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The map label for this gene is trpS

Identifier: 37522580

GI number: 37522580

Start: 3208536

End: 3209546

Strand: Direct

Name: trpS

Synonym: gvip414

Alternate gene names: 37522580

Gene position: 3208536-3209546 (Clockwise)

Preceding gene: 37522574

Following gene: 37522581

Centisome position: 68.87

GC content: 63.11

Gene sequence:

>1011_bases
ATGCCCGACGATTCGACTGCTCCCAAGCGCATCCTCTCAGGAGCCCAACCCACCGGCCAGTTGCACCTGGGCAACTACCT
GGGGGCGGTGCGCAACTGGGTGAGCGAACAGCGGCAGTACGACAGTTACTTCTGCGTGGTCGATCTGCACGCCCTCACCG
TCCCGCAGGAGGCGGCCGAATTGCGCGCGGCCACCCGCCGCACAGCCGCGCTTTATCTCGCCTGCGGCATCGACCCGGAG
CGCTCGACGGTATTCGTGCAATCCCACGTGAGCGCCCATACCGAACTGACCTGGCTGTTCAACTGCCTGACGCCCATCAA
CTGGCTGGAGCGGATGATCCAGTTCAAAGAAAAAGCGATCAAGCTGGGCGAGGAGGTGGGTATCGGGCTATTCGACTACC
CGGTACTGCAGGCGGCGGACATTCTGCTCTACGAACCCCACCTGGTGCCGGTGGGCGAGGATCAGCGCCAGCACCTGGAA
CTCACCCGCGATATTGCCCGCCGCTTCAACGACCGCTACGGCGAGAGCCTCAGGGTGCCGGAGATGCTCATCCGCAAAGA
AGGTGCGCGGGTGATGAGCCTGCAGGACGGCACCTCCAAAATGTCCAAGTCCGACCCGTCGGACCTTTCGCGCCTCAACC
TGCTCGATGCGCCCGAGAAGCTGCGCGACAAGATCAAGCGCGCCAAGAGCGACGCGGTGATGGGTCTCAAATTCGACCCG
GCCAGGCCCGAGTGCACCAACTTGCTCACCATCTACCAACTGCTCTCGGGCGAAAGTCCCGAGGCGGTCGAAGCGCGCTT
TGCCGACGCCGGTTTTGGACGTTTCAAGCCGATACTCGCCGACCTGGTCATTGAATATTTACGTCCCATCCGTGAGCGCT
ATGACGCGATTGCGGGCGAGAGCGGTTATCTTGAGGGCATCCTGCGCGAAGGCGCCCTGCGCGCCTCGAAGGTGGCCGGG
CTCACCCTGGAGCGCATCCGCGATCGTATGGGGCTGCTGCCGCCTTTTTAA

Upstream 100 bases:

>100_bases
CGCTGCTTCGATGGTAGGGGCCGGGCGTGAGCCCTGGCAACCGGAGGGCCGCTCGCCGCCGGGGCGGTAAAATCGAAAAG
CCCGTTTCGCCACCGCCGCC

Downstream 100 bases:

>100_bases
ACCGGAAGCGCCGTTCGCGAATTTTACACACACGCTTTGGAAAGGACGGGCAATTATGAGCGGCGAGTATGTTCCTGGTC
TGGAAGGCGTCCCTGCAACC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPDDSTAPKRILSGAQPTGQLHLGNYLGAVRNWVSEQRQYDSYFCVVDLHALTVPQEAAELRAATRRTAALYLACGIDPE
RSTVFVQSHVSAHTELTWLFNCLTPINWLERMIQFKEKAIKLGEEVGIGLFDYPVLQAADILLYEPHLVPVGEDQRQHLE
LTRDIARRFNDRYGESLRVPEMLIRKEGARVMSLQDGTSKMSKSDPSDLSRLNLLDAPEKLRDKIKRAKSDAVMGLKFDP
ARPECTNLLTIYQLLSGESPEAVEARFADAGFGRFKPILADLVIEYLRPIRERYDAIAGESGYLEGILREGALRASKVAG
LTLERIRDRMGLLPPF

Sequences:

