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The map label for this gene is adhA [H]

Identifier: 37522586

GI number: 37522586

Start: 3213815

End: 3214723

Strand: Reverse

Name: adhA [H]

Synonym: gll3017

Alternate gene names: 37522586

Gene position: 3214723-3213815 (Counterclockwise)

Preceding gene: 37522587

Following gene: 37522585

Centisome position: 69.0

GC content: 68.76

Gene sequence:

>909_bases
GTGTGCGCCTGCGGTGTCTGCCACTCGGACCTGCACATGATCGACAACGACTGGGGCCGCTCGCGCTATCCGCTGGTGCC
CGGGCACGAGGTGGTGGGCGAGGTGGTGGAGATCGGATCCGAGGTGCGTCACCTGAAGCCCGGCGACCGAGTCGGCGTGG
GCTGGCAGCGCTCGGCCTGTCTGCAGTGCCTCGACTGCCTGCGCGGCAACGAAAATCTGTGCGCCCACAGCCAGGCCACG
ATCGTCACCGGCTACGGCGGCTTCGGCGATTATCTGGCGATCGATGCGCGCTTTGCCTTCAAGATTCCGGCGGGGATTCC
CACCCACGTCGCAGGACCGCTTCTGTGCGGCGGGATCACGGTCTATTCGGGGTTGCGGGCGGCAGGGATGAGCTCGGGCC
AGGAGATTGGCGTCATCGGGGTGGGCGGACTCGGCCACCTGGCAGTCCAGTTCGCCGGCCGCCTCGGCAACCGGGTGACG
GTCTTCACCACCTCCGAGGACAAAGCCCGGCAGGCGGCCGCCCTCGGAGCGCACCGGGCGGTGATCGTGCCGCCGGGCGA
TTCGCCCCCGCCGCCTGTCGAACGCCTCGACATCATCATCAGCACGATCCCCTATGCCCTCGATGCGGTGGGCTATCTGG
CTCACCTCGCCACCGACGGCACCCTGGTATTCGTCGGCGTACCGCCCGAACCGCTGGCGTTGCCGGTGCGCGAACTCATC
CGGGGCCGGCGGCGCCTGATGGGATCGGGCATTGGCAGCCGCTCGCGCATCGTCGAAATGCTCTCGGTGGCCGAGCGCTT
CGGGGTGATGCCGCTGGTTGAAACCTTTGCGATGGCCGAGGCGAACGCGGCGCTCGAGCGGGTGCGCCGCAATCGGGTCC
GCTACCGCGCGGTGCTGCTGGCTGAATAA

Upstream 100 bases:

>100_bases
GATCGAAATTCACGCGCTCGCCGCCCTGGAGGCGGGTGGACCTCTCGAAGCGTTTACCTATACCCTGGGCGGGCTGGCAA
GCCAGGATTGCCTGATTCGG

Downstream 100 bases:

>100_bases
TCTCTGTAGTTATTGCATAAAGTGATTACATAAATCTTGCTTTGTGGGAAAATCTTGGCCATAAACGACCACACCTGGCC
TGCGAGGGGGTAGATGCTGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MCACGVCHSDLHMIDNDWGRSRYPLVPGHEVVGEVVEIGSEVRHLKPGDRVGVGWQRSACLQCLDCLRGNENLCAHSQAT
IVTGYGGFGDYLAIDARFAFKIPAGIPTHVAGPLLCGGITVYSGLRAAGMSSGQEIGVIGVGGLGHLAVQFAGRLGNRVT
VFTTSEDKARQAAALGAHRAVIVPPGDSPPPPVERLDIIISTIPYALDAVGYLAHLATDGTLVFVGVPPEPLALPVRELI
RGRRRLMGSGIGSRSRIVEMLSVAERFGVMPLVETFAMAEANAALERVRRNRVRYRAVLLAE

Sequences:

