Definition Gloeobacter violaceus PCC 7421 chromosome, complete genome.
Accession NC_005125
Length 4,659,019

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The map label for this gene is pyrD

Identifier: 37522649

GI number: 37522649

Start: 3280430

End: 3281491

Strand: Reverse

Name: pyrD

Synonym: gvip424

Alternate gene names: 37522649

Gene position: 3281491-3280430 (Counterclockwise)

Preceding gene: 37522650

Following gene: 37522648

Centisome position: 70.43

GC content: 62.43

Gene sequence:

>1062_bases
GTGGACCTGTATCGGCTGGCGCGTCCGCTGCTCTTTCGGGCCGATCCGGAGGATGCCCATCGCCGGGCGCTCGGGGCACT
GGCCTGGGCGGCGGAGCAGCTATGGGCCGGGTGGTTGGACTCAGTATTTGGGTACCCAGATCCCCGATTGGAAGTAAAGC
TCTGGGGACTATCTTTTGCCAATCCACTGGGGCTCGCGGCCGGATTCGATAAAAACGCCGAGGCTGTCGGTGCCTGGGAG
CACCTGGGTTTCGGTTTTGCGGAGGTGGGCACCGTCACCCGCCACGCCCAACCTGGCAATCCGCGCCCGCGATTGTTCCG
TTTACCCGCGGACCAGGCGGCGATCAACCGGATGGGTTTCAACAACGACGGGGCCGATGCCCTGGCGTTGCGGCTGGCGG
GGCGCAGGTGGGGGATCCCGATCGGAATCAACCTGGGCAAGTCGAAAGTGACGCCGCTGGAGCAGGCGAGCGACGATTAC
CTGTACAGTTTCGAGCGGCTTTATCACTTGGGCGATTATTTTGTCGTCAACGTCAGTTCCCCCAACACGCCGGGACTGCG
CGAACTGCAGCAGGCGGACCGCCTGGGGGAAATTCTGGCCCGTTTGCAATGTGCAAATCGCGAATCTAAACCGCTGCTGG
TCAAGATTGCCCCGGATCTAGGTTGGGATGCTGTCGATGCGGTAGTCGATCTGTGTGGCGAGCATCGCCTGGCGGGTGTG
ATCGCCACCAATACGACGATTGCCCGTTCGGGCCTGAGAAGCGACCTTCAGGAGACAGGAGGCTTGAGTGGAGCGCCTCT
GCGCAACCGTTCCACTGAAGTGATCGGCCATATCTGGGGGCGCACCCGGGGACAGCTACCGATTGTCGGCGTGGGAGGTA
TCTTCAGCGGCGAGGACGCCTGGGAGAAAATTGCCCATGGCGCCAGCCTGCTGCAGGTCTACACCGGCTGGATTTACGAA
GGCCCCTGGATGGTACGCCGCATCCTCGCGAGCCTGGCTACCCGATTGGAGCGCTCGGGGTTCGAGCACCTGCAGCAAGC
TACTGGCTGTGCTTTCAGTTGA

Upstream 100 bases:

>100_bases
ACAAGGGCCAAATCTTCGGCCAGAACATGGTCCATGCCTCCCCCGGCCGGATCGCTCTGGGCGATGCGCTCGAAGTGGCC
GCCCTTGCCGGGCCGGTCTA

Downstream 100 bases:

>100_bases
AGGGTATCTGGAGATTCGTTTGATGGGTTGGAGCGGCCAGCGGCTGTTCGAACTTATCGGAGCCCATGCACTCATCTAGT
ACACTAGTGGCAAAGGGTTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MDLYRLARPLLFRADPEDAHRRALGALAWAAEQLWAGWLDSVFGYPDPRLEVKLWGLSFANPLGLAAGFDKNAEAVGAWE
HLGFGFAEVGTVTRHAQPGNPRPRLFRLPADQAAINRMGFNNDGADALALRLAGRRWGIPIGINLGKSKVTPLEQASDDY
LYSFERLYHLGDYFVVNVSSPNTPGLRELQQADRLGEILARLQCANRESKPLLVKIAPDLGWDAVDAVVDLCGEHRLAGV
IATNTTIARSGLRSDLQETGGLSGAPLRNRSTEVIGHIWGRTRGQLPIVGVGGIFSGEDAWEKIAHGASLLQVYTGWIYE
GPWMVRRILASLATRLERSGFEHLQQATGCAFS

