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The map label for this gene is lpxD2

Identifier: 37522282

GI number: 37522282

Start: 2872251

End: 2873288

Strand: Direct

Name: lpxD2

Synonym: glr2713

Alternate gene names: 37522282

Gene position: 2872251-2873288 (Clockwise)

Preceding gene: 37522281

Following gene: 37522283

Centisome position: 61.65

GC content: 64.45

Gene sequence:

>1038_bases
ATGAAACTTGGGGAACTGGCGGCACACCTCGGTTGCCCGGTAGAGGGCAACCCGGATGTCGAAATTCGCGGTCTGGCCTC
GATCCAGCAGGCCGGGCCCGGCGAACTCAGCTTTATCGAAAGCGAAAAGTACGCGCGCTTTATCAAACTCACCCGCGCCG
AGGCGCTCATCCTCGACTGGCGCACCCCGGTCTCCAAGGTGCCCTGCATTCGCAGCGAGCAGCCGCGCCTCACGTTTGCC
CACGCCCTGGAACTGTTCTATCAGCCGCGCCGGCCGGCACCGGGCATTCACCCGACCGCCATTCTGGGTGCCAACGTCCA
ACTGGGCGAGAACGTACACCTGGGGGCCTACGTCGTCATTGGAGACGATGTCACGATCGGGCCTGAAGCTGTGATCTATC
CCAACTGCACGATCTACAACGACGTGCGCATCGGGGTGCGCACGGTTGTTCATGCCAACTGCGTCCTCCACGAGCGCACC
AAAATCGGTGACGAGTGCATCGTCCAGTCCGGGGCGGTGGTGGGTGGCGAAGGGTTTGGTTTTGTTCCGACCCCCGAGGG
CACCTGGCACAAGATGCCCCAATCGGGCTACGTGCGCGTCGAAGATCAAGTCGAAATCGGCTCCAACGCTGCCATCGACC
GGCCCTCGGTCGGTTTTACCCACATCGGCCGGGGCACCAAAATTGACAACCTGGTGATGGTGGGCCACGGCTGCGAGATC
GGCGAGCACTGCCTGCTGGTGGGCCAGGTGGGCCTCGCGGGCGGCGTCAAACTCGGCCGCAATGTCGTGCTGGCCGGGCA
GGTGGGAGTGGCCGGTCACGCCGCGATCGGCGATCGCACCGTGGTCTCGGCCCAAAGCGGCATCCCAAGCGATGTGGAGC
CGGGGACCGTCGTCTCCGGTTCCCCGGCCCTGCCCCACGCCCTGTGGCTGCGCACCTCGGCGCTCATCCGCAGGTTGCCG
GAACTGTTTCAAAACCTGCGCGATTTGCAGCGCAAAGTCGCTTTGTTGCAGCAGCGGCTCGATTCCGGCCACCACTGA

Upstream 100 bases:

>100_bases
GCGGCGACTCTGGCCGGCAGCCAGCCGGCCTGATCGCCGGATGCTTGCGGTTGTCGGCTCGAATACGGCACAATTCCCCT
GAGCACCACACAACAGCGCG

Downstream 100 bases:

>100_bases
GAATGTGCTAGTTTCAGGGATGTTTGCGGCCCGGACCGATGGTTGAACCCAAGGACGAACCTTCCAAGGAGCCAATGTTT
GGCTTCACCCCCTTCGCCGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKLGELAAHLGCPVEGNPDVEIRGLASIQQAGPGELSFIESEKYARFIKLTRAEALILDWRTPVSKVPCIRSEQPRLTFA
HALELFYQPRRPAPGIHPTAILGANVQLGENVHLGAYVVIGDDVTIGPEAVIYPNCTIYNDVRIGVRTVVHANCVLHERT
KIGDECIVQSGAVVGGEGFGFVPTPEGTWHKMPQSGYVRVEDQVEIGSNAAIDRPSVGFTHIGRGTKIDNLVMVGHGCEI
GEHCLLVGQVGLAGGVKLGRNVVLAGQVGVAGHAAIGDRTVVSAQSGIPSDVEPGTVVSGSPALPHALWLRTSALIRRLP
ELFQNLRDLQRKVALLQQRLDSGHH

Sequences:

