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The map label for this gene is ndhD [H]

Identifier: 37522105

GI number: 37522105

Start: 2689622

End: 2691118

Strand: Reverse

Name: ndhD [H]

Synonym: gvip348

Alternate gene names: 37522105

Gene position: 2691118-2689622 (Counterclockwise)

Preceding gene: 37522106

Following gene: 37522104

Centisome position: 57.76

GC content: 61.32

Gene sequence:

>1497_bases
ATGAGTGTGCCCTGGCTCAGTCTGATCCTCTTCTTTCCCACCCTGGGGGCTTTGGGTCTGGCCCTGCTCCCGGGCGAGGT
GAGCTACCGCTTCGCCCGCGTCTGGGCACTGACGGTGGCCGGACTGACCTTTTTGCTGAGCGGTCTGGTGGCCTACAACT
TCGACTACACCAGCACCAAGCCCCAATTTGCCGAGACCATCAACTGGTTGCCGCAGTTGGGGATTAGCTACAACATCGCG
GTGGACGGCCTCAGCCTGCCGCTGGTGCTGCTGACGGGTCTATTGGTGGTGCTGTCGATCCTGACCAGTTGGGAGCTCAA
CAAGCGCGCCCGCCTCTACTATGTCCTGATTTTGCTGCTGAGCACCGGTGTGCTGGGAGCCTTTATGGCCCGAGACACCA
TCTTGTTCTTCCTGGCCTACGAGATGGAACTCATCCCGCTGTACTTTCTCATCAGCATCTGGGGCGGCAAGCGGCGCGAG
TACGCGGGCACCAAGTTCCTGCTCTACACGTTTTTGTCGGGCGTGGCGCTATTGGTCGCTTTCTTGAGCACTTACTTCTT
CTCCGGGGTCAACAGCTTCAGTATCGACGTGCTGGCCAACCCCGCCACGCCCTATCCGCTCGCCTTCCAGTTCATCACCC
TGGGGCTCATCACCTTAGGTTTCGCCATCAAGATGCCCCTGGTGCCCTTGCACACCTGGCTTCCTGACGCCCACGTCGAG
GCGCCCACGGCGGTCTCGGTGCTGCTGGCGGGGGTCTTGCTCAAGCTCGGCACCTACGGCATCGTCCGCTTCGGCCTCGG
GATCTTCCCGGAGGCGGCCGTCCAGTTCGCCTGGCTCCTCTCGGTGCTCGCCGCCATCAACGTCGTCTATGCTTCGCTCG
CGGCGATGGCTCAGACCGATATCAAAAAGATGATCGCCTACAGTTCGATCGCCCACATGGGCTATGTGGTGCTGGGCATC
GCCTCGCTCAACGAAACCGGCCTGGGCGGTGCAATGTTCCAGATGATTAGCCACGGCATCATCTCGGGACTGTTGTTCAT
GTTGGTGGGTCTGATCTACGAAAAATCCGGCACCCGCGAACTGCCCAAGCTTGGGGGGCTGTTTGCCACCATGCCGGTAG
TGGGTGCCTTCTTCGTAGGGGCGGCGATGGCGAATGCGGGACTACCCGGCATGAGCGGCTTCGTGGCCGAATTTATGGTC
TTCTGCGGCGGCATCGAGCGCTACCCGGTGGCGACGGTGCTCTGCATCTTCGGCATCGTGCTCACCGCCATCTACATGCT
CGCGATGCTGGCGCGTGCCTTCTTCGGCAAGCTACCCGCCAATCTGGAGACCATGCCCCGCGTCAAAGCCTGGGAGCTGA
TCCCGGCCACGGTGCTTCTGGTCATCTGCGTCGGTCTGGGGCTGTTCCCGACCCTCGCCACAGGCATCTTCGAGCCGAAC
GTGGCCCAACTGGTGCAGCAACTTGATGCCAAGACCGTTGCTCAGATACCGCGCTAA

Upstream 100 bases:

>100_bases
AACCAGAGGCTCAAAGTGACCGAGACAGAGCCGCCAAAGCCGGAGATCCAGCCCCCGGCCCCCGCCCCCAAACTTTCACC
GAAAACGGAGTAAGCCCGCG

Downstream 100 bases:

>100_bases
ATCGTTGAGATAGACGCACCGCATCCAGGCAAAAGCAACTACCTGGATGCTTTGGTTTCCTTGAGGCCAATCTTTCGGAA
ATAGCCAATAAGCCTGAGGA

Product: NADH dehydrogenase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 2; NDH-1, chain 4 2 [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSVPWLSLILFFPTLGALGLALLPGEVSYRFARVWALTVAGLTFLLSGLVAYNFDYTSTKPQFAETINWLPQLGISYNIA
VDGLSLPLVLLTGLLVVLSILTSWELNKRARLYYVLILLLSTGVLGAFMARDTILFFLAYEMELIPLYFLISIWGGKRRE
YAGTKFLLYTFLSGVALLVAFLSTYFFSGVNSFSIDVLANPATPYPLAFQFITLGLITLGFAIKMPLVPLHTWLPDAHVE
APTAVSVLLAGVLLKLGTYGIVRFGLGIFPEAAVQFAWLLSVLAAINVVYASLAAMAQTDIKKMIAYSSIAHMGYVVLGI
ASLNETGLGGAMFQMISHGIISGLLFMLVGLIYEKSGTRELPKLGGLFATMPVVGAFFVGAAMANAGLPGMSGFVAEFMV
FCGGIERYPVATVLCIFGIVLTAIYMLAMLARAFFGKLPANLETMPRVKAWELIPATVLLVICVGLGLFPTLATGIFEPN
VAQLVQQLDAKTVAQIPR