>Translated_302_residues
MCACGVCHSDLHMIDNDWGRSRYPLVPGHEVVGEVVEIGSEVRHLKPGDRVGVGWQRSACLQCLDCLRGNENLCAHSQAT
IVTGYGGFGDYLAIDARFAFKIPAGIPTHVAGPLLCGGITVYSGLRAAGMSSGQEIGVIGVGGLGHLAVQFAGRLGNRVT
VFTTSEDKARQAAALGAHRAVIVPPGDSPPPPVERLDIIISTIPYALDAVGYLAHLATDGTLVFVGVPPEPLALPVRELI
RGRRRLMGSGIGSRSRIVEMLSVAERFGVMPLVETFAMAEANAALERVRRNRVRYRAVLLAE
>Mature_302_residues
MCACGVCHSDLHMIDNDWGRSRYPLVPGHEVVGEVVEIGSEVRHLKPGDRVGVGWQRSACLQCLDCLRGNENLCAHSQAT
IVTGYGGFGDYLAIDARFAFKIPAGIPTHVAGPLLCGGITVYSGLRAAGMSSGQEIGVIGVGGLGHLAVQFAGRLGNRVT
VFTTSEDKARQAAALGAHRAVIVPPGDSPPPPVERLDIIISTIPYALDAVGYLAHLATDGTLVFVGVPPEPLALPVRELI
RGRRRLMGSGIGSRSRIVEMLSVAERFGVMPLVETFAMAEANAALERVRRNRVRYRAVLLAE

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=311, Percent_Identity=25.7234726688103, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262073058, Length=311, Percent_Identity=25.7234726688103, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=338, Percent_Identity=24.2603550295858, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI34577061, Length=311, Percent_Identity=25.4019292604502, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4501929, Length=311, Percent_Identity=24.7588424437299, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87082401, Length=301, Percent_Identity=38.5382059800665, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1786518, Length=309, Percent_Identity=39.1585760517799, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87081918, Length=309, Percent_Identity=30.42071197411, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1790045, Length=246, Percent_Identity=30.8943089430894, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788407, Length=183, Percent_Identity=32.7868852459016, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI226510992, Length=261, Percent_Identity=28.735632183908, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788073, Length=186, Percent_Identity=29.5698924731183, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082125, Length=304, Percent_Identity=24.0131578947368, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787863, Length=180, Percent_Identity=28.3333333333333, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=305, Percent_Identity=30.8196721311475, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=307, Percent_Identity=31.2703583061889, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=306, Percent_Identity=31.3725490196078, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=311, Percent_Identity=32.7974276527331, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319949, Length=313, Percent_Identity=31.9488817891374, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=305, Percent_Identity=30.8196721311475, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=305, Percent_Identity=30.8196721311475, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323729, Length=307, Percent_Identity=28.3387622149837, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=305, Percent_Identity=29.8360655737705, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17737897, Length=210, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 32120; Mature: 32120

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCACGVCHSDLHMIDNDWGRSRYPLVPGHEVVGEVVEIGSEVRHLKPGDRVGVGWQRSAC
CCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LQCLDCLRGNENLCAHSQATIVTGYGGFGDYLAIDARFAFKIPAGIPTHVAGPLLCGGIT
HHHHHHHCCCCCEECCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCHHHCCHHHHHHHH
VYSGLRAAGMSSGQEIGVIGVGGLGHLAVQFAGRLGNRVTVFTTSEDKARQAAALGAHRA
HHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCE
VIVPPGDSPPPPVERLDIIISTIPYALDAVGYLAHLATDGTLVFVGVPPEPLALPVRELI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
RGRRRLMGSGIGSRSRIVEMLSVAERFGVMPLVETFAMAEANAALERVRRNRVRYRAVLL
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
AE
CC
>Mature Secondary Structure
MCACGVCHSDLHMIDNDWGRSRYPLVPGHEVVGEVVEIGSEVRHLKPGDRVGVGWQRSAC
CCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LQCLDCLRGNENLCAHSQATIVTGYGGFGDYLAIDARFAFKIPAGIPTHVAGPLLCGGIT
HHHHHHHCCCCCEECCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCHHHCCHHHHHHHH
VYSGLRAAGMSSGQEIGVIGVGGLGHLAVQFAGRLGNRVTVFTTSEDKARQAAALGAHRA
HHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCE
VIVPPGDSPPPPVERLDIIISTIPYALDAVGYLAHLATDGTLVFVGVPPEPLALPVRELI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
RGRRRLMGSGIGSRSRIVEMLSVAERFGVMPLVETFAMAEANAALERVRRNRVRYRAVLL
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
AE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]