>Translated_336_residues
MPDDSTAPKRILSGAQPTGQLHLGNYLGAVRNWVSEQRQYDSYFCVVDLHALTVPQEAAELRAATRRTAALYLACGIDPE
RSTVFVQSHVSAHTELTWLFNCLTPINWLERMIQFKEKAIKLGEEVGIGLFDYPVLQAADILLYEPHLVPVGEDQRQHLE
LTRDIARRFNDRYGESLRVPEMLIRKEGARVMSLQDGTSKMSKSDPSDLSRLNLLDAPEKLRDKIKRAKSDAVMGLKFDP
ARPECTNLLTIYQLLSGESPEAVEARFADAGFGRFKPILADLVIEYLRPIRERYDAIAGESGYLEGILREGALRASKVAG
LTLERIRDRMGLLPPF
>Mature_335_residues
PDDSTAPKRILSGAQPTGQLHLGNYLGAVRNWVSEQRQYDSYFCVVDLHALTVPQEAAELRAATRRTAALYLACGIDPER
STVFVQSHVSAHTELTWLFNCLTPINWLERMIQFKEKAIKLGEEVGIGLFDYPVLQAADILLYEPHLVPVGEDQRQHLEL
TRDIARRFNDRYGESLRVPEMLIRKEGARVMSLQDGTSKMSKSDPSDLSRLNLLDAPEKLRDKIKRAKSDAVMGLKFDPA
RPECTNLLTIYQLLSGESPEAVEARFADAGFGRFKPILADLVIEYLRPIRERYDAIAGESGYLEGILREGALRASKVAGL
TLERIRDRMGLLPPF

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=329, Percent_Identity=42.2492401215805, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=51.9553072625698, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1789786, Length=326, Percent_Identity=48.4662576687117, Blast_Score=311, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI71982800, Length=337, Percent_Identity=35.0148367952522, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71982793, Length=337, Percent_Identity=35.0148367952522, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320474, Length=345, Percent_Identity=37.9710144927536, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24666151, Length=328, Percent_Identity=42.0731707317073, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_GLOVI (Q7NCG8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925957.1
- ProteinModelPortal:   Q7NCG8
- SMR:   Q7NCG8
- GeneID:   2601412
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3011
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- ProtClustDB:   PRK00927
- BioCyc:   GVIO251221:GLR3011-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37796; Mature: 37665

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDSTAPKRILSGAQPTGQLHLGNYLGAVRNWVSEQRQYDSYFCVVDLHALTVPQEAAE
CCCCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCHHHHH
LRAATRRTAALYLACGIDPERSTVFVQSHVSAHTELTWLFNCLTPINWLERMIQFKEKAI
HHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGEEVGIGLFDYPVLQAADILLYEPHLVPVGEDQRQHLELTRDIARRFNDRYGESLRVP
HHHHHHCCCHHHHHHHHHHHHEEECCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
EMLIRKEGARVMSLQDGTSKMSKSDPSDLSRLNLLDAPEKLRDKIKRAKSDAVMGLKFDP
HHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCC
ARPECTNLLTIYQLLSGESPEAVEARFADAGFGRFKPILADLVIEYLRPIRERYDAIAGE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGYLEGILREGALRASKVAGLTLERIRDRMGLLPPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PDDSTAPKRILSGAQPTGQLHLGNYLGAVRNWVSEQRQYDSYFCVVDLHALTVPQEAAE
CCCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCHHHHH
LRAATRRTAALYLACGIDPERSTVFVQSHVSAHTELTWLFNCLTPINWLERMIQFKEKAI
HHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGEEVGIGLFDYPVLQAADILLYEPHLVPVGEDQRQHLELTRDIARRFNDRYGESLRVP
HHHHHHCCCHHHHHHHHHHHHEEECCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
EMLIRKEGARVMSLQDGTSKMSKSDPSDLSRLNLLDAPEKLRDKIKRAKSDAVMGLKFDP
HHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCC
ARPECTNLLTIYQLLSGESPEAVEARFADAGFGRFKPILADLVIEYLRPIRERYDAIAGE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGYLEGILREGALRASKVAGLTLERIRDRMGLLPPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292