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The map label for this gene is guaA

Identifier: 37522184

GI number: 37522184

Start: 2768893

End: 2770548

Strand: Direct

Name: guaA

Synonym: gvip362

Alternate gene names: 37522184

Gene position: 2768893-2770548 (Clockwise)

Preceding gene: 37522183

Following gene: 37522187

Centisome position: 59.43

GC content: 63.95

Gene sequence:

>1656_bases
ATGACCTCCAGCCCGACCGCCGCTGCACGGACCGAAGGGGAAGCCGCCCCCACCGTGCCGACCCAGGTCGAAAGCGGAAC
CGCCCAGCGCCCTGGGCTCGCCCGCGAGATGGTCGCGATCCTCGATTTCGGTTCGCAGTACTCGGAGTTGATCGCCCGCC
GCATCCGCGAGACCAAAGTCTACTCCGAGGTGCTGAGCTACCAGACGCCAATCGCCGAAATCCGGCGCCTGGCCCCCAAG
GGGATCATCCTCTCCGGCGGTCCCAATTCGGTCTACGAGGCCTACGCGCCCCAGTGCGATCCGGCCCTGTGGGAGCTGGG
CATTCCGATCTTGGGCGTCTGCTACGGGATGCAACTGATGGTCCAGCAATTGGGCGGGGCGGTCGAGCGGGCTGAGCGGG
CCGAGTACGGCAAAGCTTCGCTGTTTATCAACGATCCGACGGACCTGTTCACCAACGTCGAAGACGGCACCACCATGTGG
ATGAGCCACGCCGACTCGGTCCTGCGGATGCCCGAGGGTTTTGAGCTGTTGGCCCACACCGAGAACACCCCCTGCGCCGC
CATCGCCCACCACAGCCGCCACCTCTACGGTGTGCAGTTCCACCCGGAGGTGGTCCACTCGCGCGGCGGCATGGCCCTGT
TGCGCAACTTCGTCTACCACATCTGCGGCTGCGAACCCGAGTGGACGACCGCCGCCTTTATCGAGGAGGCGATCCGCGAG
GTGCGCGCCCGGGTGGGCGACAAACGGGTGTTACTCGCCCTTTCCGGCGGGGTCGATTCTTCGACGCTCGCCTTTTTGCT
GCACCGGGCGATCGGCGACAACTTGACGTGTATGTTCATCGACCAGGGCTTCATGCGCAAGAACGAGCCCGAGCGGTTGG
TCAAGCTTTTCAAAGAACAGTTCCACATCCCGGTGGCCTACGTCGATGCGGCCGAGCGCTTTATTGTCCGGCTGGAGGGG
GTGAGCGACCCAGAGCAAAAGCGCAAGATTATCGGCGCCGAATTTATCCGGGTATTCGAGTCGGAGTCCCAGCGGCTCGG
GCCTTTTGACTATCTGGCCCAGGGCACGCTCTATCCCGACATCATCGAGTCGGCGGGCGAAAATATCGACCCGAAGACCG
GCGAGCGGGTGGCCGTCAAGATCAAATCCCACCACAACGTCGGCGGCTTGCCCGAAAATTTGCGCTTCAAGCTGGTCGAA
CCGCTCAAGCGACTCTTCAAAGACGAAGTGCGCCAGGTGGGCCGCGCCCTGGGGCTGCCGGAGGAAATCGTCCAGCGCCA
GCCTTTTCCAGGACCGGGTCTTGCCATCCGTGTGCTGGGAGAACTCACCAAGGACAAAGTCGACATCCTGCGCGAGGCCG
ACTTCATCTTGCGCCAGGAAGTGAACCGCTCCGGCCGCTACAACGACTACTGGCAGTCGTTTGCGGTGCTGCTGCCGGTC
AAGACCGTGGGGGTGATGGGCGACCGGCGCACCTACGCCTACGCCCTCGCCCTGCGCTTTGTGACCAGCGAAGACGGCAT
GACCGCCGACTGGGCGCGGGTTCCCTACGACCTGCTGGAGCAAATCGCCAACCGCATCGTCAACGAGGTGCCGGGCATCA
ACCGGGTGGTGCTGGACATCACCTCCAAGCCGCCCGGCACGATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CGTGTCGCCCGCGGTGCGGACAGATCCGGGTACGGCTTTTCACAATCGGGCCAACCAGTCGCTATGATGTGCTGAATAAT
CTTTCGGTGAGCGCACTACC

