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The map label for this gene is yphC [C]

Identifier: 37522405

GI number: 37522405

Start: 3022041

End: 3023033

Strand: Reverse

Name: yphC [C]

Synonym: gll2836

Alternate gene names: 37522405

Gene position: 3023033-3022041 (Counterclockwise)

Preceding gene: 37522406

Following gene: 37522404

Centisome position: 64.89

GC content: 64.05

Gene sequence:

>993_bases
ATGAAAGCCGCCGTCGTTCCGAACCTGCACGGCCGTTGGGAAATCCGCGATCTGCCGATTCCCGAACCTGGGATCAACCA
GGTACTCATCCGGATCAAAGCGAGCGGCCTGTGCTACACCGACATTCACATCACCGAAGGAGCCTGGCCCGCGGACAGCT
TCCCGCGTACCCTCGGCCATGAACCAGTGGGCGAAATTGTCGCCCTCGGTGCCGGAGTACGCACGCGTCGCCTGGGCGAT
CGCGTCGGAGTGCCGTGGCTGCAGCTGGCCTGCGGGCGGTGCGAATGGTGTCGGCGCGGCAAAGCGCTCTTTTGCAAAGA
TCAACAGGGCACGGGCGTGCAGACCCAGGGCGGCCACGCCGAATATATGCTTGCCCAGGCCGAAGCGACCGTGCTGTTAC
CTGACGCCCTCGCTTACGAACAGGCGGCTTCGCTATTTTGCGCGGGCTACACCGTCTGGGCGGGGCTGCGCTTTGCCGAC
CCGAAACCCCACGAGCGCGTCGCAGTATTGGGCATCGGCGGTCTTGGGCACCTGGCGGTTCAGTACGGCAAGGCGGCGGG
CTTCGAAACTTTCGCCATCACCCACTCGCCTTCGAAAGAAAAACTGGTGCGCTCGCTCGGGGCTGACGGGGTGTTTCCCT
CCGGGGCCGCGCTGCGGGAGGCGGGGGGGGCCGATGTGATCCTCGCCTGCAGCAACTCGTATCGGGCGACCGGCGAAGCT
TTGCAAGGGCTGCGCCCGGACGGCCGGTTGGTGCTGATGGGTCTTCCCAGCGACAACCAGACCCTCGCGGTGAGTGGCGA
TCTGCTGGTCAACCGCTGGCGGATCATCGGTTCGCAGCAAAACGGCCCGGAGCACCTTTTCGAAGCCCTCGACTACGCGG
CTAAAGGCAAGGTCAAAGTCGTTGCCGAGACCTACTCGCTCGATGAAATCAACCTTGCTTTCGACCGGGTCTTCAGCGGT
GATGTGCGCTTTCGCGCCGTGATCATCCCCTAA

Upstream 100 bases:

>100_bases
GCAACTGGCCCATCTGCGCACCCGGGCGGTAGCTTACCTCGACCCGGATCGCAGCCTCTGACGTTGTCTTGAGATCACCC
GCGACAGGAGCCCGTTCTCG

Downstream 100 bases:

>100_bases
AGTCGTCTATTTCTTGCAATGGCAGTATCTGTTGCAAAACCGCTGTTCACACTTAAATTACAGAGGAGCTTGACCATGGA
CATTCGCAAAGTTTTTGTTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKAAVVPNLHGRWEIRDLPIPEPGINQVLIRIKASGLCYTDIHITEGAWPADSFPRTLGHEPVGEIVALGAGVRTRRLGD
RVGVPWLQLACGRCEWCRRGKALFCKDQQGTGVQTQGGHAEYMLAQAEATVLLPDALAYEQAASLFCAGYTVWAGLRFAD
PKPHERVAVLGIGGLGHLAVQYGKAAGFETFAITHSPSKEKLVRSLGADGVFPSGAALREAGGADVILACSNSYRATGEA
LQGLRPDGRLVLMGLPSDNQTLAVSGDLLVNRWRIIGSQQNGPEHLFEALDYAAKGKVKVVAETYSLDEINLAFDRVFSG
DVRFRAVIIP

Sequences:

>Translated_330_residues
MKAAVVPNLHGRWEIRDLPIPEPGINQVLIRIKASGLCYTDIHITEGAWPADSFPRTLGHEPVGEIVALGAGVRTRRLGD
RVGVPWLQLACGRCEWCRRGKALFCKDQQGTGVQTQGGHAEYMLAQAEATVLLPDALAYEQAASLFCAGYTVWAGLRFAD
PKPHERVAVLGIGGLGHLAVQYGKAAGFETFAITHSPSKEKLVRSLGADGVFPSGAALREAGGADVILACSNSYRATGEA
LQGLRPDGRLVLMGLPSDNQTLAVSGDLLVNRWRIIGSQQNGPEHLFEALDYAAKGKVKVVAETYSLDEINLAFDRVFSG
DVRFRAVIIP
>Mature_330_residues
MKAAVVPNLHGRWEIRDLPIPEPGINQVLIRIKASGLCYTDIHITEGAWPADSFPRTLGHEPVGEIVALGAGVRTRRLGD
RVGVPWLQLACGRCEWCRRGKALFCKDQQGTGVQTQGGHAEYMLAQAEATVLLPDALAYEQAASLFCAGYTVWAGLRFAD
PKPHERVAVLGIGGLGHLAVQYGKAAGFETFAITHSPSKEKLVRSLGADGVFPSGAALREAGGADVILACSNSYRATGEA
LQGLRPDGRLVLMGLPSDNQTLAVSGDLLVNRWRIIGSQQNGPEHLFEALDYAAKGKVKVVAETYSLDEINLAFDRVFSG
DVRFRAVIIP