Sequences:

>Translated_498_residues
MSVPWLSLILFFPTLGALGLALLPGEVSYRFARVWALTVAGLTFLLSGLVAYNFDYTSTKPQFAETINWLPQLGISYNIA
VDGLSLPLVLLTGLLVVLSILTSWELNKRARLYYVLILLLSTGVLGAFMARDTILFFLAYEMELIPLYFLISIWGGKRRE
YAGTKFLLYTFLSGVALLVAFLSTYFFSGVNSFSIDVLANPATPYPLAFQFITLGLITLGFAIKMPLVPLHTWLPDAHVE
APTAVSVLLAGVLLKLGTYGIVRFGLGIFPEAAVQFAWLLSVLAAINVVYASLAAMAQTDIKKMIAYSSIAHMGYVVLGI
ASLNETGLGGAMFQMISHGIISGLLFMLVGLIYEKSGTRELPKLGGLFATMPVVGAFFVGAAMANAGLPGMSGFVAEFMV
FCGGIERYPVATVLCIFGIVLTAIYMLAMLARAFFGKLPANLETMPRVKAWELIPATVLLVICVGLGLFPTLATGIFEPN
VAQLVQQLDAKTVAQIPR
>Mature_497_residues
SVPWLSLILFFPTLGALGLALLPGEVSYRFARVWALTVAGLTFLLSGLVAYNFDYTSTKPQFAETINWLPQLGISYNIAV
DGLSLPLVLLTGLLVVLSILTSWELNKRARLYYVLILLLSTGVLGAFMARDTILFFLAYEMELIPLYFLISIWGGKRREY
AGTKFLLYTFLSGVALLVAFLSTYFFSGVNSFSIDVLANPATPYPLAFQFITLGLITLGFAIKMPLVPLHTWLPDAHVEA
PTAVSVLLAGVLLKLGTYGIVRFGLGIFPEAAVQFAWLLSVLAAINVVYASLAAMAQTDIKKMIAYSSIAHMGYVVLGIA
SLNETGLGGAMFQMISHGIISGLLFMLVGLIYEKSGTRELPKLGGLFATMPVVGAFFVGAAMANAGLPGMSGFVAEFMVF
CGGIERYPVATVLCIFGIVLTAIYMLAMLARAFFGKLPANLETMPRVKAWELIPATVLLVICVGLGLFPTLATGIFEPNV
AQLVQQLDAKTVAQIPR

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=340, Percent_Identity=34.1176470588235, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI251831117, Length=382, Percent_Identity=26.4397905759162, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788613, Length=488, Percent_Identity=40.7786885245902, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI1788827, Length=286, Percent_Identity=28.3216783216783, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788831, Length=190, Percent_Identity=35.7894736842105, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788614, Length=475, Percent_Identity=25.4736842105263, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788829, Length=415, Percent_Identity=27.2289156626506, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693160, Length=355, Percent_Identity=28.4507042253521, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI2367154, Length=341, Percent_Identity=24.9266862170088, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53770; Mature: 53639

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPWLSLILFFPTLGALGLALLPGEVSYRFARVWALTVAGLTFLLSGLVAYNFDYTSTK
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PQFAETINWLPQLGISYNIAVDGLSLPLVLLTGLLVVLSILTSWELNKRARLYYVLILLL
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
STGVLGAFMARDTILFFLAYEMELIPLYFLISIWGGKRREYAGTKFLLYTFLSGVALLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHH
FLSTYFFSGVNSFSIDVLANPATPYPLAFQFITLGLITLGFAIKMPLVPLHTWLPDAHVE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
APTAVSVLLAGVLLKLGTYGIVRFGLGIFPEAAVQFAWLLSVLAAINVVYASLAAMAQTD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKMIAYSSIAHMGYVVLGIASLNETGLGGAMFQMISHGIISGLLFMLVGLIYEKSGTRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPKLGGLFATMPVVGAFFVGAAMANAGLPGMSGFVAEFMVFCGGIERYPVATVLCIFGIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTAIYMLAMLARAFFGKLPANLETMPRVKAWELIPATVLLVICVGLGLFPTLATGIFEPN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VAQLVQQLDAKTVAQIPR
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVPWLSLILFFPTLGALGLALLPGEVSYRFARVWALTVAGLTFLLSGLVAYNFDYTSTK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PQFAETINWLPQLGISYNIAVDGLSLPLVLLTGLLVVLSILTSWELNKRARLYYVLILLL
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
STGVLGAFMARDTILFFLAYEMELIPLYFLISIWGGKRREYAGTKFLLYTFLSGVALLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHH
FLSTYFFSGVNSFSIDVLANPATPYPLAFQFITLGLITLGFAIKMPLVPLHTWLPDAHVE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
APTAVSVLLAGVLLKLGTYGIVRFGLGIFPEAAVQFAWLLSVLAAINVVYASLAAMAQTD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKMIAYSSIAHMGYVVLGIASLNETGLGGAMFQMISHGIISGLLFMLVGLIYEKSGTRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPKLGGLFATMPVVGAFFVGAAMANAGLPGMSGFVAEFMVFCGGIERYPVATVLCIFGIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTAIYMLAMLARAFFGKLPANLETMPRVKAWELIPATVLLVICVGLGLFPTLATGIFEPN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VAQLVQQLDAKTVAQIPR
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA