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The map label for this gene is groEL

Identifier: 37522466

GI number: 37522466

Start: 3093866

End: 3095527

Strand: Direct

Name: groEL

Synonym: gvip397

Alternate gene names: 37522466

Gene position: 3093866-3095527 (Clockwise)

Preceding gene: 37522465

Following gene: 37522467

Centisome position: 66.41

GC content: 62.64

Gene sequence:

>1662_bases
ATGGCAAAGATGATTGTGTTTGACGAGACGGCCCGCCGGGCGCTCGAGCGGGGCGTCAACGCCCTGGCCGACGCGGTGCG
GGTGACCCTCGGACCCAAGGGCCGCAACGTCGTGCTTGAGAAAAAATTCGGTGCGCCCCAGATTGTCAACGACGGCGTCA
CCATCGCCAAAGAAATTGAACTCGAAGATCCGCTGGAAAATACCGGCGCTCAGCTCATCCGCGAAGTGGCCTCCAAGACC
AACGACGTGGCCGGCGACGGCACCACCACCGCCACGGTGCTCGCCCAGGCGCTCATCCGCGAGGGCCTGCGCAACGTGGC
CGCCGGGGCCAACCCGATGAGCCTCAAGCGCGGCATGGAGAAGACCGTGGCGAAGCTGGTGCAAGAAATCGCCGCCATGG
CCAAGCCGGTCGAAGACAACAAGACAATCGCCGAGGTGGCGACGATCTCCTCGGGCAACGACGAAGAAATCGGCCAGATG
ATCGCCGAGGCGATGGACAAAGTCGGCAAAGAAGGCGTGATCACCGTCGAAGAATCCAAGTCCCTGGTCACCGAACTGGA
TGTGGTCGAGGGCATGCAGTTCGACAAGGGCTACGTCTCGCCCTACTTTGTCACCGACACCGAGCGGATGATCACCGATC
TCGACGAGCCGTTCATTCTACTCACCGACAAAAAAATCTCGATTATTCAAGATCTGATCCCGGTGCTTGAGAAGGTTGCC
CGCGCCGGGCGGCCCTTGCTCATCATCTCCGAGGATCTCGAAGGCGAAGCGCTCGCGACGCTGGTGGTCAATAAACTGCG
CGGCGTGCTCAACTGCGTGGCGGTCAAGGCCCCCGGCTTCGGCGACCGGCGCAAGGCGATGCTGCAAGATATCGCGGTGC
TCACCGGCGGCGATGTGATCTCCGAGGACATCGGCCTCAAGCTCGAAAACGTCACCATCGACATGCTGGGCAAGGCCCGC
AAGGTGACGATCACCAAGGACAAAACCACGATCGTGGCCGGTACAGACAACAAAGCCGCCGTCGAGAAGCGCATCGCCCA
GATCCACAAGCAGATGGAGGACACCGACTCCGACTTTGACCGCGAGAAGCTCCAAGAGCGCCTCGCCAAGCTCGCGGGCG
GTGTGGCGGTAATCAAAGTCGGTGCGGCGACCGAGACCGAACTCAAAGACCGCAAGCTGCGCATTGAAGATGCCCTCAAC
GCCACCAAAGCGGCGGTCGAAGAAGGCATCGTGCCGGGCGGCGGTACGACCCTGCTGCACCTGACCAAGAAGATCGACGC
CATCAAGGCGGGACTGGCCGACGACGAGAAGACCGGTGCGGACTTGATCGCCCGCGCCCTGGAGGCGCCTTTGCGCCAGA
TTGCCGATAATGCCGGCGTCGAAGGGTCGGTGATCGCCCAGAAGGTGCGCGAGCTGGACTTCAACATCGGCTACGACGCC
ATGAAGGGCGAATTTGTCGACATGCTTGCCGCGGGCGTGGCCGACCCGGCCAAGGTAGTCCGCTCGGCGCTGCAGAACGC
CGCGTCGATCGCCGCGATGGTGCTCACCACCGAGGTGCTGATCGTCGACAAGCCCGAGAAGAAAAAAGCCGGCGCCGGTG
CCCCCGACATGGGCGGTATGGGTGGCATGGGCGGTATGGGTGGCATGGGCGGCATGATGTAG

Upstream 100 bases:

>100_bases
AGGTGGCGGGCGAAGAGTACATTTTGCTTGCCGAGAAAGATATCCTCGCCATCACCCTGTAGGACAGGCGGCGCGATTTT
ACTATTTGGGAGAGTGTGCA

Downstream 100 bases:

>100_bases
CCCCACCAAACCACGCCTGCAAAGCCTGCGCCGCAACCGGTGCAGGCTTTACTTTTGGTGGGGCAATCAGCCAAATGGTG
TGCGCCGTGTATTAATAGGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MAKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDPLENTGAQLIREVASKT
NDVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGMEKTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQM
IAEAMDKVGKEGVITVEESKSLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVA
RAGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVISEDIGLKLENVTIDMLGKAR
KVTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFDREKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALN
ATKAAVEEGIVPGGGTTLLHLTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDA
MKGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGMGGMGGMGGMGGMM

Sequences:

>Translated_553_residues
MAKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDPLENTGAQLIREVASKT
NDVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGMEKTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQM
IAEAMDKVGKEGVITVEESKSLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVA
RAGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVISEDIGLKLENVTIDMLGKAR
KVTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFDREKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALN
ATKAAVEEGIVPGGGTTLLHLTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDA
MKGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGMGGMGGMGGMGGMM
>Mature_552_residues
AKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDPLENTGAQLIREVASKTN
DVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGMEKTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQMI
AEAMDKVGKEGVITVEESKSLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVAR
AGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVISEDIGLKLENVTIDMLGKARK
VTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFDREKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALNA
TKAAVEEGIVPGGGTTLLHLTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDAM
KGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=48.3992467043315, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=48.3992467043315, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI38455427, Length=133, Percent_Identity=33.8345864661654, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=60.8695652173913, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=46.7924528301887, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=45.4976303317536, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=51.9924098671727, Blast_Score=529, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=47.7272727272727, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=47.7272727272727, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=45.0570342205323, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=45.0570342205323, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=45.0570342205323, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17864606, Length=557, Percent_Identity=41.6517055655296, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=35.0282485875706, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=35.0282485875706, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24583944, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_GLOVI (Q7MBB4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925843.1
- ProteinModelPortal:   Q7MBB4
- SMR:   Q7MBB4
- GeneID:   2601298
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2897
- HOGENOM:   HBG625289
- OMA:   SGEERIG
- BioCyc:   GVIO251221:GLR2897-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58588; Mature: 58456

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDPLENTGAQLIREVASKTNDVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGME
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQMIAEAMDKVGKEGVITVEESK
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHH
SLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVA
HHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCHH
SEDIGLKLENVTIDMLGKARKVTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFD
HHHHCCEEEEEEHEECCCCEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
REKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALNATKAAVEEGIVPGGGTTLLH
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
MKGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCCCCCC
GGMGGMGGMGGMM
CCCCCCCCCCCCC
>Mature Secondary Structure 
AKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDPLENTGAQLIREVASKTNDVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGME
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQMIAEAMDKVGKEGVITVEESK
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHH
SLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVA
HHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCHH
SEDIGLKLENVTIDMLGKARKVTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFD
HHHHCCEEEEEEHEECCCCEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
REKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALNATKAAVEEGIVPGGGTTLLH
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
MKGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCCCCCC
GGMGGMGGMGGMM
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292