>Translated_345_residues
MKLGELAAHLGCPVEGNPDVEIRGLASIQQAGPGELSFIESEKYARFIKLTRAEALILDWRTPVSKVPCIRSEQPRLTFA
HALELFYQPRRPAPGIHPTAILGANVQLGENVHLGAYVVIGDDVTIGPEAVIYPNCTIYNDVRIGVRTVVHANCVLHERT
KIGDECIVQSGAVVGGEGFGFVPTPEGTWHKMPQSGYVRVEDQVEIGSNAAIDRPSVGFTHIGRGTKIDNLVMVGHGCEI
GEHCLLVGQVGLAGGVKLGRNVVLAGQVGVAGHAAIGDRTVVSAQSGIPSDVEPGTVVSGSPALPHALWLRTSALIRRLP
ELFQNLRDLQRKVALLQQRLDSGHH
>Mature_345_residues
MKLGELAAHLGCPVEGNPDVEIRGLASIQQAGPGELSFIESEKYARFIKLTRAEALILDWRTPVSKVPCIRSEQPRLTFA
HALELFYQPRRPAPGIHPTAILGANVQLGENVHLGAYVVIGDDVTIGPEAVIYPNCTIYNDVRIGVRTVVHANCVLHERT
KIGDECIVQSGAVVGGEGFGFVPTPEGTWHKMPQSGYVRVEDQVEIGSNAAIDRPSVGFTHIGRGTKIDNLVMVGHGCEI
GEHCLLVGQVGLAGGVKLGRNVVLAGQVGVAGHAAIGDRTVVSAQSGIPSDVEPGTVVSGSPALPHALWLRTSALIRRLP
ELFQNLRDLQRKVALLQQRLDSGHH

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=335, Percent_Identity=33.7313432835821, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786378, Length=232, Percent_Identity=26.7241379310345, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD2_GLOVI (Q7NH24)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925659.1
- ProteinModelPortal:   Q7NH24
- SMR:   Q7NH24
- GeneID:   2601114
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2713
- NMPDR:   fig|251221.1.peg.2713
- HOGENOM:   HBG469615
- OMA:   TIHASTV
- BioCyc:   GVIO251221:GLR2713-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36899; Mature: 36899

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGELAAHLGCPVEGNPDVEIRGLASIQQAGPGELSFIESEKYARFIKLTRAEALILDW
CCHHHHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCEEEECHHHHHHHHHHHCCEEEEEEC
RTPVSKVPCIRSEQPRLTFAHALELFYQPRRPAPGIHPTAILGANVQLGENVHLGAYVVI
CCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEECCCEEEEEEEEE
GDDVTIGPEAVIYPNCTIYNDVRIGVRTVVHANCVLHERTKIGDECIVQSGAVVGGEGFG
CCCEEECCCEEECCCCEEEECCEEEEEEEEEEEEEEEHHHCCCCHHHHCCCCEECCCCCC
FVPTPEGTWHKMPQSGYVRVEDQVEIGSNAAIDRPSVGFTHIGRGTKIDNLVMVGHGCEI
CCCCCCCCHHCCCCCCCEEEECEEECCCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCC
GEHCLLVGQVGLAGGVKLGRNVVLAGQVGVAGHAAIGDRTVVSAQSGIPSDVEPGTVVSG
CCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECC
SPALPHALWLRTSALIRRLPELFQNLRDLQRKVALLQQRLDSGHH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLGELAAHLGCPVEGNPDVEIRGLASIQQAGPGELSFIESEKYARFIKLTRAEALILDW
CCHHHHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCEEEECHHHHHHHHHHHCCEEEEEEC
RTPVSKVPCIRSEQPRLTFAHALELFYQPRRPAPGIHPTAILGANVQLGENVHLGAYVVI
CCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEECCCEEEEEEEEE
GDDVTIGPEAVIYPNCTIYNDVRIGVRTVVHANCVLHERTKIGDECIVQSGAVVGGEGFG
CCCEEECCCEEECCCCEEEECCEEEEEEEEEEEEEEEHHHCCCCHHHHCCCCEECCCCCC
FVPTPEGTWHKMPQSGYVRVEDQVEIGSNAAIDRPSVGFTHIGRGTKIDNLVMVGHGCEI
CCCCCCCCHHCCCCCCCEEEECEEECCCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCC
GEHCLLVGQVGLAGGVKLGRNVVLAGQVGVAGHAAIGDRTVVSAQSGIPSDVEPGTVVSG
CCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECC
SPALPHALWLRTSALIRRLPELFQNLRDLQRKVALLQQRLDSGHH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292