Sequences:

>Translated_353_residues
MDLYRLARPLLFRADPEDAHRRALGALAWAAEQLWAGWLDSVFGYPDPRLEVKLWGLSFANPLGLAAGFDKNAEAVGAWE
HLGFGFAEVGTVTRHAQPGNPRPRLFRLPADQAAINRMGFNNDGADALALRLAGRRWGIPIGINLGKSKVTPLEQASDDY
LYSFERLYHLGDYFVVNVSSPNTPGLRELQQADRLGEILARLQCANRESKPLLVKIAPDLGWDAVDAVVDLCGEHRLAGV
IATNTTIARSGLRSDLQETGGLSGAPLRNRSTEVIGHIWGRTRGQLPIVGVGGIFSGEDAWEKIAHGASLLQVYTGWIYE
GPWMVRRILASLATRLERSGFEHLQQATGCAFS
>Mature_353_residues
MDLYRLARPLLFRADPEDAHRRALGALAWAAEQLWAGWLDSVFGYPDPRLEVKLWGLSFANPLGLAAGFDKNAEAVGAWE
HLGFGFAEVGTVTRHAQPGNPRPRLFRLPADQAAINRMGFNNDGADALALRLAGRRWGIPIGINLGKSKVTPLEQASDDY
LYSFERLYHLGDYFVVNVSSPNTPGLRELQQADRLGEILARLQCANRESKPLLVKIAPDLGWDAVDAVVDLCGEHRLAGV
IATNTTIARSGLRSDLQETGGLSGAPLRNRSTEVIGHIWGRTRGQLPIVGVGGIFSGEDAWEKIAHGASLLQVYTGWIYE
GPWMVRRILASLATRLERSGFEHLQQATGCAFS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=351, Percent_Identity=43.8746438746439, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=43.7869822485207, Blast_Score=271, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17509475, Length=359, Percent_Identity=42.8969359331476, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322633, Length=321, Percent_Identity=24.9221183800623, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=43.2601880877743, Blast_Score=260, Evalue=8e-70,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=43.2601880877743, Blast_Score=260, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_GLOVI (Q7NC99)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926026.1
- ProteinModelPortal:   Q7NC99
- SMR:   Q7NC99
- GeneID:   2601481
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3080
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   GVIO251221:GLL3080-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38641; Mature: 38641

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDLYRLARPLLFRADPEDAHRRALGALAWAAEQLWAGWLDSVFGYPDPRLEVKLWGLSFA
CCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
NPLGLAAGFDKNAEAVGAWEHLGFGFAEVGTVTRHAQPGNPRPRLFRLPADQAAINRMGF
CCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHCCC
NNDGADALALRLAGRRWGIPIGINLGKSKVTPLEQASDDYLYSFERLYHLGDYFVVNVSS
CCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHCCCEEEEEECC
PNTPGLRELQQADRLGEILARLQCANRESKPLLVKIAPDLGWDAVDAVVDLCGEHRLAGV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEE
IATNTTIARSGLRSDLQETGGLSGAPLRNRSTEVIGHIWGRTRGQLPIVGVGGIFSGEDA
EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHH
WEKIAHGASLLQVYTGWIYEGPWMVRRILASLATRLERSGFEHLQQATGCAFS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDLYRLARPLLFRADPEDAHRRALGALAWAAEQLWAGWLDSVFGYPDPRLEVKLWGLSFA
CCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
NPLGLAAGFDKNAEAVGAWEHLGFGFAEVGTVTRHAQPGNPRPRLFRLPADQAAINRMGF
CCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHCCC
NNDGADALALRLAGRRWGIPIGINLGKSKVTPLEQASDDYLYSFERLYHLGDYFVVNVSS
CCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHCCCEEEEEECC
PNTPGLRELQQADRLGEILARLQCANRESKPLLVKIAPDLGWDAVDAVVDLCGEHRLAGV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEE
IATNTTIARSGLRSDLQETGGLSGAPLRNRSTEVIGHIWGRTRGQLPIVGVGGIFSGEDA
EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHH
WEKIAHGASLLQVYTGWIYEGPWMVRRILASLATRLERSGFEHLQQATGCAFS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292