREAYTTGRGSITMR
GVAAIETIQVRGRPDREAIVITELPYQVCKAALIEKIAELVNDKRIDGISDIRDESDRDGLRAVIELKRDAYPRVVLNNL
FKLTPLQTNFGCNMLALVNGEPRLLNLKEFLQTFIDFRAEVITRRTHYELRKARERDHILMGMLVALANLESVIALIRAA
DDTASARAELVNRFELSEAQAEAILQMQLRRLTGMEAGRIEAEHRELIAKIADLSDVLERRERIDQIIRDELLTAKQRLN
DPRRTIIEKAEGEIDDADLIANQEMVVLVTEQGYIKRLPVDTFDRQRRATRGKSGARMREDDAVEHFITCCNHDTVLFFT
NRGVVYALRGYQIPAGSRTAKGTPVVQLLPIPIEEKVTSIVPVQEFASDEFLVMLTRTGFIKKTALAAFANLRANGLIAI
GLEEGDELRWVRRARAEDDILVGSRAGMAIRFRADEEQLRPLGRTARGVKSMELRKGDELVSMDILSCEQRERAEANGEC
GPWVLVVTADGFGKRVPFSEFRAQNRGGMGVIATKFRDQGDELAALRVVSCEDELMIVTARGVIIRQQSEEISQQSRAAT
GVRVQRLDEDDTIVGVAVVPESAEDGGSAFAAEEEEEAEA
>Mature_839_residues
TTIIPTNLRNEMQRSYLEYAMSVIVGRALPDARDGLKPVHRRILFAMHELGLGPDRPYRKCARVVGDVLGKYHPHGDSAV
YDALVRLAQDFSTRYLLIDGHGNFGSVDNDPPAAMRYTECRLTPLTRDTLLADLEAETVDFSDNFDGSQQEPTVLPSRLP
QLLLNGSAGIAVGMATNIPPHQLGELVDGVTALLANPNLGIPELMRYIPGPDFPTGGTILGQSGIREAYTTGRGSITMRG
VAAIETIQVRGRPDREAIVITELPYQVCKAALIEKIAELVNDKRIDGISDIRDESDRDGLRAVIELKRDAYPRVVLNNLF
KLTPLQTNFGCNMLALVNGEPRLLNLKEFLQTFIDFRAEVITRRTHYELRKARERDHILMGMLVALANLESVIALIRAAD
DTASARAELVNRFELSEAQAEAILQMQLRRLTGMEAGRIEAEHRELIAKIADLSDVLERRERIDQIIRDELLTAKQRLND
PRRTIIEKAEGEIDDADLIANQEMVVLVTEQGYIKRLPVDTFDRQRRATRGKSGARMREDDAVEHFITCCNHDTVLFFTN
RGVVYALRGYQIPAGSRTAKGTPVVQLLPIPIEEKVTSIVPVQEFASDEFLVMLTRTGFIKKTALAAFANLRANGLIAIG
LEEGDELRWVRRARAEDDILVGSRAGMAIRFRADEEQLRPLGRTARGVKSMELRKGDELVSMDILSCEQRERAEANGECG
PWVLVVTADGFGKRVPFSEFRAQNRGGMGVIATKFRDQGDELAALRVVSCEDELMIVTARGVIIRQQSEEISQQSRAATG
VRVQRLDEDDTIVGVAVVPESAEDGGSAFAAEEEEEAEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=372, Percent_Identity=27.1505376344086, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1788562, Length=857, Percent_Identity=45.1575262543757, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=618, Percent_Identity=37.7022653721683, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=358, Percent_Identity=27.9329608938547, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=358, Percent_Identity=26.8156424581006, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136538, Length=378, Percent_Identity=25.6613756613757, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93238; Mature: 93107

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIIPTNLRNEMQRSYLEYAMSVIVGRALPDARDGLKPVHRRILFAMHELGLGPDRPYR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHH
KCARVVGDVLGKYHPHGDSAVYDALVRLAQDFSTRYLLIDGHGNFGSVDNDPPAAMRYTE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
CRLTPLTRDTLLADLEAETVDFSDNFDGSQQEPTVLPSRLPQLLLNGSAGIAVGMATNIP
EEECCCCHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCC
PHQLGELVDGVTALLANPNLGIPELMRYIPGPDFPTGGTILGQSGIREAYTTGRGSITMR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHCCCCCEEEE
GVAAIETIQVRGRPDREAIVITELPYQVCKAALIEKIAELVNDKRIDGISDIRDESDRDG
EEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHH
LRAVIELKRDAYPRVVLNNLFKLTPLQTNFGCNMLALVNGEPRLLNLKEFLQTFIDFRAE
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VITRRTHYELRKARERDHILMGMLVALANLESVIALIRAADDTASARAELVNRFELSEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AEAILQMQLRRLTGMEAGRIEAEHRELIAKIADLSDVLERRERIDQIIRDELLTAKQRLN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRRTIIEKAEGEIDDADLIANQEMVVLVTEQGYIKRLPVDTFDRQRRATRGKSGARMRE
CHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCH
DDAVEHFITCCNHDTVLFFTNRGVVYALRGYQIPAGSRTAKGTPVVQLLPIPIEEKVTSI
HHHHHHHHHHCCCCEEEEEECCCEEEEEECEECCCCCCCCCCCCEEEEECCCHHHHHHHH
VPVQEFASDEFLVMLTRTGFIKKTALAAFANLRANGLIAIGLEEGDELRWVRRARAEDDI
CCHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCE
LVGSRAGMAIRFRADEEQLRPLGRTARGVKSMELRKGDELVSMDILSCEQRERAEANGEC
EEECCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCC
GPWVLVVTADGFGKRVPFSEFRAQNRGGMGVIATKFRDQGDELAALRVVSCEDELMIVTA
CCEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEEEE
RGVIIRQQSEEISQQSRAATGVRVQRLDEDDTIVGVAVVPESAEDGGSAFAAEEEEEAEA
CCEEEECCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TTIIPTNLRNEMQRSYLEYAMSVIVGRALPDARDGLKPVHRRILFAMHELGLGPDRPYR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHH
KCARVVGDVLGKYHPHGDSAVYDALVRLAQDFSTRYLLIDGHGNFGSVDNDPPAAMRYTE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
CRLTPLTRDTLLADLEAETVDFSDNFDGSQQEPTVLPSRLPQLLLNGSAGIAVGMATNIP
EEECCCCHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCC
PHQLGELVDGVTALLANPNLGIPELMRYIPGPDFPTGGTILGQSGIREAYTTGRGSITMR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHCCCCCEEEE
GVAAIETIQVRGRPDREAIVITELPYQVCKAALIEKIAELVNDKRIDGISDIRDESDRDG
EEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHH
LRAVIELKRDAYPRVVLNNLFKLTPLQTNFGCNMLALVNGEPRLLNLKEFLQTFIDFRAE
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VITRRTHYELRKARERDHILMGMLVALANLESVIALIRAADDTASARAELVNRFELSEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AEAILQMQLRRLTGMEAGRIEAEHRELIAKIADLSDVLERRERIDQIIRDELLTAKQRLN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRRTIIEKAEGEIDDADLIANQEMVVLVTEQGYIKRLPVDTFDRQRRATRGKSGARMRE
CHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCH
DDAVEHFITCCNHDTVLFFTNRGVVYALRGYQIPAGSRTAKGTPVVQLLPIPIEEKVTSI
HHHHHHHHHHCCCCEEEEEECCCEEEEEECEECCCCCCCCCCCCEEEEECCCHHHHHHHH
VPVQEFASDEFLVMLTRTGFIKKTALAAFANLRANGLIAIGLEEGDELRWVRRARAEDDI
CCHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCE
LVGSRAGMAIRFRADEEQLRPLGRTARGVKSMELRKGDELVSMDILSCEQRERAEANGEC
EEECCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCC
GPWVLVVTADGFGKRVPFSEFRAQNRGGMGVIATKFRDQGDELAALRVVSCEDELMIVTA
CCEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEEEE
RGVIIRQQSEEISQQSRAATGVRVQRLDEDDTIVGVAVVPESAEDGGSAFAAEEEEEAEA
CCEEEECCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]