Downstream 100 bases:

>100_bases
GGTTTCAACCCAGGGCATCGGGATCGATGCCCCGAGAGCGCAGGTAGTCGGCGAGCCGTTCGGCCCGTTGGCGCTCCTGT
TCGGCGCGTTGCCGTTCTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTSSPTAAARTEGEAAPTVPTQVESGTAQRPGLAREMVAILDFGSQYSELIARRIRETKVYSEVLSYQTPIAEIRRLAPK
GIILSGGPNSVYEAYAPQCDPALWELGIPILGVCYGMQLMVQQLGGAVERAERAEYGKASLFINDPTDLFTNVEDGTTMW
MSHADSVLRMPEGFELLAHTENTPCAAIAHHSRHLYGVQFHPEVVHSRGGMALLRNFVYHICGCEPEWTTAAFIEEAIRE
VRARVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKNEPERLVKLFKEQFHIPVAYVDAAERFIVRLEG
VSDPEQKRKIIGAEFIRVFESESQRLGPFDYLAQGTLYPDIIESAGENIDPKTGERVAVKIKSHHNVGGLPENLRFKLVE
PLKRLFKDEVRQVGRALGLPEEIVQRQPFPGPGLAIRVLGELTKDKVDILREADFILRQEVNRSGRYNDYWQSFAVLLPV
KTVGVMGDRRTYAYALALRFVTSEDGMTADWARVPYDLLEQIANRIVNEVPGINRVVLDITSKPPGTIEWE

Sequences:

>Translated_551_residues
MTSSPTAAARTEGEAAPTVPTQVESGTAQRPGLAREMVAILDFGSQYSELIARRIRETKVYSEVLSYQTPIAEIRRLAPK
GIILSGGPNSVYEAYAPQCDPALWELGIPILGVCYGMQLMVQQLGGAVERAERAEYGKASLFINDPTDLFTNVEDGTTMW
MSHADSVLRMPEGFELLAHTENTPCAAIAHHSRHLYGVQFHPEVVHSRGGMALLRNFVYHICGCEPEWTTAAFIEEAIRE
VRARVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKNEPERLVKLFKEQFHIPVAYVDAAERFIVRLEG
VSDPEQKRKIIGAEFIRVFESESQRLGPFDYLAQGTLYPDIIESAGENIDPKTGERVAVKIKSHHNVGGLPENLRFKLVE
PLKRLFKDEVRQVGRALGLPEEIVQRQPFPGPGLAIRVLGELTKDKVDILREADFILRQEVNRSGRYNDYWQSFAVLLPV
KTVGVMGDRRTYAYALALRFVTSEDGMTADWARVPYDLLEQIANRIVNEVPGINRVVLDITSKPPGTIEWE
>Mature_550_residues
TSSPTAAARTEGEAAPTVPTQVESGTAQRPGLAREMVAILDFGSQYSELIARRIRETKVYSEVLSYQTPIAEIRRLAPKG
IILSGGPNSVYEAYAPQCDPALWELGIPILGVCYGMQLMVQQLGGAVERAERAEYGKASLFINDPTDLFTNVEDGTTMWM
SHADSVLRMPEGFELLAHTENTPCAAIAHHSRHLYGVQFHPEVVHSRGGMALLRNFVYHICGCEPEWTTAAFIEEAIREV
RARVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKNEPERLVKLFKEQFHIPVAYVDAAERFIVRLEGV
SDPEQKRKIIGAEFIRVFESESQRLGPFDYLAQGTLYPDIIESAGENIDPKTGERVAVKIKSHHNVGGLPENLRFKLVEP
LKRLFKDEVRQVGRALGLPEEIVQRQPFPGPGLAIRVLGELTKDKVDILREADFILRQEVNRSGRYNDYWQSFAVLLPVK
TVGVMGDRRTYAYALALRFVTSEDGMTADWARVPYDLLEQIANRIVNEVPGINRVVLDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=551, Percent_Identity=39.0199637023593, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1788854, Length=527, Percent_Identity=50.0948766603416, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1789760, Length=151, Percent_Identity=34.4370860927152, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787517, Length=207, Percent_Identity=26.5700483091787, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=37.5874125874126, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=37.5874125874126, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=37.5874125874126, Blast_Score=322, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=48.7571701720841, Blast_Score=512, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322638, Length=151, Percent_Identity=31.1258278145695, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281365319, Length=568, Percent_Identity=37.6760563380282, Blast_Score=325, Evalue=6e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_GLOVI (Q7NHC2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925561.1
- ProteinModelPortal:   Q7NHC2
- SMR:   Q7NHC2
- GeneID:   2601016
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2615
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BioCyc:   GVIO251221:GLR2615-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 61533; Mature: 61402