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=27.3480662983425, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=27.1232876712329, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=27.6243093922652, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71743840, Length=207, Percent_Identity=28.0193236714976, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262073058, Length=207, Percent_Identity=28.0193236714976, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI156627571, Length=293, Percent_Identity=27.3037542662116, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=27.9569892473118, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=25.9776536312849, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.9776536312849, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87082125, Length=343, Percent_Identity=32.9446064139942, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=31.044776119403, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786518, Length=329, Percent_Identity=31.9148936170213, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI87082401, Length=328, Percent_Identity=30.7926829268293, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1790045, Length=324, Percent_Identity=28.0864197530864, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=31.25, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787863, Length=326, Percent_Identity=28.5276073619632, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788075, Length=314, Percent_Identity=26.4331210191083, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788073, Length=285, Percent_Identity=28.4210526315789, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=355, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=292, Percent_Identity=30.8219178082192, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=218, Percent_Identity=27.0642201834862, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=331, Percent_Identity=29.0030211480363, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562584, Length=328, Percent_Identity=29.5731707317073, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17562582, Length=338, Percent_Identity=28.698224852071, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=27.0029673590504, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=213, Percent_Identity=31.4553990610329, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=24.5989304812834, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=32.5443786982249, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=32.5443786982249, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=31.9526627218935, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=31.6568047337278, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323980, Length=329, Percent_Identity=28.2674772036474, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=342, Percent_Identity=27.1929824561404, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=26.0989010989011, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=24.0579710144928, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=345, Percent_Identity=24.0579710144928, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=24.5222929936306, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=27.2237196765499, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137530, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=196, Percent_Identity=30.1020408163265, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550770, Length=319, Percent_Identity=26.9592476489028, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551930, Length=319, Percent_Identity=26.9592476489028, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221457811, Length=319, Percent_Identity=26.9592476489028, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35449; Mature: 35449

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVPNLHGRWEIRDLPIPEPGINQVLIRIKASGLCYTDIHITEGAWPADSFPRTLGH
CCCEECCCCCCCEEEEECCCCCCCCCEEEEEEEECCEEEEEEEEECCCCCCCCCCHHCCC
EPVGEIVALGAGVRTRRLGDRVGVPWLQLACGRCEWCRRGKALFCKDQQGTGVQTQGGHA
CCHHHHHEECCCCHHHHCCCCCCCCHHHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCCE
EYMLAQAEATVLLPDALAYEQAASLFCAGYTVWAGLRFADPKPHERVAVLGIGGLGHLAV
EEEEEECCEEEECCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEECCHHHHHH
QYGKAAGFETFAITHSPSKEKLVRSLGADGVFPSGAALREAGGADVILACSNSYRATGEA
HHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHH
LQGLRPDGRLVLMGLPSDNQTLAVSGDLLVNRWRIIGSQQNGPEHLFEALDYAAKGKVKV
HHCCCCCCCEEEEECCCCCCEEEEECCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEE
VAETYSLDEINLAFDRVFSGDVRFRAVIIP
EEEEECCCCHHHHHHHEECCCEEEEEEEEC
>Mature Secondary Structure
MKAAVVPNLHGRWEIRDLPIPEPGINQVLIRIKASGLCYTDIHITEGAWPADSFPRTLGH
CCCEECCCCCCCEEEEECCCCCCCCCEEEEEEEECCEEEEEEEEECCCCCCCCCCHHCCC
EPVGEIVALGAGVRTRRLGDRVGVPWLQLACGRCEWCRRGKALFCKDQQGTGVQTQGGHA
CCHHHHHEECCCCHHHHCCCCCCCCHHHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCCE
EYMLAQAEATVLLPDALAYEQAASLFCAGYTVWAGLRFADPKPHERVAVLGIGGLGHLAV
EEEEEECCEEEECCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEECCHHHHHH
QYGKAAGFETFAITHSPSKEKLVRSLGADGVFPSGAALREAGGADVILACSNSYRATGEA
HHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHH
LQGLRPDGRLVLMGLPSDNQTLAVSGDLLVNRWRIIGSQQNGPEHLFEALDYAAKGKVKV
HHCCCCCCCEEEEECCCCCCEEEEECCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEE
VAETYSLDEINLAFDRVFSGDVRFRAVIIP
EEEEECCCCHHHHHHHEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]