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The map label for this gene is desA [H]

Identifier: 37522192

GI number: 37522192

Start: 2779580

End: 2780638

Strand: Direct

Name: desA [H]

Synonym: gvip364

Alternate gene names: 37522192

Gene position: 2779580-2780638 (Clockwise)

Preceding gene: 37522188

Following gene: 37522193

Centisome position: 59.66

GC content: 60.06

Gene sequence:

>1059_bases
ATGGTACAGCGACAGAGCTTCGAGGGGACAGGCCGCGACCTGGACCGTCAACGGATTGCCGCCCTGGAAAAACAGGCTTC
CCTCGGCGATGTCATCCAGACCATACCCAAAGACTGTTTTCGGATCAGCCCGGCAAAAGCCTGGGCAAGATTGGTTGTCA
ATGTGCTGCTGGTTGTCTTAGGCTACGCGGCTCTTGCTCTCAACCCCTGGTGGTGGCTGTTGCCGGCTCTATGGATTTTC
ACCGGCACGGCACTGACGGGCTTTTTCGTCATCGCCCACGACTGCGGCCACCGCAGCTTCTCGACGCGGCGGCGCATCAA
CGACATCGTCGGGCATGTGATGCTCTTGCCGTTGCTCTATCCGTTCCATGGCTGGCGGATCAAGCACAACCAGCACCACA
CCTTCACCAATCAGATCGAGATGGACAATGCCTGGCGGCCGATGTCGGTGGCGGAGTACCGCGCGCTTTCGCCGGGGGTG
CGGGCAGGCTATCGCTTTGCCCGCGGCATCGGTTGGTGGTTCGCCTCGGCGGTGCACCAGCTCAACCTGCACTTCAAGCC
GTCGCTATTCAAGCCCAAGGACCGAGCCGATATCCGGCTCTCATCCACGGCAGTGATTGCCTTTGCCTGCGTGTTGTTTC
CGGCCCTACTGTGGATGGGCGGCCCCTGGGCGGTCATCCAGTTCTGGCTGATGCCCTGGCTGGTCTATCACTTCTGGATG
AGCACCTTTACGCTCGTCCACCACACCCACCCGGACATTCCTTTTTATCCCGCCGCCACCTGGACGCCGGTGACCGGTCA
GCTGTTTTCGACTATCCACTGCGTCTACCCGGCCTGGGTCGAATTTCTCTGCCACGATATCAACGTCCACATTCCCCACC
ATGTCTCGACGGCGATCCCGAGCTACAACCTCAGAAAAGCGCACACCGCCCTCAAGGCGCACTGGTCGGACTACATGCAC
GAGACCGAATTTTCCTGGTCGCTGATGCGTTCGATCACCCGCGAGTGCCACCTGCGCGATGAAACGGGCTACTACCTGCC
CTGCCGAGAAGTAGATTAA

Upstream 100 bases:

>100_bases
GGCGGTCCTTAGCGAGCGATCCCGGGAGGCACTCTCCAGACGTGGGCTTGGGGCTTCCCGGATCCGCCTTGCGAGGGGTG
AACATTCAGTAGGAGCCCGC

Downstream 100 bases:

>100_bases
GCTCTCCTACGATCCAGCACCTTAATCTGATAGTTGATCGGGCGATCTGGATGTGGACTTCAGAGACTTTTGCTTAGATT
GACTTCCTCGCAGCATGCTG

Product: delta 12 acyl-lipid desaturase

Products: NA

Alternate protein names: Delta(12) desaturase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MVQRQSFEGTGRDLDRQRIAALEKQASLGDVIQTIPKDCFRISPAKAWARLVVNVLLVVLGYAALALNPWWWLLPALWIF
TGTALTGFFVIAHDCGHRSFSTRRRINDIVGHVMLLPLLYPFHGWRIKHNQHHTFTNQIEMDNAWRPMSVAEYRALSPGV
RAGYRFARGIGWWFASAVHQLNLHFKPSLFKPKDRADIRLSSTAVIAFACVLFPALLWMGGPWAVIQFWLMPWLVYHFWM
STFTLVHHTHPDIPFYPAATWTPVTGQLFSTIHCVYPAWVEFLCHDINVHIPHHVSTAIPSYNLRKAHTALKAHWSDYMH
ETEFSWSLMRSITRECHLRDETGYYLPCREVD