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 114-114 ACT_SITE 201-201 ACT_SITE 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPTAAARTEGEAAPTVPTQVESGTAQRPGLAREMVAILDFGSQYSELIARRIRETKV
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YSEVLSYQTPIAEIRRLAPKGIILSGGPNSVYEAYAPQCDPALWELGIPILGVCYGMQLM
HHHHHHCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHH
VQQLGGAVERAERAEYGKASLFINDPTDLFTNVEDGTTMWMSHADSVLRMPEGFELLAHT
HHHHCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
ENTPCAAIAHHSRHLYGVQFHPEVVHSRGGMALLRNFVYHICGCEPEWTTAAFIEEAIRE
CCCCHHHHHHCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VRARVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKNEPERLVKLFKEQ
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHH
FHIPVAYVDAAERFIVRLEGVSDPEQKRKIIGAEFIRVFESESQRLGPFDYLAQGTLYPD
HCCCEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHH
IIESAGENIDPKTGERVAVKIKSHHNVGGLPENLRFKLVEPLKRLFKDEVRQVGRALGLP
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EEIVQRQPFPGPGLAIRVLGELTKDKVDILREADFILRQEVNRSGRYNDYWQSFAVLLPV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KTVGVMGDRRTYAYALALRFVTSEDGMTADWARVPYDLLEQIANRIVNEVPGINRVVLDI
HHHHCCCCCHHHHHHHHHHHEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEE
TSKPPGTIEWE
CCCCCCCCCCC
>Mature Secondary Structure 
TSSPTAAARTEGEAAPTVPTQVESGTAQRPGLAREMVAILDFGSQYSELIARRIRETKV
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YSEVLSYQTPIAEIRRLAPKGIILSGGPNSVYEAYAPQCDPALWELGIPILGVCYGMQLM
HHHHHHCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHH
VQQLGGAVERAERAEYGKASLFINDPTDLFTNVEDGTTMWMSHADSVLRMPEGFELLAHT
HHHHCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
ENTPCAAIAHHSRHLYGVQFHPEVVHSRGGMALLRNFVYHICGCEPEWTTAAFIEEAIRE
CCCCHHHHHHCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VRARVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKNEPERLVKLFKEQ
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHH
FHIPVAYVDAAERFIVRLEGVSDPEQKRKIIGAEFIRVFESESQRLGPFDYLAQGTLYPD
HCCCEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHH
IIESAGENIDPKTGERVAVKIKSHHNVGGLPENLRFKLVEPLKRLFKDEVRQVGRALGLP
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EEIVQRQPFPGPGLAIRVLGELTKDKVDILREADFILRQEVNRSGRYNDYWQSFAVLLPV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KTVGVMGDRRTYAYALALRFVTSEDGMTADWARVPYDLLEQIANRIVNEVPGINRVVLDI
HHHHCCCCCHHHHHHHHHHHEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEE
TSKPPGTIEWE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292