Sequences:

>Translated_352_residues
MVQRQSFEGTGRDLDRQRIAALEKQASLGDVIQTIPKDCFRISPAKAWARLVVNVLLVVLGYAALALNPWWWLLPALWIF
TGTALTGFFVIAHDCGHRSFSTRRRINDIVGHVMLLPLLYPFHGWRIKHNQHHTFTNQIEMDNAWRPMSVAEYRALSPGV
RAGYRFARGIGWWFASAVHQLNLHFKPSLFKPKDRADIRLSSTAVIAFACVLFPALLWMGGPWAVIQFWLMPWLVYHFWM
STFTLVHHTHPDIPFYPAATWTPVTGQLFSTIHCVYPAWVEFLCHDINVHIPHHVSTAIPSYNLRKAHTALKAHWSDYMH
ETEFSWSLMRSITRECHLRDETGYYLPCREVD
>Mature_352_residues
MVQRQSFEGTGRDLDRQRIAALEKQASLGDVIQTIPKDCFRISPAKAWARLVVNVLLVVLGYAALALNPWWWLLPALWIF
TGTALTGFFVIAHDCGHRSFSTRRRINDIVGHVMLLPLLYPFHGWRIKHNQHHTFTNQIEMDNAWRPMSVAEYRALSPGV
RAGYRFARGIGWWFASAVHQLNLHFKPSLFKPKDRADIRLSSTAVIAFACVLFPALLWMGGPWAVIQFWLMPWLVYHFWM
STFTLVHHTHPDIPFYPAATWTPVTGQLFSTIHCVYPAWVEFLCHDINVHIPHHVSTAIPSYNLRKAHTALKAHWSDYMH
ETEFSWSLMRSITRECHLRDETGYYLPCREVD

Specific function: Can introduce a second cis double bond at the Delta(12) position of fatty acid bound to membranes glycerolipids. This enzyme is involved in chilling tolerance because the phase transition temperature of lipids of cellular membranes depends on the degree o

COG id: COG3239

COG function: function code I; Fatty acid desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fatty acid desaturase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17542730, Length=342, Percent_Identity=26.9005847953216, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71999459, Length=288, Percent_Identity=28.125, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005804
- InterPro:   IPR005803 [H]

Pfam domain/function: PF00487 FA_desaturase [H]

EC number: 1.14.99.-

Molecular weight: Translated: 40797; Mature: 40797

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQRQSFEGTGRDLDRQRIAALEKQASLGDVIQTIPKDCFRISPAKAWARLVVNVLLVVL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GYAALALNPWWWLLPALWIFTGTALTGFFVIAHDCGHRSFSTRRRINDIVGHVMLLPLLY
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
PFHGWRIKHNQHHTFTNQIEMDNAWRPMSVAEYRALSPGVRAGYRFARGIGWWFASAVHQ
CCCCEEEECCCCCCCCCEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LNLHFKPSLFKPKDRADIRLSSTAVIAFACVLFPALLWMGGPWAVIQFWLMPWLVYHFWM
HCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
STFTLVHHTHPDIPFYPAATWTPVTGQLFSTIHCVYPAWVEFLCHDINVHIPHHVSTAIP
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHCC
SYNLRKAHTALKAHWSDYMHETEFSWSLMRSITRECHLRDETGYYLPCREVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
>Mature Secondary Structure
MVQRQSFEGTGRDLDRQRIAALEKQASLGDVIQTIPKDCFRISPAKAWARLVVNVLLVVL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GYAALALNPWWWLLPALWIFTGTALTGFFVIAHDCGHRSFSTRRRINDIVGHVMLLPLLY
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
PFHGWRIKHNQHHTFTNQIEMDNAWRPMSVAEYRALSPGVRAGYRFARGIGWWFASAVHQ
CCCCEEEECCCCCCCCCEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LNLHFKPSLFKPKDRADIRLSSTAVIAFACVLFPALLWMGGPWAVIQFWLMPWLVYHFWM
HCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
STFTLVHHTHPDIPFYPAATWTPVTGQLFSTIHCVYPAWVEFLCHDINVHIPHHVSTAIP
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHCC
SYNLRKAHTALKAHWSDYMHETEFSWSLMRSITRECHLRDETGYYLPCREVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118597; 8905231 [H]